LOCUS       NM_201992               1742 bp    mRNA    linear   ROD 20-MAR-2023
DEFINITION  Rattus norvegicus Fc alpha receptor (Fcar), mRNA.
ACCESSION   NM_201992
VERSION     NM_201992.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1742)
  AUTHORS   Wehrli M, Cortinas-Elizondo F, Hlushchuk R, Daudel F, Villiger PM,
            Miescher S, Zuercher AW, Djonov V, Simon HU and von Gunten S.
  TITLE     Human IgA Fc receptor FcalphaRI (CD89) triggers different forms of
            neutrophil death depending on the inflammatory microenvironment
  JOURNAL   J Immunol 193 (11), 5649-5659 (2014)
   PUBMED   25339672
REFERENCE   2  (bases 1 to 1742)
  AUTHORS   Berthelot L, Papista C, Maciel TT, Biarnes-Pelicot M, Tissandie E,
            Wang PH, Tamouza H, Jamin A, Bex-Coudrat J, Gestin A, Boumediene A,
            Arcos-Fajardo M, England P, Pillebout E, Walker F, Daugas E,
            Vrtosvnik F, Flamant M, Benhamou M, Cogne M, Moura IC and Monteiro
            RC.
  TITLE     Transglutaminase is essential for IgA nephropathy development
            acting through IgA receptors
  JOURNAL   J Exp Med 209 (4), 793-806 (2012)
   PUBMED   22451718
REFERENCE   3  (bases 1 to 1742)
  AUTHORS   Kelley JM, Monach PA, Ji C, Zhou Y, Wu J, Tanaka S, Mahr AD,
            Johnson S, McAlear C, Cuthbertson D, Carette S, Davis JC Jr,
            Dellaripa PF, Hoffman GS, Khalidi N, Langford CA, Seo P, St Clair
            EW, Specks U, Stone JH, Spiera RF, Ytterberg SR, Merkel PA, Edberg
            JC and Kimberly RP.
  TITLE     IgA and IgG antineutrophil cytoplasmic antibody engagement of Fc
            receptor genetic variants influences granulomatosis with
            polyangiitis
  JOURNAL   Proc Natl Acad Sci U S A 108 (51), 20736-20741 (2011)
   PUBMED   22147912
REFERENCE   4  (bases 1 to 1742)
  AUTHORS   Watanabe T, Kanamaru Y, Liu C, Suzuki Y, Tada N, Okumura K,
            Horikoshi S and Tomino Y.
  TITLE     Negative regulation of inflammatory responses by immunoglobulin A
            receptor (FcalphaRI) inhibits the development of Toll-like
            receptor-9 signalling-accelerated glomerulonephritis
  JOURNAL   Clin Exp Immunol 166 (2), 235-250 (2011)
   PUBMED   21985370
REFERENCE   5  (bases 1 to 1742)
  AUTHORS   Kanamaru Y, Pfirsch S, Aloulou M, Vrtovsnik F, Essig M, Loirat C,
            Deschenes G, Guerin-Marchand C, Blank U and Monteiro RC.
  TITLE     Inhibitory ITAM signaling by Fc alpha RI-FcR gamma chain controls
            multiple activating responses and prevents renal inflammation
  JOURNAL   J Immunol 180 (4), 2669-2678 (2008)
   PUBMED   18250479
REFERENCE   6  (bases 1 to 1742)
  AUTHORS   Maruoka T, Nagata T and Kasahara M.
  TITLE     Identification of the rat IgA Fc receptor encoded in the leukocyte
            receptor complex
  JOURNAL   Immunogenetics 55 (10), 712-716 (2004)
   PUBMED   14647992
  REMARK    GeneRIF: The rat Fcar gene has an exon-intron structure essentially
            identical to that of the human counterpart and is encoded in the
            leukocyte receptor complex on Chromosome 1.
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from AB109766.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AB109766.1, AB109767.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN06680412, SAMN06680413
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1742
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q12"
     gene            1..1742
                     /gene="Fcar"
                     /gene_synonym="CD89"
                     /note="Fc alpha receptor"
                     /db_xref="GeneID:365183"
                     /db_xref="RGD:1303082"
     exon            1..68
                     /gene="Fcar"
                     /gene_synonym="CD89"
                     /inference="alignment:Splign:2.1.0"
     CDS             35..877
                     /gene="Fcar"
                     /gene_synonym="CD89"
                     /note="immunoglobulin alpha Fc receptor; IgA Fc receptor;
                     Fc fragment of IgA, receptor for; Fc fragment of IgA
                     receptor"
                     /codon_start=1
                     /product="immunoglobulin alpha Fc receptor precursor"
                     /protein_id="NP_973721.1"
                     /db_xref="GeneID:365183"
                     /db_xref="RGD:1303082"
                     /translation="MAPQDNTFLCLVICLGQTIWAQEDFPIPIISTATNPMVSWNESV
                     RILCRGTPEAFLYQLSLMKNSTQTVIEKKLGFQKEAEFIINHMNSTLAGCYQCQYRKK
                     NHWSEQSKPLKLVVTGLYDKPVLSTDQSLVLLPGENVSFKCSSAHNLFNRFSLAKEGE
                     ASLPLHQHKESQGNFHLGPVNADFIGKYRCYGWHNNSPYVWSAPSDALELIVSVTSLD
                     SEKHDYVMENSIRIGMAGLVLVILLVIVSEDWYSHRISHKECCQERAAKRWSKQGVRP
                     SDCR"
     exon            69..104
                     /gene="Fcar"
                     /gene_synonym="CD89"
                     /inference="alignment:Splign:2.1.0"
     exon            105..386
                     /gene="Fcar"
                     /gene_synonym="CD89"
                     /inference="alignment:Splign:2.1.0"
     exon            387..674
                     /gene="Fcar"
                     /gene_synonym="CD89"
                     /inference="alignment:Splign:2.1.0"
     exon            675..1742
                     /gene="Fcar"
                     /gene_synonym="CD89"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1724..1729
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Fcar"
                     /gene_synonym="CD89"
ORIGIN      
        1 aagaagctaa ctggtctgag gccatatcag catcatggcc cctcaggaca acaccttcct
       61 atgtcttgtg atctgcctgg gtcagacaat ttgggcacaa gaagattttc ccattcccat
      121 catatccact gcaacaaatc ctatggtttc ctggaatgag tctgtgagga tcctgtgcag
      181 gggaacaccg gaagccttcc tgtatcagtt gtccctgatg aaaaactcca cacaaacagt
      241 tatagagaag aaactaggat ttcaaaaaga ggctgaattc attatcaacc acatgaattc
      301 aacactggca ggatgttatc agtgtcagta taggaagaag aaccactggt cagagcagag
      361 taaacccctg aagctagtgg tgacaggctt gtatgacaaa cctgtcctct ccacagatca
      421 aagccttgtg ttgttaccag gagagaacgt ttccttcaag tgtagttcag cccacaacct
      481 gttcaacaga ttttcactgg ccaaagaggg agaagcttcc ttgccattgc accaacataa
      541 ggagtctcaa ggcaacttcc acctgggtcc tgtgaacgct gacttcattg gaaaatacag
      601 atgctacggc tggcacaaca acagccccta tgtgtggtca gcccccagtg atgccctgga
      661 gctcattgtc tcagttacat ctctagactc cgagaagcat gattacgtga tggagaattc
      721 aatccggata ggtatggctg ggctggtcct tgtcatactc ttggtgatag tatctgaaga
      781 ttggtacagc cacaggatct cacacaagga atgctgtcag gaacgggctg caaagagatg
      841 gagcaaacag ggtgtcagac ctagtgactg tagataaata ctgggaacca caggttcttg
      901 caaacaggaa aagccattaa aagcttggat ctatctgaag gctacaaggt ttgagcgaaa
      961 agtgtccacc acaggctcat gtgtttgaat acttactctc cagcagagga tgctgtttgg
     1021 ggagatgtat agaaccttca agttgtgata tatatagttc actggaggct actctttgaa
     1081 ggttatagtc acttcaggtt cccatctaga tgtctaccac catacactcc catggaactg
     1141 cttctatgat attcctttct gccatgatag aatactccct ctgaaaagat gagccagaat
     1201 cagtctcgtc tttcttcctg tcaggtggca aaaaaattaa ccaatacaca gagacatcag
     1261 atggtatggt catggattga tctggtgcta tatcttctct attagttagc acacaacttt
     1321 ggcgttttaa tacatttttc ttttatttgt gagcttataa tataattaca caatttcatt
     1381 cttcccttgg ataggttttg tcaacttgaa acaaactagg agcatctggg gagagggtac
     1441 tttaattgaa aaaatacttc agtcagcttg cccttcaagc aagcctgtgg ggtattttct
     1501 tgattaacgg ttgctgtggg agcagggagg ccagctcact gtgggtggca tctccctggg
     1561 caggtgtttc tgggttttag gaaaagcaaa ctgagcaagc catggagagc aagccagtaa
     1621 gcagcattct ttcgtggact ctgccttcag ctcctgcctc catgcgtatg ctttcacttt
     1681 ctaccctggc ttcccctgat gatggaatgt aacctgtaaa ccaaataaat cttttcctcc
     1741 ac
//
