LOCUS       NM_001415054            8091 bp    mRNA    linear   ROD 01-APR-2024
DEFINITION  Rattus norvegicus FYVE, RhoGEF and PH domain containing 4 (Fgd4),
            transcript variant 1, mRNA.
ACCESSION   NM_001415054 XM_039087981
VERSION     NM_001415054.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 8091)
  AUTHORS   Delague,V., Jacquier,A., Hamadouche,T., Poitelon,Y., Baudot,C.,
            Boccaccio,I., Chouery,E., Chaouch,M., Kassouri,N., Jabbour,R.,
            Grid,D., Megarbane,A., Haase,G. and Levy,N.
  TITLE     Mutations in FGD4 encoding the Rho GDP/GTP exchange factor FRABIN
            cause autosomal recessive Charcot-Marie-Tooth type 4H
  JOURNAL   Am J Hum Genet 81 (1), 1-16 (2007)
   PUBMED   17564959
REFERENCE   2  (bases 1 to 8091)
  AUTHORS   Ikeda,W., Nakanishi,H., Takekuni,K., Itoh,S. and Takai,Y.
  TITLE     Identification of splicing variants of Frabin with partly different
            functions and tissue distribution
  JOURNAL   Biochem Biophys Res Commun 286 (5), 1066-1072 (2001)
   PUBMED   11527409
REFERENCE   3  (bases 1 to 8091)
  AUTHORS   Umikawa,M., Obaishi,H., Nakanishi,H., Satoh-Horikawa,K.,
            Takahashi,K., Hotta,I., Matsuura,Y. and Takai,Y.
  TITLE     Association of frabin with the actin cytoskeleton is essential for
            microspike formation through activation of Cdc42 small G protein
  JOURNAL   J Biol Chem 274 (36), 25197-25200 (1999)
   PUBMED   10464238
REFERENCE   4  (bases 1 to 8091)
  AUTHORS   Obaishi,H., Nakanishi,H., Mandai,K., Satoh,K., Satoh,A.,
            Takahashi,K., Miyahara,M., Nishioka,H., Takaishi,K. and Takai,Y.
  TITLE     Frabin, a novel FGD1-related actin filament-binding protein capable
            of changing cell shape and activating c-Jun N-terminal kinase
  JOURNAL   J Biol Chem 273 (30), 18697-18700 (1998)
   PUBMED   9668039
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000011.1.
            
            On Dec 20, 2022 this sequence version replaced XM_039087981.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643287.27506.1,
                                           SRR26643299.49184.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760386
                                           [ECO:0000348]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-264               JAXUCZ010000011.1  97904182-97904445
            265-384             JAXUCZ010000011.1  97977212-97977331
            385-568             JAXUCZ010000011.1  97986563-97986746
            569-1076            JAXUCZ010000011.1  97996329-97996836
            1077-1166           JAXUCZ010000011.1  98007690-98007779
            1167-1312           JAXUCZ010000011.1  98010030-98010175
            1313-1469           JAXUCZ010000011.1  98010583-98010739
            1470-1608           JAXUCZ010000011.1  98013392-98013530
            1609-1667           JAXUCZ010000011.1  98016459-98016517
            1668-1814           JAXUCZ010000011.1  98016801-98016947
            1815-1987           JAXUCZ010000011.1  98025623-98025795
            1988-2018           JAXUCZ010000011.1  98033566-98033596
            2019-2111           JAXUCZ010000011.1  98033978-98034070
            2112-2237           JAXUCZ010000011.1  98034499-98034624
            2238-2378           JAXUCZ010000011.1  98044899-98045039
            2379-2519           JAXUCZ010000011.1  98048374-98048514
            2520-8091           JAXUCZ010000011.1  98049619-98055190
FEATURES             Location/Qualifiers
     source          1..8091
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="11"
                     /map="11q23"
     gene            1..8091
                     /gene="Fgd4"
                     /note="FYVE, RhoGEF and PH domain containing 4"
                     /db_xref="GeneID:246174"
                     /db_xref="RGD:708357"
     exon            1..264
                     /gene="Fgd4"
                     /inference="alignment:Splign:2.1.0"
     CDS             114..2777
                     /gene="Fgd4"
                     /note="isoform 1 is encoded by transcript variant 1; FYVE,
                     RhoGEF and PH domain-containing protein 4; FGD1-related
                     F-actin-binding protein; actin filament-binding protein
                     frabin"
                     /codon_start=1
                     /product="FYVE, RhoGEF and PH domain-containing protein 4
                     isoform 1"
                     /protein_id="NP_001401983.1"
                     /db_xref="GeneID:246174"
                     /db_xref="RGD:708357"
                     /translation="MSSESDHNFRRVAIRRKSGSYLPPGIPRPWSRPSPHLQRPDHVA
                     VRGQAAGSNTCAKVTPPHTTSSTTTEVRGINGRTPAKRSAAHPKPQVPPKPLHLQNSS
                     SSFRPQVPRHKALPSAKPRMEESNPAPTSCASKGKHSKVSDLISHFEGGSVLSSYTDV
                     QKDSTMNLNIPQTPRQHGLTSTTPQKLPSHKSPQKQEKDSDQNQGQHGCLANGVAAAQ
                     SQMECETEKEAALSPETDTQTAAASPDAHVLNGVRNETTTDSASSVTNSHDENACDSS
                     CRTQGTDLGLPSKEGEPVIEAELQERENGLSTEGLNPLDQHHEVKETNEQKLHKIATE
                     LLLTERAYVSRLNLLDQVFYCKLLEEANRGSFPAEMVNKIFSNISSINAFHSKFLLPE
                     LEKRMQEWETTPRIGDILQKLAPFLKMYGEYVKGFDNAVELVKNMTERVPQFKSVTEE
                     IQKQKICGSLTLQHHMLEPIQRIPRYEMLLKDYLKKLSPDAPDWNDAKKSLEIISTAA
                     SHSNSAIRKMENLKKLLEIYEMLGEEEDIVNPSNELIKEGQILKLAARNTSAQERYLF
                     LFNNMLLYCVPRFSLVGSKFTVRTRVGIDGMKIVETHNEEYPHTFQVSGKERTLELQA
                     SSEQDKEEWIKALQESIDAFHQRHETFRNAIAKENDIPLEVSTAELGKRAPRWIRDNE
                     VTMCMKCKESFNALTRRRHHCRACGHVVCWKCSDYKAQLEYDGGRLNKVCKDCYQIMS
                     GFAESEEKKRRGILEIESAEVSGNSEVCSFLQYMEKSKPWQKIWCVIPKQDPLVLYMY
                     GAPQDVRAQATIPLLGYIVDDMPKSADLPHSFKLTQSKSVHSFAADSEELKQKWLKII
                     LLAVTGETPDGPSEHLDTLDNLPGPKEKSEC"
     exon            265..384
                     /gene="Fgd4"
                     /inference="alignment:Splign:2.1.0"
     exon            385..568
                     /gene="Fgd4"
                     /inference="alignment:Splign:2.1.0"
     exon            569..1076
                     /gene="Fgd4"
                     /inference="alignment:Splign:2.1.0"
     exon            1077..1166
                     /gene="Fgd4"
                     /inference="alignment:Splign:2.1.0"
     exon            1167..1312
                     /gene="Fgd4"
                     /inference="alignment:Splign:2.1.0"
     exon            1313..1469
                     /gene="Fgd4"
                     /inference="alignment:Splign:2.1.0"
     exon            1470..1608
                     /gene="Fgd4"
                     /inference="alignment:Splign:2.1.0"
     exon            1609..1667
                     /gene="Fgd4"
                     /inference="alignment:Splign:2.1.0"
     exon            1668..1814
                     /gene="Fgd4"
                     /inference="alignment:Splign:2.1.0"
     exon            1815..1987
                     /gene="Fgd4"
                     /inference="alignment:Splign:2.1.0"
     exon            1988..2018
                     /gene="Fgd4"
                     /inference="alignment:Splign:2.1.0"
     exon            2019..2111
                     /gene="Fgd4"
                     /inference="alignment:Splign:2.1.0"
     exon            2112..2237
                     /gene="Fgd4"
                     /inference="alignment:Splign:2.1.0"
     exon            2238..2378
                     /gene="Fgd4"
                     /inference="alignment:Splign:2.1.0"
     exon            2379..2519
                     /gene="Fgd4"
                     /inference="alignment:Splign:2.1.0"
     exon            2520..8091
                     /gene="Fgd4"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ggagtcggag cgcagcggcc cgggaagcga ggccggcgcg gggcggcggg cgcgaggagc
       61 cgctcagcct ggacgcgcgc aggcgaggct tcccggagtg accgcaggcc accatgagca
      121 gcgagagcga ccataacttc aggcgggtgg ccatccggcg gaagtcaggc tcctacctgc
      181 ctcccgggat cccccggccc tggagcaggc cctcaccgca cttgcagcgc cctgatcatg
      241 tcgcggtcag gggccaggcc gcaggcagca atacctgtgc aaaggtcact ccacctcata
      301 caacaagcag cacaaccaca gaggttcggg gaataaatgg gaggacacca gcaaaacgct
      361 ccgctgcaca tccaaagcca caagtgcctc caaaaccatt acatctgcag aattcatctt
      421 catcctttag accccaagtc cccaggcata aagctttacc tagcgcaaag ccaaggatgg
      481 aggagtctaa tccagcccct acttcatgtg cctcaaaagg gaaacatagt aaggtgtcgg
      541 atctcatcag tcactttgaa ggaggcagtg tcctgtcaag ttacactgat gtgcaaaaag
      601 attctactat gaacctaaat attcctcaaa ctccaagaca gcatgggcta acctccacaa
      661 ctccacaaaa gcttccatcc cacaagtctc cacagaagca ggaaaaggat tcagatcaga
      721 atcagggcca acacggttgt ttggccaatg gtgtggcggc tgcacaaagc cagatggagt
      781 gtgaaaccga gaaggaggct gcccttagtc cagagacaga cactcagact gctgctgcct
      841 ctcctgatgc acatgtgctg aatggagtaa gaaacgaaac caccacagat tctgcatcct
      901 ctgtaaccaa cagccatgat gaaaacgctt gtgacagcag ctgcaggact caagggactg
      961 acttagggct tccctcaaaa gaaggagagc cagtgataga agctgaactc caggagaggg
     1021 aaaatggact gagcaccgag ggactgaatc cgctggacca gcaccatgaa gtgaaggaga
     1081 ctaatgagca gaaacttcac aaaatagcca cagaactttt gcttacagaa agagcttatg
     1141 tcagccggct caacctccta gatcaggtat tttattgcaa actattagaa gaagcaaacc
     1201 gaggctcatt tcctgcagag atggtgaata aaatcttttc taacatttca tcaataaatg
     1261 ccttccatag taaattccta ttacctgagc tggagaagcg aatgcaagaa tgggaaacta
     1321 cacccagaat tggagatatc ctgcaaaagt tggcaccatt ccttaagatg tatggagaat
     1381 acgtaaaggg atttgataat gcggtggaac tggttaaaaa catgacagag cgtgttcccc
     1441 agtttaaatc agtgactgaa gagattcaga aacagaagat ctgtggaagc ttaaccctac
     1501 agcatcacat gctggagcct atccagcgga tccctcgcta cgagatgctc cttaaggact
     1561 acctgaagaa gctgtctcct gacgccccag actggaatga tgcaaagaag tcacttgaaa
     1621 ttatatctac agcagcaagc cattctaata gtgcaataag aaaaatggag aacctgaaga
     1681 aacttttaga aatttatgag atgttgggag aagaagagga tattgtaaat ccctcaaatg
     1741 aactaataaa agaaggacaa atcctcaaac tagcagctcg gaacacatca gcacaagagc
     1801 gctacctctt cttattcaac aacatgttgc tatattgtgt gcccagattc agtttggtgg
     1861 gctcaaaatt cacagttcga accagggttg gcattgatgg aatgaaaatt gtggagactc
     1921 acaatgaaga gtatccacac actttccagg tgtctgggaa agaaagaacc ctggagctgc
     1981 aggccagttc tgagcaagac aaagaagaat ggatcaaggc acttcaagag agtattgatg
     2041 cttttcatca aaggcatgaa accttcagaa atgcaattgc aaaggaaaat gacattcccc
     2101 tagaggtttc tactgctgaa ctaggaaaac gagccccaag atggatacgt gataacgaag
     2161 tgaccatgtg catgaagtgc aaagagtctt tcaatgcact gaccaggagg cggcatcact
     2221 gccgggcgtg tggacatgtg gtttgttgga aatgttctga ctacaaagct caacttgagt
     2281 atgacggtgg aaggttgaac aaggtctgta aagactgcta ccagataatg agtggattcg
     2341 cagagagtga agaaaagaaa agaaggggca ttttagagat tgaatcagca gaagtatcag
     2401 gaaatagtga agtatgcagt tttctccagt acatggaaaa gtcaaaaccc tggcagaaaa
     2461 tatggtgtgt gatccccaag caagaccccc ttgtgctgta catgtatggc gctcctcagg
     2521 atgtcagagc ccaagcaacc atacccctcc tgggctacat tgtggatgac atgcctaaga
     2581 gtgcagatct gccgcacagt ttcaagctga cccagtccaa gtctgtgcac agttttgctg
     2641 cagacagtga ggaactgaaa cagaagtggc tgaaaattat ccttctggct gtcacgggtg
     2701 agacaccaga cggcccgagt gagcatctag acaccttaga caacctccct ggacccaagg
     2761 aaaagtcaga atgctaaact tcagcagcgg ccagtgtggg atttccagtg gtacacatag
     2821 ctcaagacat tcccagctct ccctcatcat ctcttagcac tgtgcattgg gaaatatggt
     2881 ttaataacat cttttgggga ctttcttatg tttctatgta gaaacatcag ggtgcagagc
     2941 cattcttctg ttgaagttct gaaataatgt ggaaaacgga acctttttga taagctattt
     3001 cttaactgtg tgtttgcctt gagagggggg gaaaatgtta attgattgaa tcactacctg
     3061 gttataatgg gtctttcatt taagaaatcc ttcagtgtct cgttcccatg taggacttgt
     3121 aacattgtga aagatatacc tctgtgtaac caaaatagat ctatggtata aagtacaggg
     3181 acagtgtaga gtattgtatg aacttgtcta gtttttacaa gttgtcatgc tacataagta
     3241 gtttctgttc ttatacaaca caaaaaaatt atagggtcct gatgtttata ctttttgact
     3301 taatataaaa tacttgtttt gtagaattac tcctaataat aaaatatata aaatacaaat
     3361 cagtttgcct gtatataata ttgaaataag tatgaatatg tcagcgttcc tcttcagctt
     3421 tagtttgttt tcactctggt taatttttta aatataagac ctattttatt tctaaattta
     3481 acagttttcc aaacttaaga aaaattggta atttatgttg aactgattag aatctaagtg
     3541 tattgatatt tttatagtaa aaaaaaaaca gttatttatg tggtgtagga tatagtttga
     3601 attccaacag tatttttagg gtactatttt ccttttgttc tgtacctatt taaaacagtg
     3661 cctctcttag aaggtgctat taattcttat ttagataaaa gatgagagtt tagtaaatat
     3721 taactaaacg ttattatttt taactactct gattattctc aacttaagtg cactttggtc
     3781 acagagatta aaaatgtgtg gattatttta cattttataa taacataatt gtcatagtaa
     3841 tttaatgtca acatatacaa aaacctccta aaacttgaac tatgtaagac atctgaccat
     3901 gtagagaccc gggatataca gaagacgttg gtttactatt tactgtcctc ctttccattg
     3961 gactgtcatg gtcggtaagt gaggacagca tatagttagc acaaggtgac tgggtgagct
     4021 ttctttctgt cagctacaaa gcagagctca tgcatgtatc agcttatctg ggagaagaga
     4081 gttattagta aaggaaattt atgcttaatc attcactaga aaacatagct gaaaccagga
     4141 ttgcagaatc aataatggta gatttccatg agatgggaag cattaaagaa agtgcagaat
     4201 attctccctg tttatcccac ggactctgag atgaactatg gctgtctatt ataaagtctg
     4261 ttaaggaaca gactttatta atttactaag ttgtgctggt gactaaaacc ttatgttgag
     4321 ttgactgttt aacgcaatac ttttctcata ttaaagtttt tttctttctt ttccattctt
     4381 caaacattac cacttttact gtactgttta gtagaaattc ataagaatgt ctccactata
     4441 cacaatcttt aagggctaca attgaaatgt caagtacaat ctctcagaat ttgagaccac
     4501 cactcattta tacagctcat gttgcacaaa aagtgtctct tgtgttttgt actctaaagg
     4561 agcaagggaa ccaattaggt tgctttcctc catgaaatac cagacatgac cattaacatc
     4621 aaatcatcta tttagaatca ctaatgggtg aaacaaaaag ctaacttctt attccctact
     4681 aaatgagggt cacataggaa gaaatcgtac attgtttctc ttttctagtt gtcaacattg
     4741 atactgtatt tgagtgggag aaaaggagcc aggtgtgcag ggtacctgtt gacaaaatta
     4801 aacgataact atacatcact tagtttttca tatttcaaga aaagagaagc agtaagtatg
     4861 tcaaatgact atcagaataa ggatgacttt tgtaaatatg aacagaataa tgagtgggtt
     4921 atctcactta gaagatttat gtcaggtata aataatatca aaaaatactt gatcatcaag
     4981 aagactactt gtctgactac cagcaaattc ttgaacagaa gggatgtggc tagatatttc
     5041 agtatagttt aactttgatt aatgaaagga tactcataaa aaggatttta gcatgttctt
     5101 agtgttcatt cagtaaggag tgtgggtgcc agaagaaatt ctcccgtcac cagctttact
     5161 tctccccacg ctgagccaag cacaaaccac tttccccatc tctctcaaaa taaccacaaa
     5221 tacttttagt aggagaaaaa aaagtaatag aataatatta gctacttatt aagaactcaa
     5281 ctctggggcc aaggagaatt ctatgcaagg atgagaaaca gttcaggcag atctccagaa
     5341 cctatgtaaa ggccaggcaa gcaaggccag cacaacagag gtgaggccag gaagtcttgg
     5401 tgaaggtgcc ctagccaggc gagcctgggc tgtacaggaa caggaagtaa tcttgcctcg
     5461 atgcatgagg taaataggca ccaaagaagt cacctgacat caacctcaga tctctacacg
     5521 tagcacaatt cccttaaata tatgtgaaca cacatgcatg gacaatgtac atgcacatac
     5581 atattcaaaa aattaattca aataaactct aacccaagag gttgttagaa taactaacct
     5641 ctttttgaga tagtttcatg ataaactgag cctgaacagt tcttttctga tcaaataaat
     5701 gtcccgtatg gttcataatt tgttatatcc tctaatttag tgctgtcaaa agtcatcttt
     5761 aagaaaagtg tccttccttc aaacttaaga aaatattgct ttggtaaaat tgttactcat
     5821 tcaaagcatt ccaactttca actttattgt tgctcttgtt gaaagtctac tcttgggtaa
     5881 aggtgagatg tggtgcatgc tttcgtctag cgttttatgt ggagttcaat aatgagaaat
     5941 gccactagcc acttgtgtca tagtaccaag caataaaatt ctccagctat gaatttatgc
     6001 caaaagttta acatgaaagc ccgaagctac agcatataga gagactcaac ttcctagaag
     6061 tgattcgata atccaaattg ctgagcacag gcgaaagaag ggaggcatcg tcccatggct
     6121 tcagacgtat caactgtgtt taatttctac aaaggctgtg tagagtgaag cagttcgctt
     6181 tctctgctct gttgtatcag ctgttgtaca tttctgtgaa ttgaattcag catgaaggct
     6241 gccatgctgt cttcattgga ttacctacac cattgtttta aatgtaggaa ttgacctgta
     6301 aatgttccct gtggaatttt ctataaggaa actataattc catggtactt cagggttatt
     6361 gaagaagcca ctgatgcctt ctaaacacct ctactcaaaa gtacttctgg agttcatgat
     6421 tctgtttttt ttttgggggg ggggtgtttg aggttttttg tttgttttct cctctttgtt
     6481 gacatggaag ggttttccct ccttcaatta ttttcagata tcatttgttt atttataaag
     6541 ctttaagtta ttcagagtgt attgtctgca atgcattctt aatcatgatc cctgtcagtg
     6601 cgttgtcacg gcaaatgagc gtgtataaaa ggaaatcaat tctcagaaag cacgggtctt
     6661 ctttatctct gttgttgtaa gagtaaaagg taacttagtt ttcctatatc acatgatgtt
     6721 catgttaata gatctaagat aagcacatgg tatgtataat ctaaaatttg aaagacagaa
     6781 ctatctcagt gttttcattc tttaatgttg tgatcttcaa gaatgtatga atgtaagaac
     6841 tgaggcctaa gggttcctct tgttagagtt atgttcacat ccgtagcgga ccctgtcact
     6901 tcttcattct aagtttcatt agaatcaagt tttattattt tcatataact atcaaactat
     6961 aggttcccta gatttaaaaa aaaagtatta gacaactagg tctaaaatcc ctctctgtga
     7021 ctttatatgt ataaatgtaa aaattattaa tcttcaattc tcaccaaaga acaaaatgtt
     7081 atgtaaattt taagtatttt aacaaagtta ttcacatgta tttttaatgt tataattcat
     7141 ctttacccaa gcccctcagt cttactaggt tacaggaaga gacagtgttg ttcttgttac
     7201 aggtatagag agcactgagt ttagcaactg aaaggaagga aaggagttgg ataagtgggc
     7261 tagctcctgg tatccatgtg aactacacga gggaagtaag gtagaagaca tcgatgttct
     7321 tgtttcagca ttgtattcag gccttgagct tggcctctaa attacagata atattagctt
     7381 atcatcattt tatttctcct ttagactttt ataaagtaat tttattctgt aaaccatttt
     7441 tctgctattt tttttattct aaagtcaact ttctaagcca agggaatggc aaatgctgtg
     7501 tcttttctgt atttcaagat aaaataacac atggcttcta taagatagtt atttgttgga
     7561 ggtgggggga gtcactgaaa gttacatgag gttcatactt tgccataaaa ataaaattaa
     7621 atcaaatttt agtatatttt aataagtgaa tactaaatac atcaagtaaa gacagatcat
     7681 ggagcccgtt atgatgattg cattgtgtat tttgaaatat gaagactcaa atacatagta
     7741 agtgtctttg tcatataatc attcatgtat aaaaccaaac tggtatttca tactttaaga
     7801 gacaattaac tgttatttta aaaaataagc attgttttga tttttttctt ttgacttgtt
     7861 gactgagttt caaagggcac atcagaattt tatagttgac gctaatgtga aaatataaac
     7921 gtccctattt tgcagtggtg tgaatatttg gacatgctgt atatatagtg taacatctgt
     7981 atatttgatc ataaaggcag ataattgaaa acattgtaaa cttaagccct tcaattcttg
     8041 ttaaatatga aatatttgta tcttgtaaat aaagacatcc ttaaattggt t
//
