LOCUS       NM_001108488            2799 bp    mRNA    linear   ROD 26-FEB-2024
DEFINITION  Rattus norvegicus FES proto-oncogene, tyrosine kinase (Fes), mRNA.
ACCESSION   NM_001108488 XM_001066375 XM_341876
VERSION     NM_001108488.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2799)
  AUTHORS   Kim BH, Kim YJ, Kim MH, Na YR, Jung D, Seok SH, Kim J and Kim HJ.
  TITLE     Identification of FES as a Novel Radiosensitizing Target in Human
            Cancers
  JOURNAL   Clin Cancer Res 26 (1), 265-273 (2020)
   PUBMED   31573955
REFERENCE   2  (bases 1 to 2799)
  AUTHORS   Zhang C, Ge S, Wang J, Jing X, Li H, Mei S, Zhang J, Liang K, Xu H,
            Zhang X and Zhang C.
  TITLE     Epigenomic profiling of DNA methylation for hepatocellular
            carcinoma diagnosis and prognosis prediction
  JOURNAL   J Gastroenterol Hepatol 34 (10), 1869-1877 (2019)
   PUBMED   31038805
REFERENCE   3  (bases 1 to 2799)
  AUTHORS   Hu J, Zheng L, Shen X, Zhang Y, Li C and Xi T.
  TITLE     MicroRNA-125b inhibits AML cells differentiation by directly
            targeting Fes
  JOURNAL   Gene 620, 1-9 (2017)
   PUBMED   28389358
REFERENCE   4  (bases 1 to 2799)
  AUTHORS   Kuo IY, Chang JM, Jiang SS, Chen CH, Chang IS, Sheu BS, Lu PJ,
            Chang WL, Lai WW and Wang YC.
  TITLE     Prognostic CpG methylation biomarkers identified by methylation
            array in esophageal squamous cell carcinoma patients
  JOURNAL   Int J Med Sci 11 (8), 779-787 (2014)
   PUBMED   24936140
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2799)
  AUTHORS   McPherson VA, Everingham S, Karisch R, Smith JA, Udell CM, Zheng J,
            Jia Z and Craig AW.
  TITLE     Contributions of F-BAR and SH2 domains of Fes protein tyrosine
            kinase for coupling to the FcepsilonRI pathway in mast cells
  JOURNAL   Mol Cell Biol 29 (2), 389-401 (2009)
   PUBMED   19001085
REFERENCE   6  (bases 1 to 2799)
  AUTHORS   Zirngibl R, Schulze D, Mirski SE, Cole SP and Greer PA.
  TITLE     Subcellular localization analysis of the closely related Fps/Fes
            and Fer protein-tyrosine kinases suggests a distinct role for
            Fps/Fes in vesicular trafficking
  JOURNAL   Exp Cell Res 266 (1), 87-94 (2001)
   PUBMED   11339827
REFERENCE   7  (bases 1 to 2799)
  AUTHORS   Hjermstad SJ, Peters KL, Briggs SD, Glazer RI and Smithgall TE.
  TITLE     Regulation of the human c-fes protein tyrosine kinase (p93c-fes) by
            its src homology 2 domain and major autophosphorylation site
            (Tyr-713)
  JOURNAL   Oncogene 8 (8), 2283-2292 (1993)
   PUBMED   7687763
REFERENCE   8  (bases 1 to 2799)
  AUTHORS   Yu G, Smithgall TE and Glazer RI.
  TITLE     K562 leukemia cells transfected with the human c-fes gene acquire
            the ability to undergo myeloid differentiation
  JOURNAL   J Biol Chem 264 (17), 10276-10281 (1989)
   PUBMED   2656706
REFERENCE   9  (bases 1 to 2799)
  AUTHORS   Claycomb WC and Lanson NA Jr.
  TITLE     Proto-oncogene expression in proliferating and differentiating
            cardiac and skeletal muscle
  JOURNAL   Biochem J 247 (3), 701-706 (1987)
   PUBMED   2447874
REFERENCE   10 (bases 1 to 2799)
  AUTHORS   Leibovitch,S.A., Leibovitch,M.P., Guillier,M., Hillion,J. and
            Harel,J.
  TITLE     Differential expression of protooncogenes related to transformation
            and cancer progression in rat myoblasts
  JOURNAL   Cancer Res 46 (8), 4097-4103 (1986)
   PUBMED   2425941
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from CH473980.1.
            
            On or before Oct 4, 2007 this sequence version replaced
            XM_341876.3, XM_001066375.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            RNAseq introns :: mixed sample support SAMD00132261, SAMD00132262
                              [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..2799
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q31"
     gene            1..2799
                     /gene="Fes"
                     /gene_synonym="RGD1564385"
                     /note="FES proto-oncogene, tyrosine kinase"
                     /db_xref="GeneID:361597"
                     /db_xref="RGD:1564385"
     exon            1..125
                     /gene="Fes"
                     /gene_synonym="RGD1564385"
                     /inference="alignment:Splign:2.1.0"
     exon            126..347
                     /gene="Fes"
                     /gene_synonym="RGD1564385"
                     /inference="alignment:Splign:2.1.0"
     CDS             135..2603
                     /gene="Fes"
                     /gene_synonym="RGD1564385"
                     /EC_number="2.7.10.2"
                     /note="feline sarcoma oncogene"
                     /codon_start=1
                     /product="tyrosine-protein kinase Fes/Fps"
                     /protein_id="NP_001101958.1"
                     /db_xref="GeneID:361597"
                     /db_xref="RGD:1564385"
                     /translation="MGFSSELCSPQGHGAVQQMQEAELRLLEGMRKWMAQRVKSDREY
                     AGLLHHMSLQDSGGQSWSSGPDSPVSQSWAEITSQTENLSRVLRQHAEDLNSGPLSKL
                     SVLIRERQHLRKTYNEQWQQLQQELTKTHSQDIEKLKSQYRTLTRDSAQARRKYQEAS
                     KDKDRDKAKDKYVRSLWKLFAHHNRYVLGVRAAQLHHQHYHQFMLPGLLQSLQDLHEE
                     MAGILKDILQEYLEISSLVQDDVASIHRELAAAAARIQPEFEYLGFLRQYGSAPDVPP
                     CVTFDVSLLEEGEQLEPGDLQLNELTLESVQHTLTSVTDELAVATKEVLSRQEMVSQL
                     QRELQCEEQNTHPRERVQLLGKRQVLQEAMQGLQVALCNQDKLQAQQELLQSKMEQLG
                     TGEPPAVPLLQDDRHSTSSTEQERDGGRTPTLEIIKSHFSGIFRPKFSIPPPLQLVPE
                     VQKPLHEQLWYHGAIPRAEVAELLTHSGDFLVRESQGKQEYVLSVLWDGQPRHFIIQS
                     SDNLYRLEGDGFPSIPLLITHLLSSQQPLTKKSGVVLFRAVPKDKWVLKHEDLVLGEQ
                     IGRGNFGEVFSGRLRADNTPVAVKSCRETLPPDLKAKFLQEARILKQYNHPNIVRLIG
                     VCTQKQPIYIVMELVQGGDFLTFLRTEGARLRVKTLLQMVGDAAAGMEYLESKCCIHR
                     DLAARNCLVTEKNVLKISDFGMSREEADGIYAASAGLRQVPVKWTAPEALNYGRYSSE
                     SDVWSFGILLWETFSLGASPYPNLTNQQTREFVEKGHRLPCPELCPDAVFRLMEQCWA
                     YEPGQRPSFSTICQELQSIRKRHR"
     exon            348..521
                     /gene="Fes"
                     /gene_synonym="RGD1564385"
                     /inference="alignment:Splign:2.1.0"
     exon            522..618
                     /gene="Fes"
                     /gene_synonym="RGD1564385"
                     /inference="alignment:Splign:2.1.0"
     exon            619..802
                     /gene="Fes"
                     /gene_synonym="RGD1564385"
                     /inference="alignment:Splign:2.1.0"
     exon            803..940
                     /gene="Fes"
                     /gene_synonym="RGD1564385"
                     /inference="alignment:Splign:2.1.0"
     exon            941..1060
                     /gene="Fes"
                     /gene_synonym="RGD1564385"
                     /inference="alignment:Splign:2.1.0"
     exon            1061..1183
                     /gene="Fes"
                     /gene_synonym="RGD1564385"
                     /inference="alignment:Splign:2.1.0"
     exon            1184..1370
                     /gene="Fes"
                     /gene_synonym="RGD1564385"
                     /inference="alignment:Splign:2.1.0"
     exon            1371..1454
                     /gene="Fes"
                     /gene_synonym="RGD1564385"
                     /inference="alignment:Splign:2.1.0"
     exon            1455..1664
                     /gene="Fes"
                     /gene_synonym="RGD1564385"
                     /inference="alignment:Splign:2.1.0"
     exon            1665..1787
                     /gene="Fes"
                     /gene_synonym="RGD1564385"
                     /inference="alignment:Splign:2.1.0"
     exon            1788..1841
                     /gene="Fes"
                     /gene_synonym="RGD1564385"
                     /inference="alignment:Splign:2.1.0"
     exon            1842..1960
                     /gene="Fes"
                     /gene_synonym="RGD1564385"
                     /inference="alignment:Splign:2.1.0"
     exon            1961..2055
                     /gene="Fes"
                     /gene_synonym="RGD1564385"
                     /inference="alignment:Splign:2.1.0"
     exon            2056..2179
                     /gene="Fes"
                     /gene_synonym="RGD1564385"
                     /inference="alignment:Splign:2.1.0"
     exon            2180..2337
                     /gene="Fes"
                     /gene_synonym="RGD1564385"
                     /inference="alignment:Splign:2.1.0"
     exon            2338..2460
                     /gene="Fes"
                     /gene_synonym="RGD1564385"
                     /inference="alignment:Splign:2.1.0"
     exon            2461..2799
                     /gene="Fes"
                     /gene_synonym="RGD1564385"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ccgccccgcg gcctacagca actgaaacca cggaggagga agcaggaatc aggaactggc
       61 cgggtagatt ctgggctgtt agtcggtcca ctgccacctg tcccaggagc agctgcccaa
      121 gaaaggacac cattatgggc ttctcttcag agctgtgcag cccccagggc cacggggcag
      181 tgcaacagat gcaagaagct gagcttcgtt tattggaagg gatgaggaag tggatggcgc
      241 agagggtcaa gagtgaccgg gaatatgcag gattgcttca ccacatgtcc ttgcaagaca
      301 gcgggggcca gagctggagc agtggccctg acagccctgt cagccagtcc tgggcagaga
      361 taacaagcca gacggagaac ttgagccggg tactgcggca gcatgcagaa gatctgaact
      421 cagggcccct gagcaagctg agcgtgctga tccgggagcg gcagcacctg agaaagactt
      481 acaacgagca gtggcagcag ctgcagcagg agctcaccaa gacccacagc caggacattg
      541 agaagctaaa gagccagtac cggaccctga cacgagatag tgcccaggcc aggcgcaagt
      601 accaggaagc cagcaaagac aaggatcgcg acaaggccaa agacaagtat gtacgaagcc
      661 tgtggaagct ctttgcccac cacaaccgct acgtactggg tgtgagggcc gcgcagctgc
      721 accaccagca ctaccaccaa ttcatgctgc ctggcctgct gcagtcacta caggacttgc
      781 acgaagagat ggcaggcatc ctgaaggaca tcctgcagga atacctagag atcagcagtc
      841 tggtgcagga cgatgtggca tccattcacc gtgagctggc tgcagctgct gctcgcatcc
      901 agcctgagtt tgagtaccta ggcttcctgc gacagtacgg atctgcccct gatgtcccac
      961 cttgtgtcac ttttgatgtg tcacttcttg aagagggcga acagctggaa cctggggacc
     1021 tgcagctgaa cgagctgacc ttggagagcg tgcagcacac gctgacctct gtgacagacg
     1081 aactggctgt ggccaccaaa gaggtgctga gccggcagga gatggtcagt cagctgcagc
     1141 gggagctcca gtgcgaggag cagaacaccc acccccgaga acgggtgcag cttctgggca
     1201 agaggcaggt gctgcaagag gcgatgcagg ggttgcaggt agcactgtgc aatcaggaca
     1261 agcttcaggc tcagcaggaa cttctacaga gcaagatgga gcagctcggg acaggcgagc
     1321 ccccagccgt accactcctt caggatgacc gtcattccac ctcttccacg gagcaggagc
     1381 gagatggggg aaggacaccc accctggaga tcattaaaag ccacttctct ggaatcttcc
     1441 gccccaagtt ctccatccct cctccgctgc agctcgttcc agaggtgcag aagcccctcc
     1501 acgagcagct gtggtaccat ggggctatcc ctcgggcaga ggtagctgag ctgctaacac
     1561 actccgggga cttcctggtt cgggagagcc agggcaagca ggagtatgtt ctgtctgtgc
     1621 tgtgggatgg ccagccccga cacttcatca tccaatcctc agataacctg taccggctgg
     1681 aaggggacgg ctttcccagc atccctttgc tcatcactca cctgctgtcc tcccagcagc
     1741 cccttacaaa gaagagtggt gttgtcttgt tcagggcggt acccaaggac aagtgggtac
     1801 tgaagcatga ggatctggtg ctgggagagc agatcggaag ggggaacttc ggagaggtgt
     1861 ttagtggacg tcttcgtgca gacaacaccc cggtggctgt gaagtcttgt cgagagacgc
     1921 tcccacctga cctcaaggcc aagtttctgc aagaagcgag gatcctgaaa cagtacaacc
     1981 accccaacat tgtacgtctc atcggggtct gcacacagaa acagcccatc tacattgtca
     2041 tggagctggt tcaagggggc gactttctca cctttctgcg gacagaggga gcccgcctgc
     2101 gggtgaagac cctgctgcag atggtagggg atgcagctgc tggcatggag tacttggaaa
     2161 gcaagtgctg tatccaccgg gatctggctg ctcgcaactg cctggtgaca gagaagaatg
     2221 ttctgaagat cagtgacttc gggatgtctc gagaagaggc tgacgggatc tacgcggcct
     2281 cagccggcct cagacaagtc cctgttaagt ggactgcccc tgaagctctt aattatggac
     2341 gctactcctc agaaagtgac gtgtggagct ttggcatttt gctgtgggag accttcagcc
     2401 taggggcctc accttatccc aacctcacca atcagcagac acgggagttt gtcgaaaagg
     2461 ggcatcgtct gccttgccca gagctgtgcc ctgatgcagt cttcaggctc atggagcagt
     2521 gctgggccta tgagccgggg cagaggccta gcttcagcac catctgccag gagctacaga
     2581 gtatccgaaa gcggcatcgg tgagaccagt ggcctgttcg ggcaagagtg tacgtcctca
     2641 gcagttccca ctcactgttg gacagctcca agacctgggt tccaacacta gcagcagggc
     2701 ttcgggcagg gtgcggctcc agggagggtc accatccttc ttcctgcaca aattcatctc
     2761 ttggacagaa aaataaaaca aattgtgttc atcaggtaa
//
