LOCUS       NM_024153               1786 bp    mRNA    linear   ROD 01-JUN-2024
DEFINITION  Rattus norvegicus ferredoxin reductase (Fdxr), mRNA; nuclear gene
            for mitochondrial product.
ACCESSION   NM_024153
VERSION     NM_024153.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1786)
  AUTHORS   Maio,N. and Rouault,T.A.
  TITLE     Iron-sulfur cluster biogenesis in mammalian cells: New insights
            into the molecular mechanisms of cluster delivery
  JOURNAL   Biochim Biophys Acta 1853 (6), 1493-1512 (2015)
   PUBMED   25245479
  REMARK    Review article
REFERENCE   2  (bases 1 to 1786)
  AUTHORS   Bubenek,S., Nastase,A., Niculescu,A.M., Baila,S., Herlea,V.,
            Lazar,V., Paslaru,L., Botezatu,A., Tomescu,D., Popescu,I. and
            Dima,S.
  TITLE     Assessment of gene expression profiles in peripheral occlusive
            arterial disease
  JOURNAL   Can J Cardiol 28 (6), 712-720 (2012)
   PUBMED   22721676
REFERENCE   3  (bases 1 to 1786)
  AUTHORS   Miller,W.L.
  TITLE     Androgen synthesis in adrenarche
  JOURNAL   Rev Endocr Metab Disord 10 (1), 3-17 (2009)
   PUBMED   18821018
  REMARK    Review article
REFERENCE   4  (bases 1 to 1786)
  AUTHORS   Mootha,V.K., Bunkenborg,J., Olsen,J.V., Hjerrild,M.,
            Wisniewski,J.R., Stahl,E., Bolouri,M.S., Ray,H.N., Sihag,S.,
            Kamal,M., Patterson,N., Lander,E.S. and Mann,M.
  TITLE     Integrated analysis of protein composition, tissue diversity, and
            gene regulation in mouse mitochondria
  JOURNAL   Cell 115 (5), 629-640 (2003)
   PUBMED   14651853
REFERENCE   5  (bases 1 to 1786)
  AUTHORS   Da Cruz,S., Xenarios,I., Langridge,J., Vilbois,F., Parone,P.A. and
            Martinou,J.C.
  TITLE     Proteomic analysis of the mouse liver mitochondrial inner membrane
  JOURNAL   J Biol Chem 278 (42), 41566-41571 (2003)
   PUBMED   12865426
REFERENCE   6  (bases 1 to 1786)
  AUTHORS   Sagara,Y., Watanabe,Y., Kodama,H. and Aramaki,H.
  TITLE     cDNA cloning, overproduction and characterization of rat
            adrenodoxin reductase
  JOURNAL   Biochim Biophys Acta 1434 (2), 284-295 (1999)
   PUBMED   10525147
REFERENCE   7  (bases 1 to 1786)
  AUTHORS   McLean,M.P., Nelson,S.E., Billheimer,J.T. and Gibori,G.
  TITLE     Differential capacity for cholesterol transport and processing in
            large and small rat luteal cells
  JOURNAL   Endocrinology 131 (5), 2203-2212 (1992)
   PUBMED   1425418
REFERENCE   8  (bases 1 to 1786)
  AUTHORS   Hanukoglu,I., Suh,B.S., Himmelhoch,S. and Amsterdam,A.
  TITLE     Induction and mitochondrial localization of cytochrome P450scc
            system enzymes in normal and transformed ovarian granulosa cells
  JOURNAL   J Cell Biol 111 (4), 1373-1381 (1990)
   PUBMED   2170421
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from D63761.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: D63761.1, BC088844.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMD00132261,
                                           SAMD00132262 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            gene product(s) localized to mito. :: inferred from homology
            RefSeq Select criteria             :: based on conservation,
                                                  expression, longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1786
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="W"
                     /db_xref="taxon:10116"
                     /chromosome="10"
                     /map="10q32.1"
     gene            1..1786
                     /gene="Fdxr"
                     /gene_synonym="AR"
                     /note="ferredoxin reductase"
                     /db_xref="GeneID:79122"
                     /db_xref="RGD:621648"
     exon            1..101
                     /gene="Fdxr"
                     /gene_synonym="AR"
                     /inference="alignment:Splign:2.1.0"
     CDS             23..1507
                     /gene="Fdxr"
                     /gene_synonym="AR"
                     /EC_number="1.18.1.6"
                     /note="NADPH:adrenodoxin oxidoreductase, mitochondrial;
                     ferredoxin--NADP(+) reductase; adrenodoxin reductase"
                     /codon_start=1
                     /product="NADPH:adrenodoxin oxidoreductase, mitochondrial
                     precursor"
                     /protein_id="NP_077067.1"
                     /db_xref="GeneID:79122"
                     /db_xref="RGD:621648"
                     /translation="MAPRCWRWWSWSAWPGVRPLPSRSTPTPGFCKKFSTQETTPQIC
                     VVGSGPAGFYTAQHLLKHHTRAHVDIYEKQLVPFGLVRFGVAPDHPEVKNVINTFTQT
                     ARSDRCAFRGNVVVGRDVSVPELREAYHAVVLSYGAEDHQPLEIPGEELPGVVSARAF
                     VGWYNGLPENQKLAPDLSCDTAVILGQGNVALDVARILLTPPEHLEKTDITEVALGVL
                     RQSRVKTVWIVGRRGPLQVAFTIKELREMIQLPGTQPILDPSDFLGLQDRIKDVPRPR
                     KRLTELLLRTATEKPGVEEAARRALASRAWGLRFFRSPQQVLPTPDGRRVAGIRLAVT
                     RLEGVGESTRAVPTGDVEDLPCGLLLSSVGYKSRPIDPSVPFDPKLGIIPNTEGRVVN
                     APGLYCSGWVKRGPTGVITTTMTDSFLTSQVLLKDLKAGLLPSGPRPGYTAIQALLSD
                     RGVRPVSFSDWEKLDAEEVARGQGTGKPREKLVDRREMLQLLGH"
     exon            102..205
                     /gene="Fdxr"
                     /gene_synonym="AR"
                     /inference="alignment:Splign:2.1.0"
     exon            206..301
                     /gene="Fdxr"
                     /gene_synonym="AR"
                     /inference="alignment:Splign:2.1.0"
     exon            302..424
                     /gene="Fdxr"
                     /gene_synonym="AR"
                     /inference="alignment:Splign:2.1.0"
     exon            425..538
                     /gene="Fdxr"
                     /gene_synonym="AR"
                     /inference="alignment:Splign:2.1.0"
     exon            539..640
                     /gene="Fdxr"
                     /gene_synonym="AR"
                     /inference="alignment:Splign:2.1.0"
     exon            641..748
                     /gene="Fdxr"
                     /gene_synonym="AR"
                     /inference="alignment:Splign:2.1.0"
     exon            749..833
                     /gene="Fdxr"
                     /gene_synonym="AR"
                     /inference="alignment:Splign:2.1.0"
     exon            834..1033
                     /gene="Fdxr"
                     /gene_synonym="AR"
                     /inference="alignment:Splign:2.1.0"
     exon            1034..1205
                     /gene="Fdxr"
                     /gene_synonym="AR"
                     /inference="alignment:Splign:2.1.0"
     exon            1206..1376
                     /gene="Fdxr"
                     /gene_synonym="AR"
                     /inference="alignment:Splign:2.1.0"
     exon            1377..1786
                     /gene="Fdxr"
                     /gene_synonym="AR"
                     /inference="alignment:Splign:2.1.0"
     polyA_site      1786
                     /gene="Fdxr"
                     /gene_synonym="AR"
ORIGIN      
        1 cggcgggttg ctcttctcag ccatggctcc tcgctgctgg cgctggtgga gctggtccgc
       61 gtggcctggg gttcggccgc ttccctccag gagcactccg acccctggct tctgcaagaa
      121 gttctccaca caggagacaa cccctcagat ctgtgtggtc ggcagtggcc cagctggctt
      181 ctacacagcc caacacttgt tgaagcacca cacccgggcc cacgtagaca tctatgagaa
      241 gcagctcgtc cccttcggcc tggtgcgctt tggtgtggca cctgaccatc ctgaagtaaa
      301 gaatgtcatc aacacattta cacagacagc ccgctcagac cgctgtgcct tccggggcaa
      361 tgtggtggtg ggcagggacg tgtccgttcc agagcttcgg gaagcctacc atgctgtggt
      421 tctgagttat ggagccgagg accaccaacc cctggaaatt cctggcgagg agctgcctgg
      481 agtggtctca gcccgggcct ttgtgggctg gtacaatggg cttcctgaga accagaagct
      541 ggctccggat ctgagctgtg acacggctgt gattctgggg caagggaatg tggctctgga
      601 tgtggcccgg atcctgctga ccccacctga gcacctggag aaaacagaca tcacagaggt
      661 tgcactgggg gtcctgaggc agagtcgggt gaagactgtg tggatagtgg gtcggcgtgg
      721 acccctgcaa gtagccttca ccattaagga gcttcgggag atgattcagt tgccaggaac
      781 ccagcccatt ttggatcctt cggatttctt gggcctccag gacagaatta aggatgtccc
      841 ccgtccaagg aaacggctga cagagctgct gcttcggaca gccacggaga agccaggagt
      901 ggaagaggct gcccgccggg cactggcctc tcgggcctgg ggcctccgct ttttccgaag
      961 cccccagcag gtgctaccca ccccagatgg tcgacgggta gcaggcatcc gcctggcagt
     1021 taccagactg gagggtgttg gtgagtccac acgggcagtg cccacgggag atgtggagga
     1081 cctcccttgt gggctgctgc tgagcagtgt tgggtataag agccgtccca tcgaccccag
     1141 cgtgcccttt gaccccaagc ttggaatcat ccccaacaca gagggccggg ttgtgaatgc
     1201 accaggcctc tactgcagtg gctgggtgaa gaggggaccc acaggtgtca tcaccacaac
     1261 catgacagac agcttcctca ccagccaggt gctgctgaag gacctgaagg ccgggctgct
     1321 gccctctggc cccagacctg gctatacagc cattcaagcc ctgctcagtg atcgaggggt
     1381 ccggccagtc tctttctcag attgggagaa gttggatgct gaggaagtag ctcgaggcca
     1441 gggcactggg aaaccaaggg agaagctggt ggatcgaaga gagatgctgc agctgctggg
     1501 gcactgaacc tgggccccag accccaccgt acaagaagag ctgtgctggg ttggcagttg
     1561 ggttacagtg ctgactgtcc tggcttggag gccgacctgt ggcctttcca gggccctctg
     1621 agctctgcct cagttaacct cccagtgtgg gtttaggccc aggagggaac ctgagctagg
     1681 gatggatgga ggtacggaca gaccctaccc atcttgtttc cttcctgtcg gacgatggta
     1741 ggcctctaga ctggaacaca gtggaaataa aacagacgtg cctaag
//
