LOCUS       NM_001106515            4787 bp    mRNA    linear   ROD 03-APR-2024
DEFINITION  Rattus norvegicus FERM domain containing kindlin 1 (Fermt1), mRNA.
ACCESSION   NM_001106515 XM_001079921 XM_001079930 XM_001079938 XM_001079948
            XM_001079950 XM_215844
VERSION     NM_001106515.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 4787)
  AUTHORS   Wei,J., Yin,J., Cui,Y., Wang,K., Hong,M. and Cui,J.
  TITLE     FERM domain containing kindlin 1 knockdown attenuates inflammation
            induced by intracerebral hemorrhage in rats via NLR family pyrin
            domain containing 3/nuclear factor kappa B pathway
  JOURNAL   Exp Anim 72 (3), 324-335 (2023)
   PUBMED   36740252
  REMARK    GeneRIF: FERM domain containing kindlin 1 knockdown attenuates
            inflammation induced by intracerebral hemorrhage in rats via NLR
            family pyrin domain containing 3/nuclear factor kappa B pathway.
REFERENCE   2  (bases 1 to 4787)
  AUTHORS   Zhao,B., Pan,Y., Xu,H. and Song,X.
  TITLE     Kindlin-1 Regulates Astrocyte Activation and Pain Sensitivity in
            Rats With Neuropathic Pain
  JOURNAL   Reg Anesth Pain Med 43 (5), 547-553 (2018)
   PUBMED   29677029
  REMARK    GeneRIF: Kindlin-1 silencing elevated the mechanical and thermal
            pain thresholds of chronic constriction injury rats.
REFERENCE   3  (bases 1 to 4787)
  AUTHORS   Zhao,B., He,E., Pan,Y., Xu,H. and Song,X.
  TITLE     Kindlin-1 is a key protein in hyperbaric oxygen therapy for the
            treatment of neuropathic pain
  JOURNAL   Mol Pain 13, 1744806917730254 (2017)
   PUBMED   28845732
  REMARK    GeneRIF: that kindlin-1 is a key protein in the action of
            hyperbaric oxygen therapy in the treatment of neuropathic pain
REFERENCE   4  (bases 1 to 4787)
  AUTHORS   Rognoni,E., Widmaier,M., Jakobson,M., Ruppert,R., Ussar,S.,
            Katsougkri,D., Bottcher,R.T., Lai-Cheong,J.E., Rifkin,D.B.,
            McGrath,J.A. and Fassler,R.
  TITLE     Kindlin-1 controls Wnt and TGF-beta availability to regulate
            cutaneous stem cell proliferation
  JOURNAL   Nat Med 20 (4), 350-359 (2014)
   PUBMED   24681597
REFERENCE   5  (bases 1 to 4787)
  AUTHORS   Calderwood,D.A., Campbell,I.D. and Critchley,D.R.
  TITLE     Talins and kindlins: partners in integrin-mediated adhesion
  JOURNAL   Nat Rev Mol Cell Biol 14 (8), 503-517 (2013)
   PUBMED   23860236
  REMARK    Review article
REFERENCE   6  (bases 1 to 4787)
  AUTHORS   Tan,C.L., Andrews,M.R., Kwok,J.C., Heintz,T.G., Gumy,L.F.,
            Fassler,R. and Fawcett,J.W.
  TITLE     Kindlin-1 enhances axon growth on inhibitory chondroitin sulfate
            proteoglycans and promotes sensory axon regeneration
  JOURNAL   J Neurosci 32 (21), 7325-7335 (2012)
   PUBMED   22623678
  REMARK    GeneRIF: results therefore suggest that kindlin-1 is a potential
            tool for improving axon regeneration after nervous system lesions.
REFERENCE   7  (bases 1 to 4787)
  AUTHORS   Herz,C., Aumailley,M., Schulte,C., Schlotzer-Schrehardt,U.,
            Bruckner-Tuderman,L. and Has,C.
  TITLE     Kindlin-1 is a phosphoprotein involved in regulation of polarity,
            proliferation, and motility of epidermal keratinocytes
  JOURNAL   J Biol Chem 281 (47), 36082-36090 (2006)
   PUBMED   17012746
REFERENCE   8  (bases 1 to 4787)
  AUTHORS   Ussar,S., Wang,H.V., Linder,S., Fassler,R. and Moser,M.
  TITLE     The Kindlins: subcellular localization and expression during murine
            development
  JOURNAL   Exp Cell Res 312 (16), 3142-3151 (2006)
   PUBMED   16876785
REFERENCE   9  (bases 1 to 4787)
  AUTHORS   Jobard,F., Bouadjar,B., Caux,F., Hadj-Rabia,S., Has,C., Matsuda,F.,
            Weissenbach,J., Lathrop,M., Prud'homme,J.F. and Fischer,J.
  TITLE     Identification of mutations in a new gene encoding a FERM family
            protein with a pleckstrin homology domain in Kindler syndrome
  JOURNAL   Hum Mol Genet 12 (8), 925-935 (2003)
   PUBMED   12668616
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from CH473949.1.
            
            On or before Oct 4, 2007 this sequence version replaced
            XM_001079950.1, XM_001079948.1, XM_001079930.1, XM_001079938.1,
            XM_001079921.1, XM_215844.4.
            
            ##Evidence-Data-START##
            RNAseq introns :: mixed sample support SAMEA5756307, SAMEA5760383
                              [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..4787
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="3"
                     /map="3q36"
     gene            1..4787
                     /gene="Fermt1"
                     /gene_synonym="RGD1306816"
                     /note="FERM domain containing kindlin 1"
                     /db_xref="GeneID:296179"
                     /db_xref="RGD:1306816"
     exon            1..561
                     /gene="Fermt1"
                     /gene_synonym="RGD1306816"
                     /inference="alignment:Splign:2.1.0"
     exon            562..730
                     /gene="Fermt1"
                     /gene_synonym="RGD1306816"
                     /inference="alignment:Splign:2.1.0"
     CDS             580..2613
                     /gene="Fermt1"
                     /gene_synonym="RGD1306816"
                     /note="UNC-112 related protein 1; kindlin 1; fermitin
                     family member 1"
                     /codon_start=1
                     /product="fermitin family homolog 1"
                     /protein_id="NP_001099985.1"
                     /db_xref="GeneID:296179"
                     /db_xref="RGD:1306816"
                     /translation="MLSSGDFTSASWELVVRVDHANEEQQTDITLRVSGDLHIGGVML
                     KLVEQMNIAQDWSDFALWWEQKRCWLLKTHWTLDKCGVQADAKLLFTPQHKMLRLRLP
                     NTRTVRLRVSFSAVVFKAVADICKVLNIRRPEELSLLKPSGDYCKKKKKKEKNSKEPV
                     IEDILNLESSSTSSGSPVSPGLYSKTMTPTYDPINGTPALSTMTWFGDSPLTEQNCSV
                     LAFSQPPPSPEVLAEMFQPRSLVDKAKMNAGWLDSSRSLMEQSIQEDEQLLLRFKYYT
                     FFDLNPKYDAVRINQLYEQARWAVLLEEIDCTEEEMLIFAALQYHISKLSLCAEIQDF
                     ATKSEVDEVEAALSSLEVTLEGGKADNTLEDITDIPKLADYLKLFKPKKLMLKAFKQY
                     WFVFKDTSIAYFKNQELEQGEPIEKLNIRGCEIVPDVNVAGRKFGIKLLIPVADGMNE
                     VYLRCDHEDQYARWMAACILASKGKTMADSSYQPEVVSILSFLKMKNRNSSPLVASSL
                     ESMDMNPECLVSPRCAKKHKSKQLAARILEAHHNVAQMPLVEAKLQFIQAWQSLPEFG
                     LTYYLVRFKGSKKDDILGVSYNRLIRMDAVTGIPVTTWRFANMKQWNVNWEIRQVAIE
                     FDQNVSIAFTCLSAGCKIVHEYIGGYIFLSTRSKDQNETLDEDLFHKLTGGQD"
     exon            731..964
                     /gene="Fermt1"
                     /gene_synonym="RGD1306816"
                     /inference="alignment:Splign:2.1.0"
     exon            965..1111
                     /gene="Fermt1"
                     /gene_synonym="RGD1306816"
                     /inference="alignment:Splign:2.1.0"
     exon            1112..1325
                     /gene="Fermt1"
                     /gene_synonym="RGD1306816"
                     /inference="alignment:Splign:2.1.0"
     exon            1326..1428
                     /gene="Fermt1"
                     /gene_synonym="RGD1306816"
                     /inference="alignment:Splign:2.1.0"
     exon            1429..1536
                     /gene="Fermt1"
                     /gene_synonym="RGD1306816"
                     /inference="alignment:Splign:2.1.0"
     exon            1537..1668
                     /gene="Fermt1"
                     /gene_synonym="RGD1306816"
                     /inference="alignment:Splign:2.1.0"
     exon            1669..1718
                     /gene="Fermt1"
                     /gene_synonym="RGD1306816"
                     /inference="alignment:Splign:2.1.0"
     exon            1719..1843
                     /gene="Fermt1"
                     /gene_synonym="RGD1306816"
                     /inference="alignment:Splign:2.1.0"
     exon            1844..1950
                     /gene="Fermt1"
                     /gene_synonym="RGD1306816"
                     /inference="alignment:Splign:2.1.0"
     exon            1951..2172
                     /gene="Fermt1"
                     /gene_synonym="RGD1306816"
                     /inference="alignment:Splign:2.1.0"
     exon            2173..2297
                     /gene="Fermt1"
                     /gene_synonym="RGD1306816"
                     /inference="alignment:Splign:2.1.0"
     exon            2298..2439
                     /gene="Fermt1"
                     /gene_synonym="RGD1306816"
                     /inference="alignment:Splign:2.1.0"
     exon            2440..4787
                     /gene="Fermt1"
                     /gene_synonym="RGD1306816"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 aactctgcat aggtagacaa ttgcagacag gaagggattc tccctggccc cgggtatcag
       61 tgacgaattt acctaagagg cagggaaaac gactgagcct tggattcagg gccagtactg
      121 gagggcttca gggtagccag aacgctggag gcctccaggc aaagccatat aaaagtggag
      181 gcgggagggg tggagtgtat tccaggctgc ttggctcctg cctggagcag ccctgcggct
      241 cccttcaacc cttattgtat ctgcaacctt ctcctactcg gagtgaaagc aagacctagc
      301 aggctgggct ggacgtgccc ccgcctgccc gccccgctag cctgctccgc gacgctgtgg
      361 ccccgggacg cggactgtgt ttgggcgctg ggcggcgggc tccgggagct cgcactggct
      421 gtcgcgaggt cccccgcaac gtcactcgac ccactgtacc cttgtgccgt cccgcgagac
      481 ccctgctcgc ccaaggcggc ctctaaggaa gcagctgtcc acgtgcgggc tgcagacagg
      541 acgccggggt ctccatagca gacacctgcc tggaccacaa tgttatcatc tggtgacttt
      601 acatctgcat cctgggagct tgtagtccga gttgaccatg caaatgaaga gcagcagaca
      661 gacatcacgc tgagagtgtc tggggacctg catattgggg gagtgatgct caagctggtg
      721 gaacagatga acatagccca agactggtca gactttgctc tgtggtggga acagaagcgc
      781 tgctggcttc tgaaaacgca ctggaccctg gacaagtgtg gagtccaggc cgacgccaag
      841 cttctcttca cccctcagca caagatgctt cgtcttcggc tgcccaacac caggacagtg
      901 cggcttcgag tcagcttttc tgctgtggtg tttaaggctg tagctgatat ctgcaaagta
      961 ctgaatatca gaagaccaga agaactctca ttgttaaagc cttctggtga ctattgtaaa
     1021 aagaaaaaga agaaagaaaa aaatagtaaa gagccagtga ttgaagacat cctgaacctg
     1081 gaaagttctt caacaagctc gggttcccca gtaagccctg gcttgtacag taagaccatg
     1141 acacccacat atgaccccat caacgggaca ccagccttat ccactatgac ttggtttggt
     1201 gacagccctt tgacagagca aaactgcagt gttctggcct tcagccaacc tcctccatca
     1261 ccagaggtgc tcgccgaaat gttccagcct cgatctttgg ttgacaaagc caagatgaat
     1321 gcaggctggc tggactcctc gaggtccctt atggagcaaa gcattcaaga ggatgagcag
     1381 ctgctgttga gatttaaata ctacaccttc tttgacttga atcctaaata tgatgctgtc
     1441 cgaattaacc aactctacga gcaagccaga tgggctgttc tcctggagga aatcgactgc
     1501 acagaagaag aaatgttgat ctttgcagct ctgcagtatc acatcagcaa gctgtcgctg
     1561 tgtgctgaaa tacaggactt tgcaaccaag tccgaggttg acgaggtaga agcagcgttg
     1621 tcaagtttgg aagtgaccct cgaaggcggg aaggcagaca acactttgga ggacattact
     1681 gacatcccta aactggcaga ttatctcaaa ttatttaagc ccaagaagct aatgttaaaa
     1741 gctttcaagc aatactggtt tgtctttaaa gacacatcta tagcctactt taaaaatcag
     1801 gaactcgaac aaggagagcc aatagagaag ctgaacatca gaggctgtga aattgtgcca
     1861 gatgtgaatg tagcagggag aaaatttgga atcaagttac taatccctgt tgctgatgga
     1921 atgaatgaag tgtatttgag atgtgaccat gaggatcaat atgcccggtg gatggctgcg
     1981 tgcatcttgg cctcgaaggg taaaaccatg gcagacagct cctaccagcc agaggtcgtc
     2041 agcatccttt catttctcaa gatgaaaaac cggaactcat cacctctggt ggcttccagt
     2101 ctggaaagca tggatatgaa cccggagtgc ttagtatcgc cccgctgtgc aaagaagcac
     2161 aagtctaaac agctggcagc ccggatcctg gaagctcacc acaacgtagc ccagatgcct
     2221 ctggtcgaag ccaaactgca gtttatccag gcatggcagt ccttacccga gttcggcctc
     2281 acttactacc ttgtcagatt taaaggaagc aagaaggatg acatcctggg agtttcatac
     2341 aacaggctga ttagaatgga tgcagtcact gggataccag ttacaacgtg gcgatttgcc
     2401 aatatgaagc agtggaatgt caactgggaa atccggcagg tggcaatcga gtttgaccaa
     2461 aatgtctcca tcgcattcac ctgcctaagt gcaggttgca agattgtaca cgagtacatt
     2521 ggtggctaca tcttcctgtc cacccgatcc aaggatcaaa atgaaacgct cgacgaggac
     2581 ctctttcaca aactgactgg cggtcaggac tgaagtgaag cagggctacc tggcctacat
     2641 ggacctagga atcccttcct gaatgaatag gatccatggc tttccctgtg tgtagctttc
     2701 agacccacac aatgtatgct taccatcaga cacccaggtc cttgcctcgt ctgagcacac
     2761 tgaacgcacc cctcacctta ctttgcctcc cattgccagc agtagactgg gctcctgctg
     2821 gtgtttccta taaagtgggt ggggaatgag aagcctggta cttactctgt ggatgctcta
     2881 aggcccacca tggctttcca gctctgtggc tttgcaggca cacgtaagtg ctaaccaaca
     2941 gctgacctgc ttatatgcct cattggtaag tcagcagtga gaagagcaag gtaaaagcga
     3001 tgtgtagcga gtacaaatct cattccacac actcaggtcc ttcttaacaa aactgagcgt
     3061 agctctcatc ttgccaaaat ggcagcagga gtctcatcgc cttttttctt tagaggtcag
     3121 agagatgagt ggggaggagc aggttacagt ggtcttcagt atcatcagtt tacggtgact
     3181 gtcacatctg ttaaggtgat cactcaccat ctggtctaat catcggtcct catagtattg
     3241 ctgacatgag aggctccatt cctagggaat cccacagaca cagtgaagtc cttcttaaag
     3301 acacagggat acatgggagc ccattcttag ccaagatcca tgactcggtc gatttgattc
     3361 tggacttggt ctcaagaaaa cagacccaga actctgttaa tcaaaagcac ctttaaggag
     3421 ctggaaagat agcttagcag ttaagagggc ttgctgctct tgcaggggac ctcaactgag
     3481 ttccaagtac ctagctttaa gggatctgat gccttcttct aaactccgtg atctgtttct
     3541 agagtccacc atgttgaaga tctgctttcg gagccctggt tgtcggggtt gtaagaaagt
     3601 gttcttcttc ccattcagct gcattctgga ggtggagtct acctctatga gtcttgccat
     3661 tttccctaaa caccttcagc tttgtaaatc acaggcagta acagactctc tggggctttt
     3721 tttttttcca gtatcatccc tgtcctgcta caaacataag ctcttgacag ctgcctgaat
     3781 gtcatattct ggtttttcag taggaaggaa tgagtgggtt ttgagtaggt agactgcagt
     3841 ctcagagcta aagggaggtg ttttcttctg ttgagacaca gccttctcct tccacacact
     3901 cagactgcac agataagaca agagctttcc ttgaactctg cctctctcct aggctgcatg
     3961 tttcagggtt ttggatggag cccagagacc ttcaagcctc agctgttgct ttgtttccca
     4021 accaagccac ctgggaaggg ggagttctgc aattccagga atcaagagac actcctggct
     4081 tgagaccaca gacctgagcc agaagaacct tctggaggtt tcttttagcc tatccctaga
     4141 ggtgtgtact catgaacctt tccaagttcc cactgaattt ctggggctca actttgctca
     4201 gaagtacttt aagcatttgg aagatttggt tcccatcaca aagaacttaa cttggggtgt
     4261 ttttatgcag acacatatgt taagtatgtg cagtaaacac tctgggctct actgtttagg
     4321 ctctaggcac tgtacaatat actcctaggt ataccacact aggctgggca tagcatatac
     4381 ccagtgtgtg tgcctctaat cccagaactg agaagacaga cacaggcaga cctctgtgag
     4441 tctgaggcca gccagggctc cataatcaga gccattctca aaaaaaaata tttacatgct
     4501 agagcctaga cagatgtttg aaatcctggt cacgatgacc tccttgatta tttgtcacct
     4561 tgattacatt ttgctcatga gaattcagct tccctccttc acccagacct ggccttcagg
     4621 tcagtccctc cttagctttt catggttggc tgacatttcc atgaaatgct tggaggagtt
     4681 ggctgcagac attatgcagt tttgggtagc atttctcccg tgatgacaca gctacatctc
     4741 aaaggaataa attggtataa gaagaaaatg ttaaatgcca caattct
//
