LOCUS       NP_001382075            1090 aa            linear   ROD 01-APR-2024
DEFINITION  L-fucose kinase [Rattus norvegicus].
ACCESSION   NP_001382075 XP_006255686
VERSION     NP_001382075.1
DBSOURCE    REFSEQ: accession NM_001395146.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (residues 1 to 1090)
  AUTHORS   Ng,B.G., Rosenfeld,J.A., Emrick,L., Jain,M., Burrage,L.C., Lee,B.,
            Craigen,W.J., Bearden,D.R., Graham,B.H. and Freeze,H.H.
  CONSRTM   Undiagnosed Diseases Network
  TITLE     Pathogenic Variants in Fucokinase Cause a Congenital Disorder of
            Glycosylation
  JOURNAL   Am J Hum Genet 103 (6), 1030-1037 (2018)
   PUBMED   30503518
REFERENCE   2  (residues 1 to 1090)
  AUTHORS   Niittymaki,J., Mattila,P., Roos,C., Huopaniemi,L., Sjoblom,S. and
            Renkonen,R.
  TITLE     Cloning and expression of murine enzymes involved in the salvage
            pathway of GDP-L-fucose
  JOURNAL   Eur J Biochem 271 (1), 78-86 (2004)
   PUBMED   14686921
REFERENCE   3  (residues 1 to 1090)
  AUTHORS   Jork,R., Schmitt,M., Lossner,B. and Matthies,H.
  TITLE     Dopamine stimulated L-fucose incorporation into brain proteins is
            related to an increase in fucokinase activity
  JOURNAL   Biomed Biochim Acta 43 (3), 261-270 (1984)
   PUBMED   6331424
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000019.1.
            
            On Jun 4, 2021 this sequence version replaced XP_006255686.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643290.53019.1,
                                           SRR26643294.59441.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760383,
                                           SAMEA5760386 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1090
                     /organism="Rattus norvegicus"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="19"
                     /map="19q12"
     Protein         1..1090
                     /product="L-fucose kinase"
                     /EC_number="2.7.1.52"
                     /note="fucokinase"
                     /calculated_mol_wt=119422
     Region          91..496
                     /region_name="Fucokinase"
                     /note="L-fucokinase; pfam07959"
                     /db_xref="CDD:462323"
     Region          <664..1047
                     /region_name="fkp"
                     /note="bifunctional
                     fucokinase/L-fucose-1-P-guanylyltransferase; Provisional;
                     PRK13412"
                     /db_xref="CDD:237379"
     CDS             1..1090
                     /gene="Fcsk"
                     /gene_synonym="Fuk"
                     /coded_by="NM_001395146.1:62..3334"
                     /db_xref="GeneID:307848"
                     /db_xref="RGD:1307000"
ORIGIN      
        1 mdqpkgvnwt viiltcqykd svqvfqrele vrqkreqipa gtmllavedp qtrvgsggat
       61 lnallvaaeh lsaragftvv tsdvlhsawi lilhmgrdfp fddcgraftc lpvenpqapv
      121 ealvcnldcl ldimthrlgp gsppgvwvcs tdmllsvppn pgiswdgfrg trviafpgsl
      181 ayalnhgvyl tdsqgvvldi yyqgtkaeiq rcvrpdglvp lvsgvvffsv etaehllath
      241 vsppldacty mgldsgaqpv qlslffdill cmarnmsren fvagrppemg qgdpdvaryl
      301 kgaraqlwre lrdqpltmvy vpdggysymt tdateflhrl tmpgvavaqi vhsqveepql
      361 leatcsvvsc llegpvhlgp rsvlqhchlr gpihigagcf vsgldtahse alhglelhdl
      421 ilqghhirlh gsqsrvftla grldswerqg agmylnmswn effkktgird wdlwdpdtpl
      481 sdrcllsarl fpvlhptral gpqdvlwmlh phkdrgealr awraswrlsw eqlqprldra
      541 atldfrrdlf frqalqkarh vlearqdlcl hpliraavge gcsgpllatl dkvaagaedp
      601 gvaaralacv advlgcmaeg qgglrsgpaa npewiqpfsy lergdlmrgv ealaqerekw
      661 ltrpallvra arhyegaeqi lirqavmtar hfvstqpvel papgqwvvte cparvdfsgg
      721 wsdtppiaye lggavlglav rvdgrrpiga karrilepel wlavgprqde mtvkivcrsl
      781 ddlqdycqph apgallkaaf icadivhvns evplheqllr sfnggfelht wselphgsgl
      841 gtssilagaa laalqraagr tvgtealiha vlhleqvltt gggwqdqvsg lmpgikvgrs
      901 raqlplkvev eeitvpenfv qrindhlllv ytgktrlarn llqdvlrnwy arlpvvvqna
      961 rrlvrqtekc aeafrqgnla llgqyltsyw eqkklmapgc eplavhrmmd vlapyafgqs
     1021 lagaggggfl ylltkeprqk evleavlakv eglgnysvhl vqvdtqglsl qllghdahlc
     1081 gagpsevgnt
//
