LOCUS       NM_001108912            1113 bp    mRNA    linear   ROD 02-JUN-2024
DEFINITION  Rattus norvegicus free fatty acid receptor 3 (Ffar3), mRNA.
ACCESSION   NM_001108912 XM_001079302 XM_344880
VERSION     NM_001108912.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1113)
  AUTHORS   Ballout,J., Akiba,Y., Kaunitz,J.D. and Diener,M.
  TITLE     Short-chain fatty acid receptors involved in epithelial
            acetylcholine release in rat caecum
  JOURNAL   Eur J Pharmacol 906, 174292 (2021)
   PUBMED   34216575
  REMARK    GeneRIF: Short-chain fatty acid receptors involved in epithelial
            acetylcholine release in rat caecum.
REFERENCE   2  (bases 1 to 1113)
  AUTHORS   Kaji,I., Akiba,Y., Furuyama,T., Adelson,D.W., Iwamoto,K.,
            Watanabe,M., Kuwahara,A. and Kaunitz,J.D.
  TITLE     Free fatty acid receptor 3 activation suppresses neurogenic
            motility in rat proximal colon
  JOURNAL   Neurogastroenterol Motil 30 (1) (2018)
   PUBMED   28714277
  REMARK    GeneRIF: Study demonstrates that free fatty acid receptor 3
            activation inhibited nicotine-evoked neural activity in the
            regulation of colonic motility.
REFERENCE   3  (bases 1 to 1113)
  AUTHORS   Kaji,I., Akiba,Y., Konno,K., Watanabe,M., Kimura,S., Iwanaga,T.,
            Kuri,A., Iwamoto,K., Kuwahara,A. and Kaunitz,J.D.
  TITLE     Neural FFA3 activation inversely regulates anion secretion evoked
            by nicotinic ACh receptor activation in rat proximal colon
  JOURNAL   J Physiol 594 (12), 3339-3352 (2016)
   PUBMED   26854275
  REMARK    GeneRIF: These results suggest that the short-chain fatty acid-FFA3
            pathway has a novel anti-secretory function in that it inhibits
            cholinergic neural reflexes in the enteric nervous system.
REFERENCE   4  (bases 1 to 1113)
  AUTHORS   Han,J.H., Kim,I.S., Jung,S.H., Lee,S.G., Son,H.Y. and Myung,C.S.
  TITLE     The effects of propionate and valerate on insulin responsiveness
            for glucose uptake in 3T3-L1 adipocytes and C2C12 myotubes via G
            protein-coupled receptor 41
  JOURNAL   PLoS One 9 (4), e95268 (2014)
   PUBMED   24748202
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1113)
  AUTHORS   Kim,M.H., Kang,S.G., Park,J.H., Yanagisawa,M. and Kim,C.H.
  TITLE     Short-chain fatty acids activate GPR41 and GPR43 on intestinal
            epithelial cells to promote inflammatory responses in mice
  JOURNAL   Gastroenterology 145 (2), 396-406 (2013)
   PUBMED   23665276
REFERENCE   6  (bases 1 to 1113)
  AUTHORS   Kimura,I., Inoue,D., Maeda,T., Hara,T., Ichimura,A., Miyauchi,S.,
            Kobayashi,M., Hirasawa,A. and Tsujimoto,G.
  TITLE     Short-chain fatty acids and ketones directly regulate sympathetic
            nervous system via G protein-coupled receptor 41 (GPR41)
  JOURNAL   Proc Natl Acad Sci U S A 108 (19), 8030-8035 (2011)
   PUBMED   21518883
REFERENCE   7  (bases 1 to 1113)
  AUTHORS   Liu,C., Wu,J., Zhu,J., Kuei,C., Yu,J., Shelton,J., Sutton,S.W.,
            Li,X., Yun,S.J., Mirzadegan,T., Mazur,C., Kamme,F. and
            Lovenberg,T.W.
  TITLE     Lactate inhibits lipolysis in fat cells through activation of an
            orphan G-protein-coupled receptor, GPR81
  JOURNAL   J Biol Chem 284 (5), 2811-2822 (2009)
   PUBMED   19047060
REFERENCE   8  (bases 1 to 1113)
  AUTHORS   Stoddart,L.A., Smith,N.J., Jenkins,L., Brown,A.J. and Milligan,G.
  TITLE     Conserved polar residues in transmembrane domains V, VI, and VII of
            free fatty acid receptor 2 and free fatty acid receptor 3 are
            required for the binding and function of short chain fatty acids
  JOURNAL   J Biol Chem 283 (47), 32913-32924 (2008)
   PUBMED   18801738
REFERENCE   9  (bases 1 to 1113)
  AUTHORS   Xiong,Y., Miyamoto,N., Shibata,K., Valasek,M.A., Motoike,T.,
            Kedzierski,R.M. and Yanagisawa,M.
  TITLE     Short-chain fatty acids stimulate leptin production in adipocytes
            through the G protein-coupled receptor GPR41
  JOURNAL   Proc Natl Acad Sci U S A 101 (4), 1045-1050 (2004)
   PUBMED   14722361
REFERENCE   10 (bases 1 to 1113)
  AUTHORS   Brown,A.J., Goldsworthy,S.M., Barnes,A.A., Eilert,M.M., Tcheang,L.,
            Daniels,D., Muir,A.I., Wigglesworth,M.J., Kinghorn,I., Fraser,N.J.,
            Pike,N.B., Strum,J.C., Steplewski,K.M., Murdock,P.R., Holder,J.C.,
            Marshall,F.H., Szekeres,P.G., Wilson,S., Ignar,D.M., Foord,S.M.,
            Wise,A. and Dowell,S.J.
  TITLE     The Orphan G protein-coupled receptors GPR41 and GPR43 are
            activated by propionate and other short chain carboxylic acids
  JOURNAL   J Biol Chem 278 (13), 11312-11319 (2003)
   PUBMED   12496283
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from CH473979.2.
            
            On or before Oct 4, 2007 this sequence version replaced
            XM_344880.3, XM_001079302.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC166522.1, CK603957.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMD00132291, SAMD00132306
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1113
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q21"
     gene            1..1113
                     /gene="Ffar3"
                     /gene_synonym="Gpr41"
                     /note="free fatty acid receptor 3"
                     /db_xref="GeneID:365228"
                     /db_xref="RGD:1311035"
     exon            1..52
                     /gene="Ffar3"
                     /gene_synonym="Gpr41"
                     /inference="alignment:Splign:2.1.0"
     exon            53..1113
                     /gene="Ffar3"
                     /gene_synonym="Gpr41"
                     /inference="alignment:Splign:2.1.0"
     CDS             64..1023
                     /gene="Ffar3"
                     /gene_synonym="Gpr41"
                     /note="G protein-coupled receptor 41"
                     /codon_start=1
                     /product="free fatty acid receptor 3"
                     /protein_id="NP_001102382.1"
                     /db_xref="GeneID:365228"
                     /db_xref="RGD:1311035"
                     /translation="MDTSFFPGNHWLFFSVDLLVFLVGLPLNVMALVVFVNKLRRRPV
                     AVDLLLLNLTISDLLLLLFLPFRIVEAACGMKWILPFIFCPLSGFLFFTTIYLTSLFL
                     MTVSIERFLSVAYPLWYKTRPRLAQAGLVSGICWFLASAHCSVIYVTEYWGNATYSQG
                     TNGTCYLEFREDQLAILLPVRLEMAVVLFMVPLCITSYCYSRLVWILSQGASRRRRKR
                     VMGLLVATLLIFFVCFGPYNMSHVVGYVRGESPTWRSYVLLLSTLNSCIDPLVFYFSS
                     SKFQADFHQLLSRLIRACVPWTQEVSLELKVKNGEEPSKECPS"
ORIGIN      
        1 gtaggagcta gctgggtgct gggcggcagc gtgccagctc tccaacactc tgcatctgtg
       61 accatggaca caagcttctt tcccggcaac cactggcttt tcttttcagt ggatctgttg
      121 gtgttcctcg tgggactacc cctcaacgtg atggccctgg tggtcttcgt gaacaagctg
      181 cgtcgccgcc cggtggccgt ggacttactt ttgcttaacc tgaccatttc ggacctgctt
      241 ctgctcctct tcctgccatt ccgtatagtg gaggcggcct gtggcatgaa atggattctg
      301 cccttcatct tctgccccct ttctggcttc cttttcttca ccaccatcta cctcacctcc
      361 ctcttcctga tgacggtgag catagaacgt tttctgagcg tagcctaccc actgtggtac
      421 aaaacccggc cccggctggc ccaggctggt ctggtcagtg gcatctgttg gttcttggca
      481 tcagctcact gtagtgtgat ttatgtcact gaatactggg gaaatgcaac ctacagccag
      541 gggaccaacg gaacctgcta cctggaattc cgggaggacc agctggccat cctcctcccc
      601 gtgcgactgg aaatggctgt ggtccttttc atggtgcccc tgtgtattac cagttactgc
      661 tacagtcgcc tggtgtggat tctgagccag ggagccagcc ggcgcaggcg caagagagtg
      721 atggggcttc ttgtagccac gttgctcatc ttctttgtct gcttcggccc ctacaatatg
      781 tcccacgtgg tgggctacgt gcgcggtgag agtccgacct ggcggagcta cgtgcttctc
      841 ctcagcaccc tcaactcttg tattgaccct ctggttttct acttttcatc ctccaagttc
      901 caagccgact ttcatcagct cctgtctagg ctgatcagag cttgtgtgcc ttggactcag
      961 gaagtcagct tggaactgaa ggtaaagaac ggagaagagc catccaagga atgtccgagc
     1021 tagagaaaag agtggaccgg aggaggggtg tggaaaacac tggctcagcg ctttggccag
     1081 cagagagctc tccggggtca ggaaggagtg ggc
//
