LOCUS       NM_001395758           10001 bp    mRNA    linear   ROD 03-APR-2024
DEFINITION  Rattus norvegicus FER tyrosine kinase (Fer), transcript variant 2,
            mRNA.
ACCESSION   NM_001395758 XM_039083431
VERSION     NM_001395758.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 10001)
  AUTHORS   Nizard,P., Ezan,F., Bonnier,D., Le Meur,N., Langouet,S., Baffet,G.,
            Arlot-Bonnemains,Y. and Theret,N.
  TITLE     Integrative analysis of high-throughput RNAi screen data identifies
            the FER and CRKL tyrosine kinases as new regulators of the
            mitogenic ERK-dependent pathways in transformed cells
  JOURNAL   BMC Genomics 15 (1), 1169 (2014)
   PUBMED   25540073
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 10001)
  AUTHORS   Makovski,A., Yaffe,E., Shpungin,S. and Nir,U.
  TITLE     Intronic promoter drives the BORIS-regulated expression of FerT in
            colon carcinoma cells
  JOURNAL   J Biol Chem 287 (9), 6100-6112 (2012)
   PUBMED   22223638
REFERENCE   3  (bases 1 to 10001)
  AUTHORS   Guo,C. and Stark,G.R.
  TITLE     FER tyrosine kinase (FER) overexpression mediates resistance to
            quinacrine through EGF-dependent activation of NF-kappaB
  JOURNAL   Proc Natl Acad Sci U S A 108 (19), 7968-7973 (2011)
   PUBMED   21518868
REFERENCE   4  (bases 1 to 10001)
  AUTHORS   Itoh,T., Hasegawa,J., Tsujita,K., Kanaho,Y. and Takenawa,T.
  TITLE     The tyrosine kinase Fer is a downstream target of the PLD-PA
            pathway that regulates cell migration
  JOURNAL   Sci Signal 2 (87), ra52 (2009)
   PUBMED   19738202
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 10001)
  AUTHORS   Zoubeidi,A., Rocha,J., Zouanat,F.Z., Hamel,L., Scarlata,E.,
            Aprikian,A.G. and Chevalier,S.
  TITLE     The Fer tyrosine kinase cooperates with interleukin-6 to activate
            signal transducer and activator of transcription 3 and promote
            human prostate cancer cell growth
  JOURNAL   Mol Cancer Res 7 (1), 142-155 (2009)
   PUBMED   19147545
REFERENCE   6  (bases 1 to 10001)
  AUTHORS   Iwanishi,M., Czech,M.P. and Cherniack,A.D.
  TITLE     The protein-tyrosine kinase fer associates with signaling complexes
            containing insulin receptor substrate-1 and phosphatidylinositol
            3-kinase
  JOURNAL   J Biol Chem 275 (50), 38995-39000 (2000)
   PUBMED   11006284
REFERENCE   7  (bases 1 to 10001)
  AUTHORS   Kim,L. and Wong,T.W.
  TITLE     Growth factor-dependent phosphorylation of the actin-binding
            protein cortactin is mediated by the cytoplasmic tyrosine kinase
            FER
  JOURNAL   J Biol Chem 273 (36), 23542-23548 (1998)
   PUBMED   9722593
REFERENCE   8  (bases 1 to 10001)
  AUTHORS   Kim,L. and Wong,T.W.
  TITLE     The cytoplasmic tyrosine kinase FER is associated with the
            catenin-like substrate pp120 and is activated by growth factors
  JOURNAL   Mol Cell Biol 15 (8), 4553-4561 (1995)
   PUBMED   7623846
REFERENCE   9  (bases 1 to 10001)
  AUTHORS   Hao,Q.L., Ferris,D.K., White,G., Heisterkamp,N. and Groffen,J.
  TITLE     Nuclear and cytoplasmic location of the FER tyrosine kinase
  JOURNAL   Mol Cell Biol 11 (2), 1180-1183 (1991)
   PUBMED   1990274
REFERENCE   10 (bases 1 to 10001)
  AUTHORS   Letwin,K., Yee,S.P. and Pawson,T.
  TITLE     Novel protein-tyrosine kinase cDNAs related to fps/fes and eph
            cloned using anti-phosphotyrosine antibody
  JOURNAL   Oncogene 3 (6), 621-627 (1988)
   PUBMED   2485255
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000009.1.
            
            On Aug 6, 2021 this sequence version replaced XM_039083431.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643429.34954.1,
                                           SRR26643297.32539.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760386
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-56                JAXUCZ010000009.1  110967463-110967518
            57-322              JAXUCZ010000009.1  111004947-111005212
            323-496             JAXUCZ010000009.1  111015840-111016013
            497-596             JAXUCZ010000009.1  111024268-111024367
            597-780             JAXUCZ010000009.1  111035886-111036069
            781-918             JAXUCZ010000009.1  111036747-111036884
            919-1038            JAXUCZ010000009.1  111037448-111037567
            1039-1161           JAXUCZ010000009.1  111051926-111052048
            1162-1351           JAXUCZ010000009.1  111059055-111059244
            1352-1444           JAXUCZ010000009.1  111095894-111095986
            1445-1651           JAXUCZ010000009.1  111104003-111104209
            1652-1774           JAXUCZ010000009.1  111109599-111109721
            1775-1831           JAXUCZ010000009.1  111154399-111154455
            1832-1947           JAXUCZ010000009.1  111160444-111160559
            1948-2042           JAXUCZ010000009.1  111162568-111162662
            2043-2166           JAXUCZ010000009.1  111199468-111199591
            2167-2321           JAXUCZ010000009.1  111261124-111261278
            2322-2444           JAXUCZ010000009.1  111265532-111265654
            2445-10001          JAXUCZ010000009.1  111266759-111274315
FEATURES             Location/Qualifiers
     source          1..10001
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="9"
                     /map="9q37"
     gene            1..10001
                     /gene="Fer"
                     /gene_synonym="Fert2; Flk; Flk_retired"
                     /note="FER tyrosine kinase"
                     /db_xref="GeneID:301737"
                     /db_xref="RGD:1306273"
     exon            1..56
                     /gene="Fer"
                     /gene_synonym="Fert2; Flk; Flk_retired"
                     /inference="alignment:Splign:2.1.0"
     exon            57..322
                     /gene="Fer"
                     /gene_synonym="Fert2; Flk; Flk_retired"
                     /inference="alignment:Splign:2.1.0"
     CDS             116..2587
                     /gene="Fer"
                     /gene_synonym="Fert2; Flk; Flk_retired"
                     /EC_number="2.7.10.2"
                     /note="isoform 2 is encoded by transcript variant 2;
                     proto-oncogene tyrosine-protein kinase FER; tyrosine
                     protein kinase FLK; tyrosine-protein kinase Fer; c-FER;
                     p94-FER; fer (fms/fps related) protein kinase, testis
                     specific 2; proto-oncogene c-Fer; fer (fps/fes related)
                     tyrosine kinase"
                     /codon_start=1
                     /product="tyrosine-protein kinase Fer isoform 2"
                     /protein_id="NP_001382687.1"
                     /db_xref="GeneID:301737"
                     /db_xref="RGD:1306273"
                     /translation="MGFGSDLKNSQEAVLKLQDWELRLLETVKKFMALRIKSDKEYAY
                     TLQNLCNQVDKDSTVQVNYVSNVSKSWLLMIQQTEQLSRIMKTHAEDLNSGPLHRLTM
                     MIKDKQQVKKSYVGIHQQIEAEMIKVTKTELEKLKSSYRQLIKEMNSAKEKYKEALAK
                     GKETEKAKERCDKATMKLHMLHNQYVLALKGAQLHQSQYYDTTLPLLLDSVQKMQEEM
                     IKALKGIFDEYSEITSLVTEEIVNVHKEIQMSVDQIDPSTEYNDFIDVHRTTAAKEQE
                     IEFDTSLLEENENLQANEIMWNNLTADSLQVMLKTLAEELTQTQQMLLHKEAAVLELE
                     KRIEESSETCAKKSDIVLLLGQKQALEELKQSVQQLRCTEAKCAAQKELLEQKVQEND
                     GKEPPPVVNYEEDARSVTSMERKERLSKFESIRHSIAGIIKSPKSVLGSSTQLSDVIS
                     VGEKPLAEHDWYHGAIPRIEAQELLKQQGDFLVRESHGKPGEYVLSVYSDGQRRHFII
                     QFVDNLYRFEGTGFSNIPQLIDHHFNTKQVITKKSGVVLLNPIPKDKKWVLNHEDVSL
                     GELLGKGNFGEVYKGTLKDKTPVAVKTCKEDLPQELKIKFLQEAKILKQYDHPNIVKL
                     IGVCTQRQPVYIIMELVPGGDFLSFLRKRKDELKLKQLVRFSLDVAAGMLYLEGKNCI
                     HRDLAARNCLVGENNTLKISDFGMSRQEDGGVYSSSGLKQIPIKWTAPEALNYGRYSS
                     ESDVWSFGILLWETFSLGVCPYPGMTNQQAREQVERGYRMSAPQNCPEEIFTIMMKCW
                     DYKPENRPKFSDLHKELTAIKKKIT"
     exon            323..496
                     /gene="Fer"
                     /gene_synonym="Fert2; Flk; Flk_retired"
                     /inference="alignment:Splign:2.1.0"
     exon            497..596
                     /gene="Fer"
                     /gene_synonym="Fert2; Flk; Flk_retired"
                     /inference="alignment:Splign:2.1.0"
     exon            597..780
                     /gene="Fer"
                     /gene_synonym="Fert2; Flk; Flk_retired"
                     /inference="alignment:Splign:2.1.0"
     exon            781..918
                     /gene="Fer"
                     /gene_synonym="Fert2; Flk; Flk_retired"
                     /inference="alignment:Splign:2.1.0"
     exon            919..1038
                     /gene="Fer"
                     /gene_synonym="Fert2; Flk; Flk_retired"
                     /inference="alignment:Splign:2.1.0"
     exon            1039..1161
                     /gene="Fer"
                     /gene_synonym="Fert2; Flk; Flk_retired"
                     /inference="alignment:Splign:2.1.0"
     exon            1162..1351
                     /gene="Fer"
                     /gene_synonym="Fert2; Flk; Flk_retired"
                     /inference="alignment:Splign:2.1.0"
     exon            1352..1444
                     /gene="Fer"
                     /gene_synonym="Fert2; Flk; Flk_retired"
                     /inference="alignment:Splign:2.1.0"
     exon            1445..1651
                     /gene="Fer"
                     /gene_synonym="Fert2; Flk; Flk_retired"
                     /inference="alignment:Splign:2.1.0"
     exon            1652..1774
                     /gene="Fer"
                     /gene_synonym="Fert2; Flk; Flk_retired"
                     /inference="alignment:Splign:2.1.0"
     exon            1775..1831
                     /gene="Fer"
                     /gene_synonym="Fert2; Flk; Flk_retired"
                     /inference="alignment:Splign:2.1.0"
     exon            1832..1947
                     /gene="Fer"
                     /gene_synonym="Fert2; Flk; Flk_retired"
                     /inference="alignment:Splign:2.1.0"
     exon            1948..2042
                     /gene="Fer"
                     /gene_synonym="Fert2; Flk; Flk_retired"
                     /inference="alignment:Splign:2.1.0"
     exon            2043..2166
                     /gene="Fer"
                     /gene_synonym="Fert2; Flk; Flk_retired"
                     /inference="alignment:Splign:2.1.0"
     exon            2167..2321
                     /gene="Fer"
                     /gene_synonym="Fert2; Flk; Flk_retired"
                     /inference="alignment:Splign:2.1.0"
     exon            2322..2444
                     /gene="Fer"
                     /gene_synonym="Fert2; Flk; Flk_retired"
                     /inference="alignment:Splign:2.1.0"
     exon            2445..10001
                     /gene="Fer"
                     /gene_synonym="Fert2; Flk; Flk_retired"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 acgccgggtg gcgactggct cccgggtctg aggggctcct gcttgtcagg ttctagatat
       61 gtgctgacta acaggctcac gtgcacagtg tggaggtcaa gctgtatctt acaaaatggg
      121 atttgggagt gacctgaaga actcacagga agctgtgcta aagctgcaag actgggaact
      181 acggctgctg gagacagtga agaaattcat ggctctgaga ataaaaagcg ataaagaata
      241 tgcatacacg ctgcagaacc tctgtaatca agttgataaa gacagcacgg tgcaggtgaa
      301 ttacgtcagc aacgtgtcca agtcttggct actgatgatt cagcagacag agcaactcag
      361 taggataatg aagacccatg cagaggactt gaactctgga cccttgcaca ggctcaccat
      421 gatgatcaag gacaagcagc aagtgaaaaa gagctatgta ggcattcatc agcagataga
      481 ggccgagatg atcaaggtca caaagacaga attggagaag ttgaaatcca gctatcgaca
      541 attaataaaa gagatgaatt ctgccaaaga gaaatataaa gaagccttag ccaaagggaa
      601 ggaaacagaa aaggccaagg agcgctgtga caaagccaca atgaaacttc atatgctgca
      661 taaccagtac gtgctggccc tgaagggggc gcagctccac cagagccagt attacgacac
      721 cacacttcct ctgctgctgg actccgtgca aaagatgcaa gaagaaatga taaaagcact
      781 aaaaggcata tttgacgagt atagcgagat aaccagcctt gtcacagagg agatagtgaa
      841 tgtccacaag gaaattcaaa tgtctgttga ccagatagat cctagcactg agtataatga
      901 cttcatcgac gtccacagaa caacagctgc taaggagcaa gaaatcgaat ttgatacttc
      961 cttattagaa gaaaatgaaa atcttcaggc aaacgagatc atgtggaata acttaacagc
     1021 agacagtttg caagtaatgc tgaagacttt agcagaagag ctcacacaga cccagcagat
     1081 gcttttacac aaggaggcgg cggtcctgga gctagagaag aggattgagg aatcttctga
     1141 gacctgcgca aagaagtctg acattgtgct tcttctgggc caaaagcagg cacttgaaga
     1201 gctgaaacag tcagtccagc aattgcgatg cactgaggca aagtgcgcag cacagaaaga
     1261 attgctggag caaaaagtac aggaaaatga tgggaaagag ccacctcctg tggtgaatta
     1321 cgaagaagat gcgcggtcag tcacatctat ggaaagaaag gagaggctat ccaaatttga
     1381 gtctattcgt cattcaattg ctggaataat taagtctcca aagtcggtcc tcggctcttc
     1441 aacgcagctc tctgacgtga tctctgtggg tgagaagccc ctggcggagc atgactggta
     1501 ccacggtgcc atccccagga tagaggcaca agaactgctg aagcagcagg gagacttcct
     1561 ggtgcgagag agccatggga aacctggtga atatgtcctt tctgtatatt ctgacggaca
     1621 aaggaggcac tttatcatac agtttgttga taatctatat cgatttgagg gcaccggctt
     1681 ttcaaatatc cctcaactta tagatcacca cttcaataca aagcaagtca tcaccaagaa
     1741 gtcgggggtg gttctgctga atcctattcc aaaggataag aaatgggttc tcaatcatga
     1801 agatgtttca ttgggagaat tactgggcaa ggggaatttt ggtgaggtgt acaagggcac
     1861 actgaaggat aaaacccctg ttgctgttaa aacgtgcaag gaagacctgc ctcaggaact
     1921 aaaaataaag tttttacagg aagccaaaat tctcaagcaa tatgatcacc ccaatattgt
     1981 caaacttata ggcgtgtgca cacaaagaca gcctgtctac atcattatgg aactggtccc
     2041 aggaggtgat tttctgtcct ttctgaggaa gaggaaggac gagctaaagt tgaagcagtt
     2101 ggtgaggttt tccttggacg ttgctgctgg catgctgtat ctcgagggca agaactgcat
     2161 tcacagggac ctggctgcac ggaactgcct ggtaggtgaa aataatactc tgaaaatcag
     2221 tgactttggg atgtctcggc aagaagacgg tggagtgtat tcatcttctg gcttaaagca
     2281 gattcccatt aagtggacag caccagaagc actgaattat gggagataca gctctgaaag
     2341 tgacgtgtgg agcttcggca tcctgctctg ggagactttc agcctgggag tctgtccgta
     2401 ccctgggatg acaaaccagc aagcacggga acaagtggag agagggtatc ggatgtcagc
     2461 cccacagaac tgtcccgagg aaatttttac aatcatgatg aagtgctggg attacaagcc
     2521 tgaaaaccgc cctaagttca gtgaccttca caaagagctc acggccatca agaagaaaat
     2581 cacatagtgc cacccagggc tagactccac ctgcgggact ctgtcctcag tcaccctgac
     2641 tttataccac cttactgcaa ccatctttga aggttatgtt ttttattaac tgggttttta
     2701 aagtatgttc cactttaaat atgttaaagg caaatttatt caagaaataa atagtcctac
     2761 ccagggccgt attagctaac cacaacaacc ctgccatttg atgcccctgt acagagaaga
     2821 gcaaggcctc ccaggaaggt aaaagatatc tttaataccg aagaacattg gtgttctgcc
     2881 aaagttttct actccgggca cagcctctgg gctgctgtct tctgccgtcg gccctcctca
     2941 gttggtgcta taaacagcct tggtagccca tgttttgcac aacacgtgcc caccacagtt
     3001 ggctttccac tctgccaagg caagattcta tctataaata gaatcatatg ttgggaatcg
     3061 cttggacctc ctcgggcttc tctcttcttt cctgtgagaa catcacacaa ccatgtcgtt
     3121 tgcctttcgc ttccctcagc caggccacag aaaatggtgt gtggaaaatt cccagagagc
     3181 ccaggggaca gaggtagttg cttctgcgga acagtgcaga ggacaggggt gacaaggagc
     3241 atgtgtgacc aggagggcag gttgggaaaa gagcaggtag ccagtgctca ccagggagaa
     3301 gaaagcaaga gcgccccctt cctcccagct ttccaccttc acagaacccg tgtctgggtc
     3361 tcgattcact aacaaggtct aagaaagttt tcaggattca ttgagcccat gcaaactgtc
     3421 ttaaagacac tgaagcccac agaagaacag catgattctg gttgtgtatc ttcatcctag
     3481 gagacaatcc cagaatggga ttcccttcac ttgtaccagt ttctgggtct tcagaatccc
     3541 tgattcacat ttacaaacac atccacccat atctactgaa gtgcagggcg gctatgaatg
     3601 aaatagatgg gccaggcgcc aagtcagtgt taatgaagaa aatctatagg gatgcccaca
     3661 tctccatttc ctcttccccc taaagccact cgctggaaat gttactgaga acgcagcggt
     3721 atgcaagcag ccattaaggt gaaggcaggt aagagcaggg tgtggctgag ctgcctctta
     3781 gctgcctcgg ggaacttccc atggtctgcg cagttgtctc agaaccagtg tggcccagag
     3841 atggtctcct cccttcctgg ccgtgtagag cgtggatcag actttgaagg aggcagctga
     3901 agagagaagg actctgttct attatttcaa cctccttgct aattttatac acatttaatg
     3961 gttcctacat gcaggctgaa ataaaggcac actgagcctg cccgcagcag tacactgcag
     4021 cacacaaagc agctccctcc tccgcgggca cagccctccc acgggtccga ccctgtaaat
     4081 aagcagaggc cctgatggca cacggcacgg caccccaagt gcaaactcag gcattcatgt
     4141 tgaagtgtcc tgctctccag gcatccgccg gccctcagaa agagataaga cattgcctct
     4201 cgggagccaa ctgaatctgt ctataataca ctctgtctat gaaaggggaa gaaacagcct
     4261 ctcactgctt agcagtggat gcccagcaag gggcaggagg ccggcttggc tctgactctg
     4321 tgaacaggac gagaaaggta atccctgcat tctgggtaca gagaacatgg ctggcgctga
     4381 cactcactca tccaggctct cagaatttgc aattcacatc ataactcttg gcttaagtta
     4441 aaaaggcttt tcaaaacatc atgacatctg caacatttaa attctatttt attctttgtc
     4501 ccagtgcagg cagaggtata gtttaagatt aactcatcgg gagcctttca ggatcatgtc
     4561 agtcatacag aatattaaat ttaacatagg cacgtgcatt aagaaaagct tatgcaaaac
     4621 attcttactg ttaattttgt tacgcttaaa gcataattta ttcatccctt ctgtcactga
     4681 taattattgg aattatgtac tttaggaggc taatccatac ccaaaaagtg cacatataaa
     4741 tacagttctg atttgcaagt tgatttaggg aagagagact gcagaaatgc acaaaagtct
     4801 atgatgcctt tacttaaaaa aataataatc ataaccagtg gcaccccagt aacacaggtg
     4861 tggacgcccc gaagcctggc cacagatctt tattttacta acagattagc caagagcgtt
     4921 gggggcctgc actgagcagc gagcgctcct tcaggtcagc agtctgggca cgcaggagaa
     4981 ggctggtgag catgagcgtc tgactcccaa tgcagcgcct accttgagtc accaggaaac
     5041 ctccctgaga aatgggaggt ctgtttgttg gagacagcaa acttttctcc cacagccaca
     5101 ttcgatgtgg attttgtgtg acctaagctt tcttctcaaa gccgttttct taggaaaacg
     5161 ataaagaatt actaggcctg ttttcagccc atcctgatat caggtccaca ggggaaagtc
     5221 ccaagtgatt ctttttcttt tttccaagac ttaacaggga cagtagagtc agttcccttt
     5281 tcatatctgg ccaccttctc acggatatcc cttgtacagc ctggagtcat tcagtgcgtg
     5341 ctcacggaga aaacagaact tcctacgact aagattatgt ttgtttccta aaacaaccaa
     5401 gtttccttct gtgttggcct ctgttgccat cagctggctc ctctgacatc accacagcac
     5461 tgtggtgaga cggctgtcac acaagcattt cagtggcatt acgtgccaca caccggattt
     5521 gggcagggag caagcaggca cagcaggaca gatctgtgct gtgtggcgtg accctcacat
     5581 gctctccaag tgttcagaac atcattgtaa tgtgccgggt ctgcagcatc ctgtagtcag
     5641 ccatgtgtcc ttgaagcaga gtgacatcta aggggctgtc cgcctgagtc ctcttccttt
     5701 cacaccattg gcatgatccc tgcctcttgt cagtagatgt gattgtcacg ggtgatctcc
     5761 ttggagatcg gagccctcat acaaaacagc accactgcag ctgaggaagg cggagagaaa
     5821 gctcacgtgt gtgtcaacat cttcagaagg tggaatccaa ggtttaatat gaaaaatgac
     5881 tgttagagtg gcatgagagt ttactatgaa aataaagcat ttcctcttgt taacagattt
     5941 actataccat tagaaggttt tactagattt ttactttaca tttttctggg cttattaatt
     6001 tcatgtcaaa aatgaatact tttttgagaa cccaaaatgt catttctgta taagaaaaga
     6061 ccctgattta aaagccagca agatcaccct gctaggagtt actgagacag atttaagctc
     6121 ccataatatg cccctttgaa catcgtgttc taatacaggt ggttaatcaa ctctatatcc
     6181 tcaccctgag tcagtatgag aaatgccccc ccctcacccc agaaactgtc cctctgcctt
     6241 ccactaatgc aaagatggca ttcaggaatg gcattgctgt cactctgcta acgtgacaga
     6301 tttctgggaa taaccctgct gtgaaataac tcattacagt ggccaggact agtgagctgg
     6361 ggcgcagaga tctgtcactg aattccaggt ggcctgcaga gagccaaaac aagaaagaac
     6421 cagctcccta aagcatgtag acaaagtgga cggagactgt cattgtcatc aggagccctg
     6481 aggaaacctc caggaggcca gacccttccc ctgcaaaacc agaaagagca ttcgtcccaa
     6541 agaaaccacc tcaatgccag ggcctctccc tgaagcagga gccacttggc actccaccca
     6601 gggctgacac catgtgaggt accggtcccc tcactgtctt ctacccagtg aacacgtggt
     6661 cccatgcgct cagtctagga gagtagccaa agcttctagg tcttgagctc attccttagg
     6721 tgaaggccac aatgcttccc atctcattag gacactttta tgcagtagaa caggccaggg
     6781 ctgacgtgtc ctaaatgaga acatgcttgg gctacccttg gctaaatggt tcctactgag
     6841 ggccctgctg agggaccctc ctgagcagca ctgggcgctg atgagtttga ctttacctaa
     6901 gaaacattct gaggtagagc acaggacagc agggtgaggg agtgtgtatc ccacaaaggg
     6961 gtcccaggaa ggcagcactg agaacaccaa tgagacccgg ggaaaagccc aaaagcccag
     7021 cccaaaagcc cagtgagcca gcctcgggct gtgggaggcc tgctactgcc caagacaaca
     7081 cacctcaaac ctccaagcag ttgtttgaag ggattgagtt gactgatggg cgtgtggtcc
     7141 ctgctgtctc gggaatggca agagtgcaga gggcgggaag caagcctttc ataagcatgg
     7201 gtaaactgag taacagcctt cctgtgtgtg agccgccagt gctacaggga gaggctggga
     7261 atgtttctga gttttactct attaatgaaa aactaaccgg caggtttggc ttccttacta
     7321 gccttgtaag aatcctcaaa caagaatatt gaagtctctt cttgaatttc agaactgtgc
     7381 acccaaacca gtaagatgca actggagtgc tctgtagcag ttacagacct gccacagagc
     7441 atgtcccctc gtatctgcca tgtctggccc aggagtgctc aggggcacta ttctctgatc
     7501 ttgtttttgc cttcttgtta ctttgttgct ttgccataac agaaaggcct tcaccgttgg
     7561 cttataaaca caagagtatc ttctcagggg ttcgcaccct acagggaata tgcagaccca
     7621 agaagccaga gcatacagcc tgtgagccga gctgtatgcc caggtgccac gtatgctgaa
     7681 tgagtatctt taccagcaag gcattcggac atttagggac agaaagacta ctgcccgtgg
     7741 gcatgtccat gttgaagatg tccctattct cttgggctag taagctgacc tctgcctaaa
     7801 gaaatgctgg aataatctac tgtaaagccc tgggcatccc atcttcccac atcagtctac
     7861 aataacccac tttgtattct ctgtaccctt cttaagagca gtatctaagt tattcaattt
     7921 atgtcatgtt aaatgatttt ccaaagcctc atgagagagg gcactgtgag gacctgaatt
     7981 caaagccagt ctacctaaat aaataccccc aggacactgt gaaagcatca acactccatg
     8041 gtggtttccc aatagcctcc ttcctggaaa accaaacatc actccctttc ttatttgttg
     8101 ggaatttcta tagcatcaga gtaagtgaga atgctacgag gagatccaag gcaggtccag
     8161 tagtaacctg cagggcacat ccaaaccctg cctcctcttc tcttcatgta gcactgagtg
     8221 cctgacaatc attacaggtg agcctgtctt cccggaggcc caggtctcta agtggcctat
     8281 gttggaacct tcagggctaa gagaagcaga cagacggatg tggatggatc cctgtgtaag
     8341 gaaaccatct ttttcaactc accatctcat gctttttctt tttttaacca aaaccacctt
     8401 acttaagaat cttcctctta caaagaattt ggtggggaaa actgccaact cataagaaat
     8461 gccagactag tgtgtgcacc cagtgaggct ggaaacaaac ttgctcccca cccgaggatg
     8521 gctgcacttt aattgggtgt ggggtgctgt gggtccccct tccatgctag ttatagctgc
     8581 cctcctggag cagcaatcag aagaccaatc ctacgaaggc acagtcccat caccccttag
     8641 gtcccaggcc ttccacatcc acagggcaca gtacgtgagc acacccagcg gaggcaggtt
     8701 tattcagtgt cagtgaaact gactcccagc ttcagcaggt tactgcagct tcttgaacaa
     8761 tcaaggtgat ctgatcagat ctaacataag aagctcatct gcttccaatt catgaccaaa
     8821 gtggccagag actgaaaata cccttccgtc tgctggaatt tcccctcact aacatgtctg
     8881 ttgtcctgtg atagttctcc atgtggacaa agttctttcg agaccgttct gttacatcct
     8941 ccttaaacca cccagactgc ctgttgaatc agcttctgta gttaaacacc taaagactat
     9001 gtttaaatgc ctgtaggttt tatgtttggt ttggttttgt atataaatga ttgtgcggct
     9061 ggggaccagg gatgaacgat ggtacacatt ccgttgtctt tgcattacgg tttgtgtgta
     9121 agctttttgt ttggtctgag tgcttttggt gagtcctcta aaatgctaaa actccccgaa
     9181 agcacaacca tgcggccaca caagttaagg tccctggaag tagagggaaa tacaggtgag
     9241 cgctcagagt cccacaggct actccgacgt cctcaggagt caggcccact gagacagaaa
     9301 caactgtcaa ctggtgccca ggctgcccgc ccaccattct ctgagcgcag gcccacagag
     9361 agcgggtaca gaaatgattt tctgagtcat ttctctgctt gtcactagga ggtgagatca
     9421 gtggtgagag gaagggccac cctcagtcac cagtgggcta ggtgtgccgt ctgtaattag
     9481 cactttgagc caagcacccc ggtggctctc ggagttcctc caatgccaat ggacggtcat
     9541 tttaatgtca catgaaagca cctttaatct tttgttgtta ttattttaaa agaatatatt
     9601 tgtgaagtgg ataaaagaaa cactggaaat agggtgcttc tgaaaatgtc aagcataaaa
     9661 catgggaaca aggtccgtgg tggtttctcc ggctttgtca acaaccctaa cagtggagga
     9721 agtggctggt ggtctgcctc ggccgactgt ctcagatctg tatttaacac gtatttattt
     9781 gttaaattct acattcagaa gaaatacact ttgaattttg gctaatgtta tagaacatac
     9841 tgaaaattga cttctatgtt tttttttagc acgggtccac cgtttttgta aaataaggcc
     9901 atttttggac agccttcttc taggagacca attaccatcc attggtctgc agagcctctt
     9961 tttattatgt ccttgtaata atgtaaaata ttgacagcaa a
//
