LOCUS       NM_053348               1423 bp    mRNA    linear   ROD 28-MAR-2024
DEFINITION  Rattus norvegicus fetuin B (Fetub), transcript variant 2, mRNA.
ACCESSION   NM_053348
VERSION     NM_053348.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1423)
  AUTHORS   Singh,P., Reza,M.I., Syed,A.A., Husain,A. and Gayen,J.R.
  TITLE     Pancreastatin deteriorates hepatic lipid metabolism via elevating
            fetuin B in ovariectomized rats
  JOURNAL   Biochimie 214 (Pt B), 114-122 (2023)
   PUBMED   37364770
  REMARK    GeneRIF: Pancreastatin deteriorates hepatic lipid metabolism via
            elevating fetuin B in ovariectomized rats.
REFERENCE   2  (bases 1 to 1423)
  AUTHORS   Dietzel,E., Wessling,J., Floehr,J., Schafer,C., Ensslen,S.,
            Denecke,B., Rosing,B., Neulen,J., Veitinger,T., Spehr,M.,
            Tropartz,T., Tolba,R., Renne,T., Egert,A., Schorle,H.,
            Gottenbusch,Y., Hildebrand,A., Yiallouros,I., Stocker,W.,
            Weiskirchen,R. and Jahnen-Dechent,W.
  TITLE     Fetuin-B, a liver-derived plasma protein is essential for
            fertilization
  JOURNAL   Dev Cell 25 (1), 106-112 (2013)
   PUBMED   23562279
REFERENCE   3  (bases 1 to 1423)
  AUTHORS   Price,P.A. and Lim,J.E.
  TITLE     The inhibition of calcium phosphate precipitation by fetuin is
            accompanied by the formation of a fetuin-mineral complex
  JOURNAL   J Biol Chem 278 (24), 22144-22152 (2003)
   PUBMED   12676929
  REMARK    GeneRIF: fetuin inhibits calcium phosphate precipitation and forms
            a fetuin-mineral complex
REFERENCE   4  (bases 1 to 1423)
  AUTHORS   Olivier,E., Soury,E., Ruminy,P., Husson,A., Parmentier,F.,
            Daveau,M. and Salier,J.P.
  TITLE     Fetuin-B, a second member of the fetuin family in mammals
  JOURNAL   Biochem J 350 Pt 2 (Pt 2), 589-597 (2000)
   PUBMED   10947975
REFERENCE   5  (bases 1 to 1423)
  AUTHORS   Billard,C., Gillet,P., Signoret,J.L., Uicaut,E., Bertrand,P.,
            Fardeau,M., Barthez-Carpentier,M.A. and Santini,J.J.
  TITLE     Cognitive functions in Duchenne muscular dystrophy: a reappraisal
            and comparison with spinal muscular atrophy
  JOURNAL   Neuromuscul Disord 2 (5-6), 371-378 (1992)
   PUBMED   1300185
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000011.1.
            
            On Jun 9, 2015 this sequence version replaced NM_053348.1.
            
            Transcript Variant: This variant (2) contains a different 5'
            structure, resulting in the use of a downstream start codon,
            compared to variant 1. The encoded isoform (2) has a shorter
            N-terminus compaerd to isoform 1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: FQ219048.1, FQ219500.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760476 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-376               JAXUCZ010000011.1  91594597-91594972   c
            377-487             JAXUCZ010000011.1  91594155-91594265   c
            488-575             JAXUCZ010000011.1  91592502-91592589   c
            576-739             JAXUCZ010000011.1  91590455-91590618   c
            740-838             JAXUCZ010000011.1  91589449-91589547   c
            839-940             JAXUCZ010000011.1  91588507-91588608   c
            941-1423            JAXUCZ010000011.1  91586750-91587232   c
FEATURES             Location/Qualifiers
     source          1..1423
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="11"
                     /map="11q23"
     gene            1..1423
                     /gene="Fetub"
                     /gene_synonym="Fet; IRL685; Pp63"
                     /note="fetuin B"
                     /db_xref="GeneID:83928"
                     /db_xref="RGD:69293"
     exon            1..376
                     /gene="Fetub"
                     /gene_synonym="Fet; IRL685; Pp63"
                     /inference="alignment:Splign:2.1.0"
     CDS             143..1279
                     /gene="Fetub"
                     /gene_synonym="Fet; IRL685; Pp63"
                     /note="fetuin beta; fetuin-like protein IRL685; fetuin
                     phosphoprotein"
                     /codon_start=1
                     /product="fetuin-B precursor"
                     /protein_id="NP_445800.2"
                     /db_xref="GeneID:83928"
                     /db_xref="RGD:69293"
                     /translation="MGVLRLLVLCTLAACCVARSPPAPPLPNAPFAPLRPLGCNDSEV
                     LAVAGFALQNINRVQKDGYMLTLNRVHDARVHRQEDMGSLFYLMLDVLETGCHVLSRK
                     ALKDCGPRIFYETVHGQCKAMFHVNKPRRVLYLPAYNCTLRPVSKRKIHSMCPDCPHP
                     VDLSAPSVLEAATESLAKFNSENPSKQYALVKVTKATTQWVVGPSYFVEYLIKESPCT
                     QSQDSCSLQASDSEPVGLCQGSLIKSPGVPPQRFKKTVTVSCEFFESQDQVPGGENPA
                     DTQDAKKLPQKNTAPTSSPSITAPRGSIQHLPEQEEPEDSKGKSPEEPFPVQLDLTTN
                     PQGDTLDVSFLYLEPEEKKLVVLPFPGKEQRSPECPGPEKQRTP"
     exon            377..487
                     /gene="Fetub"
                     /gene_synonym="Fet; IRL685; Pp63"
                     /inference="alignment:Splign:2.1.0"
     exon            488..575
                     /gene="Fetub"
                     /gene_synonym="Fet; IRL685; Pp63"
                     /inference="alignment:Splign:2.1.0"
     exon            576..739
                     /gene="Fetub"
                     /gene_synonym="Fet; IRL685; Pp63"
                     /inference="alignment:Splign:2.1.0"
     exon            740..838
                     /gene="Fetub"
                     /gene_synonym="Fet; IRL685; Pp63"
                     /inference="alignment:Splign:2.1.0"
     exon            839..940
                     /gene="Fetub"
                     /gene_synonym="Fet; IRL685; Pp63"
                     /inference="alignment:Splign:2.1.0"
     exon            941..1423
                     /gene="Fetub"
                     /gene_synonym="Fet; IRL685; Pp63"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cggcctcagg acctggtact tcaagtcgta tgcagctctc tgattgcaat tataaaacgg
       61 ctcaagccaa tcttgaggcc ccacagtagg gcccgtcctg tcagctcgac cctgacacgt
      121 cctggatctt gttctccaca gaatgggtgt gctacggctt ctggtgctct gcaccctggc
      181 tgcatgctgt gtggcccgct ctcccccagc tccacccctg ccaaacgccc ccttcgcacc
      241 tctgcgtccc ctgggctgta acgactctga agtgctggca gttgcaggtt ttgccctgca
      301 gaacatcaac agagtccaaa aggatggcta catgttgacc ctcaacagag tacacgatgc
      361 tcgggttcac cgtcaggaag acatgggctc tctgttctac ctcatgctgg acgtcttaga
      421 gactggctgc cacgtgctca gcaggaaggc actgaaggac tgcggaccga ggattttcta
      481 tgagactgtt catggacagt gcaaagctat gtttcacgtt aacaagccaa gaagagttct
      541 ctacttacct gcttataact gtacacttcg cccagtttct aaaaggaaga ttcattctat
      601 gtgccctgac tgcccgcatc ccgttgactt gtcagccccc agtgttctgg aagctgccac
      661 agaatcactt gcgaagttta acagcgagaa cccctcaaaa caatatgcac tcgtcaaagt
      721 caccaaggct acgacccagt gggtggttgg tccttcttac tttgtggaat atttgatcaa
      781 agagtcacca tgtacccagt ctcaggacag ctgttcactc caggcctccg actctgagcc
      841 cgttggtctt tgccaaggtt cactgattaa aagtcccggg gtccctcctc aacgctttaa
      901 aaagactgtc actgtgtcgt gcgagttttt cgaatctcag gaccaggtcc ctggaggtga
      961 gaaccctgct gatacccaag atgctaagaa actccctcag aaaaacacag cccctaccag
     1021 ctcaccctcc ataactgcac caagaggatc tatccaacac ctccctgagc aggaggagcc
     1081 tgaagactcc aagggaaaga gtcctgagga accctttcct gtgcagctgg atctaaccac
     1141 aaacccacag ggtgacacac tggatgtctc cttcctctac ctggagcctg aggaaaagaa
     1201 actggtggtc ctgcctttcc ctgggaagga acagcgctcc cctgagtgcc cggggcccga
     1261 aaagcaaaga accccctgat gctccccgct gagactcact agcagggttc cacggggtac
     1321 ggtcccctgc agtagatggg aggtggtggg cattgggaag gcacagacaa tcaaatgtag
     1381 accggctaat aaagtgtgtc ctttggatgc ttcttgatct caa
//
