LOCUS       NM_175756               1420 bp    mRNA    linear   ROD 31-MAR-2024
DEFINITION  Rattus norvegicus Fc gamma receptor 2B (Fcgr2b), mRNA.
ACCESSION   NM_175756
VERSION     NM_175756.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1420)
  AUTHORS   Zheng,X., Wang,Q., Cao,X. and Yang,Z.
  TITLE     [Up-regulated expression of FcgammaRIIB inhibits phagocytosis and
            chemotaxis of macrophages]
  JOURNAL   Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi 31 (8), 1022-1026 (2015)
   PUBMED   26271972
  REMARK    GeneRIF: Data shew that he up-regulation of Fc gamma RIIB
            (FcgammaRIIB) expression in macrophages might suppress cell
            phagocytosis and chemotaxis.
REFERENCE   2  (bases 1 to 1420)
  AUTHORS   Jeon,J.Y., Kim,K.Y., Kim,B.S., Jung,J.Y., Kim,H.A. and Suh,C.H.
  TITLE     FcgammaRIIB Gene Polymorphisms Are Associated with Disease Risk and
            Clinical Manifestations of Systemic Lupus Erythematosus in Koreans
  JOURNAL   Tohoku J Exp Med 236 (3), 185-191 (2015)
   PUBMED   26084639
REFERENCE   3  (bases 1 to 1420)
  AUTHORS   Bocchini,N., Giantin,M., Crivellente,F., Ferraresso,S.,
            Faustinelli,I., Dacasto,M. and Cristofori,P.
  TITLE     Molecular biomarkers of phospholipidosis in rat blood and heart
            after amiodarone treatment
  JOURNAL   J Appl Toxicol 35 (1), 90-103 (2015)
   PUBMED   25580480
REFERENCE   4  (bases 1 to 1420)
  AUTHORS   Psathas,J.N., Doonan,P.J., Raman,P., Freedman,B.D., Minn,A.J. and
            Thomas-Tikhonenko,A.
  TITLE     The Myc-miR-17-92 axis amplifies B-cell receptor signaling via
            inhibition of ITIM proteins: a novel lymphomagenic feed-forward
            loop
  JOURNAL   Blood 122 (26), 4220-4229 (2013)
   PUBMED   24169826
REFERENCE   5  (bases 1 to 1420)
  AUTHORS   Kam,T.I., Song,S., Gwon,Y., Park,H., Yan,J.J., Im,I., Choi,J.W.,
            Choi,T.Y., Kim,J., Song,D.K., Takai,T., Kim,Y.C., Kim,K.S.,
            Choi,S.Y., Choi,S., Klein,W.L., Yuan,J. and Jung,Y.K.
  TITLE     FcgammaRIIb mediates amyloid-beta neurotoxicity and memory
            impairment in Alzheimer's disease
  JOURNAL   J Clin Invest 123 (7), 2791-2802 (2013)
   PUBMED   23921129
REFERENCE   6  (bases 1 to 1420)
  AUTHORS   Isashi,Y., Tamakoshi,M., Nagai,Y., Sudo,T., Murakami,M. and Uede,T.
  TITLE     The rat neutrophil low-affinity Fc receptor for IgG: molecular
            cloning and functional characterization
  JOURNAL   Immunol Lett 46 (1-2), 157-163 (1995)
   PUBMED   7590913
REFERENCE   7  (bases 1 to 1420)
  AUTHORS   Bocek,P. and Pecht,I.
  TITLE     Cloning and sequence of the cDNA coding for rat type II Fc gamma
            receptor of mast cells
  JOURNAL   FEBS Lett 331 (1-2), 86-90 (1993)
   PUBMED   8405417
REFERENCE   8  (bases 1 to 1420)
  AUTHORS   Farber,D.L. and Sears,D.W.
  TITLE     Rat CD16 is defined by a family of class III Fc gamma receptors
            requiring co-expression of heteroprotein subunits
  JOURNAL   J Immunol 146 (12), 4352-4361 (1991)
   PUBMED   1710249
REFERENCE   9  (bases 1 to 1420)
  AUTHORS   Engelhardt,W., Geerds,C. and Frey,J.
  TITLE     Distribution, inducibility and biological function of the cloned
            and expressed human beta Fc receptor II
  JOURNAL   Eur J Immunol 20 (6), 1367-1377 (1990)
   PUBMED   2142460
REFERENCE   10 (bases 1 to 1420)
  AUTHORS   Zeger,D.L., Hogarth,P.M. and Sears,D.W.
  TITLE     Characterization and expression of an Fc gamma receptor cDNA cloned
            from rat natural killer cells
  JOURNAL   Proc Natl Acad Sci U S A 87 (9), 3425-3429 (1990)
   PUBMED   1692135
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000013.1.
            
            On Mar 9, 2021 this sequence version replaced NM_175756.2.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC091113.1, FQ228752.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760383,
                                           SAMEA5760389 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-185               JAXUCZ010000013.1  85740333-85740517   c
            186-206             JAXUCZ010000013.1  85735169-85735189   c
            207-464             JAXUCZ010000013.1  85733521-85733778   c
            465-719             JAXUCZ010000013.1  85731946-85732200   c
            720-842             JAXUCZ010000013.1  85731209-85731331   c
            843-880             JAXUCZ010000013.1  85726533-85726570   c
            881-1420            JAXUCZ010000013.1  85725897-85726436   c
FEATURES             Location/Qualifiers
     source          1..1420
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="13"
                     /map="13q24"
     gene            1..1420
                     /gene="Fcgr2b"
                     /gene_synonym="CD32; FcgammaRIIB2; Fcgr2; FCRII"
                     /note="Fc gamma receptor 2B"
                     /db_xref="GeneID:289211"
                     /db_xref="RGD:631331"
     exon            1..185
                     /gene="Fcgr2b"
                     /gene_synonym="CD32; FcgammaRIIB2; Fcgr2; FCRII"
                     /inference="alignment:Splign:2.1.0"
     CDS             80..967
                     /gene="Fcgr2b"
                     /gene_synonym="CD32; FcgammaRIIB2; Fcgr2; FCRII"
                     /note="FC-gamma RII; Fc gamma receptor IIb; igG Fc
                     receptor II beta; Fc receptor, IgG, low affinity IIb; Fc
                     fragment of IgG receptor IIb; low affinity immunoglobulin
                     gamma Fc region receptor II-b; low affinity immunoglobulin
                     gamma FC region receptor II; Fc fragment of IgG, low
                     affinity IIb, receptor"
                     /codon_start=1
                     /product="low affinity immunoglobulin gamma Fc region
                     receptor II precursor"
                     /protein_id="NP_786932.2"
                     /db_xref="GeneID:289211"
                     /db_xref="RGD:631331"
                     /translation="MGTLLFLPLPMDSNRTVVHVLSRTLYHMLLWTAVLNLVAESHAG
                     LPKAVVKLEPPWIQVLKEDTVTLMCEGTHNTKNCSTQWFHNGSSIWHQAQANYTFKAT
                     VNDSGEYRCRMEETGISEPIHLGVISDWLLLQTSQLVFEEGETITLRCHSWKNKQLTK
                     VLLFQNGKPVRYYHQSSNFSIPKANHSHSGNYYCKAYLGRTMHVSKPVTITVQEPKSS
                     SSLPVLTIVAAVAGIAVAAIVIILVSLVYLKKKQVPDTPSGLEEAEKNEVENTITYSL
                     LKHPEAPDEESDHDYQNHI"
     exon            186..206
                     /gene="Fcgr2b"
                     /gene_synonym="CD32; FcgammaRIIB2; Fcgr2; FCRII"
                     /inference="alignment:Splign:2.1.0"
     exon            207..464
                     /gene="Fcgr2b"
                     /gene_synonym="CD32; FcgammaRIIB2; Fcgr2; FCRII"
                     /inference="alignment:Splign:2.1.0"
     exon            465..719
                     /gene="Fcgr2b"
                     /gene_synonym="CD32; FcgammaRIIB2; Fcgr2; FCRII"
                     /inference="alignment:Splign:2.1.0"
     exon            720..842
                     /gene="Fcgr2b"
                     /gene_synonym="CD32; FcgammaRIIB2; Fcgr2; FCRII"
                     /inference="alignment:Splign:2.1.0"
     exon            843..880
                     /gene="Fcgr2b"
                     /gene_synonym="CD32; FcgammaRIIB2; Fcgr2; FCRII"
                     /inference="alignment:Splign:2.1.0"
     exon            881..1420
                     /gene="Fcgr2b"
                     /gene_synonym="CD32; FcgammaRIIB2; Fcgr2; FCRII"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 agaatttgtc tgttctctgg gtataatctg ccaaactcgg agagaagcct gtgcctgcag
       61 ctgactcact ccaggactga tgggaaccct gctgttccta ccgctcccca tggacagcaa
      121 caggactgtc gtccatgtgc tctcacggac tttgtaccat atgctactgt ggacagctgt
      181 gctaaatctt gttgctgagt ctcatgcagg tcttccgaag gctgtggtga aacttgagcc
      241 cccatggatc caggtgctta aggaagacac tgtgacactg atgtgcgaag ggacccacaa
      301 caccaagaac tgttctactc agtggtttca caatgggagc tccatctggc atcaagccca
      361 agccaactac acgtttaagg ccacagtcaa tgatagtgga gaataccggt gccgaatgga
      421 ggagaccggc atcagcgaac ccatacatct gggagtgatt tctgactggc tgctactcca
      481 gacctctcaa ctggtgtttg aagaagggga aaccatcaca ttaaggtgcc atagctggaa
      541 gaacaaacag ctgactaagg tcttgttgtt ccagaatgga aaacctgtga ggtattatca
      601 tcaaagcagc aatttttcaa tccccaaagc caaccacagt cacagtggga actactattg
      661 caaagcatat ctaggaagga caatgcacgt gtccaagcct gtcaccatca ctgtccaaga
      721 gcccaaatcc agcagttcgt tgccggtatt gacgattgta gctgctgtcg ctggaattgc
      781 tgtagctgcc attgttatta tcctggtatc cttggtctat ctcaagaaaa agcaggttcc
      841 agacactcct tctggtctcg aagaagctga gaaaaatgag gtggagaata caatcaccta
      901 ttcacttctc aagcatcctg aagctccgga tgaagaatca gatcacgact accagaacca
      961 catttagtct ctcttgagat tgggaaaagc aaaccagtaa ggccaggacc tagcgtctcc
     1021 tggtccaagg aatgctgtag atatgaaaga aaacatctag agtcccttct gtgagtcctg
     1081 aaaccaacag acactacgat attggttccc aatggttgac tgtactaatg acttccataa
     1141 cttacagctt cccaactaaa gactcttttg ctatagatcc acacagccaa taaaattaat
     1201 caacttactg ttgttaagag actacagcaa cgtgggaact gcttatatta catgctaagg
     1261 agaacaagta acattaggat gcataatctc agcgaggatc aactagacgt gtaccaacct
     1321 gtcaaaagtg atgcttcttt ataagaaact ttatttcctt atttttctat aaaggtcaca
     1381 tattactttt atagtaaaat gttgtgaaaa tgtcattcta
//
