LOCUS       NM_031840               1271 bp    mRNA    linear   ROD 05-DEC-2024
DEFINITION  Rattus norvegicus farnesyl diphosphate synthase (Fdps), mRNA.
ACCESSION   NM_031840
VERSION     NM_031840.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1271)
  AUTHORS   Du,C.Q., Liu,X.W., Zeng,G.Z., Jin,H.F. and Tang,L.J.
  TITLE     Inhibition of farnesyl pyrophosphate synthase attenuates
            angiotensin II-induced fibrotic responses in vascular smooth muscle
            cells
  JOURNAL   Int J Mol Med 35 (6), 1767-1772 (2015)
   PUBMED   25847782
  REMARK    GeneRIF: data indicate that FPPS may play an important role in Ang
            II-induced fibrotic responses in VSMCs
REFERENCE   2  (bases 1 to 1271)
  AUTHORS   Li,Z., Bi,X., Wang,M., Zhang,J., Song,J., Shen,X., Han,J., Fu,G.
            and Ye,Y.
  TITLE     Inhibition of farnesyl pyrophosphate synthase prevents angiotensin
            II-induced cardiac fibrosis in vitro
  JOURNAL   Clin Exp Immunol 176 (3), 429-437 (2014)
   PUBMED   24527834
  REMARK    GeneRIF: Inhibition of farnesyl pyrophosphate synthase prevents
            angiotensin II-induced cardiac fibrosis in vitro.
REFERENCE   3  (bases 1 to 1271)
  AUTHORS   Castello,A., Fischer,B., Eichelbaum,K., Horos,R., Beckmann,B.M.,
            Strein,C., Davey,N.E., Humphreys,D.T., Preiss,T., Steinmetz,L.M.,
            Krijgsveld,J. and Hentze,M.W.
  TITLE     Insights into RNA biology from an atlas of mammalian mRNA-binding
            proteins
  JOURNAL   Cell 149 (6), 1393-1406 (2012)
   PUBMED   22658674
REFERENCE   4  (bases 1 to 1271)
  AUTHORS   Li,L., Chen,G.P., Yang,Y., Ye,Y., Yao,L. and Hu,S.J.
  TITLE     Chronic inhibition of farnesyl pyrophosphate synthase attenuates
            cardiac hypertrophy and fibrosis in spontaneously hypertensive rats
  JOURNAL   Biochem Pharmacol 79 (3), 399-406 (2010)
   PUBMED   19800872
  REMARK    GeneRIF: This is the first report to show that chronic inhibition
            of farnesyl pyrophosphate synthase attenuates the development of
            cardiac hypertrophy and fibrosis.
REFERENCE   5  (bases 1 to 1271)
  AUTHORS   Ye,Y., Hu,S.J. and Li,L.
  TITLE     Inhibition of farnesylpyrophosphate synthase prevents angiotensin
            II-induced hypertrophic responses in rat neonatal cardiomyocytes:
            involvement of the RhoA/Rho kinase pathway
  JOURNAL   FEBS Lett 583 (18), 2997-3003 (2009)
   PUBMED   19716825
  REMARK    GeneRIF: inhibition of FPP synthase by alendronate reduces RhoA
            activation by diminishing geranylgeranylation which prevents Ang
            II-induced hypertrophic responses in neonatal cardiomyocytes.
REFERENCE   6  (bases 1 to 1271)
  AUTHORS   Spear,D.H., Kutsunai,S.Y., Correll,C.C. and Edwards,P.A.
  TITLE     Molecular cloning and promoter analysis of the rat liver farnesyl
            diphosphate synthase gene
  JOURNAL   J Biol Chem 267 (20), 14462-14469 (1992)
   PUBMED   1321149
REFERENCE   7  (bases 1 to 1271)
  AUTHORS   Nazian,S.J., Brewer,L.D. and Ness,G.C.
  TITLE     Pituitary regulation of the expression of the farnesyl
            pyrophosphate synthetase gene in the testes of the sexually
            maturing rat
  JOURNAL   J Androl 12 (4), 264-272 (1991)
   PUBMED   1917693
REFERENCE   8  (bases 1 to 1271)
  AUTHORS   Teruya,J.H., Salido,E.C., Edwards,P.A. and Clarke,C.F.
  TITLE     Testis-specific transcripts of rat farnesyl pyrophosphate
            synthetase are developmentally regulated and localized to haploid
            germ cells
  JOURNAL   Biol Reprod 44 (4), 663-671 (1991)
   PUBMED   2043737
REFERENCE   9  (bases 1 to 1271)
  AUTHORS   Teruya,J.H., Kutsunai,S.Y., Spear,D.H., Edwards,P.A. and
            Clarke,C.F.
  TITLE     Testis-specific transcription initiation sites of rat farnesyl
            pyrophosphate synthetase mRNA
  JOURNAL   Mol Cell Biol 10 (5), 2315-2326 (1990)
   PUBMED   2325654
REFERENCE   10 (bases 1 to 1271)
  AUTHORS   Ashby,M.N. and Edwards,P.A.
  TITLE     Identification and regulation of a rat liver cDNA encoding farnesyl
            pyrophosphate synthetase
  JOURNAL   J Biol Chem 264 (1), 635-640 (1989)
   PUBMED   2909544
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from M34477.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: M34477.1, FQ218556.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMD00132291, SAMEA5760383
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1271
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="2"
                     /map="2q34"
     gene            1..1271
                     /gene="Fdps"
                     /gene_synonym="Ac2-125; FPS"
                     /note="farnesyl diphosphate synthase"
                     /db_xref="GeneID:83791"
                     /db_xref="RGD:68953"
     exon            1..135
                     /gene="Fdps"
                     /gene_synonym="Ac2-125; FPS"
                     /inference="alignment:Splign:2.1.0"
     exon            136..298
                     /gene="Fdps"
                     /gene_synonym="Ac2-125; FPS"
                     /inference="alignment:Splign:2.1.0"
     CDS             158..1219
                     /gene="Fdps"
                     /gene_synonym="Ac2-125; FPS"
                     /EC_number="2.5.1.1"
                     /EC_number="2.5.1.10"
                     /note="farnesyl pyrophosphate synthetase; CR 39; FPP
                     synthetase; cholesterol-regulated 39 kDa protein; FPP
                     synthase; geranyltranstransferase;
                     dimethylallyltranstransferase; (2E,6E)-farnesyl
                     diphosphate synthase; farnesyl diphosphate synthetase;
                     testis-specific farnesyl pyrophosphate synthetase;
                     farnesyl diphosphate synthase (farnesyl pyrophosphate
                     synthetase, dimethylallyltranstransferase,
                     geranyltranstransferase)"
                     /codon_start=1
                     /product="farnesyl pyrophosphate synthase"
                     /protein_id="NP_114028.1"
                     /db_xref="GeneID:83791"
                     /db_xref="RGD:68953"
                     /translation="MNGDQKLDVHNQEKQNFIQHFSQIVKVLTEDELGHPEKGDAITR
                     IKEVLEYNTVGGKYNRGLTVVQTFQELVEPRKQDAESLQRALTVGWCVELLQAFFLVL
                     DDIMDSSHTRRGQICWYQKPGIGLDAINDALLLEAAIYRLLKFYCREQPYYLNLLELF
                     LQSSYQTEIGQTLDLITAPQGQVDLGRYTEKRYKSIVKYKTAFYSFYLPIAAAMYMAG
                     IDGEKEHANALKILLEMGEFFQIQDDYLDLFGDPSVTGKVGTDIQDNKCSWLVVQCLL
                     RATPQQRQILEENYGQKDPEKVARVKALYEELDLRSVFFKYEEDSYNRLKSLIEQCSA
                     PLPPSIFLELANKIYKRRK"
     exon            299..439
                     /gene="Fdps"
                     /gene_synonym="Ac2-125; FPS"
                     /inference="alignment:Splign:2.1.0"
     exon            440..732
                     /gene="Fdps"
                     /gene_synonym="Ac2-125; FPS"
                     /inference="alignment:Splign:2.1.0"
     exon            733..805
                     /gene="Fdps"
                     /gene_synonym="Ac2-125; FPS"
                     /inference="alignment:Splign:2.1.0"
     exon            806..883
                     /gene="Fdps"
                     /gene_synonym="Ac2-125; FPS"
                     /inference="alignment:Splign:2.1.0"
     exon            884..1018
                     /gene="Fdps"
                     /gene_synonym="Ac2-125; FPS"
                     /inference="alignment:Splign:2.1.0"
     exon            1019..1271
                     /gene="Fdps"
                     /gene_synonym="Ac2-125; FPS"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ttatatttgg gttctgccta ctgagccggg agtctgggaa ctacaactcc cagagtgctg
       61 agcggatgca cgctctgctt ttaggtgtaa gccgcaaaca tcttggaccc cgggagaatc
      121 cgcgttgaag cacagagcat ttagctcctc tgtcagaatg aatggggacc agaaactgga
      181 tgttcataac caagaaaagc agaatttcat ccagcacttc tcccagattg tcaaggtgct
      241 gactgaggat gaactgggac acccagagaa gggagatgct attacccgga tcaaagaggt
      301 cctggagtac aacactgtag gaggcaagta caatcggggt ctgacggtgg tacagacctt
      361 ccaggaactg gtggaaccaa ggaaacagga tgctgagagc ctacagcggg ccctgacggt
      421 gggctggtgt gtagaactgc tccaggcttt cttcctcgtg ttagatgaca tcatggactc
      481 ttcccacact cgccgggggc agatctgctg gtatcagaag ccgggcatag gcttggatgc
      541 catcaacgat gctctgcttc tggaagccgc tatctaccgc ctgcttaagt tctactgcag
      601 ggagcagccc tactacctca acctgctgga gctctttcta cagagttcct atcagactga
      661 gatcgggcag actctcgacc tcatcacagc accccagggc caagtggatc ttggtagata
      721 cactgaaaag aggtacaaat ctatcgtcaa gtacaagaca gctttctact ctttctacct
      781 gcctatcgcg gctgccatgt acatggctgg aattgatggg gagaaggaac acgctaatgc
      841 cctgaagatc ctgctggaga tgggcgagtt cttccagatc caggacgact accttgatct
      901 ctttggagac cccagtgtga ccggaaaggt cggcactgac atccaggaca acaaatgcag
      961 ctggctggtg gttcagtgtc tgctacgagc cactcctcag cagcgccaga tcttagagga
     1021 gaattatggg cagaaggacc cagaaaaagt ggcgcgggtg aaagcactgt acgaggagct
     1081 ggatctgcgg agtgtgttct tcaagtacga ggaagacagt tacaaccgcc tcaagagtct
     1141 catagagcag tgctccgcgc ccctgccccc atccatcttc ctggaactag caaacaagat
     1201 ctacaagcgg agaaagtaac ctcgaattgt agaggctgcg agggaggggt ctcaataaat
     1261 tattgttcaa c
//
