LOCUS       NM_031066               1697 bp    mRNA    linear   ROD 03-APR-2024
DEFINITION  Rattus norvegicus fasciculation and elongation protein zeta 1
            (Fez1), mRNA.
ACCESSION   NM_031066
VERSION     NM_031066.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1697)
  AUTHORS   Chua,J.Y., Ng,S.J., Yagensky,O., Wanker,E.E. and Chua,J.J.E.
  TITLE     FEZ1 Forms Complexes with CRMP1 and DCC to Regulate Axon and
            Dendrite Development
  JOURNAL   eNeuro 8 (2) (2021)
   PUBMED   33771901
  REMARK    GeneRIF: FEZ1 Forms Complexes with CRMP1 and DCC to Regulate Axon
            and Dendrite Development.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1697)
  AUTHORS   Gunaseelan,S., Wang,Z., Tong,V.K.J., Ming,S.W.S., Razar,R.B.B.A.,
            Srimasorn,S., Ong,W.Y., Lim,K.L. and Chua,J.J.E.
  TITLE     Loss of FEZ1, a gene deleted in Jacobsen syndrome, causes
            locomotion defects and early mortality by impairing motor neuron
            development
  JOURNAL   Hum Mol Genet 30 (1), 5-20 (2021)
   PUBMED   33395696
  REMARK    GeneRIF: Loss of FEZ1, a gene deleted in Jacobsen syndrome, causes
            locomotion defects and early mortality by impairing motor neuron
            development.
REFERENCE   3  (bases 1 to 1697)
  AUTHORS   Zhang,Y., Shi,Q., Li,X. and Xia,C.
  TITLE     Fasciculation and Elongation Protein Zeta-1 Expression in Reactive
            Astrocytes in a Rat Model of Frontal Lobe Injury
  JOURNAL   J Neuropathol Exp Neurol 79 (2), 194-208 (2020)
   PUBMED   31774489
  REMARK    GeneRIF: Results indicate that astrocytic FEZ1 and
            glutamate-glutamine cycle dysfunction may be involved in the
            pathogenesis of depression after frontal lobe injury.
REFERENCE   4  (bases 1 to 1697)
  AUTHORS   Butkevich,E., Hartig,W., Nikolov,M., Erck,C., Grosche,J.,
            Urlaub,H., Schmidt,C.F., Klopfenstein,D.R. and Chua,J.J.
  TITLE     Phosphorylation of FEZ1 by Microtubule Affinity Regulating Kinases
            regulates its function in presynaptic protein trafficking
  JOURNAL   Sci Rep 6, 26965 (2016)
   PUBMED   27247180
  REMARK    GeneRIF: Phosphorylation of FEZ1 by MARK regulates its function in
            presynaptic protein trafficking.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1697)
  AUTHORS   Lin,M.Y. and Sheng,Z.H.
  TITLE     Regulation of mitochondrial transport in neurons
  JOURNAL   Exp Cell Res 334 (1), 35-44 (2015)
   PUBMED   25612908
  REMARK    Review article
REFERENCE   6  (bases 1 to 1697)
  AUTHORS   Lee,S., Walker,C.L., Karten,B., Kuny,S.L., Tennese,A.A.,
            O'Neill,M.A. and Wevrick,R.
  TITLE     Essential role for the Prader-Willi syndrome protein necdin in
            axonal outgrowth
  JOURNAL   Hum Mol Genet 14 (5), 627-637 (2005)
   PUBMED   15649943
REFERENCE   7  (bases 1 to 1697)
  AUTHORS   Okumura,F., Hatakeyama,S., Matsumoto,M., Kamura,T. and
            Nakayama,K.I.
  TITLE     Functional regulation of FEZ1 by the U-box-type ubiquitin ligase
            E4B contributes to neuritogenesis
  JOURNAL   J Biol Chem 279 (51), 53533-53543 (2004)
   PUBMED   15466860
  REMARK    GeneRIF: E4B serves as a ubiquitin ligase for FEZ1 and thereby
            regulates its function but not its degradation
REFERENCE   8  (bases 1 to 1697)
  AUTHORS   Honda,A., Miyoshi,K., Baba,K., Taniguchi,M., Koyama,Y., Kuroda,S.,
            Katayama,T. and Tohyama,M.
  TITLE     Expression of fasciculation and elongation protein zeta-1 (FEZ1) in
            the developing rat brain
  JOURNAL   Brain Res Mol Brain Res 122 (1), 89-92 (2004)
   PUBMED   14992819
  REMARK    GeneRIF: FEZ1 showed high levels of expression, especially in
            developing hippocampal neurons.
REFERENCE   9  (bases 1 to 1697)
  AUTHORS   Miyoshi,K., Honda,A., Baba,K., Taniguchi,M., Oono,K., Fujita,T.,
            Kuroda,S., Katayama,T. and Tohyama,M.
  TITLE     Disrupted-In-Schizophrenia 1, a candidate gene for schizophrenia,
            participates in neurite outgrowth
  JOURNAL   Mol Psychiatry 8 (7), 685-694 (2003)
   PUBMED   12874605
  REMARK    GeneRIF: DISC1 participates in neurite outgrowth through its
            interaction with FEZ1.
REFERENCE   10 (bases 1 to 1697)
  AUTHORS   Kuroda,S., Nakagawa,N., Tokunaga,C., Tatematsu,K. and Tanizawa,K.
  TITLE     Mammalian homologue of the Caenorhabditis elegans UNC-76 protein
            involved in axonal outgrowth is a protein kinase C zeta-interacting
            protein
  JOURNAL   J Cell Biol 144 (3), 403-411 (1999)
   PUBMED   9971736
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from U63740.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: U63740.1, BC087740.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMD00132261, SAMD00132262
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1697
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="8"
                     /map="8q22"
     gene            1..1697
                     /gene="Fez1"
                     /note="fasciculation and elongation protein zeta 1"
                     /db_xref="GeneID:81730"
                     /db_xref="RGD:619708"
     exon            1..109
                     /gene="Fez1"
                     /inference="alignment:Splign:2.1.0"
     exon            110..465
                     /gene="Fez1"
                     /inference="alignment:Splign:2.1.0"
     CDS             155..1336
                     /gene="Fez1"
                     /function="synaptotagmin binding"
                     /note="zygin I; zygin-1; protein kinase C-binding protein
                     Zeta1"
                     /codon_start=1
                     /product="fasciculation and elongation protein zeta-1"
                     /protein_id="NP_112328.1"
                     /db_xref="GeneID:81730"
                     /db_xref="RGD:619708"
                     /translation="MEAPLVSLDEEFEDIRPCCTEDPEEKPQSLYGTSPHHLEDPSLS
                     ELENFSSEIISFKSMEDLVNEFDEKLNVCFRNYNAKTENLAPVKNQLQIQEEEETLRD
                     EEVWDALTDNYIPSLSEDWRDPNIEALNGNSSDTEIHEKEEEDEFIEKSENDSGINEE
                     PLLTADQVIEEIEEMMQNSPDPEEEVEVLEEEDGGEISSQADSVLLQEMQALTQTFNN
                     NWSYEGLRHMSGSELTELLDQVEGAIRDFSEELVHQLARRDELEFEKEVKNSFITVLI
                     EVQNKQKEQRELMKKRRKEKGLSLQSSRIEKGNQMPLKRFSMEGISNILQSGIRQTFG
                     SSGADRQYLNTVIPYEKKSSPPSVEDLQMLTNILFAMKEDNEKVPTLLTDYILKVLCP
                     T"
     exon            466..565
                     /gene="Fez1"
                     /inference="alignment:Splign:2.1.0"
     exon            566..655
                     /gene="Fez1"
                     /inference="alignment:Splign:2.1.0"
     exon            656..824
                     /gene="Fez1"
                     /inference="alignment:Splign:2.1.0"
     exon            825..1096
                     /gene="Fez1"
                     /inference="alignment:Splign:2.1.0"
     exon            1097..1177
                     /gene="Fez1"
                     /inference="alignment:Splign:2.1.0"
     exon            1178..1253
                     /gene="Fez1"
                     /inference="alignment:Splign:2.1.0"
     exon            1254..1319
                     /gene="Fez1"
                     /inference="alignment:Splign:2.1.0"
     exon            1320..1683
                     /gene="Fez1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 tagctggctt gcccgctgcc gttgcactgc accgggccac ctctagccgg tggatgggga
       61 tgtctggctg aaccccggga tccgattccc tcctccagga cctgctcagg gaaacggatc
      121 ttgacagttg ccatcattgt actacggtgc caggatggag gctccactgg tgagtctgga
      181 tgaagagttt gaagatatca ggccctgctg cactgaggac ccagaggaaa agccacaaag
      241 tctctatggc acatctcctc accacctgga ggacccttcc ctctccgagc ttgagaattt
      301 ttcttccgaa ataatcagct tcaagtccat ggaggacctc gtgaatgaat ttgatgagaa
      361 gctcaatgtc tgctttcgga actacaatgc caagaccgag aacctggctc cagtgaagaa
      421 ccagttgcag atccaggagg aggaggagac tcttcgggat gaggaggttt gggatgctct
      481 gacagacaat tacatccctt cactctcaga agactggagg gacccaaaca ttgaagctct
      541 gaatggcaac agctctgaca ctgagatcca cgagaaggaa gaagaagatg agttcattga
      601 gaagagtgaa aacgactctg gtatcaacga ggagcctctc ctcacagctg accaggtgat
      661 tgaggagatc gaagaaatga tgcagaactc cccagatcct gaggaggaag tggaggtgct
      721 ggaagaggag gatggaggag aaatctcgtc tcaggcagat tcagtcctgc tacaagagat
      781 gcaggccctg acgcagacct tcaacaacaa ctggtcctat gaagggctga gacacatgtc
      841 tgggtctgag ctgacagagc tgctggacca ggtggagggt gccatccgtg acttctcgga
      901 ggagctggtc caccagctgg cccgcagaga tgagctggag tttgagaagg aagtgaagaa
      961 ctctttcatc acggtgctca ttgaggttca gaataagcag aaggagcagc gggaactgat
     1021 gaagaagagg cggaaagaga aggggttaag cctgcagagc agtcggatag agaaggggaa
     1081 ccagatgcct ctcaagcgtt tcagcatgga gggcatctcc aacatcctgc agagtggcat
     1141 ccgccagacc tttggctcct caggagctga cagacagtac ctgaacacag tcatccctta
     1201 tgagaagaaa tcttctcctc cctctgtgga agacctgcag atgctgacaa acattctctt
     1261 cgccatgaag gaggataacg agaaggtgcc tactttgcta acggactaca ttttaaaagt
     1321 gctctgtcca acctaacctc acctttggag cagcctcact gcaggaggtc actgagcaag
     1381 aaagtcattc catcactggg attgcatgac accacgtaac ctccggcgtg tatttaaacg
     1441 tgtatagctt aacctggatt aaacatgagc aaccgcgcac gcgcggggtc ctttgctgtt
     1501 ggcttctagt gctagtaatc attggatgca tgatcgggcg tagggccagt gactctgctc
     1561 cctctaacct gtgttgggga agacaggtgc cctcaccact cattatgtag tctggctcca
     1621 gccctcaacc cagcttatac tcttcagact aattttgaaa taaaccttca tttaattaat
     1681 atcaaaaaaa aaaaaaa
//
