LOCUS       NP_001102107            1520 aa            linear   ROD 31-MAR-2024
DEFINITION  FYVE, RhoGEF and PH domain-containing protein 5 [Rattus
            norvegicus].
ACCESSION   NP_001102107 XP_001076619 XP_006225055 XP_006236987 XP_342726
VERSION     NP_001102107.2
DBSOURCE    REFSEQ: accession NM_001108637.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (residues 1 to 1520)
  AUTHORS   Gaudet,P., Livstone,M.S., Lewis,S.E. and Thomas,P.D.
  TITLE     Phylogenetic-based propagation of functional annotations within the
            Gene Ontology consortium
  JOURNAL   Brief Bioinform 12 (5), 449-462 (2011)
   PUBMED   21873635
REFERENCE   2  (residues 1 to 1520)
  AUTHORS   Bonaldo,M.F., Lennon,G. and Soares,M.B.
  TITLE     Normalization and subtraction: two approaches to facilitate gene
            discovery
  JOURNAL   Genome Res 6 (9), 791-806 (1996)
   PUBMED   8889548
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000004.1 and BI289075.1.
            
            On or before Sep 4, 2019 this sequence version replaced
            XP_006236987.1, XP_006225055.1, NP_001102107.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments. This RefSeq transcript is based on
            orthologous transcript alignments.
            
            ##Evidence-Data-START##
            RNAseq introns :: single sample supports all introns SAMN06621351,
                              SAMN06680436 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            inferred exon combination :: based on alignments, homology
            RefSeq Select criteria    :: based on conservation, longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1520
                     /organism="Rattus norvegicus"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="4"
                     /map="4q34"
     Protein         1..1520
                     /product="FYVE, RhoGEF and PH domain-containing protein 5"
                     /calculated_mol_wt=167191
     Region          113..>324
                     /region_name="PHA03169"
                     /note="hypothetical protein; Provisional"
                     /db_xref="CDD:223003"
     Region          951..1139
                     /region_name="RhoGEF"
                     /note="RhoGEF domain; pfam00621"
                     /db_xref="CDD:459876"
     Region          1158..1280
                     /region_name="PH-like"
                     /note="Pleckstrin homology-like domain; cl17171"
                     /db_xref="CDD:473070"
     Region          1294..1360
                     /region_name="FYVE_like_SF"
                     /note="FYVE domain like superfamily; cl28890"
                     /db_xref="CDD:333710"
     Site            order(1317..1322,1327,1348)
                     /site_type="other"
                     /note="phosphatidylinositol 3-phosphate binding site
                     [chemical binding]"
                     /db_xref="CDD:277249"
     Region          1424..1514
                     /region_name="PH2_FGD5_FGD6"
                     /note="FYVE, RhoGEF and PH domain containing/faciogenital
                     dysplasia proteins 5 and 6 pleckstrin homology (PH)
                     domain, C-terminus; cd13237"
                     /db_xref="CDD:270057"
     CDS             1..1520
                     /gene="Fgd5"
                     /coded_by="NM_001108637.2:234..4796"
                     /db_xref="GeneID:362402"
                     /db_xref="RGD:1305589"
ORIGIN      
        1 mhradspkpp vapkpkvttn pstppakfpa sqrpnsfpsp nsmsrgpkpp iapkprlagp
       61 seygagvyln nslskcsngr llcedpslyd ghhstlncle letdeqyimv prapqrddal
      121 tdratekqgf egeaqehgte qtgterdlaa pdeeapsrds eegvdhaled eedcdhdlet
      181 dgtptapgeg apsrdgekge edcgqdpgve ehpmseeege eeeakecvhn rddrapwdgg
      241 epflnevvlt hvcsqspevp cwepglpetp gevdedsedi cnntelgkpn qdtgqdteda
      301 smgspesevs pdvqeqeaat dspevfeeds vdaaegedqi ardeppncee dtnnretaaa
      361 tmqagedhge dgdrvqedpa eencqiipfe sdsveedcsp tltenpyelf ptestsfcnn
      421 sgslaesdkg qesvckicve evpgigpsls qgdslqdgsg eeapvpevvv vpenedpmdd
      481 alsspyvmgv gllslgegaq sdtqaasgtl sgystweegd sdggqvpvdr kniatrarph
      541 sgkvaghvpe tvleetgpea cssamgirdt gdevrkigil pegkpseslr alpakpraft
      601 lyprsfsveg resplsmfre pegagldmhr vrrkednlsl pgaigssgsf sqrshlpssg
      661 tstpssvvdi pppfdlacit krpitkssps llidgdtlek askkkkssfk rfleltfrkk
      721 teskvhvdms lsssrssses syhgparvle ldrrslsnsp qlkchtgklr asdspaslif
      781 yrdskrkgvp fsrtvsrves fedrsrppfl plpltkprsi sfpnadtsdy enipamnsdy
      841 eniqipprrp artgtftklf eeqsralsta nendgyvdms sfnafeskqq sseqeaesay
      901 tepykvcpis ttpkedltsd eeqgsseeed nasrdpslsh kgegqsrafv iaqellssek
      961 ayvqmlqhls ldfhgavlra lenveqegre plaqeelrqg lrelpaicdl hqgilesleq
     1021 rlgdcgegqq qvadiflare qefehhaahi lqfdrylgll aescllsprl attvrefeqq
     1081 ssqgggqsmk hrmlrvvqrl fqyqvlltdy lnnlcpdsae ydntqsalnl iskvtdrane
     1141 smeqgenlqk lvhieysvrg qgdllqpgre flkegtlmrv rgksrhprhl flmndtllyt
     1201 hpqkdgkyrl ksslpvanmk vsrpvmdkvp yalkietpes cltlsassca erdewhycls
     1261 ralpedyktq alaafhhsve irerlgislg erlptlvpvt hammcmncgc dfsltvrrhh
     1321 chacgkivcr ncsrnkyplk clknrmakvc dgcfrelklr ngpvpgpire rpvsmsfpls
     1381 ssrfssgstf ssvfqsisps tfkkqkkvps alaevaasge gsaisgylsr cksgkrrwkk
     1441 lwlvikgkvl ytylasedkv amesipllgf tiapekeegs sevgpvfhly hkktlfysfk
     1501 aedsssaqrw meamedasvl
//
