LOCUS       NM_020071               1604 bp    mRNA    linear   ROD 03-APR-2024
DEFINITION  Rattus norvegicus fibrinogen beta chain (Fgb), mRNA.
ACCESSION   NM_020071
VERSION     NM_020071.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1604)
  AUTHORS   Longstaff,C. and Kolev,K.
  TITLE     Basic mechanisms and regulation of fibrinolysis
  JOURNAL   J Thromb Haemost 13 Suppl 1, S98-S105 (2015)
   PUBMED   26149056
  REMARK    Review article
REFERENCE   2  (bases 1 to 1604)
  AUTHORS   Chiasserini,D., van Weering,J.R., Piersma,S.R., Pham,T.V.,
            Malekzadeh,A., Teunissen,C.E., de Wit,H. and Jimenez,C.R.
  TITLE     Proteomic analysis of cerebrospinal fluid extracellular vesicles: a
            comprehensive dataset
  JOURNAL   J Proteomics 106, 191-204 (2014)
   PUBMED   24769233
REFERENCE   3  (bases 1 to 1604)
  AUTHORS   Jiang,M., Wang,X., Shu,K., Jiang,W., Huang,Y., Lin,Y., Li,S. and
            Hu,Y.
  TITLE     [Clinical and genetic analysis of 8 Chinese pedigrees with
            inherited dysfibrinogenemia]
  JOURNAL   Zhonghua Yi Xue Yi Chuan Xue Za Zhi 31 (2), 134-139 (2014)
   PUBMED   24711018
REFERENCE   4  (bases 1 to 1604)
  AUTHORS   Walker,J.N., Crosby,H.A., Spaulding,A.R., Salgado-Pabon,W.,
            Malone,C.L., Rosenthal,C.B., Schlievert,P.M., Boyd,J.M. and
            Horswill,A.R.
  TITLE     The Staphylococcus aureus ArlRS two-component system is a novel
            regulator of agglutination and pathogenesis
  JOURNAL   PLoS Pathog 9 (12), e1003819 (2013)
   PUBMED   24367264
REFERENCE   5  (bases 1 to 1604)
  AUTHORS   Lvova,O.A., Gusev,V.V., Kuznetsov,N.N., Baranov,D.A.,
            Voroshilina,E.S. and Partylova,E.A.
  TITLE     [The inherited procoagulant and prothrombotic condition as the main
            etiological factor for ischemic stroke in infants]
  JOURNAL   Zh Nevrol Psikhiatr Im S S Korsakova 113 (9 Pt 2), 13-20 (2013)
   PUBMED   24107890
REFERENCE   6  (bases 1 to 1604)
  AUTHORS   Eastman,E.M. and Gilula,N.B.
  TITLE     Cloning and characterization of a cDNA for the B beta chain of rat
            fibrinogen: evolutionary conservation of translated and
            3'-untranslated sequences
  JOURNAL   Gene 79 (1), 151-158 (1989)
   PUBMED   2673932
REFERENCE   7  (bases 1 to 1604)
  AUTHORS   Sobczak,J., Lotti,A.M., Taroux,P. and Duguet,M.
  TITLE     Molecular cloning of mRNA sequences transiently induced during rat
            liver regeneration
  JOURNAL   Exp Cell Res 169 (1), 47-56 (1987)
   PUBMED   3817019
REFERENCE   8  (bases 1 to 1604)
  AUTHORS   Fowlkes,D.M., Mullis,N.T., Comeau,C.M. and Crabtree,G.R.
  TITLE     Potential basis for regulation of the coordinately expressed
            fibrinogen genes: homology in the 5' flanking regions
  JOURNAL   Proc Natl Acad Sci U S A 81 (8), 2313-2316 (1984)
   PUBMED   6232608
REFERENCE   9  (bases 1 to 1604)
  AUTHORS   Chung,D.W., Que,B.G., Rixon,M.W., Mace,M. Jr. and Davie,E.W.
  TITLE     Characterization of complementary deoxyribonucleic acid and genomic
            deoxyribonucleic acid for the beta chain of human fibrinogen
  JOURNAL   Biochemistry 22 (13), 3244-3250 (1983)
   PUBMED   6688356
REFERENCE   10 (bases 1 to 1604)
  AUTHORS   Hawiger,J., Timmons,S., Kloczewiak,M., Strong,D.D. and
            Doolittle,R.F.
  TITLE     gamma and alpha chains of human fibrinogen possess sites reactive
            with human platelet receptors
  JOURNAL   Proc Natl Acad Sci U S A 79 (6), 2068-2071 (1982)
   PUBMED   6281794
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC088102.1.
            
            On Oct 12, 2007 this sequence version replaced NM_020071.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC088102.1, U05675.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5756307, SAMEA5760400
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1604
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="2"
                     /map="2q34"
     gene            1..1604
                     /gene="Fgb"
                     /gene_synonym="Ab1-181; Ab1-216; Ac1-581"
                     /note="fibrinogen beta chain"
                     /db_xref="GeneID:24366"
                     /db_xref="RGD:2604"
     exon            1..119
                     /gene="Fgb"
                     /gene_synonym="Ab1-181; Ab1-216; Ac1-581"
                     /inference="alignment:Splign:2.1.0"
     CDS             42..1481
                     /gene="Fgb"
                     /gene_synonym="Ab1-181; Ab1-216; Ac1-581"
                     /note="liver regeneration-related protein
                     LRRG036/LRRG043/LRRG189; fibrinogen, B beta polypeptide;
                     fibrinogen, beta polypeptide; beta-fibrinogen"
                     /codon_start=1
                     /product="fibrinogen beta chain precursor"
                     /protein_id="NP_064456.2"
                     /db_xref="GeneID:24366"
                     /db_xref="RGD:2604"
                     /translation="MRHLWLLLLSVSLVQTQAATTDSDKVDLSIARGHRPVDRRKEEP
                     PSLRPAPPPISGGGYRARPAKVDAGQKKVERKPPDAGGCVHGDGDMGVLCPTGCELRQ
                     TLLNHERPIKNSIAELNSNINSVSETSSVTFQYLTLLKDMWKKKQAQVKDNENVINEY
                     SSILEDQKLYIDETVNDNIPLNLRVLRSILEDLRSKIQKLESDISAQTEYCHTPCTVN
                     CNIPVVSGKECEEIIRKGGETSEMYLIQPDTSSKPYRVYCDMKTENGGWTVIQNRQDG
                     SVDFGRKWDPYKKGFGNIATNEDTKKYCGLPGEYWLGNDKISQLTRIGPTELLIEMED
                     WKGDKVKAHYGGFTVQTEANKYQVSVNKYKGTAGNALMEGASQLVGENRTMTIHNGMF
                     FSTYDRDNDGWVTTDPRKQCSKEDGGGWWYNRCHAANPNGRYYWGGLYSWDMSKHGTD
                     DGVVWMNWKGSWYSMRRMSMKIRPVFPQQ"
     exon            120..311
                     /gene="Fgb"
                     /gene_synonym="Ab1-181; Ab1-216; Ac1-581"
                     /inference="alignment:Splign:2.1.0"
     exon            312..495
                     /gene="Fgb"
                     /gene_synonym="Ab1-181; Ab1-216; Ac1-581"
                     /inference="alignment:Splign:2.1.0"
     exon            496..723
                     /gene="Fgb"
                     /gene_synonym="Ab1-181; Ab1-216; Ac1-581"
                     /inference="alignment:Splign:2.1.0"
     exon            724..837
                     /gene="Fgb"
                     /gene_synonym="Ab1-181; Ab1-216; Ac1-581"
                     /inference="alignment:Splign:2.1.0"
     exon            838..963
                     /gene="Fgb"
                     /gene_synonym="Ab1-181; Ab1-216; Ac1-581"
                     /inference="alignment:Splign:2.1.0"
     exon            964..1249
                     /gene="Fgb"
                     /gene_synonym="Ab1-181; Ab1-216; Ac1-581"
                     /inference="alignment:Splign:2.1.0"
     exon            1250..1578
                     /gene="Fgb"
                     /gene_synonym="Ab1-181; Ab1-216; Ac1-581"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ggcaaagggc aactgcttgg aatttcagaa aatctgaaac catgaggcat ctatggctgc
       61 tgctcctgtc tgtttcctta gttcaaactc aagctgcaac tactgactcc gataaagtgg
      121 acctctcgat tgcccgtggt catcgacctg ttgacaggag aaaggaagag cctcctagcc
      181 taagacctgc ccctcctcct atcagcggag gtggctatcg agcccgtcca gccaaagttg
      241 atgcaggtca gaagaaagtg gaacgaaaac cccctgatgc aggaggctgt gttcacggtg
      301 acggagacat gggagtgcta tgtcctacag ggtgtgagtt gcgtcaaact ttgctaaacc
      361 acgaaaggcc aatcaaaaac agtattgctg agttaaatag caacataaac tctgtttctg
      421 agacctcttc ggtcaccttt cagtacctga ctctgctgaa agacatgtgg aaaaagaagc
      481 aggcacaagt taaagataat gaaaatgtca taaatgagta ttcctccatt ttggaagacc
      541 agaaattata tattgatgag actgtgaacg ataatatccc ccttaatctt cgtgtgctcc
      601 gctcaatcct ggaggacctg agaagcaaaa tacaaaaatt ggagtctgac atctcagctc
      661 agacggaata ctgccacact ccatgcaccg tcaactgcaa catcccggtg gtgtctggga
      721 aagagtgtga agagatcatt cggaagggag gtgagacatc cgaaatgtat ctcattcagc
      781 ctgacacctc cagcaaacca tacagagtgt actgcgacat gaagaccgaa aacggaggat
      841 ggacggtcat acagaaccgt caggatggca gcgtcgactt tggcaggaaa tgggacccat
      901 acaaaaaagg atttggaaat attgcaacca acgaagatac gaagaagtac tgtggcttgc
      961 caggcgaata ttggcttggc aatgataaga ttagccagct caccaggata ggacccacag
     1021 aactcctaat cgaaatggag gactggaaag gagacaaggt gaaggcacac tatggaggct
     1081 tcacggtgca gaccgaggcc aacaagtacc aagtgtcagt gaacaagtac aaagggactg
     1141 ctggcaacgc cctcatggaa ggggcctctc agctggtggg ggagaacaga accatgacca
     1201 tccacaacgg catgttcttc agcacctacg acagggacaa cgatggctgg gtaactacag
     1261 atccaagaaa gcagtgctca aaagaagatg gcggcggctg gtggtataac agatgccatg
     1321 cagccaatcc gaatggcaga tactactggg gtggccttta cagctgggac atgtccaagc
     1381 acggcacaga tgatggtgtg gtgtggatga actggaaggg atcgtggtac tccatgagaa
     1441 ggatgtctat gaagatcagg cccgtcttcc cacagcaata gtcccccaag catagacttt
     1501 cagccttcta tgtctgacat tttttacatt atgttattgg aattttcttt gatacattat
     1561 atccactaat gctcaaaaaa aaaaaaaaaa aaaaaaaaaa aaaa
//
