LOCUS       NM_001005877            1850 bp    mRNA    linear   ROD 18-FEB-2024
DEFINITION  Rattus norvegicus free fatty acid receptor 2 (Ffar2), mRNA.
ACCESSION   NM_001005877 XM_006228822 XM_214905
VERSION     NM_001005877.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1850)
  AUTHORS   Ballout,J., Akiba,Y., Kaunitz,J.D. and Diener,M.
  TITLE     Short-chain fatty acid receptors involved in epithelial
            acetylcholine release in rat caecum
  JOURNAL   Eur J Pharmacol 906, 174292 (2021)
   PUBMED   34216575
  REMARK    GeneRIF: Short-chain fatty acid receptors involved in epithelial
            acetylcholine release in rat caecum.
REFERENCE   2  (bases 1 to 1850)
  AUTHORS   Lu,J., Chen,P.P., Zhang,J.X., Li,X.Q., Wang,G.H., Yuan,B.Y.,
            Huang,S.J., Liu,X.Q., Jiang,T.T., Wang,M.Y., Liu,W.T., Ruan,X.Z.,
            Liu,B.C. and Ma,K.L.
  TITLE     GPR43 deficiency protects against podocyte insulin resistance in
            diabetic nephropathy through the restoration of AMPKalpha activity
  JOURNAL   Theranostics 11 (10), 4728-4742 (2021)
   PUBMED   33754024
  REMARK    GeneRIF: GPR43 deficiency protects against podocyte insulin
            resistance in diabetic nephropathy through the restoration of
            AMPKalpha activity.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1850)
  AUTHORS   Onyszkiewicz,M., Gawrys-Kopczynska,M., Konopelski,P.,
            Aleksandrowicz,M., Sawicka,A., Kozniewska,E., Samborowska,E. and
            Ufnal,M.
  TITLE     Butyric acid, a gut bacteria metabolite, lowers arterial blood
            pressure via colon-vagus nerve signaling and GPR41/43 receptors
  JOURNAL   Pflugers Arch 471 (11-12), 1441-1453 (2019)
   PUBMED   31728701
  REMARK    GeneRIF: Depends on the afferent colonic vagus nerve signaling and
            GPR41/43 receptors.
REFERENCE   4  (bases 1 to 1850)
  AUTHORS   Meza-Cuenca,F., Medina-Contreras,J.M.L., Mailloux-Salinas,P.,
            Bautista-Hernandez,L.A., Buentello-Volante,B., Dominguez-Lopez,A.,
            Garfias,Y., Correa-Lopez,P.V., Bautista de Lucio,V.M. and Bravo,G.
  TITLE     Characterization of free fatty acid receptors expression in an
            obesity rat model with high sucrose diet
  JOURNAL   J Recept Signal Transduct Res 38 (1), 76-82 (2018)
   PUBMED   29369009
  REMARK    GeneRIF: These present data have shown for the first time that
            total mRNA isolation and protein expression from both adipose
            tissues (abdominal and subcutaneous) of rat in obesity condition
            yield significative statistical difference among the control versus
            obese groups, showing that the diet high in carbohydrates modifies
            the total presence of mRNA and protein level expression of the
            receptors GPR41, 43 and 120
REFERENCE   5  (bases 1 to 1850)
  AUTHORS   Miletta,M.C., Petkovic,V., Eble,A., Ammann,R.A., Fluck,C.E. and
            Mullis,P.E.
  TITLE     Butyrate increases intracellular calcium levels and enhances growth
            hormone release from rat anterior pituitary cells via the
            G-protein-coupled receptors GPR41 and 43
  JOURNAL   PLoS One 9 (10), e107388 (2014)
   PUBMED   25310566
  REMARK    GeneRIF: By acting through GPR41 and 43, butyrate enhanced
            intracellular free cytosolic Ca2+. Gene-specific silencing of these
            receptors led to a partial inhibition of the butyrate-induced
            intracellular Ca2+ rise resulting in a decrease of hGH secretion.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1850)
  AUTHORS   Maslowski,K.M., Vieira,A.T., Ng,A., Kranich,J., Sierro,F., Yu,D.,
            Schilter,H.C., Rolph,M.S., Mackay,F., Artis,D., Xavier,R.J.,
            Teixeira,M.M. and Mackay,C.R.
  TITLE     Regulation of inflammatory responses by gut microbiota and
            chemoattractant receptor GPR43
  JOURNAL   Nature 461 (7268), 1282-1286 (2009)
   PUBMED   19865172
REFERENCE   7  (bases 1 to 1850)
  AUTHORS   Stoddart,L.A., Smith,N.J., Jenkins,L., Brown,A.J. and Milligan,G.
  TITLE     Conserved polar residues in transmembrane domains V, VI, and VII of
            free fatty acid receptor 2 and free fatty acid receptor 3 are
            required for the binding and function of short chain fatty acids
  JOURNAL   J Biol Chem 283 (47), 32913-32924 (2008)
   PUBMED   18801738
REFERENCE   8  (bases 1 to 1850)
  AUTHORS   Karaki,S., Mitsui,R., Hayashi,H., Kato,I., Sugiya,H., Iwanaga,T.,
            Furness,J.B. and Kuwahara,A.
  TITLE     Short-chain fatty acid receptor, GPR43, is expressed by
            enteroendocrine cells and mucosal mast cells in rat intestine
  JOURNAL   Cell Tissue Res 324 (3), 353-360 (2006)
   PUBMED   16453106
  REMARK    GeneRIF: The results suggest that the PYY-containing
            enteroendocrine cells and 5-HT-containing mucosal mast cells sense
            SCFAs via the GPR43 receptor.
REFERENCE   9  (bases 1 to 1850)
  AUTHORS   Hong,Y.H., Nishimura,Y., Hishikawa,D., Tsuzuki,H., Miyahara,H.,
            Gotoh,C., Choi,K.C., Feng,D.D., Chen,C., Lee,H.G., Katoh,K.,
            Roh,S.G. and Sasaki,S.
  TITLE     Acetate and propionate short chain fatty acids stimulate
            adipogenesis via GPCR43
  JOURNAL   Endocrinology 146 (12), 5092-5099 (2005)
   PUBMED   16123168
REFERENCE   10 (bases 1 to 1850)
  AUTHORS   Brown,A.J., Goldsworthy,S.M., Barnes,A.A., Eilert,M.M., Tcheang,L.,
            Daniels,D., Muir,A.I., Wigglesworth,M.J., Kinghorn,I., Fraser,N.J.,
            Pike,N.B., Strum,J.C., Steplewski,K.M., Murdock,P.R., Holder,J.C.,
            Marshall,F.H., Szekeres,P.G., Wilson,S., Ignar,D.M., Foord,S.M.,
            Wise,A. and Dowell,S.J.
  TITLE     The Orphan G protein-coupled receptors GPR41 and GPR43 are
            activated by propionate and other short chain carboxylic acids
  JOURNAL   J Biol Chem 278 (13), 11312-11319 (2003)
   PUBMED   12496283
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JACYVU010000033.1.
            
            [WARNING] On Apr 3, 2024 this sequence was replaced by
            NM_001005877.3.
            
            On or before Oct 12, 2022 this sequence version replaced
            XM_006228822.4, NM_001005877.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            RNAseq introns :: single sample supports all introns SAMN06680420,
                              SAMN06680435 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-48                JACYVU010000033.1  9951545-9951592     c
            49-110              JACYVU010000033.1  9951077-9951138     c
            111-1850            JACYVU010000033.1  9948809-9950548     c
FEATURES             Location/Qualifiers
     source          1..1850
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q21"
     gene            1..1850
                     /gene="Ffar2"
                     /gene_synonym="Gpr43"
                     /note="free fatty acid receptor 2"
                     /db_xref="GeneID:292794"
                     /db_xref="RGD:1359614"
     exon            1..48
                     /gene="Ffar2"
                     /gene_synonym="Gpr43"
                     /inference="alignment:Splign:2.1.0"
     exon            49..110
                     /gene="Ffar2"
                     /gene_synonym="Gpr43"
                     /inference="alignment:Splign:2.1.0"
     exon            111..1850
                     /gene="Ffar2"
                     /gene_synonym="Gpr43"
                     /inference="alignment:Splign:2.1.0"
     CDS             112..1104
                     /gene="Ffar2"
                     /gene_synonym="Gpr43"
                     /note="G-protein coupled receptor 43"
                     /codon_start=1
                     /product="free fatty acid receptor 2"
                     /protein_id="NP_001005877.1"
                     /db_xref="GeneID:292794"
                     /db_xref="RGD:1359614"
                     /translation="MTPDWHSSLILTAYILIFLTGLPANLLALRAFVSRVRQPQPAPV
                     HILLLNLTLADLLLLLLLPFRIVEAASNFRWYLPKIVCALTGFGFYSSIYCSTWLLAG
                     ISIERYLGVAFPVQYKLSRRPLYGVIAALVAWIMSFGHCTIVIIVQYLNSTEQVGTEN
                     QITCYENFTQAQLDVVLPVRLELCLVLFFVPMTVTIFCYWRFVWIMLTQPHVGAQRRR
                     RAVGLAVVTLLNFLVCFGPYNMSHLVGFHLRQSPSWRVEAVVFSSLNASLDPLLFYFS
                     SSVVRRAFGKGLLLLRNPGSSMLGRGAEETVEGTKTDRGGSQTEGAQSSDFVTE"
ORIGIN      
        1 ctcttgcacc tcaggaaccc ccaagaaacc tatcagaagc caagcaagga tccacagccc
       61 tggaccagag gagaaccagg tggaagaaac ccctgaactt gcccaaggag aatgacccca
      121 gactggcaca gttccttgat cctcacggcc tacatcctca tctttcttac tgggctccct
      181 gccaacctgc tggccctgcg ggccttcgtg agccgggttc gccagcccca gcctgcaccc
      241 gtgcacatcc tcctgcttaa tctgaccctg gcggacttgc tgttgttgct gctgctgccc
      301 ttccggatcg tggaagctgc atccaacttc cgctggtacc taccaaagat cgtgtgcgcg
      361 ctcacgggct tcggcttcta cagcagtatc tactgcagca cgtggctgct ggcgggcatc
      421 agcatagaac gctacctggg agtggctttc ccggtgcagt acaagctatc ccgccggcca
      481 ctgtacggag tgatcgctgc tctggtggcc tggatcatgt cctttggcca ttgcaccatc
      541 gtcatcatcg ttcagtacct gaactcaacc gagcaggtgg gcaccgagaa ccaaatcacc
      601 tgctatgaga acttcaccca agcgcagctg gatgtggtgc tgcccgtgcg actggagctg
      661 tgcctggtcc tctttttcgt ccccatgaca gtcaccatct tctgctattg gcgctttgtg
      721 tggatcatgc tcacacagcc ccatgttggg gctcagaggc gacgccgggc ggtgggcctg
      781 gctgtggtga cgcttcttaa tttcctggtg tgctttggac cttacaacat gtcccacctg
      841 gtggggttcc acttgaggca gagtccctcg tggcgggtgg aggctgtggt gttcagttcc
      901 ctcaatgcca gcctggaccc tctgctattc tacttctcct cctccgtggt acgcagggcc
      961 ttcgggaaag gtttgctact actccgcaat cccggctcct ctatgctggg caggggagcc
     1021 gaagagacag tggaggggac caagacagac aggggtggga gtcaaacaga aggggcacag
     1081 agctctgact ttgtcaccga gtgagtatag agtcgcccgg atcttcccga gcgtctaggt
     1141 cactcagaag ttgggctggt tagcagagct cctgagactt ggtaaaagat aaaaggttat
     1201 aaaaaaaaga aagacacccc ttcacacaca cacacacccc acccctttgc cactgttctc
     1261 tcggatctgc agaacctctt ggctgaattt tcctgcccaa ggaagcacag ctccaggata
     1321 caagaagaaa tggctgcacc cctgcacccc ttttcacacc tgtgaaatta cactggaggc
     1381 aggggctcag aggcaaggtg actaatagga gtgtggctgt tttcttcaag gttggaaaca
     1441 ccacctagag acattggtct ggctggtgat gctgggaaga agccaatgga aaagacaggg
     1501 gagagatggt gggaagaaga ggaattctgg gaaagctcta agccacgggc ttgcgggggg
     1561 gggggggtac agggctccca tctctggtga tcttggtctt tctgtatccg attgagctgt
     1621 gccttgcaca tgtgctccgc tgatgttcgt atttcggtct tgtctccgcc gttacactgg
     1681 gatctgggtt acccagtgcc tggtttatcc tcagtgtcac tgccccggga ctaggtgcag
     1741 atccatgtct tggtacccat ctgtctgaca ttgacaatga cctgcatgga aagaaaaaac
     1801 aaatctggtt tggcaggttt aaaataaata ttatgaaagt ctgaagcaaa
//
