LOCUS       NM_001008724            2607 bp    mRNA    linear   ROD 13-FEB-2025
DEFINITION  Rattus norvegicus fibrinogen alpha chain (Fga), transcript variant
            1, mRNA.
ACCESSION   NM_001008724 XM_006232533 XM_342267
VERSION     NM_001008724.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2607)
  AUTHORS   Wang,J., Zhang,Y., Liu,Y.M., Yang,X.C., Chen,Y.Y., Wu,G.J.,
            He,X.H., Duan,L., Dong,Y. and Ma,R.F.
  TITLE     Uncovering the protective mechanism of Huoxue Anxin Recipe against
            coronary heart disease by network analysis and experimental
            validation
  JOURNAL   Biomed Pharmacother 121, 109655 (2020)
   PUBMED   31734577
REFERENCE   2  (bases 1 to 2607)
  AUTHORS   Xu,S., Zhao,J., Liu,J. and Gou,W.
  TITLE     Fibrinopeptide A Induces Expression of C-Reactive Protein via the
            ROS-ERK1/2/ P38-NF-kappaB Signal Pathway in Vascular Smooth Muscle
            Cells
  JOURNAL   Cell Physiol Biochem 47 (1), 266-278 (2018)
   PUBMED   29768263
  REMARK    GeneRIF: Fibrinopeptide A induces CRP expression in Vascular Smooth
            Muscle Cells via Reactive Oxygen Species-ERK1/2/p38-NF-kappaB
            signal pathway.
REFERENCE   3  (bases 1 to 2607)
  AUTHORS   Huang,Z., Song,Y., Pang,Z., Li,M., Guliya,Y., Shen,Y., Qian,J. and
            Ge,J.
  TITLE     Fibrin-targeting delivery: a novel platform for cardiac
            regenerative medicine
  JOURNAL   J Cell Mol Med 20 (12), 2410-2413 (2016)
   PUBMED   27469290
  REMARK    GeneRIF: Studies suggest fibrin as a homing target molecule in
            regenerative medicine and the fibrin-targeting therapy may be a
            generalizable platform technology for tissue injury.
REFERENCE   4  (bases 1 to 2607)
  AUTHORS   Longstaff,C. and Kolev,K.
  TITLE     Basic mechanisms and regulation of fibrinolysis
  JOURNAL   J Thromb Haemost 13 Suppl 1, S98-S105 (2015)
   PUBMED   26149056
  REMARK    Review article
REFERENCE   5  (bases 1 to 2607)
  AUTHORS   Bai,J., He,A., Huang,C., Yang,J., Zhang,W., Wang,J., Yang,Y.,
            Zhang,P., Zhang,Y. and Zhou,F.
  TITLE     Serum peptidome based biomarkers searching for monitoring minimal
            residual disease in adult acute lymphocytic leukemia
  JOURNAL   Proteome Sci 12 (1), 49 (2014)
   PUBMED   25317080
  REMARK    Erratum:[Proteome Sci. 2020 Oct 24;18:9. doi:
            10.1186/s12953-020-00166-4.. PMID: 33110398]
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 2607)
  AUTHORS   Nicholson,N.S., Panzer-Knodle,S.G., Salyers,A.K., Taite,B.B.,
            King,L.W., Miyano,M., Gorczynski,R.J., Williams,M.H., Zupec,M.E.,
            Tjoeng,F.S. et al.
  TITLE     Antiplatelet and antithrombotic effects of platelet glycoprotein
            IIb/IIIa (GPIIb/IIIa) inhibition by arginine-glycine-aspartic
            acid-serine (RGDS) and arginine-glycine-aspartic acid (RGD) (O-me)Y
            (SC-46749)
  JOURNAL   J Pharmacol Exp Ther 256 (3), 876-882 (1991)
   PUBMED   2005585
REFERENCE   7  (bases 1 to 2607)
  AUTHORS   Evans,E., Courtois,G.M., Kilian,P.L., Fuller,G.M. and Crabtree,G.R.
  TITLE     Induction of fibrinogen and a subset of acute phase response genes
            involves a novel monokine which is mimicked by phorbol esters
  JOURNAL   J Biol Chem 262 (22), 10850-10854 (1987)
   PUBMED   2440878
REFERENCE   8  (bases 1 to 2607)
  AUTHORS   Sobczak,J., Lotti,A.M., Taroux,P. and Duguet,M.
  TITLE     Molecular cloning of mRNA sequences transiently induced during rat
            liver regeneration
  JOURNAL   Exp Cell Res 169 (1), 47-56 (1987)
   PUBMED   3817019
REFERENCE   9  (bases 1 to 2607)
  AUTHORS   Procyk,R., Devlin,T.M. and Ch'ih,J.J.
  TITLE     Cycloheximide as a probe of fibrinogen synthesis
  JOURNAL   Biochem J 178 (2), 501-504 (1979)
   PUBMED   444225
REFERENCE   10 (bases 1 to 2607)
  AUTHORS   John,D.W. and Miller,L.L.
  TITLE     Effect of whole x-irradiation of rats on net synthesis of albumin,
            fibrinogen, alpha-1-acid glycoprotein, and alpha-2-globulin (acute
            phase globulin) by the isolated, perfused rat liver
  JOURNAL   J Biol Chem 243 (2), 268-273 (1968)
   PUBMED   4170424
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000002.1.
            
            On or before Mar 11, 2021 this sequence version replaced
            XM_006232533.4, NM_001008724.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: FQ209852.1, SRR26643286.7498.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760393, SAMEA5760400
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-112               JAXUCZ010000002.1  170672169-170672280
            113-241             JAXUCZ010000002.1  170674389-170674517
            242-425             JAXUCZ010000002.1  170674940-170675123
            426-571             JAXUCZ010000002.1  170676085-170676230
            572-1697            JAXUCZ010000002.1  170676874-170677999
            1698-2607           JAXUCZ010000002.1  170678663-170679572
FEATURES             Location/Qualifiers
     source          1..2607
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="2"
                     /map="2q34"
     gene            1..2607
                     /gene="Fga"
                     /gene_synonym="Ac1873; Fba5e"
                     /note="fibrinogen alpha chain"
                     /db_xref="GeneID:361969"
                     /db_xref="RGD:2603"
     exon            1..112
                     /gene="Fga"
                     /gene_synonym="Ac1873; Fba5e"
                     /inference="alignment:Splign:2.1.0"
     CDS             59..2407
                     /gene="Fga"
                     /gene_synonym="Ac1873; Fba5e"
                     /note="isoform 1 precursor is encoded by transcript
                     variant 1; fibrinogen, alpha polypeptide; fibrinogen, A
                     alpha polypeptide"
                     /codon_start=1
                     /product="fibrinogen alpha chain isoform 1 precursor"
                     /protein_id="NP_001008724.1"
                     /db_xref="GeneID:361969"
                     /db_xref="RGD:2603"
                     /translation="MLSLRVACLILSLASTVWTADTGTTSEFIEAGGDIRGPRIVERQ
                     PSQCKETDWPFCSDEDWNHKCPSGCRMKGLIDEANQDFTNRINKLKNSLFDFQKNNKD
                     SNSLTRNIMEYLRGDFANANNFDNTFGQVSEDLRRRIEILKRKVIEKAQQIQVLQKDV
                     RDQLIDMKRLEVDIDIKIRSCKGSCSRSVSREINLKDYEGQQKQLEQVIAKELLPAKD
                     RQYLPAIKMSPVPDLVPGSFKSQLQEGPPEWKALTEMRQMRMELERPGKDGASRGDLP
                     GDSRGDSATRGPGSKIENPMTPGHGGSGYWRPGSSGSGSDGNWGSGTTGSDDTGTWGA
                     GSSRPSSGSGNLKPSNPDWGEFSEFGGSSSPATRKEYHTGKLVTSKGDKELLIGNEKV
                     TSTGTSTTRRSCSKTITKTVLGNDGHREVVKEVVTSDDGSDCGDGMDLGLTHSFSGRL
                     DELSRMHPELGSFYDSRFGSLTSNFKEFGSKTSDSDIFTDIENPSSHVPEFSSSSKTS
                     TVRKQVTKSYKMADEAASEAHQEGDTRTTKRGRARTMRDCDDVLQTHPSGAQNGIFSI
                     KLPGSSKIFSVYCDQETSLGGWLLIQQRMDGSLNFNRTWQDYKRGFGSLNDKGEGEFW
                     LGNDYLHLLTLRGSVLRVELEDWAGKEAYAEYHFRVGSEAEGYALQVSSYQGTAGDAL
                     MEGSVEEGTEYTSHSNMQFSTFDRDADQWEENCAEVYGGGWWYNSCQAANLNGIYYPG
                     GTYDPRNNSPYEIENGVVWVPFRGADYSLRAVRMKIRPLVGQ"
     exon            113..241
                     /gene="Fga"
                     /gene_synonym="Ac1873; Fba5e"
                     /inference="alignment:Splign:2.1.0"
     exon            242..425
                     /gene="Fga"
                     /gene_synonym="Ac1873; Fba5e"
                     /inference="alignment:Splign:2.1.0"
     exon            426..571
                     /gene="Fga"
                     /gene_synonym="Ac1873; Fba5e"
                     /inference="alignment:Splign:2.1.0"
     exon            572..1697
                     /gene="Fga"
                     /gene_synonym="Ac1873; Fba5e"
                     /inference="alignment:Splign:2.1.0"
     exon            1698..2607
                     /gene="Fga"
                     /gene_synonym="Ac1873; Fba5e"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 agtcctcctt cccttcagct tcggtgcttc ccatgagcca tccctgcaat cagaaactat
       61 gctttccctg agggtcgcct gcctcatcct gagcttggcc agcacagtct ggactgcaga
      121 caccggcacc acaagtgaat tcatagaagc aggaggagat attcgtggcc caagaattgt
      181 ggagagacag cctagtcaat gcaaggagac agattggccc ttctgctctg atgaagactg
      241 gaaccacaaa tgcccttcag gctgcaggat gaaagggttg attgatgaag ccaatcagga
      301 ctttacaaac agaatcaaca agctcaaaaa ctcactattt gattttcaaa agaacaacaa
      361 ggattctaat tcactgacca ggaatatcat ggagtatttg agaggggact tcgctaacgc
      421 caacaacttt gataacactt tcgggcaagt gtcagaggac ctgaggcgca gaattgagat
      481 cctaaagcgc aaagtcatag agaaagcgca acagattcag gttctgcaga aagacgtccg
      541 ggatcagctg atagacatga agcgcctgga ggtggacatt gatatcaaga tccgctcttg
      601 caaaggatcc tgcagcaggt ctgtaagccg tgagataaat ctaaaggact acgaaggtca
      661 gcaaaagcaa cttgaacagg tcattgctaa agagttgctt ccggcaaaag acaggcagta
      721 cttgccagca ataaaaatgt ctccagttcc cgacttggtt cccggaagtt ttaagagcca
      781 gcttcaggag gggcccccag agtggaaggc attaacagaa atgaggcaga tgagaatgga
      841 gctggagagg cccgggaagg atggggcttc gcgaggagat ttaccaggag attcgcgagg
      901 agactctgca acacgtggac cagggtcgaa gatagaaaac cccatgaccc ctggacatgg
      961 tgggtctggg tattggcgtc ctgggagctc cggatctgga agtgatggaa attggggctc
     1021 tgggacaacg gggtctgatg acactggaac ctggggtgca ggaagctcca gacctagctc
     1081 aggctctggg aaccttaagc ctagcaaccc tgactggggt gagttttcag agtttggagg
     1141 gagtagcagc ccagcgacaa gaaaagagta tcacacagga aaactggtca cttctaaagg
     1201 agataaagag ctcctcattg gaaacgagaa agttacctct actggcacaa gcaccacacg
     1261 tcgttcatgc tctaaaacca ttactaagac tgttttgggt aatgatggtc accgggaagt
     1321 ggtcaaagaa gtggtcactt cggatgatgg ttctgactgc ggtgatggca tggacttagg
     1381 cctgacccac agttttagtg gcagacttga cgaactttcc cgaatgcatc ctgaacttgg
     1441 ttccttttat gacagccgct ttggttcact cacaagtaac ttcaaagaat ttggcagtaa
     1501 gacctctgat tctgacatct tcacagacat cgagaaccct agctcccatg tacctgagtt
     1561 ttcttccagt agtaaaacct caactgtcag gaaacaagta accaagagct ataaaatggc
     1621 agatgaggca gcaagtgaag ctcaccaaga aggagacact cgaaccacca agaggggccg
     1681 agctcgcaca atgagagact gcgatgatgt ccttcaaaca catccttcag gtgcccaaaa
     1741 tggcattttc agtatcaagc tacctggatc cagtaagata ttttctgttt attgcgatca
     1801 agagaccagt ttgggaggat ggcttttgat ccagcaaaga atggatggat cactgaattt
     1861 taaccggacc tggcaagact acaagagagg tttcggcagc ctgaatgaca agggggaagg
     1921 agagttctgg ctaggcaatg actacctcca cttactcact ctgagaggct ctgtcctcag
     1981 ggttgaatta gaggactggg ctggaaaaga ggcttatgcg gagtaccact tccgggtagg
     2041 ctctgaggca gagggctatg cactgcaggt ctcctcctac cagggtaccg ctggagatgc
     2101 tctgatggag ggctctgtgg aggaggggac agaatacact tcacacagca acatgcagtt
     2161 cagtaccttt gacagagatg cagaccaatg ggaagagaac tgtgccgagg tctacggggg
     2221 aggctggtgg tacaatagct gtcaagccgc caatctcaat ggcatttact accctggggg
     2281 cacctatgac cccaggaaca acagtcccta tgagatagag aacggagtgg tctgggttcc
     2341 cttcagagga gcggattatt ctctgagggc cgttcggatg aaaatcagac cgctggtggg
     2401 acagtagctg aaggaatgga aagtgggggc tctgctttct ttgcttggtt agccgagaag
     2461 aatgatcaga agaggaaggt gtcacggatc ttgtgaactt tttagaaatt ccctggtgct
     2521 attccattgt tctttgtact gtagctgaac acagctgaga tgcgttactg ctttgaaaaa
     2581 aaaataaagt tttacatttt ttcccca
//
