LOCUS       NM_019238               3173 bp    mRNA    linear   ROD 02-JUN-2024
DEFINITION  Rattus norvegicus farnesyl diphosphate farnesyl transferase 1
            (Fdft1), mRNA.
ACCESSION   NM_019238
VERSION     NM_019238.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3173)
  AUTHORS   Lin,X., Wang,H. and Pu,X.
  TITLE     Protective mechanism of fdft1 in steroid hormone synthesis pathway
            in SD rats with acute hypoxic injury
  JOURNAL   Genes Genomics 42 (11), 1319-1326 (2020)
   PUBMED   32980992
  REMARK    GeneRIF: Protective mechanism of fdft1 in steroid hormone synthesis
            pathway in SD rats with acute hypoxic injury.
REFERENCE   2  (bases 1 to 3173)
  AUTHORS   Mori,M., Sawashita,J. and Higuchi,K.
  TITLE     Functional polymorphisms of the Lss and Fdft1 genes in laboratory
            rats
  JOURNAL   Exp Anim 56 (2), 93-101 (2007)
   PUBMED   17460354
  REMARK    GeneRIF: The hypomorphic Lss(S) and Fdft1(S) alleles are not
            specific to the SCR strain, but are widely prevalent in several
            other laboratory rat strains.
REFERENCE   3  (bases 1 to 3173)
  AUTHORS   Waterham,H.R.
  TITLE     Defects of cholesterol biosynthesis
  JOURNAL   FEBS Lett 580 (23), 5442-5449 (2006)
   PUBMED   16876788
  REMARK    Review article
REFERENCE   4  (bases 1 to 3173)
  AUTHORS   Mori,M., Li,G., Abe,I., Nakayama,J., Guo,Z., Sawashita,J.,
            Ugawa,T., Nishizono,S., Serikawa,T., Higuchi,K. and Shumiya,S.
  TITLE     Lanosterol synthase mutations cause cholesterol
            deficiency-associated cataracts in the Shumiya cataract rat
  JOURNAL   J Clin Invest 116 (2), 395-404 (2006)
   PUBMED   16440058
REFERENCE   5  (bases 1 to 3173)
  AUTHORS   Stamellos,K.D., Shackelford,J.E., Shechter,I., Jiang,G., Conrad,D.,
            Keller,G.A. and Krisans,S.K.
  TITLE     Subcellular localization of squalene synthase in rat hepatic cells.
            Biochemical and immunochemical evidence
  JOURNAL   J Biol Chem 268 (17), 12825-12836 (1993)
   PUBMED   8509416
REFERENCE   6  (bases 1 to 3173)
  AUTHORS   McKenzie,T.L., Jiang,G., Straubhaar,J.R., Conrad,D.G. and
            Shechter,I.
  TITLE     Molecular cloning, expression, and characterization of the cDNA for
            the rat hepatic squalene synthase
  JOURNAL   J Biol Chem 267 (30), 21368-21374 (1992)
   PUBMED   1400448
REFERENCE   7  (bases 1 to 3173)
  AUTHORS   Shechter,I., Klinger,E., Rucker,M.L., Engstrom,R.G., Spirito,J.A.,
            Islam,M.A., Boettcher,B.R. and Weinstein,D.B.
  TITLE     Solubilization, purification, and characterization of a truncated
            form of rat hepatic squalene synthetase
  JOURNAL   J Biol Chem 267 (12), 8628-8635 (1992)
   PUBMED   1569107
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BC081810.1, JAXUCZ010000015.1 and BE104849.1.
            
            On Dec 1, 2005 this sequence version replaced NM_019238.1.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data because no single transcript from the same
            strain was available for the full length of the gene.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC081810.1, SRR26643287.31619.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760383,
                                           SAMEA5760386 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1650              BC081810.1         1-1650
            1651-2793           JAXUCZ010000015.1  41588480-41589622   c
            2794-3173           BE104849.1         1-380               c
FEATURES             Location/Qualifiers
     source          1..3173
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="Sprague-Dawley"
                     /db_xref="taxon:10116"
                     /chromosome="15"
                     /map="15p12"
     gene            1..3173
                     /gene="Fdft1"
                     /note="farnesyl diphosphate farnesyl transferase 1"
                     /db_xref="GeneID:29580"
                     /db_xref="RGD:61834"
     exon            1..175
                     /gene="Fdft1"
                     /inference="alignment:Splign:2.1.0"
     CDS             77..1327
                     /gene="Fdft1"
                     /EC_number="2.5.1.21"
                     /note="squalene synthetase; SS; SQS; FPP:FPP
                     farnesyltransferase; farnesyl diphosphate
                     farnesyltransferase"
                     /codon_start=1
                     /product="squalene synthase"
                     /protein_id="NP_062111.1"
                     /db_xref="GeneID:29580"
                     /db_xref="RGD:61834"
                     /translation="MEFVKCLGHPEEFYNLLRFRMGGRRNFIPKMDRNSLSNSLKTCY
                     KYLDQTSRSFAAVIQALDGDIRHAVCVFYLILRAMDTVEDDMAISVEKKIPLLRNFHT
                     FLYEPEWRFTESKEKHRVVLEDFPTISLEFRNLAEKYQTVIADICHRMGCGMAEFLNK
                     DVTSKQDWDKYCHYVAGLVGIGLSRLFSASEFEDPIVGEDTECANSMGLFLQKTNIIR
                     DYLEDQQEGRQFWPQEVWGKYVKKLEDFVKPENVDVAVKCLNELITNALQHIPDVITY
                     LSRLRNQSVFNFCAIPQVMAIATLAACYNNHQVFKGVVKIRKGQAVTLMMDATNMPAV
                     KAIIYQYIEEIYHRVPNSDPSASKAKQLISNIRTQSLPNCQLISRSHYSPIYLSFIML
                     LAALSWQYLSTLSQVTEDYVQREH"
     exon            176..273
                     /gene="Fdft1"
                     /inference="alignment:Splign:2.1.0"
     exon            274..457
                     /gene="Fdft1"
                     /inference="alignment:Splign:2.1.0"
     exon            458..586
                     /gene="Fdft1"
                     /inference="alignment:Splign:2.1.0"
     exon            587..778
                     /gene="Fdft1"
                     /inference="alignment:Splign:2.1.0"
     exon            779..955
                     /gene="Fdft1"
                     /inference="alignment:Splign:2.1.0"
     exon            956..1108
                     /gene="Fdft1"
                     /inference="alignment:Splign:2.1.0"
     exon            1109..3159
                     /gene="Fdft1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gcctaccgcc ggcatctaaa cacaggtggg agtgggagat cccgacaggt gagccccgcg
       61 ccccgcagcc acaaggatgg agttcgtgaa gtgtctaggc cacccggagg agttctacaa
      121 cctgctgcga ttccgcatgg gaggccggcg gaatttcata cccaagatgg accggaactc
      181 gctcagcaac agcttgaaga cttgctataa gtatcttgat cagaccagtc gcagcttcgc
      241 cgcggttatc caggcgctgg atggggacat acgtcatgcg gtgtgtgtgt tttacctgat
      301 cctccgagcc atggacacag tggaggatga catggccatc agtgtggaga agaagatccc
      361 actgctgcga aactttcaca ctttcctcta tgagccggag tggcggttca ccgagagcaa
      421 ggagaagcac cgagtagtgc tggaggactt ccccacgatc tccctggagt ttagaaattt
      481 ggctgagaaa tatcaaacag tgatcgctga catctgtcac aggatgggat gtgggatggc
      541 agaatttcta aacaaggatg taacctccaa acaggactgg gacaagtact gtcactatgt
      601 tgctggactg gtgggaatcg gcctttctcg cctattctct gcctcagagt ttgaagatcc
      661 catagttggt gaagacacag agtgtgccaa ttctatgggt ctgtttctgc agaaaacaaa
      721 tatcattcgt gattatctgg aagaccaaca agaaggaaga cagttttggc ctcaagaggt
      781 atggggcaaa tatgttaaga agctggaaga ctttgttaag ccagagaacg tagatgtggc
      841 cgtgaagtgc ttgaatgaac tcataaccaa cgccctacaa cacatccctg acgtcatcac
      901 ctacctgtca aggctccgga accaaagtgt gtttaacttc tgtgccattc cacaggtaat
      961 ggccattgct acgctggctg cctgttacaa taaccatcag gtattcaagg gagtagtgaa
     1021 gattcggaag gggcaagcag ttaccctcat gatggatgcc accaacatgc cagctgtcaa
     1081 agctatcata taccagtaca tagaagagat ttatcaccgg gtccccaact cagacccgtc
     1141 agctagcaag gccaagcagc tcatctccaa catcaggacg cagagccttc ccaattgcca
     1201 gctcatctcc cgaagccact actcccccat ttacctgtcc ttcatcatgc tcttggctgc
     1261 cctgagctgg cagtacttga gcactctgtc ccaggtcaca gaagactatg tccagagaga
     1321 acactgactt tgtttagctg gaagcggaag tccacgtgaa gtgggttttt cttcttcccc
     1381 cagctggatt ttgacttccc ttggtttttc cttctactct aatctttcgg agaactgagt
     1441 gtgggacctt taggaactct gaagaggaaa ggacgccttg ccctcagcag cctggtgctt
     1501 cctggatgtg gtccctgcct cttgtagcca ctggcatcat gttgaccgaa gcactggaaa
     1561 ggccacatgt gatcctagtg aacctggcta gaatgctgat tgaatctatt taatttgaaa
     1621 cagcctttga atacctatca cagtagaaaa tgaagtgact ggtcctctct ttctcatcag
     1681 cttgacgata gaagggatta atcgtcgata ttctaggtga taactgccaa gcttcccgag
     1741 tgcaggcgtg gcttccctgc ccagggggca gcacaagcag tcagtcatct tgtgctggtg
     1801 gccacctgtc agaagcatgc cctccaggaa aggcttggga tcttgagatt tttataatag
     1861 catgaaagcc caggcagatg gcttggtgat ctcaggacac agatctcagt atctgtctca
     1921 acagccagtt agcagggact gggaagggct cgatggctgc cctgtgttgc tggtgagggt
     1981 aagcaggcaa tgtgtacctg ctgcttccgc ctgccactgg cacttcccta ctagacacct
     2041 ccacagccat ttgttagggt tttccttgaa gtctcaagac aaatgatgac agaaaggacc
     2101 agttctgtat tggtggttag taggctacgt tgtcatggtg gcctctggca acccaggtac
     2161 ctgaaaacca gtttcaggga cagcagtgga gaacatactc taggcaaaca tactggcctg
     2221 tttcctatta taacaagata cctaaggcca actacttttt ttaccaagag aagaggtttg
     2281 ttacagcaca agatgaggtg gccctgtcgt tagcccttga agggccatgt ggaaaataac
     2341 acgtggtgag ggaacatgtg acaggaagca ggagtcaagc cctacaccag gctgacactg
     2401 cacgctctaa ctagctcaga ctggcctgca agtctatgta gccttgaact tgagtgatcc
     2461 cactgtctct cagccttctg aatttcagtt acagacatga gccaccccac tcttgtcctg
     2521 gaaggctagc attgagccct tttgagaaca gtgcctccaa aacctgatca ccttgcacag
     2581 ggcctcagtc acctcactgt caccctttgg gggacaccac agacacagtc tgctcccctt
     2641 ttcagcctga tgggcatgtt gacttcgcga gatgctccag ccagcttggt ggtccattca
     2701 gcttaagtga agtctctgtg ccccagtggt aaatctgttt gtatacagac tctgctaaat
     2761 tgctcacttg aggctctcag ccttgaacaa acaccatcct gttgaaacca aagtaatgtt
     2821 ccatggttct ttaacttctg ttacagaagc acaaaggtct taatgttcat cctttctgga
     2881 agctacaact cttagcagtc atcccagcat gtggtaggtg gaggcagaag agattcaaat
     2941 tcctaatcag ttataggcta cacaggacac tgtctctccc aaaaacctgg gtctgagtga
     3001 tagcacccag tagttcttcc agaggtccta agttcaattc ccaacaaccc catagtggct
     3061 cacaaccatc tatgaggtct gattccttct gatgtgtatg aagacagcac tcatatacat
     3121 aaactgcatg aataaatctt taaaaagagg agggacagaa aaaaaaaaaa aaa
//
