LOCUS       NM_001033924            2025 bp    mRNA    linear   ROD 23-MAR-2023
DEFINITION  Rattus norvegicus Fc epsilon receptor II (Fcer2), transcript
            variant 1, mRNA.
ACCESSION   NM_001033924
VERSION     NM_001033924.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2025)
  AUTHORS   Buschow SI, van Balkom BW, Aalberts M, Heck AJ, Wauben M and
            Stoorvogel W.
  TITLE     MHC class II-associated proteins in B-cell exosomes and potential
            functional implications for exosome biogenesis
  JOURNAL   Immunol Cell Biol 88 (8), 851-856 (2010)
   PUBMED   20458337
REFERENCE   2  (bases 1 to 2025)
  AUTHORS   Perrigoue JG, Zaph C, Guild K, Du Y and Artis D.
  TITLE     IL-31-IL-31R interactions limit the magnitude of Th2
            cytokine-dependent immunity and inflammation following intestinal
            helminth infection
  JOURNAL   J Immunol 182 (10), 6088-6094 (2009)
   PUBMED   19414760
REFERENCE   3  (bases 1 to 2025)
  AUTHORS   Kurita N, Honda S, Usui K, Shimizu Y, Miyamoto A, Tahara-Hanaoka S,
            Shibuya K and Shibuya A.
  TITLE     Identification of the Fcalpha/muR isoform specifically expressed in
            the kidney tubules
  JOURNAL   Mol Immunol 46 (4), 749-753 (2009)
   PUBMED   19027165
  REMARK    GeneRIF: Immunohistochemical analyses suggested that the
            Fcalpha/muR isoform was expressed in the tubular epithelial cells,
            but not in the glomeruli.
REFERENCE   4  (bases 1 to 2025)
  AUTHORS   Li,H., Tang,N.L., Chan,P.K., Wang,C.Y., Hui,D.S., Luk,C., Kwok,R.,
            Huang,W., Sung,J.J., Kong,Q.P. and Zhang,Y.P.
  TITLE     Polymorphisms in the C-type lectin genes cluster in chromosome 19
            and predisposition to severe acute respiratory syndrome coronavirus
            (SARS-CoV) infection
  JOURNAL   J Med Genet 45 (11), 752-758 (2008)
   PUBMED   18697825
REFERENCE   5  (bases 1 to 2025)
  AUTHORS   Safeukui I, Vatan R, Dethoua M, Agbo H, Haumont G, Moynet D, Malvy
            D, Vincendeau P, Mossalayi D and Millet P.
  TITLE     A role of IgE and CD23/NO immune pathway in age-related resistance
            of Lewis rats to Plasmodium berghei Anka?
  JOURNAL   Microbes Infect 10 (12-13), 1411-1416 (2008)
   PUBMED   18761417
  REMARK    GeneRIF: These data suggest that IgE and CD23/NO could play an
            important role in the resistance of adult rats experiencing
            Plasmoidum berghei Anka primary intraerythrocytic development.
REFERENCE   6  (bases 1 to 2025)
  AUTHORS   Apasov SG, Blackburn MR, Kellems RE, Smith PT and Sitkovsky MV.
  TITLE     Adenosine deaminase deficiency increases thymic apoptosis and
            causes defective T cell receptor signaling
  JOURNAL   J Clin Invest 108 (1), 131-141 (2001)
   PUBMED   11435465
REFERENCE   7  (bases 1 to 2025)
  AUTHORS   Kong YY, Kishihara K, Sumichika H, Nakamura T, Kaneko M and Nomoto
            K.
  TITLE     Differential requirements of CD45 for lymphocyte development and
            function
  JOURNAL   Eur J Immunol 25 (12), 3431-3436 (1995)
   PUBMED   8566034
REFERENCE   8  (bases 1 to 2025)
  AUTHORS   Vouldoukis I, Riveros-Moreno V, Dugas B, Ouaaz F, Becherel P, Debre
            P, Moncada S and Mossalayi MD.
  TITLE     The killing of Leishmania major by human macrophages is mediated by
            nitric oxide induced after ligation of the Fc epsilon RII/CD23
            surface antigen
  JOURNAL   Proc Natl Acad Sci U S A 92 (17), 7804-7808 (1995)
   PUBMED   7544003
REFERENCE   9  (bases 1 to 2025)
  AUTHORS   Fujiwara H, Kikutani H, Suematsu S, Naka T, Yoshida K, Yoshida K,
            Tanaka T, Suemura M, Matsumoto N, Kojima S et al.
  TITLE     The absence of IgE antibody-mediated augmentation of immune
            responses in CD23-deficient mice
  JOURNAL   Proc Natl Acad Sci U S A 91 (15), 6835-6839 (1994)
   PUBMED   8041705
REFERENCE   10 (bases 1 to 2025)
  AUTHORS   Roes J and Rajewsky K.
  TITLE     Immunoglobulin D (IgD)-deficient mice reveal an auxiliary receptor
            function for IgD in antigen-mediated recruitment of B cells
  JOURNAL   J Exp Med 177 (1), 45-55 (1993)
   PUBMED   8418208
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BC078749.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC078749.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN16676785 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-2025              BC078749.1         1-2025
FEATURES             Location/Qualifiers
     source          1..2025
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="12"
                     /map="12p12"
     gene            1..2025
                     /gene="Fcer2"
                     /gene_synonym="CD23; Fcer2a"
                     /note="Fc epsilon receptor II"
                     /db_xref="GeneID:171075"
                     /db_xref="RGD:619997"
     exon            1..22
                     /gene="Fcer2"
                     /gene_synonym="CD23; Fcer2a"
                     /inference="alignment:Splign:2.1.0"
     exon            23..136
                     /gene="Fcer2"
                     /gene_synonym="CD23; Fcer2a"
                     /inference="alignment:Splign:2.1.0"
     CDS             115..1110
                     /gene="Fcer2"
                     /gene_synonym="CD23; Fcer2a"
                     /note="isoform a is encoded by transcript variant 1; Fc
                     receptor, IgE, low affinity II, alpha polypeptide; Fcalpha
                     muR; Fcalpha RII; Fc receptor alpha multiple ligand
                     receptor; low affinity immunoglobulin epsilon Fc receptor;
                     Fc fragment of IgE, low affinity II, receptor for (CD23);
                     Fc fragment of IgE receptor II"
                     /codon_start=1
                     /product="low affinity immunoglobulin epsilon Fc receptor
                     isoform a"
                     /protein_id="NP_001029096.1"
                     /db_xref="GeneID:171075"
                     /db_xref="RGD:619997"
                     /translation="MEENEYSGYWEPPRRRCCCARRGTQLVLVGLLTTVMWAGLLALL
                     LLWHWETEKSLKQLGDAAIQNVSHVTKDLQNYQSNQLAQKSQALQMSQNLEELQAEQK
                     QMKSQDSQLSQNLNELQEDLINVKSQNSELSQNLNTLQEDLVNVKSQGLNEKRAASDS
                     LEKLQEEVAKLWIEILMSKGTACNVCPKDWLHFQQKCYYFGEGSKQWIQAKFTCSDLE
                     GRLVSIHSQKEQDFLMQHINKKESWIGLQDLNMEGEFVWPDGSPVGYSNWSPGEPNNG
                     GQGEDCVMMRGSGQWNDAFCRSYLDAWVCEQLATCDLSAPLASVTPTGPTPKNEP"
     exon            137..256
                     /gene="Fcer2"
                     /gene_synonym="CD23; Fcer2a"
                     /inference="alignment:Splign:2.1.0"
     exon            257..310
                     /gene="Fcer2"
                     /gene_synonym="CD23; Fcer2a"
                     /inference="alignment:Splign:2.1.0"
     exon            311..373
                     /gene="Fcer2"
                     /gene_synonym="CD23; Fcer2a"
                     /inference="alignment:Splign:2.1.0"
     exon            374..436
                     /gene="Fcer2"
                     /gene_synonym="CD23; Fcer2a"
                     /inference="alignment:Splign:2.1.0"
     exon            437..499
                     /gene="Fcer2"
                     /gene_synonym="CD23; Fcer2a"
                     /inference="alignment:Splign:2.1.0"
     exon            500..562
                     /gene="Fcer2"
                     /gene_synonym="CD23; Fcer2a"
                     /inference="alignment:Splign:2.1.0"
     exon            563..652
                     /gene="Fcer2"
                     /gene_synonym="CD23; Fcer2a"
                     /inference="alignment:Splign:2.1.0"
     exon            653..804
                     /gene="Fcer2"
                     /gene_synonym="CD23; Fcer2a"
                     /inference="alignment:Splign:2.1.0"
     exon            805..911
                     /gene="Fcer2"
                     /gene_synonym="CD23; Fcer2a"
                     /inference="alignment:Splign:2.1.0"
     exon            912..2001
                     /gene="Fcer2"
                     /gene_synonym="CD23; Fcer2a"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 caaggacaga ctccaagttc aagtcactta cagagctgtg accacctgtg cagtggcaac
       61 taccttggca gatagtgcat gccccatcac tgaaaggatc caagcaagac tgccatggaa
      121 gaaaacgaat actcaggata ctgggagcct cctaggagac gatgctgctg tgcaagacgg
      181 gggactcagc tcgtgctggt ggggctactg accacagtaa tgtgggctgg cctgctggcc
      241 ctgctccttc tatggcactg ggaaacggag aagagtctaa aacagctggg agacgctgca
      301 atccagaacg tctcccatgt taccaaggac ttacaaaatt accagagtaa tcagttggcc
      361 cagaagtccc aggctcttca gatgtcacaa aacttggaag agctccaagc tgaacagaag
      421 caaatgaaat ctcaggactc tcagctctcc cagaacctga acgaactcca agaggatcta
      481 atcaacgtca aatcccagaa ctctgaactc tcccagaacc tgaacacact ccaagaggat
      541 ctagtcaacg tcaaatccca gggcttgaat gagaagcgcg cggcctcaga ttctctggag
      601 aagctacagg aagaggtggc aaaactgtgg attgagatac tgatgtcaaa gggaacggca
      661 tgcaacgtgt gtcccaagga ctggctccat ttccaacaga agtgctacta tttcggtgag
      721 ggctccaagc agtggatcca ggccaagttc acctgcagtg acctggaagg acggctagtc
      781 agcattcaca gccagaagga gcaggacttc ctgatgcaac atatcaacaa gaaggagtcc
      841 tggattggtc tccaggatct caacatggag ggagagttcg tatggccaga tgggagcccc
      901 gtgggttata gcaactggag tccaggggag cccaacaatg ggggccaggg tgaggactgt
      961 gtcatgatgc ggggatctgg ccagtggaat gacgccttct gccgcagcta cctggatgcc
     1021 tgggtgtgtg agcagctggc aacctgtgac ctatccgccc ccttagcctc tgtgacgcca
     1081 acaggaccca cccccaagaa tgaaccctga ctaagttctg tgcttcctct cctggatttc
     1141 tcctctacct ttgtcatgga aacaaccagg ccttgaggat gcccctgtca aggcccgatt
     1201 gctctctgtg actgaggcta ggattatgtc ccctcccaaa ctgaagtggc tggtggaggc
     1261 cagctcctgc cagctatcca gaaagcctct cccgctaagc tgaccattcc attccgtctg
     1321 ccctcttcaa acctgagccc cagccatact ggcatctgtg ggcagttaag ccaacccagg
     1381 agctactgag aacaaagatt ctgaggaagg cttcttctgc agtccccacc gcctatcaag
     1441 tcttccattt tcttctacgc tgcatcggag aacagaggtt ccctctcccc aggatccgga
     1501 agtgagtcct cccatcaagt gtgcaccagt gaaatccagt catggctggt ccccagcatt
     1561 cctaccctct ttggagctgc actaggtgta ctcctggtgt ggtacttatt gaagggactg
     1621 tggccagctc cagcgtggtg agcttggctc tgggaggcct tgcccttctc tcccattccc
     1681 tctgccttgc taaaagtgtt agatcacatt cctgaggcta gaccccaagg tctatcccct
     1741 tatttggcca ctttctcctc ctgaggccgc ctacaaaggt ccagctatcc aagtattaaa
     1801 gtccagcaat caaaagcccc cttcagtttc acctaattaa catacccaat cagaatacaa
     1861 cataacccag cctaccagac cgcctttttc tcttcataaa aattacacct gcaaggtcat
     1921 cggatgctgt ttttctgcct gagtcagaaa gcagccactt aacttttctt ccctgcttaa
     1981 taaagggtct ctctgagaaa aaaaaaaaaa aaaaaaaaaa aaaaa
//
