LOCUS       NM_153304                905 bp    mRNA    linear   ROD 05-DEC-2024
DEFINITION  Rattus norvegicus free fatty acid receptor 1 (Ffar1), mRNA.
ACCESSION   NM_153304
VERSION     NM_153304.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 905)
  AUTHORS   Li,S.N., Yu,Y.L., Wang,B.Y., Qiao,S.Y., Hu,M.M., Wang,H., Fu,C.N.
            and Dong,B.
  TITLE     Overexpression of G Protein-Coupled Receptor 40 Protects
            Obesity-Induced Cardiomyopathy Through the SIRT1/LKB1/AMPK Pathway
  JOURNAL   Hum Gene Ther 33 (11-12), 598-613 (2022)
   PUBMED   35018806
  REMARK    GeneRIF: Overexpression of G Protein-Coupled Receptor 40 Protects
            Obesity-Induced Cardiomyopathy Through the SIRT1/LKB1/AMPK Pathway.
REFERENCE   2  (bases 1 to 905)
  AUTHORS   Xiao,J., Cai,T., Fang,Y., Liu,R., Flores,J.J., Wang,W., Gao,L.,
            Liu,Y., Lu,Q., Tang,L., Zhang,J.H., Lu,H. and Tang,J.
  TITLE     Activation of GPR40 attenuates neuroinflammation and improves
            neurological function via PAK4/CREB/KDM6B pathway in an
            experimental GMH rat model
  JOURNAL   J Neuroinflammation 18 (1), 160 (2021)
   PUBMED   34275493
  REMARK    GeneRIF: Activation of GPR40 attenuates neuroinflammation and
            improves neurological function via PAK4/CREB/KDM6B pathway in an
            experimental GMH rat model.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 905)
  AUTHORS   Cho,Y.J., Choi,S.H., Lee,R., Hwang,H., Rhim,H., Cho,I.H., Kim,H.C.,
            Lee,J.I., Hwang,S.H. and Nah,S.Y.
  TITLE     Ginseng Gintonin Contains Ligands for GPR40 and GPR55
  JOURNAL   Molecules 25 (5), 1102 (2020)
   PUBMED   32121640
  REMARK    GeneRIF: Ginseng Gintonin Contains Ligands for GPR40 and GPR55.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 905)
  AUTHORS   Kim,C.S., Joo,S.Y., Kim,I.J., Choi,H.I., Bae,E.H., Kim,S.W. and
            Ma,S.K.
  TITLE     Anti-Apoptotic Effect of G-Protein-Coupled Receptor 40 Activation
            on Tumor Necrosis Factor-alpha-Induced Injury of Rat Proximal
            Tubular Cells
  JOURNAL   Int J Mol Sci 20 (14), 3386 (2019)
   PUBMED   31295865
  REMARK    GeneRIF: our results demonstrate that GPR40 activation rescued cell
            death and activated the pro-apoptotic signaling pathway in
            TNF-alpha-induced injury of NRK52E cells.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 905)
  AUTHORS   Feng,X.T., Duan,H.M. and Li,S.L.
  TITLE     Protective role of Pollen Typhae total flavone against the palmitic
            acid-induced impairment of glucose-stimulated insulin secretion
            involving GPR40 signaling in INS-1 cells
  JOURNAL   Int J Mol Med 40 (3), 922-930 (2017)
   PUBMED   28731171
  REMARK    GeneRIF: The results indicate that Pollen Typhae total flavone
            exerts a protective role against PA-induced impairment of GSIS
            involving GPR40 signaling in INS-1 cells.
REFERENCE   6  (bases 1 to 905)
  AUTHORS   Stoddart,L.A., Brown,A.J. and Milligan,G.
  TITLE     Uncovering the pharmacology of the G protein-coupled receptor
            GPR40: high apparent constitutive activity in guanosine
            5'-O-(3-[35S]thio)triphosphate binding studies reflects binding of
            an endogenous agonist
  JOURNAL   Mol Pharmacol 71 (4), 994-1005 (2007)
   PUBMED   17200419
  REMARK    GeneRIF: GPR40 responded to fatty acids with different on-rates,
            and could be occupied by endogenous agonists before assay, masking
            the pharmacology of the receptor
REFERENCE   7  (bases 1 to 905)
  AUTHORS   Fujiwara,K., Maekawa,F. and Yada,T.
  TITLE     Oleic acid interacts with GPR40 to induce Ca2+ signaling in rat
            islet beta-cells: mediation by PLC and L-type Ca2+ channel and link
            to insulin release
  JOURNAL   Am J Physiol Endocrinol Metab 289 (4), E670-E677 (2005)
   PUBMED   15914509
  REMARK    GeneRIF: These results demonstrate that OA interacts with GPR40 to
            increase [Ca(2+)](i) via PLC- and L-type Ca(2+) channel-mediated
            pathway in rat islet beta-cells, which may be link to insulin
            release.
REFERENCE   8  (bases 1 to 905)
  AUTHORS   Shapiro,H., Shachar,S., Sekler,I., Hershfinkel,M. and Walker,M.D.
  TITLE     Role of GPR40 in fatty acid action on the beta cell line INS-1E
  JOURNAL   Biochem Biophys Res Commun 335 (1), 97-104 (2005)
   PUBMED   16081037
  REMARK    GeneRIF: GPR40 promotes Ca2+ influx through up-regulation of L-type
            calcium channels pre-activated by glucose and membrane
            depolarization
REFERENCE   9  (bases 1 to 905)
  AUTHORS   Briscoe,C.P., Tadayyon,M., Andrews,J.L., Benson,W.G.,
            Chambers,J.K., Eilert,M.M., Ellis,C., Elshourbagy,N.A., Goetz,A.S.,
            Minnick,D.T., Murdock,P.R., Sauls,H.R. Jr., Shabon,U.,
            Spinage,L.D., Strum,J.C., Szekeres,P.G., Tan,K.B., Way,J.M.,
            Ignar,D.M., Wilson,S. and Muir,A.I.
  TITLE     The orphan G protein-coupled receptor GPR40 is activated by medium
            and long chain fatty acids
  JOURNAL   J Biol Chem 278 (13), 11303-11311 (2003)
   PUBMED   12496284
REFERENCE   10 (bases 1 to 905)
  AUTHORS   Itoh,Y., Kawamata,Y., Harada,M., Kobayashi,M., Fujii,R.,
            Fukusumi,S., Ogi,K., Hosoya,M., Tanaka,Y., Uejima,H., Tanaka,H.,
            Maruyama,M., Satoh,R., Okubo,S., Kizawa,H., Komatsu,H.,
            Matsumura,F., Noguchi,Y., Shinohara,T., Hinuma,S., Fujisawa,Y. and
            Fujino,M.
  TITLE     Free fatty acids regulate insulin secretion from pancreatic beta
            cells through GPR40
  JOURNAL   Nature 422 (6928), 173-176 (2003)
   PUBMED   12629551
  REMARK    GeneRIF: Free fatty acids regulate insulin secretion from
            pancreatic beta cells through GPR40
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from AF539810.1.
            
            On Aug 31, 2012 this sequence version replaced NM_153304.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript is intronless :: AF539810.1, AB095744.1 [ECO:0000345]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-905               AF539810.1         3-907
FEATURES             Location/Qualifiers
     source          1..905
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="Sprague-Dawley"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q21"
     gene            1..905
                     /gene="Ffar1"
                     /gene_synonym="Gpr40"
                     /note="free fatty acid receptor 1"
                     /db_xref="GeneID:266607"
                     /db_xref="RGD:628613"
     exon            1..905
                     /gene="Ffar1"
                     /gene_synonym="Gpr40"
                     /inference="alignment:Splign:2.1.0"
     CDS             3..905
                     /gene="Ffar1"
                     /gene_synonym="Gpr40"
                     /note="G-protein coupled receptor 40"
                     /codon_start=1
                     /product="free fatty acid receptor 1"
                     /protein_id="NP_695216.1"
                     /db_xref="GeneID:266607"
                     /db_xref="RGD:628613"
                     /translation="MDLPPQLSFALYVSAFALGFPLNLLAIRGAVSHAKLRLTPSLVY
                     TLHLACSDLLLAITLPLKAVEALASGVWPLPLPFCPVFALAHFAPLYAGGGFLAALSA
                     GRYLGAAFPFGYQAIRRPCYSWGVCVAIWALVLCHLGLALGLEAPRGWVDNTTSSLGI
                     NIPVNGSPVCLEAWDPDSARPARLSFSILLFFLPLVITAFCYVGCLRALVHSGLSHKR
                     KLRAAWVAGGALLTLLLCLGPYNASNVASFINPDLEGSWRKLGLITGAWSVVLNPLVT
                     GYLGTGPGQGTICVTRTPRGTIQK"
ORIGIN      
        1 ccatggacct gcccccacag ctctccttcg ctctctatgt atcagccttt gcactaggct
       61 ttccattgaa cttgttagcc atccgaggtg cagtgtccca cgcgaaactg cgactcaccc
      121 ccagcttggt ctacactctc catttggcct gctctgacct cctactggcc atcaccctgc
      181 ccctgaaggc tgtggaggcc ctggcttctg gggtctggcc cctgccactc cccttctgcc
      241 cagtctttgc cttggcccac tttgcgcccc tctatgcagg tggaggcttc ctggctgctc
      301 tcagtgctgg ccgctacctg ggagctgcct tcccctttgg ataccaagcc atccggaggc
      361 cctgctattc ctggggtgtg tgtgtggcta tatgggccct tgtcctttgc cacctgggac
      421 tggctcttgg cttggaggct cccagaggct gggtggataa caccaccagt tccctgggca
      481 tcaacatacc cgtgaatggc tccccggtct gcctggaagc gtgggatcct gactctgccc
      541 gccctgcccg actcagtttc tcgattctgc tcttctttct gcccttggtt atcactgctt
      601 tctgctatgt gggctgcctc cgggccctgg tgcactcggg cctgagccac aaacggaagc
      661 tcagggcagc ttgggtggct ggaggagcac ttctcacact cctgctctgc ctggggccct
      721 ataatgcttc caatgtggct agtttcataa acccggactt agaaggctcc tggaggaagt
      781 tggggctcat cacaggagcc tggagtgtgg tgctcaaccc actggtcact ggctacttgg
      841 gaacaggtcc tggacagggg acaatatgtg tgaccaggac tccaagaggg acaattcaga
      901 agtag
//
