LOCUS       NM_012724               1108 bp    mRNA    linear   ROD 01-JUN-2024
DEFINITION  Rattus norvegicus Fc epsilon receptor Ia (Fcer1a), mRNA.
ACCESSION   NM_012724
VERSION     NM_012724.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1108)
  AUTHORS   Chen,Y.C., Chang,Y.C., Chang,H.A., Lin,Y.S., Tsao,C.W., Shen,M.R.
            and Chiu,W.T.
  TITLE     Differential Ca2+ mobilization and mast cell degranulation by
            FcepsilonRI- and GPCR-mediated signaling
  JOURNAL   Cell Calcium 67, 31-39 (2017)
   PUBMED   29029788
  REMARK    GeneRIF: Differential Ca(2+) mobilization and mast cell
            degranulation by FcepsilonRI- and GPCR-mediated signaling has been
            reported.
REFERENCE   2  (bases 1 to 1108)
  AUTHORS   Kassas,A., Moura,I.C., Yamashita,Y., Scheffel,J.,
            Guerin-Marchand,C., Blank,U., Sims,P.J., Wiedmer,T., Monteiro,R.C.,
            Rivera,J., Charles,N. and Benhamou,M.
  TITLE     Regulation of the tyrosine phosphorylation of Phospholipid
            Scramblase 1 in mast cells that are stimulated through the
            high-affinity IgE receptor
  JOURNAL   PLoS One 9 (10), e109800 (2014)
   PUBMED   25289695
  REMARK    GeneRIF: This study reveals a complex regulation for PLSCR1
            tyrosine phosphorylation in FcepsilonRI-activated mast cells, and
            that PLSCR1 sits at a crossroads between Lyn and Fyn pathways.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1108)
  AUTHORS   Motohashi,S., Koizumi,K., Honda,R., Maruyama,A., Palmer,H.E. and
            Mashima,K.
  TITLE     Protein tyrosine phosphatase-PEST (PTP-PEST) regulates mast
            cell-activating signals in PTP activity-dependent and -independent
            manners
  JOURNAL   Cell Immunol 289 (1-2), 128-134 (2014)
   PUBMED   24791697
  REMARK    GeneRIF: PTP-PEST expression was significantly induced upon
            FcepsilonRI-crosslinking, and aggregation of FcepsilonRI induced
            the phosphorylation of PTP-PEST at Ser39, thus resulting in the
            suppression of PTP activity.
REFERENCE   4  (bases 1 to 1108)
  AUTHORS   Zheng,M., Cho,D.I., Le,H.T., Cheon,S.H. and Kim,K.M.
  TITLE     Dual regulation of mast cell degranulation through IgE
            receptor-mediated modulation of M-type pyruvate kinase
  JOURNAL   Arch Pharm Res 37 (9), 1177-1182 (2014)
   PUBMED   24497038
  REMARK    GeneRIF: Data suggest M2PK (M2-type pyruvate kinase) is modulated
            in mast cell degranulation via IgE/FCERI signaling; immediate
            inhibition of M2PK involves tyrosine phosphorylation; subsequently
            fructose-1,6-biphosphate accumulates and activates M2PK.
REFERENCE   5  (bases 1 to 1108)
  AUTHORS   Fang,X., Hu,H., Xie,J., Zhu,H., Zhang,D., Mo,W., Zhang,R. and Yu,M.
  TITLE     An involvement of neurokinin-1 receptor in FcepsilonRIota-mediated
            RBL-2H3 mast cell activation
  JOURNAL   Inflamm Res 61 (11), 1257-1263 (2012)
   PUBMED   22820943
  REMARK    GeneRIF: NK-1 receptor is required for the activation of RBL-2H3
            cells following FcepsilonRIota engagement and involved in the
            regulation of mitogen-activated protein kinase signaling pathways
REFERENCE   6  (bases 1 to 1108)
  AUTHORS   Kuster,H., Zhang,L., Brini,A.T., MacGlashan,D.W. and Kinet,J.P.
  TITLE     The gene and cDNA for the human high affinity immunoglobulin E
            receptor beta chain and expression of the complete human receptor
  JOURNAL   J Biol Chem 267 (18), 12782-12787 (1992)
   PUBMED   1535625
REFERENCE   7  (bases 1 to 1108)
  AUTHORS   Ra,C., Jouvin,M.H. and Kinet,J.P.
  TITLE     Complete structure of the mouse mast cell receptor for IgE (Fc
            epsilon RI) and surface expression of chimeric receptors
            (rat-mouse-human) on transfected cells
  JOURNAL   J Biol Chem 264 (26), 15323-15327 (1989)
   PUBMED   2527850
REFERENCE   8  (bases 1 to 1108)
  AUTHORS   Tepler,I., Shimizu,A. and Leder,P.
  TITLE     The gene for the rat mast cell high affinity IgE receptor alpha
            chain. Structure and alternative mRNA splicing patterns
  JOURNAL   J Biol Chem 264 (10), 5912-5915 (1989)
   PUBMED   2522441
REFERENCE   9  (bases 1 to 1108)
  AUTHORS   Shimizu,A., Tepler,I., Benfey,P.N., Berenstein,E.H.,
            Siraganian,R.P. and Leder,P.
  TITLE     Human and rat mast cell high-affinity immunoglobulin E receptors:
            characterization of putative alpha-chain gene products
  JOURNAL   Proc Natl Acad Sci U S A 85 (6), 1907-1911 (1988)
   PUBMED   2964640
REFERENCE   10 (bases 1 to 1108)
  AUTHORS   Kinet,J.P., Metzger,H., Hakimi,J. and Kochan,J.
  TITLE     A cDNA presumptively coding for the alpha subunit of the receptor
            with high affinity for immunoglobulin E
  JOURNAL   Biochemistry 26 (15), 4605-4610 (1987)
   PUBMED   2959318
  REMARK    Erratum:[Biochemistry 1988 Nov 15;27(23):8694]
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from J03606.1.
            
            On Dec 21, 2006 this sequence version replaced NM_012724.3.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: J03606.1, M17153.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760476,
                                           SAMN06680453 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on expression, longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1108
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="13"
                     /map="13q24"
     gene            1..1108
                     /gene="Fcer1a"
                     /gene_synonym="Iger01; RATIGER01"
                     /note="Fc epsilon receptor Ia"
                     /db_xref="GeneID:25047"
                     /db_xref="RGD:2597"
     exon            1..102
                     /gene="Fcer1a"
                     /gene_synonym="Iger01; RATIGER01"
                     /inference="alignment:Splign:2.1.0"
     CDS             54..791
                     /gene="Fcer1a"
                     /gene_synonym="Iger01; RATIGER01"
                     /note="high affinity immunoglobulin epsilon receptor
                     subunit alpha; fcERI; fc-epsilon RI-alpha; igE Fc receptor
                     subunit alpha; Fc fragment of IgE, high affinity I,
                     receptor for; alpha polypeptide; Fc receptor, IgE, high
                     affinity I, alpha polypeptide; Fc fragment of IgE receptor
                     Ia"
                     /codon_start=1
                     /product="high affinity immunoglobulin epsilon receptor
                     subunit alpha precursor"
                     /protein_id="NP_036856.1"
                     /db_xref="GeneID:25047"
                     /db_xref="RGD:2597"
                     /translation="MDTGGSARLCLALVLISLGVMLTATQKSVVSLDPPWIRILTGDK
                     VTLICNGNNSSQMNSTKWIHNDSISNVKSSHWVIVSATIQDSGKYICQKQGFYKSKPV
                     YLNVMQEWLLLQSSADVVLDNGSFDIRCRSWKKWKVHKVIYYKDDIAFKYSYDSNNIS
                     IRKATFNDSGSYHCTGYLNKVECKSDKFSIAVVKDYTIEYRWLQLIFPSLAVILFAVD
                     TGLWFSTHKQFESILKIQKTGKGKKKG"
     exon            103..123
                     /gene="Fcer1a"
                     /gene_synonym="Iger01; RATIGER01"
                     /inference="alignment:Splign:2.1.0"
     exon            124..378
                     /gene="Fcer1a"
                     /gene_synonym="Iger01; RATIGER01"
                     /inference="alignment:Splign:2.1.0"
     exon            379..636
                     /gene="Fcer1a"
                     /gene_synonym="Iger01; RATIGER01"
                     /inference="alignment:Splign:2.1.0"
     exon            637..1108
                     /gene="Fcer1a"
                     /gene_synonym="Iger01; RATIGER01"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 acttttgaag ccgtagctca ctggtgcagt tagcacctga aggcacaggg gcaatggata
       61 ctggaggatc tgcccggctg tgcctagcat tagtgctcat atctctgggt gtcatgctaa
      121 cagccactca gaaatctgta gtgtccttgg acccaccgtg gattagaata cttacaggag
      181 ataaagtgac tcttatatgc aatgggaaca attcctctca aatgaactct actaaatgga
      241 tccacaatga tagcatctct aatgtgaaat cgtcacattg ggtcattgtg agtgccacca
      301 ttcaagacag tggaaaatac atatgtcaga agcaaggatt ttataagagc aaacctgtgt
      361 acttgaacgt gatgcaagag tggctgctgc tccaatcttc tgctgacgtg gtcttagaca
      421 atggatcctt tgacatcaga tgccgtagct ggaagaaatg gaaagtccac aaggtgatct
      481 actacaagga cgacattgct ttcaagtact cttatgacag caacaacatc tccattagaa
      541 aggccacatt taatgacagt ggcagctacc actgcacagg ctatttgaac aaggttgaat
      601 gtaaatctga taaattcagt attgctgtag taaaagatta cacaattgag tatcgttggc
      661 tacaactcat tttcccatca ttggcggtga ttctgtttgc tgtggacact gggttatggt
      721 tctcaaccca caaacagttc gaatccatct tgaagattca gaagactgga aaaggcaaaa
      781 aaaaaggttg aaacctaact cttaaccaag gtatataaag gaactaatgt catcgcttaa
      841 gagacaattc ttaacaatta tttcccacag tatcttcaat agcctttcaa ctgtcaaagg
      901 acactcatgt tatccataga aatgtctgta ccccaggaat tgcataaatg cttcattaaa
      961 ccaacagcag ctggttaagt gacatgcaat aaataacaaa tactcaataa acactggttt
     1021 aagaagttaa agaatgagct gattgctttg tctatatctg taaaagagaa gtacaatttg
     1081 aataaagtat ggaatcatgt agaatggt
//
