LOCUS       NM_001414732            4468 bp    mRNA    linear   ROD 31-MAR-2024
DEFINITION  Rattus norvegicus FYVE, RhoGEF and PH domain containing 1 (Fgd1),
            transcript variant 1, mRNA.
ACCESSION   NM_001414732 XM_039099871
VERSION     NM_001414732.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 4468)
  AUTHORS   Al-Semari,A., Wakil,S.M., Al-Muhaizea,M.A., Dababo,M., Al-Amr,R.,
            Alkuraya,F. and Meyer,B.F.
  TITLE     Novel FGD1 mutation underlying Aarskog-Scott syndrome with myopathy
            and distal arthropathy
  JOURNAL   Clin Dysmorphol 22 (1), 13-17 (2013)
   PUBMED   23211637
REFERENCE   2  (bases 1 to 4468)
  AUTHORS   Orrico,A., Galli,L., Faivre,L., Clayton-Smith,J.,
            Azzarello-Burri,S.M., Hertz,J.M., Jacquemont,S., Taurisano,R.,
            Arroyo Carrera,I., Tarantino,E., Devriendt,K., Melis,D., Thelle,T.,
            Meinhardt,U. and Sorrentino,V.
  TITLE     Aarskog-Scott syndrome: clinical update and report of nine novel
            mutations of the FGD1 gene
  JOURNAL   Am J Med Genet A 152A (2), 313-318 (2010)
   PUBMED   20082460
REFERENCE   3  (bases 1 to 4468)
  AUTHORS   Ayala,I., Giacchetti,G., Caldieri,G., Attanasio,F., Mariggio,S.,
            Tete,S., Polishchuk,R., Castronovo,V. and Buccione,R.
  TITLE     Faciogenital dysplasia protein Fgd1 regulates invadopodia
            biogenesis and extracellular matrix degradation and is up-regulated
            in prostate and breast cancer
  JOURNAL   Cancer Res 69 (3), 747-752 (2009)
   PUBMED   19141649
REFERENCE   4  (bases 1 to 4468)
  AUTHORS   Shalev,S.A., Chervinski,E., Weiner,E., Mazor,G., Friez,M.J. and
            Schwartz,C.E.
  TITLE     Clinical variation of Aarskog syndrome in a large family with
            2189delA in the FGD1 gene
  JOURNAL   Am J Med Genet A 140 (2), 162-165 (2006)
   PUBMED   16353258
REFERENCE   5  (bases 1 to 4468)
  AUTHORS   Hou,P., Estrada,L., Kinley,A.W., Parsons,J.T., Vojtek,A.B. and
            Gorski,J.L.
  TITLE     Fgd1, the Cdc42 GEF responsible for Faciogenital Dysplasia,
            directly interacts with cortactin and mAbp1 to modulate cell shape
  JOURNAL   Hum Mol Genet 12 (16), 1981-1993 (2003)
   PUBMED   12913069
REFERENCE   6  (bases 1 to 4468)
  AUTHORS   Lebel,R.R., May,M., Pouls,S., Lubs,H.A., Stevenson,R.E. and
            Schwartz,C.E.
  TITLE     Non-syndromic X-linked mental retardation associated with a
            missense mutation (P312L) in the FGD1 gene
  JOURNAL   Clin Genet 61 (2), 139-145 (2002)
   PUBMED   11940089
REFERENCE   7  (bases 1 to 4468)
  AUTHORS   Zheng,Y., Fischer,D.J., Santos,M.F., Tigyi,G., Pasteris,N.G.,
            Gorski,J.L. and Xu,Y.
  TITLE     The faciogenital dysplasia gene product FGD1 functions as a
            Cdc42Hs-specific guanine-nucleotide exchange factor
  JOURNAL   J Biol Chem 271 (52), 33169-33172 (1996)
   PUBMED   8969170
REFERENCE   8  (bases 1 to 4468)
  AUTHORS   Pasteris,N.G., Cadle,A., Logie,L.J., Porteous,M.E., Schwartz,C.E.,
            Stevenson,R.E., Glover,T.W., Wilroy,R.S. and Gorski,J.L.
  TITLE     Isolation and characterization of the faciogenital dysplasia
            (Aarskog-Scott syndrome) gene: a putative Rho/Rac guanine
            nucleotide exchange factor
  JOURNAL   Cell 79 (4), 669-678 (1994)
   PUBMED   7954831
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000021.1.
            
            On Dec 8, 2022 this sequence version replaced XM_039099871.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643429.58744.1,
                                           SRR26643299.67682.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760393, SAMEA5760400
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1091              JAXUCZ010000021.1  23467530-23468620
            1092-1265           JAXUCZ010000021.1  23487373-23487546
            1266-1443           JAXUCZ010000021.1  23487939-23488116
            1444-1888           JAXUCZ010000021.1  23488243-23488687
            1889-1978           JAXUCZ010000021.1  23490126-23490215
            1979-2127           JAXUCZ010000021.1  23491105-23491253
            2128-2284           JAXUCZ010000021.1  23493631-23493787
            2285-2423           JAXUCZ010000021.1  23493889-23494027
            2424-2482           JAXUCZ010000021.1  23499413-23499471
            2483-2629           JAXUCZ010000021.1  23499615-23499761
            2630-2722           JAXUCZ010000021.1  23500301-23500393
            2723-2802           JAXUCZ010000021.1  23500513-23500592
            2803-2833           JAXUCZ010000021.1  23505665-23505695
            2834-2935           JAXUCZ010000021.1  23506152-23506253
            2936-3061           JAXUCZ010000021.1  23506592-23506717
            3062-3223           JAXUCZ010000021.1  23506895-23507056
            3224-3367           JAXUCZ010000021.1  23508020-23508163
            3368-4468           JAXUCZ010000021.1  23508673-23509773
FEATURES             Location/Qualifiers
     source          1..4468
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="X"
                     /map="Xq12"
     gene            1..4468
                     /gene="Fgd1"
                     /note="FYVE, RhoGEF and PH domain containing 1"
                     /db_xref="GeneID:363460"
                     /db_xref="RGD:1565188"
     exon            1..1091
                     /gene="Fgd1"
                     /inference="alignment:Splign:2.1.0"
     CDS             785..3673
                     /gene="Fgd1"
                     /note="isoform 1 is encoded by transcript variant 1; FYVE,
                     RhoGEF and PH domain-containing protein 1; FYVE, RhoGEF
                     and PH domain-containing protein 1-like"
                     /codon_start=1
                     /product="FYVE, RhoGEF and PH domain-containing protein 1
                     isoform 1"
                     /protein_id="NP_001401661.1"
                     /db_xref="GeneID:363460"
                     /db_xref="RGD:1565188"
                     /translation="MHGHRVPGGPGPSDPERSAANTPGAAPLACADSDPGALEPGLPV
                     RRGSGSALGGPLDPQFVGPSDASLGAPPSSRVLPCGPSPQHHRALRFSYHLEGSQPRP
                     GLHQGNRILVKSLSLDPGQSLEPHPEGPQRLRSDPGPPTEIPGPRPSPLKRAPGPKPQ
                     VPPKPSYLQMPRVLPPPEPIPPPPSRPLPADPRVAKGLAPRAEASTSSAAVSSLIEKF
                     EREPVIVASDRPAPGPCPVPPEPAMLPQPPPQPTGSQLPEGEASRCLFLLAPGPRDGE
                     KVPNRDSGIDSISSPSNSEETCFVSDDGPPSHSLCPGPPALASMPVALADPHRPGSQE
                     VDSDLEEEEEEEEEEEEKEREIPVPPMERQESVELTVQQKVFHIANELLQTEKAYVSR
                     LHLLDQVFCARLLEEARNRSSFPADVVHGIFSNICSIYCFHQQFLLPELEKRMEEWDR
                     YPRIGDILQKLAPFLKMYGEYVKNFDRAVELVNTWTERSTQFKVIIHEVQKEEACGNL
                     TLQHHMLEPVQRIPRYELLLKDYLLKLPHGSPDSKDAQKSLELIATAAEHSNAAIRKM
                     ERMHKLLKVYELLGGEEDIVSPTKELIKEGHILKLSAKNGTTQDRYLILFNDRLLYCV
                     PRLRLLGQKFSVRARIDVDGMELKESSNLNMPRTFLVSGKQRSLELQARTEEEKKDWV
                     QAINSTLLKHEQTLETFKLLNSTNRDDEDTPPNSPNVDLGKRAPTPIREKEVTMCMRC
                     QEPFNSITKRRHHCKACGHVVCGKCSEFRARLIYDNNRSNRVCTDCYVALHGAPGSSP
                     ACSQHTPQRRRSILEKQASVAAENSVICSFLHYMEKGGKGWHKAWFVVPENEPLVLYI
                     YGAPQDVKAQRSLPLIGFEVGPPEAGERPDRRHVFKITQSHLSWYFSPETEELQRRWM
                     AVLGRAGRGDTFCPGPTLSEDKEMEETTVAASGATAEPPEASQTRDKT"
     exon            1092..1265
                     /gene="Fgd1"
                     /inference="alignment:Splign:2.1.0"
     exon            1266..1443
                     /gene="Fgd1"
                     /inference="alignment:Splign:2.1.0"
     exon            1444..1888
                     /gene="Fgd1"
                     /inference="alignment:Splign:2.1.0"
     exon            1889..1978
                     /gene="Fgd1"
                     /inference="alignment:Splign:2.1.0"
     exon            1979..2127
                     /gene="Fgd1"
                     /inference="alignment:Splign:2.1.0"
     exon            2128..2284
                     /gene="Fgd1"
                     /inference="alignment:Splign:2.1.0"
     exon            2285..2423
                     /gene="Fgd1"
                     /inference="alignment:Splign:2.1.0"
     exon            2424..2482
                     /gene="Fgd1"
                     /inference="alignment:Splign:2.1.0"
     exon            2483..2629
                     /gene="Fgd1"
                     /inference="alignment:Splign:2.1.0"
     exon            2630..2722
                     /gene="Fgd1"
                     /inference="alignment:Splign:2.1.0"
     exon            2723..2802
                     /gene="Fgd1"
                     /inference="alignment:Splign:2.1.0"
     exon            2803..2833
                     /gene="Fgd1"
                     /inference="alignment:Splign:2.1.0"
     exon            2834..2935
                     /gene="Fgd1"
                     /inference="alignment:Splign:2.1.0"
     exon            2936..3061
                     /gene="Fgd1"
                     /inference="alignment:Splign:2.1.0"
     exon            3062..3223
                     /gene="Fgd1"
                     /inference="alignment:Splign:2.1.0"
     exon            3224..3367
                     /gene="Fgd1"
                     /inference="alignment:Splign:2.1.0"
     exon            3368..4468
                     /gene="Fgd1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 aactgggtct cagcgccgcg gtggctgcgg ctgtctcagc aacggctcgc gcctccccat
       61 cccccagttc ccagagctct tcccgcctgc cgcggtggag acccaggccg aaggcgggga
      121 aggccggtcc agcccgttcc tctgcccgcg cggcgggagc atcgttccgg aggactgccc
      181 gaaggcaagc ctcgcagccg gagagcgcgg cgcacacgcg cgcctcccgg ccgcggccgt
      241 cctctcttcc ctccttcctc tcctctctcc cctcccctct cctccgcccc caacctctgc
      301 tgcggcggga ggaagaaccc ttcccgacta gcccagagaa cccaggtcga ttctcattcc
      361 cggagaaaga gaccctcttg gtgggatccg gctggtcgct cgccccccgg ccacggaagt
      421 gactggtcgt ctattgggag agctcgcttc tagcgcagcc cccgaccctc acccagccgc
      481 agccgcatag acagcgctcc ccagcgggcc cccggccccg ccgagcccac tccccgcttg
      541 gggccagggc cggcgatgcc tggcgcggca acggcggtgg ccgcggctgc tgctgctgcc
      601 gccacggctg ctggccggag cccgggtcgg gggctcgagt ctccgcagtg gggctgagcc
      661 cgcagccccg ccccccgagc ctgaggccgc tgctccgccg ggcgccgggc cttctccgcc
      721 cgcgcctccg ccccaggaac tggagccaag cggggagccc gggccccgcg cccaggcccg
      781 gaccatgcat ggccaccgag tcccgggggg ccctgggcct tcggatcccg aacgctcagc
      841 ggcaaatacc cctggcgccg ctccgctggc ctgtgccgac tcggaccctg gagccttgga
      901 acccggactg ccggtgcgca ggggctcagg ctcggctctt ggaggccctt tggatcctca
      961 gtttgttgga ccctcggacg ccagcctggg agcgcctcca agctcccggg tcttgccctg
     1021 cggccctagc cctcagcacc accgggccct gcgcttctcc taccacctgg agggctcgca
     1081 gcctcggcct ggactgcacc agggaaaccg gatcctggtt aaaagtttgt cccttgaccc
     1141 tggccagagc cttgagcctc atccagaagg tccccaacgg cttcgctcag atccaggccc
     1201 tcccactgaa atccctggcc cacgtccttc accactaaag cgggcaccag gcccaaagcc
     1261 acaggtcccc ccaaagccca gctacctgca gatgccccgg gtgcttcctc ctcctgagcc
     1321 cattcctccg ccaccatcac gccctctgcc tgcagaccct agagtggcca agggtcttgc
     1381 ccccagagct gaggccagca ctagttctgc agcagtatca tcattgatcg agaagtttga
     1441 aagagagcct gtgattgtcg cttcggatag gccagcccct ggcccctgcc cagttccccc
     1501 agagccagcc atgttgccac agccaccccc gcagccaaca gggtcccagc tccctgaggg
     1561 tgaggcttct cgctgcctgt tcctgctggc tcctgggccc cgggatggtg agaaggtgcc
     1621 taaccgggac agcggcattg acagcatcag ctcgccatcc aacagtgaag agacctgctt
     1681 cgtcagtgat gacgggcccc ccagccacag cctctgtcct gggccccctg ccctggctag
     1741 tatgccagtg gctttggccg acccccaccg gcctggctcc caggaggttg acagtgacct
     1801 ggaagaggaa gaggaggagg aggaagaaga ggaggaaaag gaaagagaaa ttccagtgcc
     1861 cccgatggag agacaggagt ctgtggagct gaccgtgcag cagaaggtat tccatattgc
     1921 caatgaactc ctgcaaactg agaaggccta tgtttccagg cttcatctcc tggatcaggt
     1981 attctgtgcc cggctgctgg aagaagctcg gaaccgcagt tccttccctg cagatgttgt
     2041 ccatggcatc ttctctaaca tctgctccat ctactgcttc catcagcagt tcctgctgcc
     2101 tgagctggag aagcgcatgg aggaatggga ccgctaccca cgcattggtg acatccttca
     2161 gaagttggca cccttcctca agatgtatgg cgagtatgtg aaaaactttg accgggctgt
     2221 agagctggtc aacacatgga cagagcgttc tacccagttt aaagtcatca tccatgaagt
     2281 acagaaggag gaagcctgtg gcaacctgac cctgcagcac cacatgctgg agcccgtgca
     2341 gcgtatcccc cgctatgagc ttcttcttaa ggactatctg ttaaagctgc ctcatggctc
     2401 cccggacagc aaggatgccc agaagtcttt ggagctgata gccacagcag cagaacactc
     2461 taatgctgcc atccgtaaaa tggaacgaat gcacaagctg ctgaaggtct atgagctgct
     2521 agggggtgag gaggacattg tcagtcccac caaagagctc ataaaagaag gtcatatcct
     2581 taagctgtca gcaaagaatg ggaccactca agatcgatac ctcatattat tcaacgaccg
     2641 ccttctttac tgcgtgccca ggctgcggct ccttggccag aagtttagcg tgcgggcacg
     2701 cattgatgta gatggcatgg agctaaagga aagctccaac ctcaacatgc ctcggacctt
     2761 cttggtgtca ggaaaacagc gctctcttga actccaggcc aggactgagg aggagaagaa
     2821 agactgggtc caggccatca attctaccct cctgaagcat gaacagaccc tggagacttt
     2881 caaactgttg aactcaacaa acagggatga tgaagatact ccccctaact ctccaaacgt
     2941 ggatcttggg aagagggcac ctacgcctat ccgggaaaag gaagtcacca tgtgcatgcg
     3001 ctgccaggag cccttcaatt ccatcaccaa acgcaggcac cactgcaagg cctgtgggca
     3061 tgtggtttgt gggaaatgct ctgagttccg agcacgactc atctatgaca acaatcgttc
     3121 caaccgtgtg tgcactgatt gctatgtggc cttgcatgga gcacccggga gcagtccagc
     3181 ctgtagccaa catacacccc agcgcaggag gtccatccta gagaaacagg cctcagtggc
     3241 tgctgagaac agcgtcatct gcagcttcct gcactacatg gagaagggtg ggaaaggatg
     3301 gcacaaggca tggtttgtgg ttcccgagaa tgaacccttg gtgctgtaca tctatggagc
     3361 ccctcaggat gtgaaagccc aacgcagcct gcccctcatt ggctttgagg tggggcctcc
     3421 tgaggcaggg gagcggccag acaggaggca tgtcttcaag atcacccaga gccacctaag
     3481 ctggtacttc agcccagaga cagaagaact ccagcggcgc tggatggctg tgcttggcag
     3541 ggcgggccgt ggggacacat tctgcccagg gcccacactg tctgaggaca aggagatgga
     3601 ggagacaaca gtggcagctt caggagccac tgctgaacct cctgaagcct cccagacccg
     3661 agacaagacc tagagggttt ggggggggaa ctgggagttc ctgccccaca ctccagctgc
     3721 ccatgttcaa ttgggggctc tagcccactc ccaatgcagt caatacttga attcccatca
     3781 agggcacttt caatcccgaa tgctgggtct tgggtttttt aattcatctt ttcacaaaat
     3841 gtgggctttt taaaaaagaa agacaaacta ttcctacatt gatgttaatt ttttaaatcc
     3901 ctgtccccag ggagggcagg agctaattgc tagactcact tgaattagtc tgtttcctcc
     3961 cagtacccca cagatcctac tttcatctag ttccccacaa aagtaccaga ggcaggagac
     4021 ctggattcaa gtgccagctc tgctactgac cctgggaccc caatccaccc tttcctcctc
     4081 agccagtgtc ttcacatgta tgactttaca tggggtggtg actagaccct tcttgccttt
     4141 cccatggctt atagcttcta cctagcccca aagcaatcca gtattttatc gtccagatcc
     4201 atggcagggc cactgggcag gacgggaatg ggggggcggg aggggaggac aatggatact
     4261 gttttttaaa gaaaaataca gtttatttca ggcgtacagt aactttcaga gcactgctat
     4321 ggtccgtccg tttgtccgaa gtcccaggct actaagggag aggggagggt gcagaaacta
     4381 ctctcttgat gaattttgaa gctcagctct cagaaagctg attccaaggt taaatcatga
     4441 attaaacaag aaagtgttat gttattaa
//
