LOCUS       NM_001395742            4543 bp    mRNA    linear   ROD 29-MAR-2024
DEFINITION  Rattus norvegicus FCH and double SH3 domains 2 (Fchsd2), mRNA.
ACCESSION   NM_001395742 XM_017589186
VERSION     NM_001395742.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 4543)
  AUTHORS   Almeida-Souza,L., Frank,R.A.W., Garcia-Nafria,J., Colussi,A.,
            Gunawardana,N., Johnson,C.M., Yu,M., Howard,G., Andrews,B.,
            Vallis,Y. and McMahon,H.T.
  TITLE     A Flat BAR Protein Promotes Actin Polymerization at the Base of
            Clathrin-Coated Pits
  JOURNAL   Cell 174 (2), 325-337 (2018)
   PUBMED   29887380
REFERENCE   2  (bases 1 to 4543)
  AUTHORS   Becalska,A.N., Kelley,C.F., Berciu,C., Stanishneva-Konovalova,T.B.,
            Fu,X., Wang,S., Sokolova,O.S., Nicastro,D. and Rodal,A.A.
  TITLE     Formation of membrane ridges and scallops by the F-BAR protein
            Nervous Wreck
  JOURNAL   Mol Biol Cell 24 (15), 2406-2418 (2013)
   PUBMED   23761074
REFERENCE   3  (bases 1 to 4543)
  AUTHORS   Cao,H., Yin,X., Cao,Y., Jin,Y., Wang,S., Kong,Y., Chen,Y., Gao,J.,
            Heller,S. and Xu,Z.
  TITLE     FCHSD1 and FCHSD2 are expressed in hair cell stereocilia and
            cuticular plate and regulate actin polymerization in vitro
  JOURNAL   PLoS One 8 (2), e56516 (2013)
   PUBMED   23437151
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000001.1.
            
            On Aug 4, 2021 this sequence version replaced XM_017589186.2.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643287.1719.1,
                                           SRR26643292.3000.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760389
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-476               JAXUCZ010000001.1  164870840-164871315
            477-574             JAXUCZ010000001.1  164872977-164873074
            575-620             JAXUCZ010000001.1  164904428-164904473
            621-697             JAXUCZ010000001.1  164959109-164959185
            698-842             JAXUCZ010000001.1  164975262-164975406
            843-976             JAXUCZ010000001.1  164980391-164980524
            977-1031            JAXUCZ010000001.1  164984937-164984991
            1032-1160           JAXUCZ010000001.1  164986607-164986735
            1161-1283           JAXUCZ010000001.1  165036642-165036764
            1284-1379           JAXUCZ010000001.1  165044145-165044240
            1380-1496           JAXUCZ010000001.1  165052839-165052955
            1497-1601           JAXUCZ010000001.1  165055090-165055194
            1602-1763           JAXUCZ010000001.1  165069932-165070093
            1764-1898           JAXUCZ010000001.1  165080327-165080461
            1899-1982           JAXUCZ010000001.1  165085493-165085576
            1983-2160           JAXUCZ010000001.1  165085699-165085876
            2161-2381           JAXUCZ010000001.1  165086284-165086504
            2382-2511           JAXUCZ010000001.1  165087270-165087399
            2512-2594           JAXUCZ010000001.1  165087490-165087572
            2595-4543           JAXUCZ010000001.1  165095443-165097391
FEATURES             Location/Qualifiers
     source          1..4543
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q32"
     gene            1..4543
                     /gene="Fchsd2"
                     /note="FCH and double SH3 domains 2"
                     /db_xref="GeneID:308864"
                     /db_xref="RGD:1304812"
     exon            1..476
                     /gene="Fchsd2"
                     /inference="alignment:Splign:2.1.0"
     CDS             456..2678
                     /gene="Fchsd2"
                     /note="FCH and double SH3 domains protein 2"
                     /codon_start=1
                     /product="F-BAR and double SH3 domains protein 2"
                     /protein_id="NP_001382671.1"
                     /db_xref="GeneID:308864"
                     /db_xref="RGD:1304812"
                     /translation="MQPPPRKVKVTQELRNIQGEQMTKLQAKHQAECDLLEDMRTFSQ
                     KKAAIEREYAQGIQKLASQYLKRDWPGIKTDDRNDYRSMYPVWKSFLEATMQVAQSRI
                     NICENYKNFISEPARAVRSLKEQQLKRCVDQLTKIQTELQETVKDLVKGKKKYFETEQ
                     MAHAVREKADIEAKSKLSLFQSRISLQKASVKLKARRTECNTKATHARNDYLLTLAAA
                     NAHQDRYYQTDLLNIMKALDGNVYDHLKDYLIAFSRTELEACQAMQNTFQFLLENSSK
                     VVRDYNLQLFLQENAVFHKPQPFQFQPCDSDTSRQLESETGTTEEHSLNKEARKWATR
                     VAREHKNIVHQQRVLNELECHGVAVSEQSRAELEQKIDEARENIRKAEIIKLKAEARL
                     DLLKQIGVSVDTWLKSAMNQVMEELENERWARPPAVTSNGTLHSLNADAEREEGEEFE
                     DNMDVFDDSSSSPSGTLRNYPLTCKVVYSYKASQPDELTIEEHEVLEVIEDGDMEDWV
                     KARNKVGQVGYVPEKYLQFPTSNSLLSMLQSLAALDSRSHTSSNSTEAELVSGSLNGD
                     ASVCFVKALYDYEGQTDDELSFPEGAIIRIVNKENQDDDGFWEGEFSGRIGVFPSVLV
                     EELSASENGDTPWTRDIQVSPSPKPHTSLPPLPLYDQPPSSPYPSPDKRSSQFFPRSP
                     SANENCLHAESPGFSQASRQTPDTSYGKLRPVRAAPPPPTQTHRRTAEKMEDVEITLV
                     "
     exon            477..574
                     /gene="Fchsd2"
                     /inference="alignment:Splign:2.1.0"
     exon            575..620
                     /gene="Fchsd2"
                     /inference="alignment:Splign:2.1.0"
     exon            621..697
                     /gene="Fchsd2"
                     /inference="alignment:Splign:2.1.0"
     exon            698..842
                     /gene="Fchsd2"
                     /inference="alignment:Splign:2.1.0"
     exon            843..976
                     /gene="Fchsd2"
                     /inference="alignment:Splign:2.1.0"
     exon            977..1031
                     /gene="Fchsd2"
                     /inference="alignment:Splign:2.1.0"
     exon            1032..1160
                     /gene="Fchsd2"
                     /inference="alignment:Splign:2.1.0"
     exon            1161..1283
                     /gene="Fchsd2"
                     /inference="alignment:Splign:2.1.0"
     exon            1284..1379
                     /gene="Fchsd2"
                     /inference="alignment:Splign:2.1.0"
     exon            1380..1496
                     /gene="Fchsd2"
                     /inference="alignment:Splign:2.1.0"
     exon            1497..1601
                     /gene="Fchsd2"
                     /inference="alignment:Splign:2.1.0"
     exon            1602..1763
                     /gene="Fchsd2"
                     /inference="alignment:Splign:2.1.0"
     exon            1764..1898
                     /gene="Fchsd2"
                     /inference="alignment:Splign:2.1.0"
     exon            1899..1982
                     /gene="Fchsd2"
                     /inference="alignment:Splign:2.1.0"
     exon            1983..2160
                     /gene="Fchsd2"
                     /inference="alignment:Splign:2.1.0"
     exon            2161..2381
                     /gene="Fchsd2"
                     /inference="alignment:Splign:2.1.0"
     exon            2382..2511
                     /gene="Fchsd2"
                     /inference="alignment:Splign:2.1.0"
     exon            2512..2594
                     /gene="Fchsd2"
                     /inference="alignment:Splign:2.1.0"
     exon            2595..4543
                     /gene="Fchsd2"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ccgggctgcc agagtgggtg gggggccgcc gcgtcagcca gctgcagccg ggccgcggca
       61 ggcggcgagc gcggacgacg cggccgctcc tcctcagccg ccgggcaagc ggcgagcccc
      121 ccagcgcccc tgctcgcggc ccccgccccc tggccgtctc cgcctccttt cctcacacac
      181 cccccgggcc gcccgggccc caggccttcc ccgcgctcct ccttctctcc acactcgctg
      241 ctgcgacccg ggtgctcctg ccgctcgcct gcctcgcagc ctctgggccg attgattcct
      301 cttccttctc cttctcaggc tctcctttca cacacgcaca cgcgcgcgcc ctgcagcttg
      361 ctgggccgcc cccttttctc caaccctcct caccctcaca gtcttttaaa cgccgccgtc
      421 gggggtgggc ggaggattga tgtcccttca gcatcatgca gccgccgccg aggaaggtga
      481 aagttacaca agaactgaga aacattcaag gtgagcagat gacaaaactt caagccaaac
      541 atcaagcaga atgcgattta cttgaagata tgaggacttt cagtcagaag aaggctgcta
      601 ttgaaagaga atatgcacag ggtatccaga agttggctag tcaatacctg aaaagagatt
      661 ggcctggaat aaaaactgat gatcggaatg attacaggag tatgtatcct gtttggaaat
      721 cttttctcga ggcaacaatg caggtagccc agtctcggat caatatatgt gaaaactata
      781 aaaacttcat ttctgaacct gcaagagcag taagaagctt aaaagaacaa caactaaagc
      841 ggtgtgtgga tcagttgaca aagatccaaa cagaattaca agaaactgtg aaagatttag
      901 tgaaaggcaa aaagaagtac tttgagactg aacagatggc tcatgcagta agagagaaag
      961 ctgacatcga agcaaagtct aaacttagtc tttttcaatc aagaatcagt ttacagaaag
     1021 caagtgtgaa gttaaaagcc cggcgaactg aatgtaatac caaagctacc cacgcaagga
     1081 atgattacct tcttacgcta gccgcagcaa atgcacatca ggaccgctac tatcaaacag
     1141 acttacttaa catcatgaag gctcttgatg gaaatgtata tgaccatctc aaggattact
     1201 taatagcctt cagccggacc gagctagaag cttgccaggc tatgcagaat acattccagt
     1261 ttttactaga aaactccagc aaggtggtac gggactataa ccttcagctg tttctacaag
     1321 agaatgctgt atttcacaag cctcagccct tccagttcca gccttgtgac agtgatacta
     1381 gtcgacaatt agaatcagaa actggtacca cagaagaaca cagtctaaat aaggaggctc
     1441 gaaaatgggc cactcgtgtg gcacgtgagc acaaaaatat tgttcatcag cagcgggttc
     1501 taaatgaact agaatgccat ggagttgctg tatcagaaca gagccgagca gagctggaac
     1561 agaaaataga tgaagctaga gaaaatatcc gtaaagctga gatcattaaa ttgaaagctg
     1621 aggctcggct agacctactg aagcagattg gggtttctgt agatacgtgg ttaaagagtg
     1681 ccatgaacca ggtgatggag gaactggaaa atgagcggtg ggcccgccct ccggccgtga
     1741 ccagcaacgg cactctacac tcgcttaatg cagatgctga aagagaagaa ggagaagagt
     1801 ttgaagacaa catggatgtt tttgatgaca gcagctccag cccttctggc accttaagaa
     1861 attatccact cacctgcaaa gttgtttatt cctataaggc ttctcaacca gatgagttga
     1921 ccattgagga acatgaggtg ttagaagtga ttgaagatgg agatatggaa gactgggtaa
     1981 aggctcgaaa taaagttggc caagtgggtt atgtgccaga aaaataccta cagtttccca
     2041 cctcaaacag cctactgagc atgctacagt ctctggctgc tttggacagt cggtcacaca
     2101 cgtccagcaa ttccacagaa gcagaacttg tttcaggcag cctgaatgga gatgctagtg
     2161 tctgttttgt gaaagcactt tatgattatg agggccagac agatgatgag ttgtcctttc
     2221 ccgagggagc aattatccgc attgtgaaca aagagaacca agatgatgat ggcttctggg
     2281 aaggggaatt cagtggccga attggtgttt tcccatcggt gctagtggaa gagctctcag
     2341 cctctgagaa tggcgacact ccatggacaa gagatattca ggtctctcca tcccccaagc
     2401 ctcacacatc cctgcctcca ctgcctctgt atgaccagcc tcccagcagc ccttacccca
     2461 gtccagataa gaggagctcc cagttcttcc cccggtctcc ttcagccaat gaaaactgcc
     2521 ttcatgctga gtcaccagga ttctcacagg cctcaagaca gactcctgac acctcgtatg
     2581 gcaagctgcg gcctgttcgg gcggcacccc caccacccac acagacccac cgacggacag
     2641 ctgagaagat ggaggatgtg gagatcacac tggtgtgacc atggatttac ctccgttcct
     2701 gctacaatca aggccaggct tggggtttgg ccagtctctt tcttaggcac ctttgcatga
     2761 tgatgactct tgaacagagc aaaaccaagg aggattcgat gtgactggtt ggcctgattg
     2821 tgcctttttt gttgtcattt tctatgtcat ctctcctacc atagcacaat tcatagcggg
     2881 tcctagaagc agaggggagc agctctcatg ccttatggtg gcccattttt atatgagact
     2941 caaggccagg cctagatcca gggcacagac ccagaattac caattgtgtg aactcgtaca
     3001 gtatattact gtggccacga ggctgtggca aagatctcat ctttcctcaa gtggattttg
     3061 ctcttctgat tattattcaa atcatgttga ctgtgtaagg aaatgaggga tccaggagag
     3121 gctggctcct ccccaggttc attcccatac tgaaaatgca actttattgg gaagaaggtg
     3181 gactgtctga gcttagcgcc aattgcatta atgcacatct cttccacaac taacagattt
     3241 aaaataacag tgtcctttgt attaatattt acgccattca tttagtatta gtgggctgac
     3301 ctggaggggc tgaggccaca tctttcccat cacatagact agaagggagg ctggggaaga
     3361 cgcagagatg cagcttccac gtcggaaatg agccacttta atgctctttt tacctttggg
     3421 tattttcctc ttggttttta cagtgtatat ccttctgacc agtgtccttt gaatccaagt
     3481 gtccggctgc attgaggaca aaggcctata tcgctcagct tctctactgg ggaggccctt
     3541 attttattcc caagccagag tactggccta gacatctggg ttgattggtg cagacttgtt
     3601 gtcgccttct gaaagcacag cttcaggtcc cactaccctg acatttgtct gggggtgaag
     3661 aatctgtagg ccctggaggg aacctgcttt ctgtggaaag gataaaggac tgcacacctg
     3721 cccaggtgag accaaggagg ccagcacctc ctgcaggtca tggaagaggt tcatggtgct
     3781 ccccttggct cagcctagaa gggccgagca ctctggactg tagatcttga cctagggaac
     3841 aaagcaatgc ttgccaattt gtcttttacc ttgactggga aaagaaaatc agatttaaag
     3901 gttttatgat gctttgaatt ttccatccct cctgagaatc tctaaaaact tgaaatggtc
     3961 atatgtcccc atgggatttt gactgatatc agagctgaag ggattttcag tcattcaata
     4021 actttagcaa tgatactctg atgaatcttc tccatgaatt tggatttttg gtttttgcat
     4081 ttatctgttg atctatttga ggtcttttta tgtttatcaa acttattctt aagtttaaaa
     4141 aattgaaagg gtattttaag attttcaaat ttgctgatct tcaaagtgct gataatagag
     4201 cagttcctgc cacccatatt ctgttgagct aaccaaattg tccatggatt tgagtttccc
     4261 ataacctcag agttattcga actcttttgt tatattttaa aatatttttt ggaagagctg
     4321 ctaattttat tttaagaaac aaagttgtaa aaatatatgc ctccttttta aaaaaaaaaa
     4381 aataaataac ccttctctcc aggccgaata acccggcatc accgtgcaca ggtcagggct
     4441 cagagagagc ctccgtgcag atgcgctttc tttacagtgg ctgtaaaaag tttgtattta
     4501 ttatgtataa aatgttgaat aataaaaagt gaaattaagt ttt
//
