LOCUS       NM_001419015            1604 bp    mRNA    linear   ROD 23-APR-2024
DEFINITION  Rattus norvegicus Fc gamma receptor 2A (Fcgr2a), transcript variant
            2, mRNA.
ACCESSION   NM_001419015 XM_006250303
VERSION     NM_001419015.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1604)
  AUTHORS   Luo,J., Jin,G., Cui,S., Wang,H. and Liu,Q.
  TITLE     Regulatory mechanism of FCGR2A in macrophage polarization and its
            effects on intervertebral disc degeneration
  JOURNAL   J Physiol 602 (7), 1341-1369 (2024)
   PUBMED   38544414
  REMARK    GeneRIF: Regulatory mechanism of FCGR2A in macrophage polarization
            and its effects on intervertebral disc degeneration.
REFERENCE   2  (bases 1 to 1604)
  AUTHORS   Ghesquieres,H., Larrabee,B.R., Haioun,C., Link,B.K., Verney,A.,
            Slager,S.L., Ketterer,N., Ansell,S.M., Delarue,R., Maurer,M.J.,
            Fitoussi,O., Habermann,T.M., Peyrade,F., Dogan,A., Molina,T.J.,
            Novak,A.J., Tilly,H., Cerhan,J.R. and Salles,G.
  TITLE     FCGR3A/2A polymorphisms and diffuse large B-cell lymphoma outcome
            treated with immunochemotherapy: a meta-analysis on 1134 patients
            from two prospective cohorts
  JOURNAL   Hematol Oncol 35 (4), 447-455 (2017)
   PUBMED   27282998
REFERENCE   3  (bases 1 to 1604)
  AUTHORS   Meyer,T., Robles-Carrillo,L., Davila,M., Brodie,M., Desai,H.,
            Rivera-Amaya,M., Francis,J.L. and Amirkhosravi,A.
  TITLE     CD32a antibodies induce thrombocytopenia and type II
            hypersensitivity reactions in FCGR2A mice
  JOURNAL   Blood 126 (19), 2230-2238 (2015)
   PUBMED   26396093
REFERENCE   4  (bases 1 to 1604)
  AUTHORS   Mohsin,S.N., Mahmood,S., Amar,A., Ghafoor,F., Raza,S.M. and
            Saleem,M.
  TITLE     Association of FcgammaRIIa Polymorphism with Clinical Outcome of
            Dengue Infection: First Insight from Pakistan
  JOURNAL   Am J Trop Med Hyg 93 (4), 691-696 (2015)
   PUBMED   26240159
REFERENCE   5  (bases 1 to 1604)
  AUTHORS   Nazarova,E.L., Shardakov,V.I., Dem'ianova,V.T., Zagoskina,T.P. and
            Zotina,E.N.
  TITLE     [The diagnostic of defects of inborn immunity under B-cell tumors
            of lymphatic system]
  JOURNAL   Klin Lab Diagn 59 (11), 39-42 (2014)
   PUBMED   25850245
REFERENCE   6  (bases 1 to 1604)
  AUTHORS   Nakama,T.
  TITLE     Relationships between eosinophil-associated parameters and disease
            severity in atopic dermatitis
  JOURNAL   Kurume Med J 42 (2), 95-106 (1995)
   PUBMED   7564170
REFERENCE   7  (bases 1 to 1604)
  AUTHORS   Boros,P., Odin,J.A., Chen,J. and Unkeless,J.C.
  TITLE     Specificity and class distribution of Fc gamma R-specific
            autoantibodies in patients with autoimmune disease
  JOURNAL   J Immunol 152 (1), 302-306 (1994)
   PUBMED   8254199
REFERENCE   8  (bases 1 to 1604)
  AUTHORS   Vedeler,C.A., Conti,G., Bannerman,P. and Pleasure,D.
  TITLE     Expression of genes encoding receptors for IgG (FcRIII) and for
            C3b/C4b (Crry) in rat sciatic nerve during development and
            Wallerian degeneration
  JOURNAL   J Neurosci Res 31 (4), 654-661 (1992)
   PUBMED   1533683
REFERENCE   9  (bases 1 to 1604)
  AUTHORS   Farber,D.L. and Sears,D.W.
  TITLE     Rat CD16 is defined by a family of class III Fc gamma receptors
            requiring co-expression of heteroprotein subunits
  JOURNAL   J Immunol 146 (12), 4352-4361 (1991)
   PUBMED   1710249
REFERENCE   10 (bases 1 to 1604)
  AUTHORS   Zeger,D.L., Hogarth,P.M. and Sears,D.W.
  TITLE     Characterization and expression of an Fc gamma receptor cDNA cloned
            from rat natural killer cells
  JOURNAL   Proc Natl Acad Sci U S A 87 (9), 3425-3429 (1990)
   PUBMED   1692135
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000013.1.
            
            On Mar 27, 2023 this sequence version replaced XM_006250303.4.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643294.48531.1,
                                           SRR26643295.47347.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN16676784, SAMN16676807
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on manual assertion, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-251               JAXUCZ010000013.1  85828435-85828685   c
            252-377             JAXUCZ010000013.1  85822608-85822733   c
            378-398             JAXUCZ010000013.1  85821797-85821817   c
            399-656             JAXUCZ010000013.1  85820913-85821170   c
            657-911             JAXUCZ010000013.1  85816058-85816312   c
            912-1604            JAXUCZ010000013.1  85813516-85814208   c
FEATURES             Location/Qualifiers
     source          1..1604
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="13"
                     /map="13q24"
     gene            1..1604
                     /gene="Fcgr2a"
                     /gene_synonym="fc-gamma RIII; Fcgr3; Fcgr3a; fcRIII"
                     /note="Fc gamma receptor 2A"
                     /db_xref="GeneID:116591"
                     /db_xref="RGD:71069"
     exon            1..251
                     /gene="Fcgr2a"
                     /gene_synonym="fc-gamma RIII; Fcgr3; Fcgr3a; fcRIII"
                     /inference="alignment:Splign:2.1.0"
     exon            252..377
                     /gene="Fcgr2a"
                     /gene_synonym="fc-gamma RIII; Fcgr3; Fcgr3a; fcRIII"
                     /inference="alignment:Splign:2.1.0"
     CDS             293..1096
                     /gene="Fcgr2a"
                     /gene_synonym="fc-gamma RIII; Fcgr3; Fcgr3a; fcRIII"
                     /note="isoform 1 is encoded by transcript variant 2; Fc
                     receptor, IgG, low affinity III; low affinity
                     immunoglobulin gamma Fc region receptor III; Fc fragment
                     of IgG receptor IIa; igG Fc receptor III; Fc fragment of
                     IgG low affinity IIa receptor for (CD32); Fc gamma
                     receptor IIa; Fc fragment of IgG, low affinity IIa,
                     receptor (CD32)"
                     /codon_start=1
                     /product="low affinity immunoglobulin gamma Fc region
                     receptor III isoform 1"
                     /protein_id="NP_001405944.1"
                     /db_xref="GeneID:116591"
                     /db_xref="RGD:71069"
                     /translation="MTLETQMFQNAHSGSQWLLPPLTMLLLFAFADRQTGDLLKAVVK
                     RDPPWIQVLKDDTVTLTCEGTHNPGNSSTQWFHNQSSTWGQVQASYTFKATVNDSGEY
                     RCRMAHTSLSDPVHLEVISDWLLLQTPQLVFLEGERITLRCHGWKSIQLARISFLQNG
                     EFVSFHPYNVSYSISNANHSHSGDYYCKAYLGRTEHVSKPVTITVQGSATASTSSLVW
                     FHAAFCLVMCLLFAVDTGLYFCVRRNLQTSGEDWRRSLSVGKYKAPQDK"
     exon            378..398
                     /gene="Fcgr2a"
                     /gene_synonym="fc-gamma RIII; Fcgr3; Fcgr3a; fcRIII"
                     /inference="alignment:Splign:2.1.0"
     exon            399..656
                     /gene="Fcgr2a"
                     /gene_synonym="fc-gamma RIII; Fcgr3; Fcgr3a; fcRIII"
                     /inference="alignment:Splign:2.1.0"
     exon            657..911
                     /gene="Fcgr2a"
                     /gene_synonym="fc-gamma RIII; Fcgr3; Fcgr3a; fcRIII"
                     /inference="alignment:Splign:2.1.0"
     exon            912..1604
                     /gene="Fcgr2a"
                     /gene_synonym="fc-gamma RIII; Fcgr3; Fcgr3a; fcRIII"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gggcgctggg cgccgtgtgg tggcagtcgg cggcgacgtg ggggtgtggg tccggctgtg
       61 cggcgttggt ggtatagtgg tgctgccttc caagcagttg acccgggttc gattcctggc
      121 caacgtagcg tgcccaactt ttgccaaggt cctcacccag gacgcgccga ccgggaccct
      181 gcgtggagcc gcggagcttg ggcccaggct ctactaggcg gggaagatcg gaaagcgcca
      241 gaccttttca gttcatctcc tagacctcat cagactctga cccagttctt gaatgacttt
      301 ggagacccag atgtttcaga atgcacattc tggaagccaa tggctactcc caccactgac
      361 aatgttgctg ctgtttgctt ttgcagacag gcagacggga gatcttctga aggctgtggt
      421 gaaacgtgat cccccatgga tccaggtgct caaggacgac actgtgacgc tgacgtgcga
      481 agggacccac aatcctggaa actcttctac ccagtggttc cacaaccaga gctccacctg
      541 gggccaggtc caagccagct acacgtttaa ggccacagtc aatgacagtg gagaataccg
      601 gtgccgaatg gcgcacacca gcctcagcga ccccgtacat ctggaagtga tttctgactg
      661 gctgctgctc cagacccctc aactggtgtt tctggaagga gaaagaatca cattgaggtg
      721 tcacggctgg aagagcatac agctggccag gatttcattc ctccagaatg gagaatttgt
      781 gtcatttcat ccttataatg ttagctactc catctcaaac gccaaccaca gtcacagtgg
      841 ggactactac tgcaaagcat atctaggaag gacagaacac gtgtccaagc ctgtcaccat
      901 cactgtccaa ggttcagcaa cggcgtccac cagctctcta gtgtggttcc atgccgcttt
      961 ctgcctagtg atgtgcctcc tgtttgcagt ggacaccggc ctgtatttct gtgtacggag
     1021 aaatcttcaa acctcggggg aggactggag gagatccctg tcagtcggaa agtacaaggc
     1081 tccacaggac aaatgacatc ccatcgtatg gctaaacagc ggcagcttct tttcagccac
     1141 accgccactt catctacagc cttcctttga aagcaactta ccaccaggct ggatatttgg
     1201 tcctgcaatc acaactgcta ggaggctgag gcaggaggat caccaaaggc tgcccgggtt
     1261 ttagagaaga gagagtgcaa gtctatcctg gataacccaa taagaccctg ggtttagatg
     1321 gcttatcagg aaagagcacc cattgctaag ctcacagaca agaccacaga ttgatcccta
     1381 aggacacagg gcaaagggag agaacaaatt cctgaaagtt gtcctctgac ctccacaggt
     1441 ccaccatggc agatgcacac aataaacaaa ttaaaatgta atatatatat tttaaacaag
     1501 aggtggggga aggctggggg ttggtggcac agtttttatc caggacacat gatgctctgg
     1561 gtttgacctc ctataataaa acagaaatca atctgggcca agga
//
