LOCUS       NM_001047088            1388 bp    mRNA    linear   ROD 02-APR-2024
DEFINITION  Rattus norvegicus free fatty acid receptor 4 (Ffar4), mRNA.
ACCESSION   NM_001047088 XM_001080642 XM_215281
VERSION     NM_001047088.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1388)
  AUTHORS   Hilgendorf,K.I., Johnson,C.T., Mezger,A., Rice,S.L., Norris,A.M.,
            Demeter,J., Greenleaf,W.J., Reiter,J.F., Kopinke,D. and
            Jackson,P.K.
  TITLE     Omega-3 Fatty Acids Activate Ciliary FFAR4 to Control Adipogenesis
  JOURNAL   Cell 179 (6), 1289-1305 (2019)
   PUBMED   31761534
REFERENCE   2  (bases 1 to 1388)
  AUTHORS   Chen,Y.L., Lin,Y.P., Sun,C.K., Huang,T.H., Yip,H.K. and Chen,Y.T.
  TITLE     Extracorporeal shockwave against inflammation mediated by GPR120
            receptor in cyclophosphamide-induced rat cystitis model
  JOURNAL   Mol Med 24 (1), 60 (2018)
   PUBMED   30482157
  REMARK    GeneRIF: These findings suggest that GPR120, the sensing receptor
            for extracorporeal shockwave treatment, may be useful in the
            treatment of interstitial cystitis by inhibiting inflammatory
            response in bladder cells.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1388)
  AUTHORS   Schilperoort,M., van Dam,A.D., Hoeke,G., Shabalina,I.G., Okolo,A.,
            Hanyaloglu,A.C., Dib,L.H., Mol,I.M., Caengprasath,N., Chan,Y.W.,
            Damak,S., Miller,A.R., Coskun,T., Shimpukade,B., Ulven,T.,
            Kooijman,S., Rensen,P.C. and Christian,M.
  TITLE     The GPR120 agonist TUG-891 promotes metabolic health by stimulating
            mitochondrial respiration in brown fat
  JOURNAL   EMBO Mol Med 10 (3) (2018)
   PUBMED   29343498
REFERENCE   4  (bases 1 to 1388)
  AUTHORS   Meza-Cuenca,F., Medina-Contreras,J.M.L., Mailloux-Salinas,P.,
            Bautista-Hernandez,L.A., Buentello-Volante,B., Dominguez-Lopez,A.,
            Garfias,Y., Correa-Lopez,P.V., Bautista de Lucio,V.M. and Bravo,G.
  TITLE     Characterization of free fatty acid receptors expression in an
            obesity rat model with high sucrose diet
  JOURNAL   J Recept Signal Transduct Res 38 (1), 76-82 (2018)
   PUBMED   29369009
  REMARK    GeneRIF: These present data have shown for the first time that
            total mRNA isolation and protein expression from both adipose
            tissues (abdominal and subcutaneous) of rat in obesity condition
            yield significative statistical difference among the control versus
            obese groups, showing that the diet high in carbohydrates modifies
            the total presence of mRNA and protein level expression of the
            receptors GPR41, 43 and 120
REFERENCE   5  (bases 1 to 1388)
  AUTHORS   Satapati,S., Qian,Y., Wu,M.S., Petrov,A., Dai,G., Wang,S.P.,
            Zhu,Y., Shen,X., Muise,E.S., Chen,Y., Zycband,E., Weinglass,A., Di
            Salvo,J., Debenham,J.S., Cox,J.M., Lan,P., Shah,V., Previs,S.F.,
            Erion,M., Kelley,D.E., Wang,L., Howard,A.D. and Shang,J.
  TITLE     GPR120 suppresses adipose tissue lipolysis and synergizes with
            GPR40 in antidiabetic efficacy
  JOURNAL   J Lipid Res 58 (8), 1561-1578 (2017)
   PUBMED   28583918
  REMARK    GeneRIF: GPR120 suppresses adipose tissue lipolysis and synergizes
            with GPR40 in antidiabetic efficacy
REFERENCE   6  (bases 1 to 1388)
  AUTHORS   Oh,D.Y., Talukdar,S., Bae,E.J., Imamura,T., Morinaga,H., Fan,W.,
            Li,P., Lu,W.J., Watkins,S.M. and Olefsky,J.M.
  TITLE     GPR120 is an omega-3 fatty acid receptor mediating potent
            anti-inflammatory and insulin-sensitizing effects
  JOURNAL   Cell 142 (5), 687-698 (2010)
   PUBMED   20813258
REFERENCE   7  (bases 1 to 1388)
  AUTHORS   Cartoni,C., Yasumatsu,K., Ohkuri,T., Shigemura,N., Yoshida,R.,
            Godinot,N., le Coutre,J., Ninomiya,Y. and Damak,S.
  TITLE     Taste preference for fatty acids is mediated by GPR40 and GPR120
  JOURNAL   J Neurosci 30 (25), 8376-8382 (2010)
   PUBMED   20573884
REFERENCE   8  (bases 1 to 1388)
  AUTHORS   Tanaka,T., Yano,T., Adachi,T., Koshimizu,T.A., Hirasawa,A. and
            Tsujimoto,G.
  TITLE     Cloning and characterization of the rat free fatty acid receptor
            GPR120: in vivo effect of the natural ligand on GLP-1 secretion and
            proliferation of pancreatic beta cells
  JOURNAL   Naunyn Schmiedebergs Arch Pharmacol 377 (4-6), 515-522 (2008)
   PUBMED   18320172
  REMARK    GeneRIF: rat GPR120 is a G-protein-coupled receptor whose ligand is
            a free fatty acid, and it may play an important role in the
            FFA-associated physiological responses.
REFERENCE   9  (bases 1 to 1388)
  AUTHORS   Katsuma,S., Hatae,N., Yano,T., Ruike,Y., Kimura,M., Hirasawa,A. and
            Tsujimoto,G.
  TITLE     Free fatty acids inhibit serum deprivation-induced apoptosis
            through GPR120 in a murine enteroendocrine cell line STC-1
  JOURNAL   J Biol Chem 280 (20), 19507-19515 (2005)
   PUBMED   15774482
REFERENCE   10 (bases 1 to 1388)
  AUTHORS   Hirasawa,A., Tsumaya,K., Awaji,T., Katsuma,S., Adachi,T.,
            Yamada,M., Sugimoto,Y., Miyazaki,S. and Tsujimoto,G.
  TITLE     Free fatty acids regulate gut incretin glucagon-like peptide-1
            secretion through GPR120
  JOURNAL   Nat Med 11 (1), 90-94 (2005)
   PUBMED   15619630
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from AB207868.1.
            
            On or before Sep 7, 2006 this sequence version replaced
            XM_215281.4, XM_001080642.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AB207868.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN06680412, SAMN06680416
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1388
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q53"
     gene            1..1388
                     /gene="Ffar4"
                     /gene_synonym="Gpr120; O3far1"
                     /note="free fatty acid receptor 4"
                     /db_xref="GeneID:294075"
                     /db_xref="RGD:1308252"
     exon            1..612
                     /gene="Ffar4"
                     /gene_synonym="Gpr120; O3far1"
                     /inference="alignment:Splign:2.1.0"
     CDS             46..1131
                     /gene="Ffar4"
                     /gene_synonym="Gpr120; O3far1"
                     /note="G-protein coupled receptor 120; omega-3 fatty acid
                     receptor 1"
                     /codon_start=1
                     /product="free fatty acid receptor 4"
                     /protein_id="NP_001040553.1"
                     /db_xref="GeneID:294075"
                     /db_xref="RGD:1308252"
                     /translation="MSPECAQTTGPGPSRTPDQVNRTHFPFFSDVKGDHRLVLSVLET
                     TVLGLIFVVSLLGNVCALVLVVRRRRRGATVSLVLNLFCADLLFTSAIPLVLVVRWTE
                     AWLLGPVVCHLLFYVMTMSGSVTILTLAAVSLERMVCIVRLRRGLSGPGRRTQAALLA
                     FIWGYSALAALPLCILFRVVPQRLPGGDQEIPICTLDWPNRIGEISWDVFFVTLNFLV
                     PGLVIVISYSKILQITKASRKRLTLSLAYSESHQIRVSQQDYRLFRTLFLLMVSFFIM
                     WSPIIITILLILIQNFRQDLVIWPSLFFWVVAFTFANSALNPILYNMSLFRSEWRKIF
                     CCFFFPEKGAIFTETSIRRNDLSVIST"
     exon            613..741
                     /gene="Ffar4"
                     /gene_synonym="Gpr120; O3far1"
                     /inference="alignment:Splign:2.1.0"
     exon            742..1388
                     /gene="Ffar4"
                     /gene_synonym="Gpr120; O3far1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gcagatgaac gctctcacag acagcggcgc ggccgggcgc ccggcatgtc ccctgagtgt
       61 gcgcagacga cgggccctgg cccctcgcgc accccggacc aagtcaatcg cacccacttc
      121 cctttcttct cggatgtcaa gggcgaccac cggctggtgc tgagcgtcct ggagaccacc
      181 gttctgggac tcatctttgt ggtctcactg ctgggcaacg tgtgtgccct ggtgctggtg
      241 gtgcgccgtc ggcgccgtgg ggcgacagtc agcttggtgc tcaacctctt ctgcgcggat
      301 ttgctcttca ccagcgccat ccctctagtg ctcgtggtgc gctggactga agcctggctg
      361 ctggggcccg tcgtctgcca cctgctcttc tacgtgatga ccatgagcgg cagcgtcacg
      421 atcctcacgc tggccgcggt cagcctggag cgcatggtgt gcatcgtgcg cctgcggcgc
      481 ggcttgagcg gcccggggcg gcggactcag gcggcgctgc tggctttcat atggggttac
      541 tcggcgctcg ccgcgctgcc cctctgcatc ttgttccgcg tggtcccgca gcgccttccc
      601 ggcggggacc aggaaattcc gatctgcaca ttggattggc ccaaccgcat aggagaaatc
      661 tcatgggatg tgttttttgt gactttgaac ttcctggtac caggactggt cattgtgatc
      721 agctactcca agattttaca gatcacgaaa gcctcgcgga agaggcttac gctgagcttg
      781 gcatactccg agagccacca gatccgagtg tcccagcagg actaccggct cttccgaacg
      841 ctcttcctgc tcatggtttc cttcttcatc atgtggagtc ccatcatcat caccatcctc
      901 ctcatcttga tccagaactt ccggcaggac ctggttatct ggccgtccct tttcttctgg
      961 gtggtggcct tcacgtttgc caactccgcc ctaaacccca ttctgtacaa catgtcgctg
     1021 ttcaggagcg agtggaggaa gattttttgc tgcttctttt tcccagagaa gggagccatt
     1081 tttacagaaa cgtctatcag gcgaaatgac ttgtctgtta tttccaccta actgctggtg
     1141 ccaggtaaac catggtgtgc atgtaaaggg agttaaacac caggaaaagc ccaccagggt
     1201 accctgatta aaaaatgttc aacttccaac agtgcgcatc tacaggacca gcaaattaag
     1261 gaacgatcgc tcagtataaa aaatattttt ccttaaaaga actttctatg ggttcctttt
     1321 gtgaactctt atttagtgtg tttgtattat gatcaagtta ataaattttt atttatcgct
     1381 gttcctac
//
