LOCUS       NM_001100836            1265 bp    mRNA    linear   ROD 26-FEB-2024
DEFINITION  Rattus norvegicus Fc gamma receptor 1A (Fcgr1a), mRNA.
ACCESSION   NM_001100836 XM_001062370 XM_215643
VERSION     NM_001100836.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1265)
  AUTHORS   Liu F, Shen X, Su S, Cui H, Fang Y, Wang T, Zhang L, Huang Y and Ma
            C.
  TITLE     Fcgamma Receptor I-Coupled Signaling in Peripheral Nociceptors
            Mediates Joint Pain in a Rat Model of Rheumatoid Arthritis
  JOURNAL   Arthritis Rheumatol 72 (10), 1668-1678 (2020)
   PUBMED   32510872
  REMARK    GeneRIF: Fcgamma Receptor I-Coupled Signaling in Peripheral
            Nociceptors Mediates Joint Pain in a Rat Model of Rheumatoid
            Arthritis.
REFERENCE   2  (bases 1 to 1265)
  AUTHORS   Liang Y, Zhang Z, Juan Z, Zhang R and Zhang C.
  TITLE     The high-affinity IgG receptor FcgammaRI modulates peripheral nerve
            injury-induced neuropathic pain in rats
  JOURNAL   Mol Brain 12 (1), 83 (2019)
   PUBMED   31640731
  REMARK    GeneRIF: FcgammaRI is a critical player for peripheral nerve
            injury-induced neuropathic pain.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1265)
  AUTHORS   Ono A, Hirooka K, Nakano Y, Nitta E, Nishiyama A and Tsujikawa A.
  TITLE     Gene expression changes in the retina after systemic administration
            of aldosterone
  JOURNAL   Jpn J Ophthalmol 62 (4), 499-507 (2018)
   PUBMED   29713904
REFERENCE   4  (bases 1 to 1265)
  AUTHORS   Sarvari M, Kallo I, Hrabovszky E, Solymosi N and Liposits Z.
  TITLE     Ovariectomy and subsequent treatment with estrogen receptor
            agonists tune the innate immune system of the hippocampus in
            middle-aged female rats
  JOURNAL   PLoS One 9 (2), e88540 (2014)
   PUBMED   24551115
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1265)
  AUTHORS   Zhang J, Niu N, Wang M, McNutt MA, Zhang D, Zhang B, Lu S, Liu Y
            and Liu Z.
  TITLE     Neuron-derived IgG protects dopaminergic neurons from insult by
            6-OHDA and activates microglia through the FcgammaR I and TLR4
            pathways
  JOURNAL   Int J Biochem Cell Biol 45 (8), 1911-1920 (2013)
   PUBMED   23791745
  REMARK    GeneRIF: Expression of TNF-alpha and IL-10 in microglia was
            elevated to protective levels by neuron-derived IgG at a
            physiologic level via the FcgammaR I and TLR4 pathways.
REFERENCE   6  (bases 1 to 1265)
  AUTHORS   Ioan-Facsinay A, de Kimpe SJ, Hellwig SM, van Lent PL, Hofhuis FM,
            van Ojik HH, Sedlik C, da Silveira SA, Gerber J, de Jong YF,
            Roozendaal R, Aarden LA, van den Berg WB, Saito T, Mosser D,
            Amigorena S, Izui S, van Ommen GJ, van Vugt M, van de Winkel JG and
            Verbeek JS.
  TITLE     FcgammaRI (CD64) contributes substantially to severity of
            arthritis, hypersensitivity responses, and protection from
            bacterial infection
  JOURNAL   Immunity 16 (3), 391-402 (2002)
   PUBMED   11911824
REFERENCE   7  (bases 1 to 1265)
  AUTHORS   Barnes N, Gavin AL, Tan PS, Mottram P, Koentgen F and Hogarth PM.
  TITLE     FcgammaRI-deficient mice show multiple alterations to inflammatory
            and immune responses
  JOURNAL   Immunity 16 (3), 379-389 (2002)
   PUBMED   11911823
REFERENCE   8  (bases 1 to 1265)
  AUTHORS   Ulyanova T, Blasioli J, Woodford-Thomas TA and Thomas ML.
  TITLE     The sialoadhesin CD33 is a myeloid-specific inhibitory receptor
  JOURNAL   Eur J Immunol 29 (11), 3440-3449 (1999)
   PUBMED   10556798
REFERENCE   9  (bases 1 to 1265)
  AUTHORS   Gavin AL, Barnes N, Dijstelbloem HM and Hogarth PM.
  TITLE     Identification of the mouse IgG3 receptor: implications for
            antibody effector function at the interface between innate and
            adaptive immunity
  JOURNAL   J Immunol 160 (1), 20-23 (1998)
   PUBMED   9551950
REFERENCE   10 (bases 1 to 1265)
  AUTHORS   Maresco DL, Blue LE, Culley LL, Kimberly RP, Anderson CL and Theil
            KS.
  TITLE     Localization of FCGR1 encoding Fcgamma receptor class I in
            primates: molecular evidence for two pericentric inversions during
            the evolution of human chromosome 1
  JOURNAL   Cytogenet Cell Genet 82 (1-2), 71-74 (1998)
   PUBMED   9763663
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from CO555980.1,
            CF113031.1 and AA859169.1.
            
            On or before Oct 25, 2007 this sequence version replaced
            XM_001062370.1, XM_215643.4.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC158809.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5756307,
                                           SAMEA5760383 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-661               CO555980.1         34-694
            662-943             CF113031.1         260-541
            944-1265            AA859169.1         1-322               c
FEATURES             Location/Qualifiers
     source          1..1265
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="2"
                     /map="2q34"
     gene            1..1265
                     /gene="Fcgr1a"
                     /gene_synonym="FcgammaRI; Fcgr1; Fcgr1b"
                     /note="Fc gamma receptor 1A"
                     /db_xref="GeneID:295279"
                     /db_xref="RGD:1309912"
     exon            1..46
                     /gene="Fcgr1a"
                     /gene_synonym="FcgammaRI; Fcgr1; Fcgr1b"
                     /inference="alignment:Splign:2.1.0"
     CDS             16..1077
                     /gene="Fcgr1a"
                     /gene_synonym="FcgammaRI; Fcgr1; Fcgr1b"
                     /note="high-affinity immunoglobulin gamma Fc receptor I;
                     Fc receptor, IgG, high affinity I; Fc gamma receptor Ia;
                     high affinity IgG Fc receptor, subunit beta; Fc fragment
                     of IgG, high affinity Ib, receptor for (CD64); Fc fragment
                     of IgG high affinity Ib receptor; Fc fragment of IgG
                     receptor Ia; Fc fragment of IgG, high affinity Ia,
                     receptor (CD64)"
                     /codon_start=1
                     /product="high affinity immunoglobulin gamma Fc receptor I
                     precursor"
                     /protein_id="NP_001094306.1"
                     /db_xref="GeneID:295279"
                     /db_xref="RGD:1309912"
                     /translation="MWLLTTLLLWVPVGGQVVNATKAVVTLQPPWLSIFQEENVTLLC
                     EGPHLGDSSTKWFINSTAIQISTPTYSILKASFKDSGEYKCQTGLSMPSDPVQLEIYR
                     DWLLLQTSHRVLTEGEPLALRCHPWQNKKVYNVAFYRNGESLDFSQGSEVTILKTNLS
                     HSGIYHCSAMGKKLFKSAGVSVTVKELFATPVLRVSLSSPFPEGSLVILNCETRLFLQ
                     SPGLRLYFSFYVGSKILEDRSTSSEYHIPRAEREDDGSYWCEVATEDGRVLKRSTKLE
                     LFGPQSSDPVWFHILFYLSVGIMFLVNTVLYVKIHRLQREKKYNLEVPLVSEKGKKAT
                     SFQQVRSDDVYEEVTATVR"
     exon            47..67
                     /gene="Fcgr1a"
                     /gene_synonym="FcgammaRI; Fcgr1; Fcgr1b"
                     /inference="alignment:Splign:2.1.0"
     exon            68..322
                     /gene="Fcgr1a"
                     /gene_synonym="FcgammaRI; Fcgr1; Fcgr1b"
                     /inference="alignment:Splign:2.1.0"
     exon            323..571
                     /gene="Fcgr1a"
                     /gene_synonym="FcgammaRI; Fcgr1; Fcgr1b"
                     /inference="alignment:Splign:2.1.0"
     exon            572..850
                     /gene="Fcgr1a"
                     /gene_synonym="FcgammaRI; Fcgr1; Fcgr1b"
                     /inference="alignment:Splign:2.1.0"
     exon            851..1249
                     /gene="Fcgr1a"
                     /gene_synonym="FcgammaRI; Fcgr1; Fcgr1b"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cagcttggag gtgacatgtg gcttctaacg actctgctac tttgggttcc agttggtggg
       61 caagtagtta atgccacaaa ggctgtggtc accttgcagc ccccatggct cagcattttc
      121 caggaggaaa atgtcacttt gttgtgtgag ggacctcacc tgggagacag ttccacaaag
      181 tggtttatca acagcacagc cattcagatc tccacaccta cctatagcat cctcaaggcc
      241 agtttcaagg acagtggtga atacaagtgt cagacaggtc tctcaatgcc aagtgaccct
      301 gtgcagttag aaatctacag agattggctg ctactccaga cctcccacag agtcctcaca
      361 gaaggagagc ctctggcctt gaggtgtcac ccgtggcaga ataagaaagt gtacaatgtg
      421 gctttctatc gaaatggaga atcccttgac ttttctcaag gttcagaggt caccattctg
      481 aaaaccaacc tgagtcacag cggcatctat cactgctcag ccatgggaaa aaaactcttc
      541 aagtctgcag gagtgtctgt caccgtgaaa gagctatttg ccacaccagt gctgagagtg
      601 tccttgtcat ctcccttccc ggaggggagt ctggtcatcc tgaactgtga gacaagattg
      661 ttcctgcaga gtcctggctt acggctttac ttctccttct atgtgggcag taagatcctg
      721 gaggacagga gcacatcctc cgagtaccac ataccaaggg ctgaaaggga agatgatgga
      781 tcatactggt gcgaggtagc cacggaggac ggccgtgtcc ttaagcgcag caccaagttg
      841 gagctatttg gtccccagtc atcagatcct gtctggtttc acatcctatt ttatctgtca
      901 gtgggaataa tgtttttggt gaacacagtt ctctatgtga aaatacacag gctgcagaga
      961 gagaaaaaat acaatttaga agtccctttg gtttctgaga aggggaagaa agcaacttcc
     1021 tttcagcaag ttagaagcga tgacgtgtat gaagaagtaa cagccactgt aagataggcc
     1081 accccaaaag aagctcctga aggacctcaa aactcaggtg accctggacc ttagcagcct
     1141 gaaccacttc ctctctgtgg cagtaccgtg gcacaaactt cccaaacttg accctgaaac
     1201 tgtgggacca aggcacacaa ctcttaaata aagcaaatat tcagactgaa aaaaaaaaaa
     1261 aaaaa
//
