LOCUS       NP_077067                494 aa            linear   ROD 01-JUN-2024
DEFINITION  NADPH:adrenodoxin oxidoreductase, mitochondrial precursor [Rattus
            norvegicus].
ACCESSION   NP_077067
VERSION     NP_077067.1
DBSOURCE    REFSEQ: accession NM_024153.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (residues 1 to 494)
  AUTHORS   Maio,N. and Rouault,T.A.
  TITLE     Iron-sulfur cluster biogenesis in mammalian cells: New insights
            into the molecular mechanisms of cluster delivery
  JOURNAL   Biochim Biophys Acta 1853 (6), 1493-1512 (2015)
   PUBMED   25245479
  REMARK    Review article
REFERENCE   2  (residues 1 to 494)
  AUTHORS   Bubenek,S., Nastase,A., Niculescu,A.M., Baila,S., Herlea,V.,
            Lazar,V., Paslaru,L., Botezatu,A., Tomescu,D., Popescu,I. and
            Dima,S.
  TITLE     Assessment of gene expression profiles in peripheral occlusive
            arterial disease
  JOURNAL   Can J Cardiol 28 (6), 712-720 (2012)
   PUBMED   22721676
REFERENCE   3  (residues 1 to 494)
  AUTHORS   Miller,W.L.
  TITLE     Androgen synthesis in adrenarche
  JOURNAL   Rev Endocr Metab Disord 10 (1), 3-17 (2009)
   PUBMED   18821018
  REMARK    Review article
REFERENCE   4  (residues 1 to 494)
  AUTHORS   Mootha,V.K., Bunkenborg,J., Olsen,J.V., Hjerrild,M.,
            Wisniewski,J.R., Stahl,E., Bolouri,M.S., Ray,H.N., Sihag,S.,
            Kamal,M., Patterson,N., Lander,E.S. and Mann,M.
  TITLE     Integrated analysis of protein composition, tissue diversity, and
            gene regulation in mouse mitochondria
  JOURNAL   Cell 115 (5), 629-640 (2003)
   PUBMED   14651853
REFERENCE   5  (residues 1 to 494)
  AUTHORS   Da Cruz,S., Xenarios,I., Langridge,J., Vilbois,F., Parone,P.A. and
            Martinou,J.C.
  TITLE     Proteomic analysis of the mouse liver mitochondrial inner membrane
  JOURNAL   J Biol Chem 278 (42), 41566-41571 (2003)
   PUBMED   12865426
REFERENCE   6  (residues 1 to 494)
  AUTHORS   Sagara,Y., Watanabe,Y., Kodama,H. and Aramaki,H.
  TITLE     cDNA cloning, overproduction and characterization of rat
            adrenodoxin reductase
  JOURNAL   Biochim Biophys Acta 1434 (2), 284-295 (1999)
   PUBMED   10525147
REFERENCE   7  (residues 1 to 494)
  AUTHORS   McLean,M.P., Nelson,S.E., Billheimer,J.T. and Gibori,G.
  TITLE     Differential capacity for cholesterol transport and processing in
            large and small rat luteal cells
  JOURNAL   Endocrinology 131 (5), 2203-2212 (1992)
   PUBMED   1425418
REFERENCE   8  (residues 1 to 494)
  AUTHORS   Hanukoglu,I., Suh,B.S., Himmelhoch,S. and Amsterdam,A.
  TITLE     Induction and mitochondrial localization of cytochrome P450scc
            system enzymes in normal and transformed ovarian granulosa cells
  JOURNAL   J Cell Biol 111 (4), 1373-1381 (1990)
   PUBMED   2170421
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from D63761.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: D63761.1, BC088844.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMD00132261,
                                           SAMD00132262 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            gene product(s) localized to mito. :: inferred from homology
            RefSeq Select criteria             :: based on conservation,
                                                  expression, longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..494
                     /organism="Rattus norvegicus"
                     /strain="W"
                     /db_xref="taxon:10116"
                     /chromosome="10"
                     /map="10q32.1"
     Protein         1..494
                     /product="NADPH:adrenodoxin oxidoreductase, mitochondrial
                     precursor"
                     /EC_number="1.18.1.6"
                     /note="NADPH:adrenodoxin oxidoreductase, mitochondrial;
                     ferredoxin--NADP(+) reductase; adrenodoxin reductase"
                     /calculated_mol_wt=50317
     transit_peptide 1..34
                     /calculated_mol_wt=4064
     Region          20..489
                     /region_name="PLN02852"
                     /note="ferredoxin-NADP+ reductase; cl30539"
                     /db_xref="CDD:357415"
     mat_peptide     35..494
                     /product="NADPH:adrenodoxin oxidoreductase, mitochondrial"
                     /calculated_mol_wt=50317
     Site            313
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:P22570; propagated from
                     UniProtKB/Swiss-Prot (P56522.1)"
     CDS             1..494
                     /gene="Fdxr"
                     /gene_synonym="AR"
                     /coded_by="NM_024153.1:23..1507"
                     /db_xref="GeneID:79122"
                     /db_xref="RGD:621648"
ORIGIN      
        1 maprcwrwws wsawpgvrpl psrstptpgf ckkfstqett pqicvvgsgp agfytaqhll
       61 khhtrahvdi yekqlvpfgl vrfgvapdhp evknvintft qtarsdrcaf rgnvvvgrdv
      121 svpelreayh avvlsygaed hqpleipgee lpgvvsaraf vgwynglpen qklapdlscd
      181 tavilgqgnv aldvarillt ppehlektdi tevalgvlrq srvktvwivg rrgplqvaft
      241 ikelremiql pgtqpildps dflglqdrik dvprprkrlt elllrtatek pgveeaarra
      301 lasrawglrf frspqqvlpt pdgrrvagir lavtrlegvg estravptgd vedlpcglll
      361 ssvgyksrpi dpsvpfdpkl giipntegrv vnapglycsg wvkrgptgvi tttmtdsflt
      421 sqvllkdlka gllpsgprpg ytaiqallsd rgvrpvsfsd wekldaeeva rgqgtgkpre
      481 klvdrremlq llgh
//
