LOCUS       NM_001127543            2511 bp    mRNA    linear   ROD 26-FEB-2024
DEFINITION  Rattus norvegicus FERM domain containing kindlin 3 (Fermt3), mRNA.
ACCESSION   NM_001127543 XM_001076361 XM_219540
VERSION     NM_001127543.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2511)
  AUTHORS   Oksala N, Parssinen J, Seppala I, Klopp N, Illig T, Laaksonen R,
            Levula M, Raitoharju E, Kholova I, Sioris T, Kahonen M, Lehtimaki T
            and Hytonen VP.
  TITLE     Kindlin 3 (FERMT3) is associated with unstable atherosclerotic
            plaques, anti-inflammatory type II macrophages and upregulation of
            beta-2 integrins in all major arterial beds
  JOURNAL   Atherosclerosis 242 (1), 145-154 (2015)
   PUBMED   26188538
REFERENCE   2  (bases 1 to 2511)
  AUTHORS   Calderwood DA, Campbell ID and Critchley DR.
  TITLE     Talins and kindlins: partners in integrin-mediated adhesion
  JOURNAL   Nat Rev Mol Cell Biol 14 (8), 503-517 (2013)
   PUBMED   23860236
  REMARK    Review article
REFERENCE   3  (bases 1 to 2511)
  AUTHORS   Frobel J, Cadeddu RP, Hartwig S, Bruns I, Wilk CM, Kundgen A,
            Fischer JC, Schroeder T, Steidl UG, Germing U, Lehr S, Haas R and
            Czibere A.
  TITLE     Platelet proteome analysis reveals integrin-dependent aggregation
            defects in patients with myelodysplastic syndromes
  JOURNAL   Mol Cell Proteomics 12 (5), 1272-1280 (2013)
   PUBMED   23382103
REFERENCE   4  (bases 1 to 2511)
  AUTHORS   Huang Y, Zhang X, Jiang W, Wang Y, Jin H, Liu X and Xu C.
  TITLE     Discovery of serum biomarkers implicated in the onset and
            progression of serous ovarian cancer in a rat model using iTRAQ
            technique
  JOURNAL   Eur J Obstet Gynecol Reprod Biol 165 (1), 96-103 (2012)
   PUBMED   22818854
REFERENCE   5  (bases 1 to 2511)
  AUTHORS   Wu WB, Zhang Q, Li Y, Shan SL, Li XY, Tian Z, Tang KJ, Wang M, Rao
            Q and Mi YC.
  TITLE     [Expression of Kindlins and angiopoietins in acute myeloid
            leukemia]
  JOURNAL   Zhongguo Shi Yan Xue Ye Xue Za Zhi 20 (1), 7-11 (2012)
   PUBMED   22391155
REFERENCE   6  (bases 1 to 2511)
  AUTHORS   Kuijpers TW, van de Vijver E, Weterman MA, de Boer M, Tool AT, van
            den Berg TK, Moser M, Jakobs ME, Seeger K, Sanal O, Unal S, Cetin
            M, Roos D, Verhoeven AJ and Baas F.
  TITLE     LAD-1/variant syndrome is caused by mutations in FERMT3
  JOURNAL   Blood 113 (19), 4740-4746 (2009)
   PUBMED   19064721
REFERENCE   7  (bases 1 to 2511)
  AUTHORS   Moser M, Bauer M, Schmid S, Ruppert R, Schmidt S, Sixt M, Wang HV,
            Sperandio M and Fassler R.
  TITLE     Kindlin-3 is required for beta2 integrin-mediated leukocyte
            adhesion to endothelial cells
  JOURNAL   Nat Med 15 (3), 300-305 (2009)
   PUBMED   19234461
REFERENCE   8  (bases 1 to 2511)
  AUTHORS   Malinin NL, Zhang L, Choi J, Ciocea A, Razorenova O, Ma YQ, Podrez
            EA, Tosi M, Lennon DP, Caplan AI, Shurin SB, Plow EF and Byzova TV.
  TITLE     A point mutation in KINDLIN3 ablates activation of three integrin
            subfamilies in humans
  JOURNAL   Nat Med 15 (3), 313-318 (2009)
   PUBMED   19234460
REFERENCE   9  (bases 1 to 2511)
  AUTHORS   Moser M, Nieswandt B, Ussar S, Pozgajova M and Fassler R.
  TITLE     Kindlin-3 is essential for integrin activation and platelet
            aggregation
  JOURNAL   Nat Med 14 (3), 325-330 (2008)
   PUBMED   18278053
REFERENCE   10 (bases 1 to 2511)
  AUTHORS   Ussar S, Wang HV, Linder S, Fassler R and Moser M.
  TITLE     The Kindlins: subcellular localization and expression during murine
            development
  JOURNAL   Exp Cell Res 312 (16), 3142-3151 (2006)
   PUBMED   16876785
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC166607.1.
            
            On or before May 23, 2008 this sequence version replaced
            XM_219540.4, XM_001076361.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC166607.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMD00132261,
                                           SAMD00132262 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..2511
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q43"
     gene            1..2511
                     /gene="Fermt3"
                     /gene_synonym="RGD1310168"
                     /note="FERM domain containing kindlin 3"
                     /db_xref="GeneID:309186"
                     /db_xref="RGD:1310168"
     exon            1..92
                     /gene="Fermt3"
                     /gene_synonym="RGD1310168"
                     /inference="alignment:Splign:2.1.0"
     exon            93..269
                     /gene="Fermt3"
                     /gene_synonym="RGD1310168"
                     /inference="alignment:Splign:2.1.0"
     CDS             110..2107
                     /gene="Fermt3"
                     /gene_synonym="RGD1310168"
                     /note="fermitin family member 3"
                     /codon_start=1
                     /product="fermitin family homolog 3"
                     /protein_id="NP_001121015.1"
                     /db_xref="GeneID:309186"
                     /db_xref="RGD:1310168"
                     /translation="MAGMKTASGDYIDSSWELRVFVGEEDPEAQSVTLRVTGESHIGG
                     VLLKIVEEINRKQDWSDHAIWWEQKKQWLLQTHWTLDKYGILADARLFFGPQHRPVIL
                     RLPNRRVLRLRASFSKPLFQTVAAICRLLSIRHPEELSLLRAPEKKEKKKKEKEPEEE
                     VHDLTRVVLAGGVAPTLFRGMPAHFSDSAQTEACYHMLSRPQPAPDPLLLQRLPRPSS
                     LLDKTQLHSRWLDSSRCLMQQGIKAGDVLWLRFKYYSFFDLDPKTDPVRLTQLYEQAR
                     WDLLTEEIDCTEEEMMVFAALQYHINKVTLSGDVGELASGDPGLDDLDAALNNLEVKL
                     KGSAPSDMLDSLTTIPELKDHLRIFRPRKLTLKGYRQHWVIFKDTTLSYYKSQDEAPG
                     DPIQQLNLKGCEVVPDVNVSGQKFCIKLLVPSPEGMSEIYLRCQDEQQYAQWMAACRL
                     ASKGRTMADSSYASEVQAILAFLSLQRAGGTNGGSGNKPQGLEASAEGLNPYGLVAPR
                     FQRKFKAKQLTPRILEAHQNVAQLSLTEAQLRFIQAWQSLPDFGISYVIVRFKGSRKD
                     EILGIANNRLIRIDLAVGDVVKTWRFSNMRQWNVNWDIRQVAIEFDEHINVAFSCVSA
                     SCRIVHEYIGGYIFLSTRERARGEELDEDLFLQLTGGHEAF"
     exon            270..503
                     /gene="Fermt3"
                     /gene_synonym="RGD1310168"
                     /inference="alignment:Splign:2.1.0"
     exon            504..623
                     /gene="Fermt3"
                     /gene_synonym="RGD1310168"
                     /inference="alignment:Splign:2.1.0"
     exon            624..792
                     /gene="Fermt3"
                     /gene_synonym="RGD1310168"
                     /inference="alignment:Splign:2.1.0"
     exon            793..895
                     /gene="Fermt3"
                     /gene_synonym="RGD1310168"
                     /inference="alignment:Splign:2.1.0"
     exon            896..1003
                     /gene="Fermt3"
                     /gene_synonym="RGD1310168"
                     /inference="alignment:Splign:2.1.0"
     exon            1004..1138
                     /gene="Fermt3"
                     /gene_synonym="RGD1310168"
                     /inference="alignment:Splign:2.1.0"
     exon            1139..1188
                     /gene="Fermt3"
                     /gene_synonym="RGD1310168"
                     /inference="alignment:Splign:2.1.0"
     exon            1189..1313
                     /gene="Fermt3"
                     /gene_synonym="RGD1310168"
                     /inference="alignment:Splign:2.1.0"
     exon            1314..1420
                     /gene="Fermt3"
                     /gene_synonym="RGD1310168"
                     /inference="alignment:Splign:2.1.0"
     exon            1421..1660
                     /gene="Fermt3"
                     /gene_synonym="RGD1310168"
                     /inference="alignment:Splign:2.1.0"
     exon            1661..1785
                     /gene="Fermt3"
                     /gene_synonym="RGD1310168"
                     /inference="alignment:Splign:2.1.0"
     exon            1786..1927
                     /gene="Fermt3"
                     /gene_synonym="RGD1310168"
                     /inference="alignment:Splign:2.1.0"
     exon            1928..2456
                     /gene="Fermt3"
                     /gene_synonym="RGD1310168"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ctgaaggaag gaactgagca gcacaaggcc agcccgggcc agggtaacag gtgttccact
       61 gccatctgca gctgcagccc tttgcaggct agcagaagca gctgcagtca tggcggggat
      121 gaagacagcc tccggagact atatcgactc ttcctgggag ctgagggtgt ttgtgggcga
      181 ggaagaccct gaggctcagt ctgtcacact ccgagtcaca ggggagtccc acattggtgg
      241 ggtgcttctg aagatcgtgg aggagatcaa tcgcaagcag gactggtctg accatgccat
      301 ttggtgggag cagaagaaac agtggctgct acagacacac tggactctgg acaagtatgg
      361 gattctggca gatgcccgcc tcttctttgg gccacagcac cgacctgtga tcctgcgact
      421 gcccaatagg cgggtgctgc gcctccgtgc cagcttctcc aagcccctct tccagactgt
      481 ggctgccatc tgccgcctcc tcagtatcag gcacccagag gagctctctc tgctgcgcgc
      541 tccagaaaag aaggagaaga agaagaaaga gaaggagcct gaggaagagg tgcatgacct
      601 gacaagggtt gttctagccg gcggtgtggc ccccacctta ttccgaggca tgccagcaca
      661 cttctcggac agcgcccaga ccgaggcctg ttaccacatg ctgagccggc cacagccagc
      721 acctgaccct ctcctgctcc agcgcctgcc gaggcccagc tccctgcttg acaagaccca
      781 actccacagc aggtggctgg attcatctcg gtgcctcatg cagcaaggta tcaaggctgg
      841 ggacgtgctt tggctgcgat ttaagtacta cagctttttc gacctggacc ccaagacaga
      901 cccggtacgg ctgacccagc tgtatgagca ggcacgctgg gatttactga cagaggaaat
      961 cgactgtact gaggaggaga tgatggtgtt tgctgcccta cagtaccata tcaacaaagt
     1021 gactctgagt ggggatgtgg gtgagctggc ctctggggac ccggggctgg atgacctgga
     1081 tgcagccttg aacaacctgg aggtgaagct gaaggggtca gcaccctcag acatgctgga
     1141 tagcctcacc accatcccag aactcaagga ccatctccga atcttccggc cccggaagct
     1201 gaccttgaag ggctaccgcc agcactgggt gatattcaag gacaccacac tgtcctacta
     1261 taagagccaa gatgaagcac cgggggaccc tatccagcag ctcaacctca agggctgtga
     1321 agtggtccct gatgtcaatg tctctggcca gaagttctgc atcaaactcc tggtaccctc
     1381 accagagggc atgagtgaga tctacttgag atgccaggat gaacagcagt atgcacagtg
     1441 gatggctgcc tgccggcttg cctccaaggg ccgcaccatg gcggacagca gctatgccag
     1501 tgaggtgcag gccattctgg ccttcctcag cctgcagcgg gcaggcggta ccaacggagg
     1561 ctcagggaac aaaccccagg gtcttgaagc ctctgctgag ggccttaacc cctacggcct
     1621 tgtggctccc cgattccagc gaaagttcaa ggccaagcag ctcacccccc ggatcctgga
     1681 agctcaccag aatgtggccc aactctcgct gaccgaggcc cagctgcgct tcatccaggc
     1741 ctggcaatcc ctgcctgatt ttggcatctc ctatgtgata gtcaggttca agggcagcag
     1801 gaaggatgag attctgggca tcgccaacaa ccgactgatc cgaattgatc tggccgtggg
     1861 tgacgtggtc aagacctggc gcttcagcaa catgcggcaa tggaacgtca actgggacat
     1921 acggcaggtg gccattgagt tcgatgaaca tatcaatgtg gccttcagct gtgtgtctgc
     1981 tagctgccgc atcgtgcacg agtacatcgg gggctacatt ttcctgtcca ctcgagagcg
     2041 ggcccgaggg gaggagctgg acgaggatct gttcctacag cttactggag ggcatgaggc
     2101 cttctaaaga cagcccctgc tctacccaca ccctccaggg actctcccat ggccacgccc
     2161 acctgaactc tcccagcatg caccctgctg ggcaccctca cttgtcctca ggtaggccag
     2221 ggccctcact ggggtagatg ctaccaccac ccagcctagg gacgatgggc cctgagccac
     2281 acgaagcccc tcctcttgcc ctattggcac aagctcacac ccttgaccta tatgtagtct
     2341 ctaagcacat gatgaatgcc aaatatggat aaggaacagg aaatcctggt ttgaagctgg
     2401 actttctttt tgcgtgtttc aggttttttt taataaataa atattttatt attggaaaaa
     2461 aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa a
//
