LOCUS       NM_207603               1174 bp    mRNA    linear   ROD 30-MAR-2024
DEFINITION  Rattus norvegicus Fc gamma receptor 3A (Fcgr3a), mRNA.
ACCESSION   NM_207603 XM_222878
VERSION     NM_207603.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1174)
  AUTHORS   Ghesquieres,H., Larrabee,B.R., Haioun,C., Link,B.K., Verney,A.,
            Slager,S.L., Ketterer,N., Ansell,S.M., Delarue,R., Maurer,M.J.,
            Fitoussi,O., Habermann,T.M., Peyrade,F., Dogan,A., Molina,T.J.,
            Novak,A.J., Tilly,H., Cerhan,J.R. and Salles,G.
  TITLE     FCGR3A/2A polymorphisms and diffuse large B-cell lymphoma outcome
            treated with immunochemotherapy: a meta-analysis on 1134 patients
            from two prospective cohorts
  JOURNAL   Hematol Oncol 35 (4), 447-455 (2017)
   PUBMED   27282998
REFERENCE   2  (bases 1 to 1174)
  AUTHORS   Negishi-Koga,T., Gober,H.J., Sumiya,E., Komatsu,N., Okamoto,K.,
            Sawa,S., Suematsu,A., Suda,T., Sato,K., Takai,T. and Takayanagi,H.
  TITLE     Immune complexes regulate bone metabolism through FcRgamma
            signalling
  JOURNAL   Nat Commun 6, 6637 (2015)
   PUBMED   25824719
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1174)
  AUTHORS   Chen,J.Y., Wang,C.M., Chang,S.W., Cheng,C.H., Wu,Y.J., Lin,J.C.,
            Yang,B., Ho,H.H. and Wu,J.
  TITLE     Association of FCGR3A and FCGR3B copy number variations with
            systemic lupus erythematosus and rheumatoid arthritis in Taiwanese
            patients
  JOURNAL   Arthritis Rheumatol 66 (11), 3113-3121 (2014)
   PUBMED   25154742
REFERENCE   4  (bases 1 to 1174)
  AUTHORS   Zhen,A., Krutzik,S.R., Levin,B.R., Kasparian,S., Zack,J.A. and
            Kitchen,S.G.
  TITLE     CD4 ligation on human blood monocytes triggers macrophage
            differentiation and enhances HIV infection
  JOURNAL   J Virol 88 (17), 9934-9946 (2014)
   PUBMED   24942581
REFERENCE   5  (bases 1 to 1174)
  AUTHORS   Stork,A.C., Notermans,N.C., van den Berg,L.H., Schellevis,R.D.,
            Niermeijer,J.M., Nederend,M., Leusen,J.H. and van der Pol,W.L.
  TITLE     Fcgamma receptor IIIA genotype is associated with rituximab
            response in antimyelin-associated glycoprotein neuropathy
  JOURNAL   J Neurol Neurosurg Psychiatry 85 (8), 918-920 (2014)
   PUBMED   24487381
REFERENCE   6  (bases 1 to 1174)
  AUTHORS   Foster,C.B., Zhu,S., Erichsen,H.C., Lehrnbecher,T., Hart,E.S.,
            Choi,E., Stein,S., Smith,M.W., Steinberg,S.M., Imbach,P., Kuhne,T.
            and Chanock,S.J.
  CONSRTM   Early Chronic ITP Study Group
  TITLE     Polymorphisms in inflammatory cytokines and Fcgamma receptors in
            childhood chronic immune thrombocytopenic purpura: a pilot study
  JOURNAL   Br J Haematol 113 (3), 596-599 (2001)
   PUBMED   11380443
REFERENCE   7  (bases 1 to 1174)
  AUTHORS   Lee,S.C., Brummet,M.E., Shahabuddin,S., Woodworth,T.G.,
            Georas,S.N., Leiferman,K.M., Gilman,S.C., Stellato,C., Gladue,R.P.,
            Schleimer,R.P. and Beck,L.A.
  TITLE     Cutaneous injection of human subjects with macrophage inflammatory
            protein-1 alpha induces significant recruitment of neutrophils and
            monocytes
  JOURNAL   J Immunol 164 (6), 3392-3401 (2000)
   PUBMED   10706735
REFERENCE   8  (bases 1 to 1174)
  AUTHORS   de Vries,E., Koene,H.R., Vossen,J.M., Gratama,J.W., von dem
            Borne,A.E., Waaijer,J.L., Haraldsson,A., de Haas,M. and van
            Tol,M.J.
  TITLE     Identification of an unusual Fc gamma receptor IIIa (CD16) on
            natural killer cells in a patient with recurrent infections
  JOURNAL   Blood 88 (8), 3022-3027 (1996)
   PUBMED   8874200
REFERENCE   9  (bases 1 to 1174)
  AUTHORS   Kahan,A., Collantes-Estevez,E., Barel,M., Frade,R. and Amor,B.
  TITLE     Expression of complement receptors (CR1 and CR3) and Fc gamma RIII
            on polymorphonuclears from patients with spondylarthropathies
  JOURNAL   Clin Exp Rheumatol 11 (1), 27-34 (1993)
   PUBMED   8453794
REFERENCE   10 (bases 1 to 1174)
  AUTHORS   Ory,P.A., Clark,M.R., Kwoh,E.E., Clarkson,S.B. and Goldstein,I.M.
  TITLE     Sequences of complementary DNAs that encode the NA1 and NA2 forms
            of Fc receptor III on human neutrophils
  JOURNAL   J Clin Invest 84 (5), 1688-1691 (1989)
   PUBMED   2478590
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from
            JAXUCZ010000013.1.
            
            On Nov 27, 2020 this sequence version replaced NM_207603.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AY219230.1, BC166877.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760393, SAMEA5760400
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-64                JAXUCZ010000013.1  85782636-85782699
            65-85               JAXUCZ010000013.1  85783209-85783229
            86-340              JAXUCZ010000013.1  85783577-85783831
            341-595             JAXUCZ010000013.1  85788742-85788996
            596-1174            JAXUCZ010000013.1  85792078-85792656
FEATURES             Location/Qualifiers
     source          1..1174
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="13"
                     /map="13q24"
     gene            1..1174
                     /gene="Fcgr3a"
                     /gene_synonym="CD16-2; Fcgr4"
                     /note="Fc gamma receptor 3A"
                     /db_xref="GeneID:304966"
                     /db_xref="RGD:1303067"
     exon            1..64
                     /gene="Fcgr3a"
                     /gene_synonym="CD16-2; Fcgr4"
                     /inference="alignment:Splign:2.1.0"
     CDS             25..774
                     /gene="Fcgr3a"
                     /gene_synonym="CD16-2; Fcgr4"
                     /note="Fc fragment of IgG intermediate affinity IV
                     receptor; transmembrane receptor FcgammaRIII-X; Fc
                     fragment of IgG, low affinity IIIa, receptor for (CD16);
                     Fc fragment of IgG receptor IIIa; Fc gamma receptor IIIa;
                     fcgammaRIV; IgG Fc receptor III-A; low affinity
                     immunoglobulin gamma Fc region receptor III-A"
                     /codon_start=1
                     /product="low affinity immunoglobulin gamma Fc region
                     receptor III-A precursor"
                     /protein_id="NP_997486.2"
                     /db_xref="GeneID:304966"
                     /db_xref="RGD:1303067"
                     /translation="MWYLLLPTALLLTVSSGVGAGLQKAVVILDPEWVRVLEEDCVIL
                     RCQGTFSPEDNSTKWFHNKSLISHQDANYVIQSARVKDSGMYRCQTAFSALSDPVQLD
                     VHADWLLLQTTKRLFQEGDPIRLRCHSWRNTPVFKVTYLQNGKGKKYFHRNSELSISK
                     ATHADSGSYFCRGIIGRNNISSASLQISIGDPTSPSSFLPWHQITFCLLIGLLFAIDT
                     VLYFSVQRSLQSSVAVYEEPKLHWSKEPQDK"
     exon            65..85
                     /gene="Fcgr3a"
                     /gene_synonym="CD16-2; Fcgr4"
                     /inference="alignment:Splign:2.1.0"
     exon            86..340
                     /gene="Fcgr3a"
                     /gene_synonym="CD16-2; Fcgr4"
                     /inference="alignment:Splign:2.1.0"
     exon            341..595
                     /gene="Fcgr3a"
                     /gene_synonym="CD16-2; Fcgr4"
                     /inference="alignment:Splign:2.1.0"
     exon            596..1174
                     /gene="Fcgr3a"
                     /gene_synonym="CD16-2; Fcgr4"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ttttctgtct gctgctgcag cagcatgtgg tacctactac taccaacggc actgctactt
       61 acggtttcct ctggcgttgg agctggtctc caaaaggctg tggtgatcct agaccctgaa
      121 tgggtcaggg ttctcgagga agactgtgtg atcctcaggt gccagggcac cttctccccc
      181 gaggacaatt ctaccaaatg gttccataac aaaagcctca tctcgcacca ggacgccaac
      241 tatgtcatcc aaagtgccag agttaaggac agtggaatgt acagatgcca gacagccttc
      301 tccgcgctca gtgacccggt gcagctagac gtccatgcag actggctatt gcttcagacc
      361 actaagcggc tgttccagga gggggacccc attcgtctga gatgccatag ctggcgaaac
      421 acgcctgtat ttaaggttac ctatttacag aatggcaaag gcaagaagta tttccatagg
      481 aattctgaac tcagtatttc aaaagctacg cacgccgaca gtggttccta cttctgcaga
      541 gggatcattg gacgcaacaa catatcttca gcatccttgc agataagcat aggagatccg
      601 acgtctccct ccagctttct accgtggcat caaatcactt tctgcctgct gataggactc
      661 ttgtttgcaa tagacacagt gctgtatttc tcggtgcaga ggagtcttca aagttccgtg
      721 gcagtctatg aggaacccaa acttcactgg agcaaggaac ctcaggacaa gtgagccctc
      781 gtctcatggg atgaggagag caatagcgta gaatctatta gcttccctgt ggacttgcga
      841 cctcaccatc tgcatcggca ccaagtttga gtggcaggaa taatacagag gcccctcccc
      901 taactttttt ttttttttgg tgttgtatgt ttgttgtttg tttgtctctc tccaatggac
      961 aatctcaggg gaaagagaaa gcctggggtc ttccaggacc aacagcaaag cagcgatgag
     1021 cacacagctg ccctcccaag aagcgatgct tcagagtttt actctttctc tgccccaaac
     1081 attttgttgt cagagcaaag cagcagcacc ggcgttgggt gatgacccct ttctgtgctt
     1141 aacaattgtt cctaaataaa cttctggaga aaag
//
