LOCUS       NM_001108434            2964 bp    mRNA    linear   ROD 20-SEP-2024
DEFINITION  Rattus norvegicus ferrochelatase (Fech), mRNA; nuclear gene for
            mitochondrial product.
ACCESSION   NM_001108434 XM_001060280 XM_001060349 XM_341622
VERSION     NM_001108434.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2964)
  AUTHORS   Morgenstern,M., Peikert,C.D., Lubbert,P., Suppanz,I., Klemm,C.,
            Alka,O., Steiert,C., Naumenko,N., Schendzielorz,A., Melchionda,L.,
            Muhlhauser,W.W.D., Knapp,B., Busch,J.D., Stiller,S.B.,
            Dannenmaier,S., Lindau,C., Licheva,M., Eickhorst,C., Galbusera,R.,
            Zerbes,R.M., Ryan,M.T., Kraft,C., Kozjak-Pavlovic,V., Drepper,F.,
            Dennerlein,S., Oeljeklaus,S., Pfanner,N., Wiedemann,N. and
            Warscheid,B.
  TITLE     Quantitative high-confidence human mitochondrial proteome and its
            dynamics in cellular context
  JOURNAL   Cell Metab 33 (12), 2464-2483 (2021)
   PUBMED   34800366
REFERENCE   2  (bases 1 to 2964)
  AUTHORS   Kadara,H., Nemer,G., Safi,R., Rebeiz,N., Daou,L., Delbani,D.,
            Btadini,W., Abbas,O., Tofaili,M., Bitar,F., Kibbi,A.G.,
            Shimomura,Y. and Kurban,M.
  TITLE     Erythropoietic protoporphyria a clinical and molecular study from
            Lebanon: Ferrochelatase a potential tumor suppressor gene in colon
            cancer
  JOURNAL   Clin Genet 92 (5), 495-502 (2017)
   PUBMED   28075030
REFERENCE   3  (bases 1 to 2964)
  AUTHORS   Piel,R.B. 3rd, Shiferaw,M.T., Vashisht,A.A., Marcero,J.R.,
            Praissman,J.L., Phillips,J.D., Wohlschlegel,J.A. and Medlock,A.E.
  TITLE     A Novel Role for Progesterone Receptor Membrane Component 1
            (PGRMC1): A Partner and Regulator of Ferrochelatase
  JOURNAL   Biochemistry 55 (37), 5204-5217 (2016)
   PUBMED   27599036
REFERENCE   4  (bases 1 to 2964)
  AUTHORS   Barupala,D.P., Dzul,S.P., Riggs-Gelasco,P.J. and Stemmler,T.L.
  TITLE     Synthesis, delivery and regulation of eukaryotic heme and Fe-S
            cluster cofactors
  JOURNAL   Arch Biochem Biophys 592, 60-75 (2016)
   PUBMED   26785297
  REMARK    Review article
REFERENCE   5  (bases 1 to 2964)
  AUTHORS   Farrag,M.S., Kucerova,J., Slachtova,L., Seda,O., Sperl,J. and
            Martasek,P.
  TITLE     A Novel Mutation in the FECH Gene in a Czech Family with
            Erythropoietic Protoporphyria and a Population Study of IVS3-48C
            Variant Contributing to the Disease
  JOURNAL   Folia Biol (Praha) 61 (6), 227-232 (2015)
   PUBMED   26789144
REFERENCE   6  (bases 1 to 2964)
  AUTHORS   Canepa,E.T., Pereda,M.P., Llambias,E.B. and Grinstein,M.
  TITLE     Regulation of phenobarbital-induced ferrochelatase mRNA activity by
            dibutyryl cAMP and glucose in normal and diabetic rat hepatocytes
  JOURNAL   Biochem Cell Biol 70 (1), 26-33 (1992)
   PUBMED   1316128
REFERENCE   7  (bases 1 to 2964)
  AUTHORS   Tutois,S., Montagutelli,X., Da Silva,V., Jouault,H.,
            Rouyer-Fessard,P., Leroy-Viard,K., Guenet,J.L., Nordmann,Y.,
            Beuzard,Y. and Deybach,J.C.
  TITLE     Erythropoietic protoporphyria in the house mouse. A recessive
            inherited ferrochelatase deficiency with anemia, photosensitivity,
            and liver disease
  JOURNAL   J Clin Invest 88 (5), 1730-1736 (1991)
   PUBMED   1939658
REFERENCE   8  (bases 1 to 2964)
  AUTHORS   Woods,J.S. and Fowler,B.A.
  TITLE     Metal alteration of uroporphyrinogen decarboxylase and
            coproporphyrinogen oxidase
  JOURNAL   Ann N Y Acad Sci 514, 55-64 (1987)
   PUBMED   3327437
  REMARK    Review article
REFERENCE   9  (bases 1 to 2964)
  AUTHORS   Woods,J.S. and Fowler,B.A.
  TITLE     Effects of chronic arsenic exposure on hematopoietic function in
            adult mammalian liver
  JOURNAL   Environ Health Perspect 19, 209-213 (1977)
   PUBMED   908300
REFERENCE   10 (bases 1 to 2964)
  AUTHORS   Bonkowsky,H.L., Bloomer,J.R., Ebert,P.S. and Mahoney,M.J.
  TITLE     Heme synthetase deficiency in human protoporphyria. Demonstration
            of the defect in liver and cultured skin fibroblasts
  JOURNAL   J Clin Invest 56 (5), 1139-1148 (1975)
   PUBMED   1184741
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from CH473971.1.
            
            On or before Oct 4, 2007 this sequence version replaced
            XM_001060349.1, XM_341622.3, XM_001060280.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            RNAseq introns :: single sample supports all introns SAMEA5760494
                              [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            gene product(s) localized to mito. :: inferred from homology
            RefSeq Select criteria             :: based on conservation,
                                                  expression
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..2964
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="18"
                     /map="18q12.1"
     gene            1..2964
                     /gene="Fech"
                     /note="ferrochelatase"
                     /db_xref="GeneID:361338"
                     /db_xref="RGD:1307556"
     exon            1..164
                     /gene="Fech"
                     /inference="alignment:Splign:2.1.0"
     CDS             98..1366
                     /gene="Fech"
                     /EC_number="4.98.1.1"
                     /codon_start=1
                     /product="ferrochelatase, mitochondrial"
                     /protein_id="NP_001101904.1"
                     /db_xref="GeneID:361338"
                     /db_xref="RGD:1307556"
                     /translation="MLSAGANMAAALRAAGALFREPLVYGSSRACQPWRCQSGPAVVA
                     TTEKAHHAKTTKPQAQPERRKPKTGILMLNMGGPETLGEVQDFLQRLFLDRDLMTLPI
                     QNKLAPFIAKRRTPKIQEQYRRIGGGSPIKMWTSKQGEGMVKLLDELSPDTAPHKYYI
                     GFRYVHPLTEEAIEEMERDGLERAIAFTQYPQYSCSTTGSSLNAIYRYYNEVGRKPTM
                     KWSTIDRWPTHPLLIQCFADHILKELDHFPEEKRSEVVILFSAHSLPMSVVNRGDPYP
                     QEVGATVHRVMEQLGYPNPYRLVWQSKVGPVPWLGPQTDEAIKGLCERGRKNILLVPI
                     AFTSDHIETLYELDIEYSQVLAQKCGAENIRRAESLNGNPLFSKALADLVHSHIQSNK
                     LCSTQLSLSCPLCVNPVCRKTKSFFTSQQL"
     exon            165..288
                     /gene="Fech"
                     /inference="alignment:Splign:2.1.0"
     exon            289..408
                     /gene="Fech"
                     /inference="alignment:Splign:2.1.0"
     exon            409..557
                     /gene="Fech"
                     /inference="alignment:Splign:2.1.0"
     exon            558..692
                     /gene="Fech"
                     /inference="alignment:Splign:2.1.0"
     exon            693..799
                     /gene="Fech"
                     /inference="alignment:Splign:2.1.0"
     exon            800..898
                     /gene="Fech"
                     /inference="alignment:Splign:2.1.0"
     exon            899..1006
                     /gene="Fech"
                     /inference="alignment:Splign:2.1.0"
     exon            1007..1171
                     /gene="Fech"
                     /inference="alignment:Splign:2.1.0"
     exon            1172..1231
                     /gene="Fech"
                     /inference="alignment:Splign:2.1.0"
     exon            1232..2964
                     /gene="Fech"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 tgattaggcg ctggggcgcg ggtgtagagc gctgccaggt cggcgttccc gggccttgcc
       61 tgagcgccgc ggtagaggat ccctggctgt cccggaaatg ctttcggccg gcgccaacat
      121 ggctgcggcc ctgcgggctg cgggcgctct gttccgcgag ccgctggtgt atggcagctc
      181 gagggcctgt cagccatgga ggtgccaatc gggtccagca gtggtggcca ctacggagaa
      241 agcgcatcat gccaaaacca caaaaccaca agctcaacca gaaaggagga agcccaaaac
      301 gggcatatta atgttaaaca tgggaggccc cgaaaccctt ggagaagttc aagacttcct
      361 tcagaggctc ttcctggacc gagacctcat gacccttccc attcaaaata agctggcacc
      421 attcatcgcc aaacgccgaa cccccaaaat tcaagagcag tatcgcagaa tcggaggtgg
      481 atcccccatc aagatgtgga cttccaagca aggagaaggc atggtgaagc tgctggatga
      541 gctgtcccct gacacagcac ctcacaaata ctatattgga ttccggtacg tccatccctt
      601 gacagaagag gcaattgaag agatggagag agatggacta gaaagggcca ttgctttcac
      661 acagtatcca cagtacagct gctccaccac aggcagcagc ttaaatgcca tttacagata
      721 ctataacgag gtggggcgga agcccaccat gaagtggagc actatcgaca ggtggcccac
      781 gcaccccctc ctcatccagt gctttgcaga ccacattctg aaagagctgg accattttcc
      841 agaggagaag agaagtgagg tggtcattct gttttctgcc cactccctgc cgatgtctgt
      901 tgtcaacaga ggggacccct atccccaaga ggtaggagcc actgtccaca gagtcatgga
      961 gcagctgggt tatccgaacc cctaccgact ggtctggcag tccaaggttg gtccagtacc
     1021 ctggttgggc cctcaaacag atgaggctat caaagggctt tgtgagcggg ggaggaagaa
     1081 tatcctcttg gttccaatag catttaccag tgatcacatt gagacccttt atgaactgga
     1141 cattgaatac tctcaagtgt tagctcagaa gtgtggagct gaaaacatca gaagagcaga
     1201 gtctcttaat ggaaatccat tgttctccaa ggcccttgct gacctggtgc actcccacat
     1261 ccagtcaaac aagctgtgct ccacgcagtt gagtctgagc tgtccgctct gtgtaaatcc
     1321 tgtctgcagg aagactaaat ccttcttcac cagccaacag ctgtgaccct gcctgaggac
     1381 ccgtgggatt cgcagatgta cagcctccca acatctccga tagggacgat ggggacggaa
     1441 gccacattag tctggacaca gactataatt tctccctgcc tgtgttttgt tttgtcttgt
     1501 tttgttttgt tttattttat ttcttgcttc cctatgtagg acaaactggc ctccagtgtg
     1561 cttcctgctc ctgtttcctg agtgtggcta gcattacaga cacacaaaat tgtgttcctt
     1621 ggagaatgga ctcaattctg actgagattt ctattttcat gtacacatac agtgaacact
     1681 cacaaccctt tctggggttg gtttatgaat gtgggatatc tgtctactgg gtcatcccag
     1741 ggatgagttt cacattttta tcttatgaga tacgcacaga ttctgcactt attgcccaaa
     1801 acaacttcct aaatcagtat agtgtgtctc ctctacgagc tgccagtggt gaccgagatg
     1861 tttacagtct tacggatata gctagagctt cagtgaatat ggcgaattta cgaaatataa
     1921 tttgtaaaag acttagcctg agtgcatagc ttagggctgt gtgcttgccc tgcaaggctc
     1981 ctgctttgag ccccagctgt gaacgcacac attatgtcac cgactcggcc ctaagtccat
     2041 gggtacggga gtgcgggagt cggagtggtc gcctgtcact gcttctattg gcagtgcagg
     2101 caccgttcac tggccactgc cgtgtctgtg gaaaccaaaa caagtgcgtg cttcaagagt
     2161 gctgagatgc cccaggcgca tagcctaata aacgtgtgga agttcagtcc tcgctgttta
     2221 tgccttaatt taagtcatgt tgcctcagga aagggtgctt tctgtctttt tcccatttcc
     2281 aagaacagtg ccaccaggaa atgctactga tggattaggg cttgtctctc cggggccaag
     2341 gaaccttcca gcgccaagtg cttattttat aaagttgacc gtgtttgata gccttgaatt
     2401 ttcttcatga ataagttttt attataaaag ttttatggtc atagactagg ccatttgtaa
     2461 aacacagaga aataactact ctaatgtggt aattatcatt gtattctaat cttttcctgc
     2521 atgtgtatgt gtgtatacac atacatacat atatatatat atatacacat acacagagat
     2581 acacatacat atataacaca catacatata cacatataca cacatacata tacacatata
     2641 tatacacaca catgtatata cacacgtaca tatatacaca tacatatata catacataca
     2701 tatacacaca tacatatata tacacataca catacataca tatatatagt cttcaacgta
     2761 ttccttcatc atagtcggcc tcctttccct tcataactaa ttcatgcctg aatttgtaat
     2821 gaaaagttat tctaaaaatg taaaaactat gtgaaggcag aatctgatct tctagatttg
     2881 gatttaaatg gatttgaaag tctttgggat cgttgaagga tttataataa tcactttgtc
     2941 taaaactttg ttcttcaaac agaa
//
