LOCUS       NM_033351               1550 bp    mRNA    linear   ROD 03-JUN-2024
DEFINITION  Rattus norvegicus Fc gamma receptor and transporter (Fcgrt), mRNA.
ACCESSION   NM_033351
VERSION     NM_033351.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1550)
  AUTHORS   Yadav,S.P.S., Sandoval,R.M., Zhao,J., Huang,Y., Wang,E., Kumar,S.,
            Campos-Bilderback,S.B., Rhodes,G., Mechref,Y., Molitoris,B.A. and
            Wagner,M.C.
  TITLE     Mechanism of how carbamylation reduces albumin binding to FcRn
            contributing to increased vascular clearance
  JOURNAL   Am J Physiol Renal Physiol 320 (1), F114-F129 (2021)
   PUBMED   33283642
  REMARK    GeneRIF: Mechanism of how carbamylation reduces albumin binding to
            FcRn contributing to increased vascular clearance.
REFERENCE   2  (bases 1 to 1550)
  AUTHORS   Wagner,M.C., Myslinski,J., Pratap,S., Flores,B., Rhodes,G.,
            Campos-Bilderback,S.B., Sandoval,R.M., Kumar,S., Patel,M., Ashish
            and Molitoris,B.A.
  TITLE     Mechanism of increased clearance of glycated albumin by proximal
            tubule cells
  JOURNAL   Am J Physiol Renal Physiol 310 (10), F1089-F1102 (2016)
   PUBMED   26887834
  REMARK    GeneRIF: significant structural changes occur to albumin with
            glycation, particularly in the FcRn-binding region, which could
            explain the reduced affinity to FcRn
REFERENCE   3  (bases 1 to 1550)
  AUTHORS   Abdiche,Y.N., Yeung,Y.A., Chaparro-Riggers,J., Barman,I., Strop,P.,
            Chin,S.M., Pham,A., Bolton,G., McDonough,D., Lindquist,K., Pons,J.
            and Rajpal,A.
  TITLE     The neonatal Fc receptor (FcRn) binds independently to both sites
            of the IgG homodimer with identical affinity
  JOURNAL   MAbs 7 (2), 331-343 (2015)
   PUBMED   25658443
  REMARK    GeneRIF: The neonatal Fc receptor (FcRn) binds independently to
            both sites of the IgG homodimer with identical affinity.
REFERENCE   4  (bases 1 to 1550)
  AUTHORS   Neuber,T., Frese,K., Jaehrling,J., Jager,S., Daubert,D.,
            Felderer,K., Linnemann,M., Hohne,A., Kaden,S., Kolln,J., Tiller,T.,
            Brocks,B., Ostendorp,R. and Pabst,S.
  TITLE     Characterization and screening of IgG binding to the neonatal Fc
            receptor
  JOURNAL   MAbs 6 (4), 928-942 (2014)
   PUBMED   24802048
  REMARK    GeneRIF: Characterization and screening of IgG binding to the
            neonatal Fc receptor.
REFERENCE   5  (bases 1 to 1550)
  AUTHORS   Kliwinski,C., Cooper,P.R., Perkinson,R., Mabus,J.R., Tam,S.H.,
            Wilkinson,T.M., Giles-Komar,J., Scallon,B., Powers,G.D. and
            Hornby,P.J.
  TITLE     Contribution of FcRn binding to intestinal uptake of IgG in
            suckling rat pups and human FcRn-transgenic mice
  JOURNAL   Am J Physiol Gastrointest Liver Physiol 304 (3), G262-G270 (2013)
   PUBMED   23220220
  REMARK    GeneRIF: The suckling rat pup intestine is a mechanistic model of
            FcRn-IgG-mediated transcytosis
REFERENCE   6  (bases 1 to 1550)
  AUTHORS   Vaughn,D.E. and Bjorkman,P.J.
  TITLE     Structural basis of pH-dependent antibody binding by the neonatal
            Fc receptor
  JOURNAL   Structure 6 (1), 63-73 (1998)
   PUBMED   9493268
REFERENCE   7  (bases 1 to 1550)
  AUTHORS   Story,C.M., Mikulska,J.E. and Simister,N.E.
  TITLE     A major histocompatibility complex class I-like Fc receptor cloned
            from human placenta: possible role in transfer of immunoglobulin G
            from mother to fetus
  JOURNAL   J Exp Med 180 (6), 2377-2381 (1994)
   PUBMED   7964511
REFERENCE   8  (bases 1 to 1550)
  AUTHORS   Burmeister,W.P., Huber,A.H. and Bjorkman,P.J.
  TITLE     Crystal structure of the complex of rat neonatal Fc receptor with
            Fc
  JOURNAL   Nature 372 (6504), 379-383 (1994)
   PUBMED   7969498
REFERENCE   9  (bases 1 to 1550)
  AUTHORS   Simister,N.E. and Mostov,K.E.
  TITLE     An Fc receptor structurally related to MHC class I antigens
  JOURNAL   Nature 337 (6203), 184-187 (1989)
   PUBMED   2911353
REFERENCE   10 (bases 1 to 1550)
  AUTHORS   Simister,N.E. and Mostov,K.E.
  TITLE     Cloning and expression of the neonatal rat intestinal Fc receptor,
            a major histocompatibility complex class I antigen homolog
  JOURNAL   Cold Spring Harb Symp Quant Biol 54 Pt 1, 571-580 (1989)
   PUBMED   2534798
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from M35495.1.
            
            On Aug 31, 2012 this sequence version replaced NM_033351.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: M35495.1, SRR8487227.114136.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760476, SAMEA5760494
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1550              M35495.1           3-1552
FEATURES             Location/Qualifiers
     source          1..1550
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q22"
     gene            1..1550
                     /gene="Fcgrt"
                     /gene_synonym="FcRn"
                     /note="Fc gamma receptor and transporter"
                     /db_xref="GeneID:29558"
                     /db_xref="RGD:61811"
     exon            1..272
                     /gene="Fcgrt"
                     /gene_synonym="FcRn"
                     /inference="alignment:Splign:2.1.0"
     CDS             203..1303
                     /gene="Fcgrt"
                     /gene_synonym="FcRn"
                     /note="neonatal Fc receptor; igG receptor FcRn large
                     subunit p51; igG Fc fragment receptor transporter alpha
                     chain; Fc fragment immunoglobulin G receptor; Fc receptor,
                     IgG, alpha chain transporter; Fc fragment of IgG,
                     receptor, transporter, alpha; Fc fragment of IgG receptor
                     and transporter"
                     /codon_start=1
                     /product="IgG receptor FcRn large subunit p51 precursor"
                     /protein_id="NP_203502.1"
                     /db_xref="GeneID:29558"
                     /db_xref="RGD:61811"
                     /translation="MGMSQPGVLLSLLLVLLPQTWGAEPRLPLMYHLAAVSDLSTGLP
                     SFWATGWLGAQQYLTYNNLRQEADPCGAWIWENQVSWYWEKETTDLKSKEQLFLEAIR
                     TLENQINGTFTLQGLLGCELAPDNSSLPTAVFALNGEEFMRFNPRTGNWSGEWPETDI
                     VGNLWMKQPEAARKESEFLLTSCPERLLGHLERGRQNLEWKEPPSMRLKARPGNSGSS
                     VLTCAAFSFYPPELKFRFLRNGLASGSGNCSTGPNGDGSFHAWSLLEVKRGDEHHYQC
                     QVEHEGLAQPLTVDLDSPARSSVPVVGIILGLLLVVVAIAGGVLLWNRMRSGLPAPWL
                     SLSGDDSGDLLPGGNLPPEAEPQGVNAFPATS"
     exon            273..530
                     /gene="Fcgrt"
                     /gene_synonym="FcRn"
                     /inference="alignment:Splign:2.1.0"
     exon            531..806
                     /gene="Fcgrt"
                     /gene_synonym="FcRn"
                     /inference="alignment:Splign:2.1.0"
     exon            807..1076
                     /gene="Fcgrt"
                     /gene_synonym="FcRn"
                     /inference="alignment:Splign:2.1.0"
     exon            1077..1193
                     /gene="Fcgrt"
                     /gene_synonym="FcRn"
                     /inference="alignment:Splign:2.1.0"
     exon            1194..1550
                     /gene="Fcgrt"
                     /gene_synonym="FcRn"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 agttctgtaa ttaattaact aacgtggatc aaatgagaag gtgaaagttc acacaggagc
       61 actcctgtcg tcttggactg ggtctccatc ccaccatcca gtgccctggt ctacgaagag
      121 tccacaggga ccttgtgaag aatcaacaag gcggggtcca gaggagtcac gtgtgccttc
      181 cactccgggt cgccctgtca ggatggggat gtcccagccc ggggtcctcc tcagcctctt
      241 attggtcctc ctgcctcaga cctggggagc ggagccccgt ctcccactga tgtatcatct
      301 tgcagctgtg tctgacttat caacggggct tccctctttc tgggccacgg gctggctggg
      361 tgctcagcaa tatctgacct acaacaacct gcggcaggag gctgacccct gtggggcctg
      421 gatatgggaa aaccaggtgt cttggtattg ggagaaggag accacggatc tgaaaagcaa
      481 agaacagctc ttcttggagg ccatcaggac cctggagaac caaataaatg ggaccttcac
      541 actgcagggc ctgctgggct gtgaactggc ccctgataat tcttcattgc ccacggctgt
      601 gtttgccctc aatggtgagg agttcatgcg gttcaaccca agaacgggca actggagtgg
      661 ggagtggccg gagacagata tcgttggtaa tctgtggatg aagcaacctg aggcggccag
      721 gaaggagagc gagttcctgc taacttcttg tcctgagcgg ctgctaggcc acctggagag
      781 gggccgtcag aacctggagt ggaaggagcc gccatctatg cgcctgaagg cccgtcctgg
      841 caactctggc tcctcagtac tgacctgtgc tgctttctcc ttctacccgc cggagctcaa
      901 gtttcgattc ctgcgcaatg ggctagcctc aggctctggg aattgcagca ctggtcccaa
      961 tggtgatgga tctttccatg catggtcatt gctagaggtc aaacgtggag atgaacacca
     1021 ttaccaatgt caagtggagc atgaggggct ggcccagcct ctcactgtgg acctagattc
     1081 gcccgccaga tcttctgtgc ctgtggtcgg aatcattctt ggtttattgc tggtggtagt
     1141 ggccatcgca gggggtgtgc tgctatggaa caggatgcga agtgggctgc cagccccatg
     1201 gctttctctc agtggtgatg actctggcga cctattgcct ggtgggaact tgcccccgga
     1261 ggctgaacct caaggtgtaa atgcctttcc ggccacttcc tgatgccaac ccaggcccca
     1321 tacccattgc agcctgtggg gctgtgtgac ctcctgaact gtctctgagc ctcccgaggg
     1381 agccctgggc tggatgtcct cctcgtggat cccttctttt gtggcctgct tcagtttccc
     1441 ctcttaatgt caatggctat ttccatctcc acataaattt gggcccaaat ctgtgtgtgc
     1501 atcgttattc tcaggtttca ggcagccgga ataaattgaa caagtttgag
//
