LOCUS       NP_001014843             426 aa            linear   ROD 04-AUG-2024
DEFINITION  immunoglobulin mu Fc receptor precursor [Rattus norvegicus].
ACCESSION   NP_001014843
VERSION     NP_001014843.1
DBSOURCE    REFSEQ: accession NM_001014843.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (residues 1 to 426)
  AUTHORS   Song,Y. and Jacob,C.O.
  TITLE     The mouse cell surface protein TOSO regulates Fas/Fas
            ligand-induced apoptosis through its binding to Fas-associated
            death domain
  JOURNAL   J Biol Chem 280 (10), 9618-9626 (2005)
   PUBMED   15632112
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BC088197.1 and JAXUCZ010000013.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC088197.1, SRR26643284.16114.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760386, SAMEA5760393
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            CDS uses downstream in-frame AUG :: downstream AUG is associated
                                                with N-terminal localization
                                                signal
            RefSeq Select criteria           :: based on conservation,
                                                expression, longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..426
                     /organism="Rattus norvegicus"
                     /db_xref="taxon:10116"
                     /chromosome="13"
                     /map="13q13"
     Protein         1..426
                     /product="immunoglobulin mu Fc receptor precursor"
                     /note="regulator of Fas-induced apoptosis Toso; Fas
                     apoptotic inhibitory molecule 3; IgM Fc fragment receptor;
                     Fc fragment of IgM receptor; immunoglobulin mu Fc
                     receptor"
                     /calculated_mol_wt=46120
     sig_peptide     1..16
                     /note="/evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (Q5M871.1)"
                     /calculated_mol_wt=1953
     mat_peptide     17..426
                     /product="Immunoglobulin mu Fc receptor.
                     /id=PRO_0000284423"
                     /note="propagated from UniProtKB/Swiss-Prot (Q5M871.1)"
                     /calculated_mol_wt=46120
     Region          18..120
                     /region_name="IgV_pIgR_like"
                     /note="Immunoglobulin (Ig)-like domain in the polymeric Ig
                     receptor (pIgR) and similar proteins; cd05716"
                     /db_xref="CDD:409381"
     Region          18..37
                     /region_name="FR1"
                     /note="FR1 [structural motif]"
                     /db_xref="CDD:409381"
     Region          18..20
                     /region_name="Ig strand A"
                     /note="Ig strand A [structural motif]"
                     /db_xref="CDD:409381"
     Region          23..29
                     /region_name="Ig strand A'"
                     /note="Ig strand A' [structural motif]"
                     /db_xref="CDD:409381"
     Region          31..38
                     /region_name="Ig strand B"
                     /note="Ig strand B [structural motif]"
                     /db_xref="CDD:409381"
     Region          38..44
                     /region_name="CDR1"
                     /note="CDR1 [structural motif]"
                     /db_xref="CDD:409381"
     Region          44..49
                     /region_name="Ig strand C"
                     /note="Ig strand C [structural motif]"
                     /db_xref="CDD:409381"
     Site            44..46
                     /site_type="other"
                     /note="CDR1-dIgA binding residues [polypeptide binding]"
                     /db_xref="CDD:409381"
     Region          45..49
                     /region_name="FR2"
                     /note="FR2 [structural motif]"
                     /db_xref="CDD:409381"
     Region          50..69
                     /region_name="CDR2"
                     /note="CDR2 [structural motif]"
                     /db_xref="CDD:409381"
     Region          59..63
                     /region_name="Ig strand C'"
                     /note="Ig strand C' [structural motif]"
                     /db_xref="CDD:409381"
     Region          67..69
                     /region_name="Ig strand C'"
                     /note="Ig strand C' [structural motif]"
                     /db_xref="CDD:409381"
     Region          74..105
                     /region_name="FR3"
                     /note="FR3 [structural motif]"
                     /db_xref="CDD:409381"
     Region          74..80
                     /region_name="Ig strand D"
                     /note="Ig strand D [structural motif]"
                     /db_xref="CDD:409381"
     Region          84..92
                     /region_name="Ig strand E"
                     /note="Ig strand E [structural motif]"
                     /db_xref="CDD:409381"
     Site            91
                     /site_type="phosphorylation"
                     /note="Phosphothreonine.
                     /evidence=ECO:0007744|PubMed:16641100; propagated from
                     UniProtKB/Swiss-Prot (Q5M871.1)"
     Region          98..105
                     /region_name="Ig strand F"
                     /note="Ig strand F [structural motif]"
                     /db_xref="CDD:409381"
     Region          106..114
                     /region_name="CDR3"
                     /note="CDR3 [structural motif]"
                     /db_xref="CDD:409381"
     Region          114..120
                     /region_name="FR4"
                     /note="FR4 [structural motif]"
                     /db_xref="CDD:409381"
     Region          114..120
                     /region_name="Ig strand G"
                     /note="Ig strand G [structural motif]"
                     /db_xref="CDD:409381"
     Region          178..212
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q5M871.1)"
     Site            267..287
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (Q5M871.1)"
     Site            268
                     /site_type="other"
                     /note="Receptor capping.
                     /evidence=ECO:0000250|UniProtKB:O60667; propagated from
                     UniProtKB/Swiss-Prot (Q5M871.1)"
     Region          306..346
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q5M871.1)"
     Site            386
                     /site_type="other"
                     /note="Receptor-mediated endocytosis.
                     /evidence=ECO:0000250|UniProtKB:O60667; propagated from
                     UniProtKB/Swiss-Prot (Q5M871.1)"
     Region          401..426
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q5M871.1)"
     Site            405
                     /site_type="other"
                     /note="Receptor-mediated endocytosis.
                     /evidence=ECO:0000250|UniProtKB:O60667; propagated from
                     UniProtKB/Swiss-Prot (Q5M871.1)"
     CDS             1..426
                     /gene="Fcmr"
                     /gene_synonym="Faim3; FAIM3g; IgM FcR; Toso"
                     /coded_by="NM_001014843.2:96..1376"
                     /db_xref="GeneID:548326"
                     /db_xref="RGD:1359282"
ORIGIN      
        1 mnlwlwllyf lpvsgtlkvl pevrlevelg gsvfiecplp qthvrmylcr qmtnpaicat
       61 vvsnifvkke ykrrvtlkps lnkklflvem tqltkddegi yacgvgtntd lgktqkvtln
      121 vrnefpeype pfwddeptse psprwwlhry peelpwlkmg ehaspsgfid kvttlspkte
      181 appvhqpstn tsvsrhprvy gassetptkp sallpattaf ktsarqasrl leasyshhtr
      241 lhgertphyg sqygredrgl hisipefhil iptflgflll vllglvvkra iqrrrafsrr
      301 vgrmarrmrg rgpsrqiptq rrdapqrprs qnnvysacpr rarepdnvgs aealllnapa
      361 sappalplvi etswphtpsl kmsceyvslg hqpavnvedq dsndyinipg lphlpskppg
      421 prpsrq
//
