LOCUS       NM_031348               1291 bp    mRNA    linear   ROD 30-JUL-2024
DEFINITION  Rattus norvegicus ficolin A (Fcna), mRNA.
ACCESSION   NM_031348
VERSION     NM_031348.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1291)
  AUTHORS   Schelenz,S., Kirchhof,N., Bidula,S., Wallis,R. and Sexton,D.W.
  TITLE     Opsonizing properties of rat ficolin-A in the defence against
            Cryptococcus neoformans
  JOURNAL   Immunobiology 218 (4), 477-483 (2013)
   PUBMED   22789560
  REMARK    GeneRIF: ficolin-A binds acapsular C. neoformans via their
            carbohydrate recognizing fibrinogen-like domains leading to
            enhanced uptake by lung epithelial cells in vitro.
REFERENCE   2  (bases 1 to 1291)
  AUTHORS   Verma,A., White,M., Vathipadiekal,V., Tripathi,S., Mbianda,J.,
            Ieong,M., Qi,L., Taubenberger,J.K., Takahashi,K., Jensenius,J.C.,
            Thiel,S. and Hartshorn,K.L.
  TITLE     Human H-ficolin inhibits replication of seasonal and pandemic
            influenza A viruses
  JOURNAL   J Immunol 189 (5), 2478-2487 (2012)
   PUBMED   22851708
REFERENCE   3  (bases 1 to 1291)
  AUTHORS   Bastos-Amador,P., Royo,F., Gonzalez,E., Conde-Vancells,J.,
            Palomo-Diez,L., Borras,F.E. and Falcon-Perez,J.M.
  TITLE     Proteomic analysis of microvesicles from plasma of healthy donors
            reveals high individual variability
  JOURNAL   J Proteomics 75 (12), 3574-3584 (2012)
   PUBMED   22516433
REFERENCE   4  (bases 1 to 1291)
  AUTHORS   Girija,U.V., Dodds,A.W., Roscher,S., Reid,K.B. and Wallis,R.
  TITLE     Localization and characterization of the mannose-binding lectin
            (MBL)-associated-serine protease-2 binding site in rat ficolin-A:
            equivalent binding sites within the collagenous domains of MBLs and
            ficolins
  JOURNAL   J Immunol 179 (1), 455-462 (2007)
   PUBMED   17579066
  REMARK    GeneRIF: The mannose-binding lectin (MBL)-associated-serine
            protease (MASP)-2 binding site on rat ficolin-A is located within
            the collagen-like domain and encompasses a conserved motif that is
            present in both MBLs and ficolins.
REFERENCE   5  (bases 1 to 1291)
  AUTHORS   Endo,Y., Nakazawa,N., Liu,Y., Iwaki,D., Takahashi,M., Fujita,T.,
            Nakata,M. and Matsushita,M.
  TITLE     Carbohydrate-binding specificities of mouse ficolin A, a splicing
            variant of ficolin A and ficolin B and their complex formation with
            MASP-2 and sMAP
  JOURNAL   Immunogenetics 57 (11), 837-844 (2005)
   PUBMED   16328467
REFERENCE   6  (bases 1 to 1291)
  AUTHORS   Kuraya,M., Ming,Z., Liu,X., Matsushita,M. and Fujita,T.
  TITLE     Specific binding of L-ficolin and H-ficolin to apoptotic cells
            leads to complement activation
  JOURNAL   Immunobiology 209 (9), 689-697 (2005)
   PUBMED   15804047
REFERENCE   7  (bases 1 to 1291)
  AUTHORS   Matsushita,M., Kuraya,M., Hamasaki,N., Tsujimura,M., Shiraki,H. and
            Fujita,T.
  TITLE     Activation of the lectin complement pathway by H-ficolin (Hakata
            antigen)
  JOURNAL   J Immunol 168 (7), 3502-3506 (2002)
   PUBMED   11907111
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC088128.1.
            
            On Jan 2, 2005 this sequence version replaced NM_031348.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC088128.1, AB026057.2 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760494, SAMN06680417
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1291
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="3"
                     /map="3p13"
     gene            1..1291
                     /gene="Fcna"
                     /gene_synonym="Fcn1"
                     /note="ficolin A"
                     /db_xref="GeneID:83517"
                     /db_xref="RGD:621221"
     exon            1..181
                     /gene="Fcna"
                     /gene_synonym="Fcn1"
                     /inference="alignment:Splign:2.1.0"
     CDS             94..1101
                     /gene="Fcna"
                     /gene_synonym="Fcn1"
                     /note="ficolin-1; M-ficolin; ficolin-alpha;
                     collagen/fibrinogen domain-containing protein 1; ficolin
                     (collagen/fibrinogen domain containing) 1"
                     /codon_start=1
                     /product="ficolin-1 precursor"
                     /protein_id="NP_112638.2"
                     /db_xref="GeneID:83517"
                     /db_xref="RGD:621221"
                     /translation="MWWPMLWAFPVLLCLCSSQALGQESGACPDVKIVGLGAQDKVAV
                     IQSCPSFPGPPGPKGEPGSPAGRGERGLQGSPGKMGPAGSKGEPGTMGPPGVKGEKGE
                     RGTASPLGQKELGDALCRRGPRSCKDLLTRGIFLTGWYTIYLPDCRPLTVLCDMDVDG
                     GGWTVFQRRVDGSINFYRDWDSYKRGFGNLGTEFWLGNDYLHLLTANGNQELRVDLRE
                     FQGQTSFAKYSSFQVSGEQEKYKLTLGQFLEGTAGDSLTKHNNMAFSTHDQDNDTNGG
                     KNCAALFHGAWWYHDCHQSNLNGRYLPGSHESYADGINWLSGRGHRYSYKVAEMKIRA
                     S"
     exon            182..295
                     /gene="Fcna"
                     /gene_synonym="Fcn1"
                     /inference="alignment:Splign:2.1.0"
     exon            296..349
                     /gene="Fcna"
                     /gene_synonym="Fcn1"
                     /inference="alignment:Splign:2.1.0"
     exon            350..385
                     /gene="Fcna"
                     /gene_synonym="Fcn1"
                     /inference="alignment:Splign:2.1.0"
     exon            386..421
                     /gene="Fcna"
                     /gene_synonym="Fcn1"
                     /inference="alignment:Splign:2.1.0"
     exon            422..457
                     /gene="Fcna"
                     /gene_synonym="Fcn1"
                     /inference="alignment:Splign:2.1.0"
     exon            458..585
                     /gene="Fcna"
                     /gene_synonym="Fcn1"
                     /inference="alignment:Splign:2.1.0"
     exon            586..715
                     /gene="Fcna"
                     /gene_synonym="Fcn1"
                     /inference="alignment:Splign:2.1.0"
     exon            716..850
                     /gene="Fcna"
                     /gene_synonym="Fcn1"
                     /inference="alignment:Splign:2.1.0"
     exon            851..1260
                     /gene="Fcna"
                     /gene_synonym="Fcn1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gtccaggcag cgagggtctt tgcttcatac atcattcacc agcctctcag cccagagcca
       61 gggcgccaag gagtgaccgc tgtgtccaga gcaatgtggt ggcctatgct gtgggccttt
      121 ccagtactgc tctgtctctg ttcctcccag gccctgggtc aggagagtgg tgcctgtcca
      181 gatgttaaga tcgtaggtct gggggcccag gacaaggtgg ctgtcatcca aagttgccct
      241 agctttcctg gcccacctgg acccaaaggg gagcctggaa gtcctgctgg gagaggggaa
      301 cggggcttac agggcagccc agggaagatg ggacccgccg gcagcaaagg agagccagga
      361 accatggggc ccccaggagt caaaggggag aaaggagaga gaggaactgc atcaccactg
      421 ggtcagaagg agctgggaga cgcactgtgc cggagagggc cccggagctg caaagacttg
      481 ctgacacggg ggatcttcct gactggctgg tacaccatct atcttcctga ctgccggcca
      541 ctgactgtgc tctgtgacat ggatgtggat ggtgggggct ggaccgtttt tcaacgacga
      601 gtggatgggt ccatcaactt ctaccgagac tgggattcct ataaaagagg ctttggcaac
      661 ctgggcacag agttctggtt gggtaatgac taccttcacc tgctcacagc caatgggaac
      721 caagagctcc gggttgactt aagagagttc caaggtcaaa cctcctttgc caaatacagc
      781 tcattccagg tatctggaga acaggagaaa tacaagctga ccttggggca gtttctggag
      841 ggcactgcag gagactccct gacaaagcac aacaacatgg cattctcaac tcatgaccaa
      901 gataatgata cgaatggcgg gaagaactgt gcagctttgt tccacggagc ctggtggtac
      961 cacgactgtc accagtccaa cctcaacggg cgctacttgc ctggctccca tgaaagttat
     1021 gcggatggca tcaactggct aagtggccga ggccaccgct actcctacaa ggttgctgag
     1081 atgaaaatcc gggcatcata aggtgcccca gcctccaccc acccctgcag ccatgcccag
     1141 gccatgtggg gacactgaag gaaggggtca cgagaagatg gggtctgtgg ctgtatgtcg
     1201 tgtgctctgg acactgtcca gcactgacca gtatgcacta ataaaggtca gagaagcaga
     1261 aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa a
//
