LOCUS       NM_053634               1188 bp    mRNA    linear   ROD 31-MAR-2024
DEFINITION  Rattus norvegicus ficolin B (Fcnb), mRNA.
ACCESSION   NM_053634
VERSION     NM_053634.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1188)
  AUTHORS   Verma,A., White,M., Vathipadiekal,V., Tripathi,S., Mbianda,J.,
            Ieong,M., Qi,L., Taubenberger,J.K., Takahashi,K., Jensenius,J.C.,
            Thiel,S. and Hartshorn,K.L.
  TITLE     Human H-ficolin inhibits replication of seasonal and pandemic
            influenza A viruses
  JOURNAL   J Immunol 189 (5), 2478-2487 (2012)
   PUBMED   22851708
REFERENCE   2  (bases 1 to 1188)
  AUTHORS   Girija,U.V., Mitchell,D.A., Roscher,S. and Wallis,R.
  TITLE     Carbohydrate recognition and complement activation by rat ficolin-B
  JOURNAL   Eur J Immunol 41 (1), 214-223 (2011)
   PUBMED   21182092
  REMARK    GeneRIF: Rat ficolin-B activated MASP-2 comparable to ficolin-A.
REFERENCE   3  (bases 1 to 1188)
  AUTHORS   Zhang,J., Yang,L., Ang,Z., Yoong,S.L., Tran,T.T., Anand,G.S.,
            Tan,N.S., Ho,B. and Ding,J.L.
  TITLE     Secreted M-ficolin anchors onto monocyte transmembrane G
            protein-coupled receptor 43 and cross talks with plasma C-reactive
            protein to mediate immune signaling and regulate host defense
  JOURNAL   J Immunol 185 (11), 6899-6910 (2010)
   PUBMED   21037097
REFERENCE   4  (bases 1 to 1188)
  AUTHORS   Honore,C., Rorvig,S., Hummelshoj,T., Skjoedt,M.O., Borregaard,N.
            and Garred,P.
  TITLE     Tethering of Ficolin-1 to cell surfaces through recognition of
            sialic acid by the fibrinogen-like domain
  JOURNAL   J Leukoc Biol 88 (1), 145-158 (2010)
   PUBMED   20400674
REFERENCE   5  (bases 1 to 1188)
  AUTHORS   Endo,Y., Nakazawa,N., Liu,Y., Iwaki,D., Takahashi,M., Fujita,T.,
            Nakata,M. and Matsushita,M.
  TITLE     Carbohydrate-binding specificities of mouse ficolin A, a splicing
            variant of ficolin A and ficolin B and their complex formation with
            MASP-2 and sMAP
  JOURNAL   Immunogenetics 57 (11), 837-844 (2005)
   PUBMED   16328467
REFERENCE   6  (bases 1 to 1188)
  AUTHORS   Kuraya,M., Ming,Z., Liu,X., Matsushita,M. and Fujita,T.
  TITLE     Specific binding of L-ficolin and H-ficolin to apoptotic cells
            leads to complement activation
  JOURNAL   Immunobiology 209 (9), 689-697 (2005)
   PUBMED   15804047
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000003.1.
            
            On Apr 13, 2023 this sequence version replaced NM_053634.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: FQ220557.1, FQ233041.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN06680430,
                                           SAMN09767679 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-111               JAXUCZ010000003.1  31800078-31800188   c
            112-225             JAXUCZ010000003.1  31798200-31798313   c
            226-279             JAXUCZ010000003.1  31796119-31796172   c
            280-315             JAXUCZ010000003.1  31795810-31795845   c
            316-348             JAXUCZ010000003.1  31795179-31795211   c
            349-476             JAXUCZ010000003.1  31794899-31795026   c
            477-606             JAXUCZ010000003.1  31794384-31794513   c
            607-741             JAXUCZ010000003.1  31793489-31793623   c
            742-1188            JAXUCZ010000003.1  31791750-31792196   c
FEATURES             Location/Qualifiers
     source          1..1188
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="3"
                     /map="3p12"
     gene            1..1188
                     /gene="Fcnb"
                     /gene_synonym="Fcn2"
                     /note="ficolin B"
                     /db_xref="GeneID:114091"
                     /db_xref="RGD:621222"
     exon            1..111
                     /gene="Fcnb"
                     /gene_synonym="Fcn2"
                     /inference="alignment:Splign:2.1.0"
     CDS             30..989
                     /gene="Fcnb"
                     /gene_synonym="Fcn2"
                     /note="ficolin-2; L-ficolin; ficolin-beta;
                     collagen/fibrinogen domain-containing protein 2"
                     /codon_start=1
                     /product="ficolin-2 precursor"
                     /protein_id="NP_446086.1"
                     /db_xref="GeneID:114091"
                     /db_xref="RGD:621222"
                     /translation="MVLGSAALFVLSLCVTELTLHAADTCPEVKVLDLEGSNKLTILQ
                     GCPGLPGALGPKGEAGAKGDRGESGLPGHPGKAGPTGPKGDRGEKGVRGEKGDTGPSQ
                     SCATGPRTCKELLTRGYFLTGWYTIYLPDCRPLTVLCDMDTDGGGWTVFQRRIDGTVD
                     FFRDWTSYKQGFGSQLGEFWLGNDNIHALTTQGTNELRVDLADFDGNHDFAKYSSFQI
                     QGEAEKYKLILGNFLGGGAGDSLTSQNNMLFSTKDQDNDQGSSNCAVRYHGAWWYSDC
                     HTSNLNGLYLRGLHKSYANGVNWKSWKGYNYSYKVSEMKVRLI"
     exon            112..225
                     /gene="Fcnb"
                     /gene_synonym="Fcn2"
                     /inference="alignment:Splign:2.1.0"
     exon            226..279
                     /gene="Fcnb"
                     /gene_synonym="Fcn2"
                     /inference="alignment:Splign:2.1.0"
     exon            280..315
                     /gene="Fcnb"
                     /gene_synonym="Fcn2"
                     /inference="alignment:Splign:2.1.0"
     exon            316..348
                     /gene="Fcnb"
                     /gene_synonym="Fcn2"
                     /inference="alignment:Splign:2.1.0"
     exon            349..476
                     /gene="Fcnb"
                     /gene_synonym="Fcn2"
                     /inference="alignment:Splign:2.1.0"
     exon            477..606
                     /gene="Fcnb"
                     /gene_synonym="Fcn2"
                     /inference="alignment:Splign:2.1.0"
     exon            607..741
                     /gene="Fcnb"
                     /gene_synonym="Fcn2"
                     /inference="alignment:Splign:2.1.0"
     exon            742..1188
                     /gene="Fcnb"
                     /gene_synonym="Fcn2"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 attgaggggc tgcgagctga gcagttgcca tggtcctggg atctgctgca ctattcgtct
       61 tgagcctgtg tgtcactgag ctgaccctcc atgctgctga cacctgccca gaggtgaagg
      121 tcctggatct ggagggctcc aacaaactca ccatccttca aggctgccct ggcttgcctg
      181 gagccctggg gcccaaggga gaggctggtg ccaaaggaga tagaggagag agtggccttc
      241 ctggacaccc tggaaaggcg gggccaactg gacccaaagg agaccgagga gagaagggag
      301 tgcgtggaga aaaaggagac accgggccct cccagtcatg tgctacagga cctcggacct
      361 gcaaggagtt gctcacccgg ggctactttc tcactggctg gtataccatc tacctgccag
      421 actgcaggcc cctgaccgtg ctgtgtgata tggacacaga tggtggaggc tggaccgtct
      481 ttcagagaag gatcgacggc acggtggact tctttcggga ctggacctca tacaaacaag
      541 gcttcggcag ccagctgggg gagttctggc tggggaacga taacatccat gctttaacca
      601 cccagggaac caatgagctg cgggtggatc ttgcagactt cgacggcaac catgactttg
      661 ccaagtacag ctccttccag atccagggag aggccgagaa atacaagctc attctgggga
      721 acttcctcgg tggtggtgct ggtgactccc tgacttccca aaacaacatg cttttctcca
      781 ccaaagacca agacaacgac cagggatcct ccaactgtgc cgtgcgttac catggagcct
      841 ggtggtactc tgattgtcac acttccaacc tgaatggcct ctaccttagg ggtctccata
      901 agagctatgc aaacggtgtc aattggaagt catggaaagg gtacaactac agctacaagg
      961 tttctgaaat gaaggtgcgc ctcatctagc tccccacaaa gagagtgccc ctcccaaact
     1021 ctagcatacc agcaacagga gtcttctatc tttcttcagc caaggaagga gtgtgccacc
     1081 ccgcccggct ctgctcattg cccacattcc acacagccca tgacctctga cctggctctc
     1141 ttcacatacc tatattctca ccacaaagaa aaaattgaat ttacaaaa
//
