LOCUS       NM_001395146            3853 bp    mRNA    linear   ROD 01-APR-2024
DEFINITION  Rattus norvegicus fucose kinase (Fcsk), mRNA.
ACCESSION   NM_001395146 XM_006255624
VERSION     NM_001395146.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3853)
  AUTHORS   Ng,B.G., Rosenfeld,J.A., Emrick,L., Jain,M., Burrage,L.C., Lee,B.,
            Craigen,W.J., Bearden,D.R., Graham,B.H. and Freeze,H.H.
  CONSRTM   Undiagnosed Diseases Network
  TITLE     Pathogenic Variants in Fucokinase Cause a Congenital Disorder of
            Glycosylation
  JOURNAL   Am J Hum Genet 103 (6), 1030-1037 (2018)
   PUBMED   30503518
REFERENCE   2  (bases 1 to 3853)
  AUTHORS   Niittymaki,J., Mattila,P., Roos,C., Huopaniemi,L., Sjoblom,S. and
            Renkonen,R.
  TITLE     Cloning and expression of murine enzymes involved in the salvage
            pathway of GDP-L-fucose
  JOURNAL   Eur J Biochem 271 (1), 78-86 (2004)
   PUBMED   14686921
REFERENCE   3  (bases 1 to 3853)
  AUTHORS   Jork,R., Schmitt,M., Lossner,B. and Matthies,H.
  TITLE     Dopamine stimulated L-fucose incorporation into brain proteins is
            related to an increase in fucokinase activity
  JOURNAL   Biomed Biochim Acta 43 (3), 261-270 (1984)
   PUBMED   6331424
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000019.1.
            
            On Jun 4, 2021 this sequence version replaced XM_006255624.4.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643290.53019.1,
                                           SRR26643294.59441.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760383,
                                           SAMEA5760386 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-38                JAXUCZ010000019.1  55783751-55783788   c
            39-143              JAXUCZ010000019.1  55780642-55780746   c
            144-295             JAXUCZ010000019.1  55780146-55780297   c
            296-346             JAXUCZ010000019.1  55779950-55780000   c
            347-472             JAXUCZ010000019.1  55777166-55777291   c
            473-545             JAXUCZ010000019.1  55776541-55776613   c
            546-643             JAXUCZ010000019.1  55775984-55776081   c
            644-724             JAXUCZ010000019.1  55775434-55775514   c
            725-844             JAXUCZ010000019.1  55774706-55774825   c
            845-1016            JAXUCZ010000019.1  55774360-55774531   c
            1017-1129           JAXUCZ010000019.1  55773791-55773903   c
            1130-1231           JAXUCZ010000019.1  55772550-55772651   c
            1232-1402           JAXUCZ010000019.1  55772264-55772434   c
            1403-1467           JAXUCZ010000019.1  55771758-55771822   c
            1468-1838           JAXUCZ010000019.1  55771008-55771378   c
            1839-2049           JAXUCZ010000019.1  55769557-55769767   c
            2050-2216           JAXUCZ010000019.1  55769250-55769416   c
            2217-2438           JAXUCZ010000019.1  55768949-55769170   c
            2439-2582           JAXUCZ010000019.1  55768455-55768598   c
            2583-2702           JAXUCZ010000019.1  55768181-55768300   c
            2703-2890           JAXUCZ010000019.1  55765721-55765908   c
            2891-2990           JAXUCZ010000019.1  55765526-55765625   c
            2991-3214           JAXUCZ010000019.1  55764923-55765146   c
            3215-3853           JAXUCZ010000019.1  55764133-55764771   c
FEATURES             Location/Qualifiers
     source          1..3853
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="19"
                     /map="19q12"
     gene            1..3853
                     /gene="Fcsk"
                     /gene_synonym="Fuk"
                     /note="fucose kinase"
                     /db_xref="GeneID:307848"
                     /db_xref="RGD:1307000"
     exon            1..38
                     /gene="Fcsk"
                     /gene_synonym="Fuk"
                     /inference="alignment:Splign:2.1.0"
     exon            39..143
                     /gene="Fcsk"
                     /gene_synonym="Fuk"
                     /inference="alignment:Splign:2.1.0"
     CDS             62..3334
                     /gene="Fcsk"
                     /gene_synonym="Fuk"
                     /EC_number="2.7.1.52"
                     /note="fucokinase"
                     /codon_start=1
                     /product="L-fucose kinase"
                     /protein_id="NP_001382075.1"
                     /db_xref="GeneID:307848"
                     /db_xref="RGD:1307000"
                     /translation="MDQPKGVNWTVIILTCQYKDSVQVFQRELEVRQKREQIPAGTML
                     LAVEDPQTRVGSGGATLNALLVAAEHLSARAGFTVVTSDVLHSAWILILHMGRDFPFD
                     DCGRAFTCLPVENPQAPVEALVCNLDCLLDIMTHRLGPGSPPGVWVCSTDMLLSVPPN
                     PGISWDGFRGTRVIAFPGSLAYALNHGVYLTDSQGVVLDIYYQGTKAEIQRCVRPDGL
                     VPLVSGVVFFSVETAEHLLATHVSPPLDACTYMGLDSGAQPVQLSLFFDILLCMARNM
                     SRENFVAGRPPEMGQGDPDVARYLKGARAQLWRELRDQPLTMVYVPDGGYSYMTTDAT
                     EFLHRLTMPGVAVAQIVHSQVEEPQLLEATCSVVSCLLEGPVHLGPRSVLQHCHLRGP
                     IHIGAGCFVSGLDTAHSEALHGLELHDLILQGHHIRLHGSQSRVFTLAGRLDSWERQG
                     AGMYLNMSWNEFFKKTGIRDWDLWDPDTPLSDRCLLSARLFPVLHPTRALGPQDVLWM
                     LHPHKDRGEALRAWRASWRLSWEQLQPRLDRAATLDFRRDLFFRQALQKARHVLEARQ
                     DLCLHPLIRAAVGEGCSGPLLATLDKVAAGAEDPGVAARALACVADVLGCMAEGQGGL
                     RSGPAANPEWIQPFSYLERGDLMRGVEALAQEREKWLTRPALLVRAARHYEGAEQILI
                     RQAVMTARHFVSTQPVELPAPGQWVVTECPARVDFSGGWSDTPPIAYELGGAVLGLAV
                     RVDGRRPIGAKARRILEPELWLAVGPRQDEMTVKIVCRSLDDLQDYCQPHAPGALLKA
                     AFICADIVHVNSEVPLHEQLLRSFNGGFELHTWSELPHGSGLGTSSILAGAALAALQR
                     AAGRTVGTEALIHAVLHLEQVLTTGGGWQDQVSGLMPGIKVGRSRAQLPLKVEVEEIT
                     VPENFVQRINDHLLLVYTGKTRLARNLLQDVLRNWYARLPVVVQNARRLVRQTEKCAE
                     AFRQGNLALLGQYLTSYWEQKKLMAPGCEPLAVHRMMDVLAPYAFGQSLAGAGGGGFL
                     YLLTKEPRQKEVLEAVLAKVEGLGNYSVHLVQVDTQGLSLQLLGHDAHLCGAGPSEVG
                     NT"
     exon            144..295
                     /gene="Fcsk"
                     /gene_synonym="Fuk"
                     /inference="alignment:Splign:2.1.0"
     exon            296..346
                     /gene="Fcsk"
                     /gene_synonym="Fuk"
                     /inference="alignment:Splign:2.1.0"
     exon            347..472
                     /gene="Fcsk"
                     /gene_synonym="Fuk"
                     /inference="alignment:Splign:2.1.0"
     exon            473..545
                     /gene="Fcsk"
                     /gene_synonym="Fuk"
                     /inference="alignment:Splign:2.1.0"
     exon            546..643
                     /gene="Fcsk"
                     /gene_synonym="Fuk"
                     /inference="alignment:Splign:2.1.0"
     exon            644..724
                     /gene="Fcsk"
                     /gene_synonym="Fuk"
                     /inference="alignment:Splign:2.1.0"
     exon            725..844
                     /gene="Fcsk"
                     /gene_synonym="Fuk"
                     /inference="alignment:Splign:2.1.0"
     exon            845..1016
                     /gene="Fcsk"
                     /gene_synonym="Fuk"
                     /inference="alignment:Splign:2.1.0"
     exon            1017..1129
                     /gene="Fcsk"
                     /gene_synonym="Fuk"
                     /inference="alignment:Splign:2.1.0"
     exon            1130..1231
                     /gene="Fcsk"
                     /gene_synonym="Fuk"
                     /inference="alignment:Splign:2.1.0"
     exon            1232..1402
                     /gene="Fcsk"
                     /gene_synonym="Fuk"
                     /inference="alignment:Splign:2.1.0"
     exon            1403..1467
                     /gene="Fcsk"
                     /gene_synonym="Fuk"
                     /inference="alignment:Splign:2.1.0"
     exon            1468..1838
                     /gene="Fcsk"
                     /gene_synonym="Fuk"
                     /inference="alignment:Splign:2.1.0"
     exon            1839..2049
                     /gene="Fcsk"
                     /gene_synonym="Fuk"
                     /inference="alignment:Splign:2.1.0"
     exon            2050..2216
                     /gene="Fcsk"
                     /gene_synonym="Fuk"
                     /inference="alignment:Splign:2.1.0"
     exon            2217..2438
                     /gene="Fcsk"
                     /gene_synonym="Fuk"
                     /inference="alignment:Splign:2.1.0"
     exon            2439..2582
                     /gene="Fcsk"
                     /gene_synonym="Fuk"
                     /inference="alignment:Splign:2.1.0"
     exon            2583..2702
                     /gene="Fcsk"
                     /gene_synonym="Fuk"
                     /inference="alignment:Splign:2.1.0"
     exon            2703..2890
                     /gene="Fcsk"
                     /gene_synonym="Fuk"
                     /inference="alignment:Splign:2.1.0"
     exon            2891..2990
                     /gene="Fcsk"
                     /gene_synonym="Fuk"
                     /inference="alignment:Splign:2.1.0"
     exon            2991..3214
                     /gene="Fcsk"
                     /gene_synonym="Fuk"
                     /inference="alignment:Splign:2.1.0"
     exon            3215..3853
                     /gene="Fcsk"
                     /gene_synonym="Fuk"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gttaaagagc cggctctgcg agctctgggc ggacgcagga agcccctcca ttttggccag
       61 aatggaccag ccaaaggggg tcaattggac ggtcattatc ctgacatgcc agtacaagga
      121 cagtgtccag gtctttcaga gagagctgga ggtaaggcag aagcgggagc agatccctgc
      181 cgggacgatg ttactggctg tggaggaccc ccagacccga gtaggcagtg gaggagctac
      241 tctcaatgca ctgctggtgg ctgctgagca cctgagtgcc cgagctggct tcaccgtggt
      301 cacgtcagat gtcctgcact cggcttggat tctcatcttg cacatgggcc gagacttccc
      361 ctttgatgac tgtggcaggg ccttcacttg cctccctgtg gagaatccac aggcccctgt
      421 ggaggccttg gtatgcaacc tggactgcct gttggatatc atgacccacc ggctgggtcc
      481 aggatcccca ccaggtgtgt gggtctgcag caccgacatg cttctgtctg ttcctccaaa
      541 ccctgggatc agttgggatg gcttccgggg aaccagagtg atcgcctttc ctgggagcct
      601 ggcctacgct ctaaaccacg gggtctacct cactgactcg cagggcgtgg ttttggacat
      661 ttactaccag ggcactaagg cagagataca acggtgtgtc aggcctgatg gactggtacc
      721 actggtctct ggggttgtct tcttctctgt ggagactgct gagcacctcc tagccaccca
      781 cgtgagccca ccgctggacg cctgcaccta tatgggcttg gactctggag cccagcctgt
      841 gcagctgtct ctgtttttcg acatcctgct ctgcatggct cggaatatga gcagggagaa
      901 cttcgtggct gggcggcccc cggagatggg gcaaggtgac ccggatgtag cacgttacct
      961 gaagggagcc cgggcccagc tgtggaggga gcttcgagat cagcccctca ctatggtgta
     1021 tgtccctgat ggcggttaca gttacatgac aactgatgcc acggagttcc tgcacagact
     1081 cacgatgcct ggagtagctg tggcccagat tgttcactct caggtggagg agccacagct
     1141 gctagaggct acgtgctccg tggtcagctg cctgctggag ggtcccgtgc acctggggcc
     1201 tcgaagtgtc ctgcagcact gtcacctgag gggccccatt catattggcg ctggctgctt
     1261 tgtgagtggc ctggataccg cccactccga ggcactgcat ggcctggagc ttcatgacct
     1321 catccttcag ggacaccaca tacggctgca tggctcccag agtcgtgtat tcactcttgc
     1381 tggccgtctg gacagctggg aaagacaggg ggcaggcatg tatctcaaca tgtcctggaa
     1441 tgagttcttc aagaagacag gcattcgaga ctgggacctg tgggacccag atacacccct
     1501 ctcagatcga tgccttctca gtgcccgcct tttccctgtg ctccacccca cgagggctct
     1561 ggggccccag gatgtgctgt ggatgctgca tcctcataag gacagaggcg aggccctgcg
     1621 tgcctggaga gcctcctggc gtctgtcctg ggagcagctg caacctcgcc tggaccgggc
     1681 tgccacactg gacttccgtc gggatctgtt cttccgccag gccttgcaga aggcgaggca
     1741 tgtgttagag gcccggcagg acctctgcct acatccactg atccgggctg ctgtcggtga
     1801 aggttgctct gggcccctgc tggccacact tgacaaggtt gcagcagggg cagaagatcc
     1861 tggtgtggca gcccgggctc tggcttgtgt ggcagatgta ctcggctgca tggcagaggg
     1921 ccaaggaggc ttgcgcagtg ggccagctgc caaccctgag tggattcagc ctttctcata
     1981 cttggaacgt ggagacctca tgaggggtgt ggaggcactt gcccaggaaa gagagaagtg
     2041 gctgaccagg cctgccttgt tggttcgagc tgcccgccat tatgaggggg ctgagcagat
     2101 cctgatccga caggctgtga tgacagcccg gcacttcgtc tccacccagc cagtggaatt
     2161 gccagcacct gggcagtggg tggtgactga gtgcccagcc cgtgtggatt tctctggggg
     2221 ctggagtgac acaccaccca ttgcctatga gcttggtgga gcagtattgg gcctggctgt
     2281 tcgggtggat ggccgccggc ccatcggggc caaggcacgc cgcatcctag agcctgagct
     2341 ctggctggca gtgggacctc gacaggatga gatgaccgtg aagatagtgt gccggagcct
     2401 tgatgacctg caggattact gccagcctca tgccccaggt gccttgctga aggcagcctt
     2461 tatctgtgcg gatattgtgc atgtcaactc agaggtccct ctgcatgaac agttgctacg
     2521 ctcgtttaat ggtggctttg agctgcacac atggtcagag ctgccacacg gctctggtct
     2581 tggcactagc agcatcttgg caggggctgc cctggctgct ttgcagcggg ctgcaggccg
     2641 gacagtgggc acagaggctc tcatccatgc agtgttgcac ctggagcagg tgctcaccac
     2701 aggaggtggc tggcaggacc aagtgagtgg cctaatgcct ggcatcaagg tggggcgctc
     2761 tcgggcacag ctgcccctaa aggtggaggt ggaggaaatc actgtgcctg agaactttgt
     2821 ccagaggatc aatgaccatc tgctcctggt ttatactggc aagacccggc tggcacggaa
     2881 tctgctgcag gacgtgctaa ggaactggta tgctcggttg cctgttgtgg tacagaatgc
     2941 ccgcagactg gttcgacaga ctgagaagtg tgctgaagct ttccgccaag gaaacttggc
     3001 tctgctggga cagtacctga cctcatactg ggagcagaag aagcttatgg ccccaggctg
     3061 tgagccgctg gctgtgcatc ggatgatgga tgtcctggcc ccttatgcct tcggccaaag
     3121 tctggcaggg gcaggcggtg ggggctttct ctatctgttg accaaggaac cccggcagaa
     3181 agaggtccta gaagctgtgc tggccaaggt ggagggcctc ggcaactaca gcgtccacct
     3241 ggtgcaagtg gacactcagg gcctgagcct gcagctgcta ggacatgacg cccatctttg
     3301 cggggctggg ccctctgaag tgggcaacac ctagagccac agctgtattt cccttgagcg
     3361 gagctcggtt tgctattcct catctacctc ttcaagtctg ccgataagga agcaagcagg
     3421 acttgggcag aagaggcagt gtttgcaaac agtactgtac ttcatggtgg gcagtggcta
     3481 agacttggcc cctgtttcat ctggattaag ggaggtcttg gtcacagtgt cccatgtgga
     3541 ctttacaaat tccatggctc agtataggcc tcctagggcc ccggaaggga tgacaatcag
     3601 accagctctg aaggtacacc ttcaggcatt cccataccaa gtgtgagcct tggccttcta
     3661 cggtaggggc aggaagagtg gagctgtttt caggtctgtg gcagtgaacc atttcctgcc
     3721 acagtccacg gcaagttttg ataacctaag cctttccaac aacactacag tgtcaaagga
     3781 acctgatggt aataggttct cagtaccggc attcttggaa taaattttaa ttttcaaggt
     3841 tgtcttcaga aaa
//
