LOCUS       NM_001419528            5178 bp    mRNA    linear   ROD 19-FEB-2024
DEFINITION  Rattus norvegicus F-box and WD repeat domain containing 7 (Fbxw7),
            mRNA.
ACCESSION   NM_001419528 XM_039103740
VERSION     NM_001419528.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 5178)
  AUTHORS   Wang,F. and Wu,Y.
  TITLE     lncRNA DLX6-AS1 Promotes Myocardial Ischemia-Reperfusion Injury
            through Mediating the miR-204-5p/FBXW7 Axis
  JOURNAL   Mediators Inflamm 2023, 9380398 (2023)
   PUBMED   36660176
  REMARK    GeneRIF: lncRNA DLX6-AS1 Promotes Myocardial Ischemia-Reperfusion
            Injury through Mediating the miR-204-5p/FBXW7 Axis.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 5178)
  AUTHORS   Li,S., Deng,J., Sun,D., Chen,S., Yao,X., Wang,N., Zhang,J., Gu,Q.,
            Zhang,S., Wang,J., Zhu,S., Zhu,H., Li,H., Xu,X. and Wei,F.
  TITLE     FBXW7 alleviates hyperglycemia-induced endothelial oxidative stress
            injury via ROS and PARP inhibition
  JOURNAL   Redox Biol 58, 102530 (2022)
   PUBMED   36427396
  REMARK    GeneRIF: FBXW7 alleviates hyperglycemia-induced endothelial
            oxidative stress injury via ROS and PARP inhibition.
REFERENCE   3  (bases 1 to 5178)
  AUTHORS   Sun,L.
  TITLE     F-box and WD repeat domain-containing 7 (FBXW7) mediates the
            hypoxia inducible factor-1alpha (HIF-1alpha)/vascular endothelial
            growth factor (VEGF) signaling pathway to affect hypoxic-ischemic
            brain damage in neonatal rats
  JOURNAL   Bioengineered 13 (1), 560-572 (2022)
   PUBMED   34951343
  REMARK    GeneRIF: F-box and WD repeat domain-containing 7 (FBXW7) mediates
            the hypoxia inducible factor-1alpha (HIF-1alpha)/vascular
            endothelial growth factor (VEGF) signaling pathway to affect
            hypoxic-ischemic brain damage in neonatal rats.
REFERENCE   4  (bases 1 to 5178)
  AUTHORS   Ko,Y.U., Song,H.Y., Kim,W.K., Yune,T.Y., Yun,N. and Oh,Y.J.
  TITLE     Calpain-mediated cleavage of Fbxw7 during excitotoxicity
  JOURNAL   Neurosci Lett 736, 135265 (2020)
   PUBMED   32707070
  REMARK    GeneRIF: Calpain-mediated cleavage of Fbxw7 during excitotoxicity.
REFERENCE   5  (bases 1 to 5178)
  AUTHORS   Li,X., Zhang,N., Zhang,Y., Jia,P., Guo,Y., Tian,Y., You,S., Wu,S.
            and Sun,Y.
  TITLE     E3 ligase Fbw7 participates in oxidative stress-induced myocardial
            cell injury via interacting with Mcl-1
  JOURNAL   Mol Med Rep 20 (2), 1561-1568 (2019)
   PUBMED   31257502
  REMARK    GeneRIF: Fbw7 participates in oxidative stress-induced myocardial
            cell injury via interacting with Mcl1.
REFERENCE   6  (bases 1 to 5178)
  AUTHORS   Yada,M., Hatakeyama,S., Kamura,T., Nishiyama,M., Tsunematsu,R.,
            Imaki,H., Ishida,N., Okumura,F., Nakayama,K. and Nakayama,K.I.
  TITLE     Phosphorylation-dependent degradation of c-Myc is mediated by the
            F-box protein Fbw7
  JOURNAL   EMBO J 23 (10), 2116-2125 (2004)
   PUBMED   15103331
REFERENCE   7  (bases 1 to 5178)
  AUTHORS   Staropoli,J.F., McDermott,C., Martinat,C., Schulman,B., Demireva,E.
            and Abeliovich,A.
  TITLE     Parkin is a component of an SCF-like ubiquitin ligase complex and
            protects postmitotic neurons from kainate excitotoxicity
  JOURNAL   Neuron 37 (5), 735-749 (2003)
   PUBMED   12628165
REFERENCE   8  (bases 1 to 5178)
  AUTHORS   Li,J., Pauley,A.M., Myers,R.L., Shuang,R., Brashler,J.R., Yan,R.,
            Buhl,A.E., Ruble,C. and Gurney,M.E.
  TITLE     SEL-10 interacts with presenilin 1, facilitates its ubiquitination,
            and alters A-beta peptide production
  JOURNAL   J Neurochem 82 (6), 1540-1548 (2002)
   PUBMED   12354302
REFERENCE   9  (bases 1 to 5178)
  AUTHORS   Maruyama,S., Hatakeyama,S., Nakayama,K., Ishida,N., Kawakami,K. and
            Nakayama,K.
  TITLE     Characterization of a mouse gene (Fbxw6) that encodes a homologue
            of Caenorhabditis elegans SEL-10
  JOURNAL   Genomics 78 (3), 214-222 (2001)
   PUBMED   11735228
REFERENCE   10 (bases 1 to 5178)
  AUTHORS   Gupta-Rossi,N., Le Bail,O., Gonen,H., Brou,C., Logeat,F., Six,E.,
            Ciechanover,A. and Israel,A.
  TITLE     Functional interaction between SEL-10, an F-box protein, and the
            nuclear form of activated Notch1 receptor
  JOURNAL   J Biol Chem 276 (37), 34371-34378 (2001)
   PUBMED   11425854
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JACYVU010000069.1.
            
            [WARNING] On Apr 3, 2024 this sequence was replaced by
            NM_001419528.2.
            
            On Apr 7, 2023 this sequence version replaced XM_039103740.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            RNAseq introns :: single sample supports all introns SAMD00132291,
                              SAMD00132295 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            inferred exon combination :: based on alignments, homology
            RefSeq Select criteria    :: based on manual assertion,
                                         conservation, expression, longest
                                         protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1154              JACYVU010000069.1  36622126-36623279
            1155-1202           JACYVU010000069.1  36671240-36671287
            1203-1266           JACYVU010000069.1  36671412-36671475
            1267-1854           JACYVU010000069.1  36709445-36710032
            1855-1937           JACYVU010000069.1  36758249-36758331
            1938-2079           JACYVU010000069.1  36762382-36762523
            2080-2214           JACYVU010000069.1  36769648-36769782
            2215-2338           JACYVU010000069.1  36772051-36772174
            2339-2475           JACYVU010000069.1  36773834-36773970
            2476-2589           JACYVU010000069.1  36775532-36775645
            2590-2771           JACYVU010000069.1  36777029-36777210
            2772-2997           JACYVU010000069.1  36779020-36779245
            2998-3208           JACYVU010000069.1  36780765-36780975
            3209-5178           JACYVU010000069.1  36781987-36783956
FEATURES             Location/Qualifiers
     source          1..5178
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="2"
                     /map="2q34"
     gene            1..5178
                     /gene="Fbxw7"
                     /gene_synonym="Fbw7"
                     /note="F-box and WD repeat domain containing 7"
                     /db_xref="GeneID:100360914"
                     /db_xref="RGD:2321145"
     exon            1..1154
                     /gene="Fbxw7"
                     /gene_synonym="Fbw7"
                     /inference="alignment:Splign:2.1.0"
     exon            1155..1202
                     /gene="Fbxw7"
                     /gene_synonym="Fbw7"
                     /inference="alignment:Splign:2.1.0"
     exon            1203..1266
                     /gene="Fbxw7"
                     /gene_synonym="Fbw7"
                     /inference="alignment:Splign:2.1.0"
     exon            1267..1854
                     /gene="Fbxw7"
                     /gene_synonym="Fbw7"
                     /inference="alignment:Splign:2.1.0"
     CDS             1336..3477
                     /gene="Fbxw7"
                     /gene_synonym="Fbw7"
                     /note="F-box and WD-40 domain protein 7; F-box and WD
                     repeat domain containing 7, E3 ubiquitin protein ligase"
                     /codon_start=1
                     /product="F-box/WD repeat-containing protein 7"
                     /protein_id="NP_001406457.1"
                     /db_xref="GeneID:100360914"
                     /db_xref="RGD:2321145"
                     /translation="MNQELLSVGSKRRRTGGSLRGNASSSQVDEEQMNRVVEEDPQQQ
                     PRHQEEEHTARNGELVGADPRPGAQNDSQQGQVEENNNRFVSVDEDSSGNQEEQEEDE
                     EHAGEQEEEEEEEEEEEEEEEMDQESDDFDQSDDSSREDEHTHNSNVTNCTSVVDLPI
                     NQLSSPFYTKTTKMKRKLDHGSEVRSFSLGKKPCKVSDYTSTTGLVPCSATPTTFGDL
                     RAANGQGQQRRRITSVQPPTGLQEWLKMFQSWSGPEKLLALDELIDSCEPTQVKHMMQ
                     VIEPQFQRDFISLLPKELALYVLSFLEPKDLLQAAQTCRYWRILAEDNLLWREKCKEE
                     GIDEPLHIKRRKIIKPGFIHSPWKSAYIRQHRIDTNWRRGELRSPKVLKGHDDHVITC
                     LQFCGNRIVSGSDDNTLKVWSAVTGKCLRTLVGHTGGVWSSQMRDNIIISGSTDRTLK
                     VWNAETGECIHTLYGHTSTVRCMHLHEKRVVSGSRDATLRVWDIETGQCLHVLMGHVA
                     AVRCVQYDGRRVVSGAYDFMVKVWDPETETCLHTLQGHTNRVYSLQFDGIHVVSGSLD
                     TSIRVWDVETGNCIHTLTGHQSLTSGMELKDNILVSGNADSTVKIWDIKTGQCLQTLQ
                     GPSKHQSAVTCLQFNKNFVITSSDDGTVKLWDLKTGEFIRNLVTLESGGSGGVVWRIR
                     ASNTKLVCAVGSRNGTEETKLLVLDFDVDMK"
     exon            1855..1937
                     /gene="Fbxw7"
                     /gene_synonym="Fbw7"
                     /inference="alignment:Splign:2.1.0"
     exon            1938..2079
                     /gene="Fbxw7"
                     /gene_synonym="Fbw7"
                     /inference="alignment:Splign:2.1.0"
     exon            2080..2214
                     /gene="Fbxw7"
                     /gene_synonym="Fbw7"
                     /inference="alignment:Splign:2.1.0"
     exon            2215..2338
                     /gene="Fbxw7"
                     /gene_synonym="Fbw7"
                     /inference="alignment:Splign:2.1.0"
     exon            2339..2475
                     /gene="Fbxw7"
                     /gene_synonym="Fbw7"
                     /inference="alignment:Splign:2.1.0"
     exon            2476..2589
                     /gene="Fbxw7"
                     /gene_synonym="Fbw7"
                     /inference="alignment:Splign:2.1.0"
     exon            2590..2771
                     /gene="Fbxw7"
                     /gene_synonym="Fbw7"
                     /inference="alignment:Splign:2.1.0"
     exon            2772..2997
                     /gene="Fbxw7"
                     /gene_synonym="Fbw7"
                     /inference="alignment:Splign:2.1.0"
     exon            2998..3208
                     /gene="Fbxw7"
                     /gene_synonym="Fbw7"
                     /inference="alignment:Splign:2.1.0"
     exon            3209..5178
                     /gene="Fbxw7"
                     /gene_synonym="Fbw7"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cccgcccctc tctggagtga ggcgagagcc ccgcacagag cgagagagac agcgagctga
       61 gcttcgggcg ctgccgccgc cgccggtgag agcgagtgag tgagcgagcg agcatccgag
      121 agacccggca cccgtgcact ggccgccgcc gagaccttcg ccgcagcccg ggccatcggg
      181 agccgtggcc gccgtctgct ccccccctta ccttcccggc cggcagcggc tgctgcacac
      241 gccgaagcgg gagccccagc cagagccgga gccagagccg gagccggagc ccgcggccgg
      301 ggggcaggga ggcggctgcc gccggtcggg actcgtagct gctcagccgg gagaggacgc
      361 ccgcgagggg ctgggctttc tgcctcgccc cggagtgtgg ggcgaaggac cccccgaggt
      421 gtagggaggg ggtcccggcc gccgcgacac atgcgggagc cgggagcggg ggcggcgccg
      481 atccgagccc gccgggtccc cagccttgcc gccgtccaga ccggccgacc cgggccgtag
      541 catcccatag cggagtgtat gaaccggggc ccccagccca ggagccacct ccgggccggg
      601 ggggcgggga ccccgatgtg aaacggccgc ggcggcgtgg tgagcggccc gggcgccgct
      661 gtcctctcct tcccctcccc tccccttcac cccctctggg gggcttctcc ttgggcccgc
      721 cgccgcaccc cggctcctcg gcgggactcc aggagttctc ggcgccccct ccccgcccca
      781 gccccccagg gcggcggggc cgggggggac tcggggggcc ggctgcagcc tccgcccaga
      841 ggaaacttta cccaaacaaa atcttcgagc tttctgattg tgactgtccc gggacaagtg
      901 gcccaggacg ggctgaagcc acagcctgca gagacccagg aagagaaaaa gcggtgagcg
      961 gggctgctgc cgctgccgcc gccgccgcct cagcttctat cccggcagcg cggaagagac
     1021 ccgggtagct gctccgtgga gcgacgctag caccgcttct tagttccgcg cctagccttc
     1081 cgcagctgcc cgcctcagcc cgaaggagga agggagccag ccacattgtc agcgccaccg
     1141 ctcgtctctg aagcgaaatc tctgctatca acgagacttt taaaaggctc tctaaatatt
     1201 tggtacgaga atttcttctc tttatatctt ttgtgatccc tctacacatt gtgtctaggc
     1261 aatcagaatg tgaaaatctt tgcatcttct gatagtctag ccaaggtcca agaagtagca
     1321 agctggcttt tggaaatgaa tcaggaactg ctctctgtgg gcagcaaaag acgacgaact
     1381 ggaggctctc tgagagggaa tgcttcctca agccaggttg atgaggagca gatgaatcgc
     1441 gtggttgagg aggacccaca gcagcagccg agacatcagg aggaggagca cactgcgcgg
     1501 aatggtgaac ttgtgggtgc agaccctagg cctggagccc agaacgattc ccagcaagga
     1561 caagtggaag aaaataataa ccgctttgtt tcagtagatg aggactcttc gggaaaccag
     1621 gaagagcagg aggaagatga agaacatgct ggggaacagg aggaggagga ggaagaagag
     1681 gaggaagagg aggaggagga ggagatggac caggagagtg atgattttga ccagtctgat
     1741 gacagtagca gggaagatga acatactcac aatagcaatg tcacaaactg cactagtgtc
     1801 gtggacctgc ccatcaacca gctctcctcc ccattctata ccaagacaac aaagatgaaa
     1861 agaaagttgg accatggctc tgaggtccgt tccttttctt tgggaaagaa accatgcaaa
     1921 gtctcagatt ataccagtac cactgggctt gtaccatgtt cagcaacacc aacaactttt
     1981 ggggacctga gagcagccaa tgggcaaggg cagcaacggc ggaggattac atctgtgcag
     2041 ccgcccacag gcctccaaga gtggctgaaa atgtttcaga gctggagtgg accagagaag
     2101 ttgctggcct tagatgagct catcgatagc tgtgaaccca cacaagtgaa gcacatgatg
     2161 caagtgatcg agccccagtt ccagcgagac ttcatctcct tgctccccaa agagctggca
     2221 ctctatgtac tttcattcct ggaacccaaa gacctgctgc aagcggctca gacgtgtcga
     2281 tactggagga ttttggctga ggataacctt ctctggagag agaaatgtaa agaagagggg
     2341 attgatgaac cgttgcacat caagagaaga aaaataataa aaccaggttt catacacagc
     2401 ccatggaaga gtgcgtacat cagacagcac agaattgata caaactggag gcgaggagaa
     2461 ctcagatctc ctaaggtgct gaaagggcat gatgatcatg tgattacgtg cctacagttt
     2521 tgtggtaacc gcatagttag tggttctgat gacaacactt taaaagtttg gtcagcggtc
     2581 acgggtaagt gtctgaggac gttagtggga cacaccggtg gagtgtggtc ttcacagatg
     2641 agagacaata tcatcattag tggatctact gaccggactc tcaaagtgtg gaatgcagag
     2701 actggagagt gtatacatac gttatatggg cacacctcca ctgtacggtg tatgcatctc
     2761 catgaaaaaa gggttgtgag cggttctcga gatgccactc tcagggtttg ggatattgag
     2821 accggccagt gtttacacgt cttgatgggc catgtggcag cagtccgctg tgttcagtat
     2881 gatggcagga gggttgttag tggagcatat gattttatgg tgaaggtgtg ggatccagag
     2941 accgagacct gtctacacac gttacaggga cacactaata gagtctattc gttacagttt
     3001 gacggcatcc atgtggtgag tggatctctt gatacatcaa tccgagtctg ggatgtggag
     3061 acagggaatt gcattcacac gctaacagga caccagtcgt taacaagtgg aatggaactc
     3121 aaagacaata ttctggtctc tgggaatgca gattctacag ttaaaatctg ggatatcaaa
     3181 acaggacagt gtttacagac attgcaaggt cccagcaagc atcagagcgc tgtgacctgc
     3241 ttacagttca acaagaactt tgtaattacc agctcagacg atggaacggt aaaactctgg
     3301 gacttgaaaa cgggtgaatt tatccgaaac ctagtcacat tggagagtgg ggggagcggg
     3361 ggagtcgtgt ggcggatcag ggcctcaaac acgaagctgg tgtgtgcagt tgggagtcgg
     3421 aatgggactg aggagaccaa gctgctggtg ctggactttg atgtggacat gaaatgaaaa
     3481 gcagacaaga tgaattttgt ccgactgtgt agacaatata ctccctgccc ttccccctcg
     3541 caacaaacaa acaaacaaac aaaaaatgaa aaaaaaaaca gaaaaaaaaa agaaaaaaga
     3601 aaagaaaaaa aaatcccttg tactcagtgg tgcaggatgt tggcttggga caacagactg
     3661 aaaagaccta cagactaagg aggtaagaag aagacaagag accgtaactg accggaggcg
     3721 gcagctgtcg catcacccaa aggcctcact tctgactgag gggcagcttg gcgaaaggag
     3781 actctaaacc caaccaggtg caattgttct ttattttctt ctccagtggt cactgggcag
     3841 agcttcatca gcgttgttac cttcaccaag gagcagtggt ggtgatctcc aaacacgggc
     3901 tggttatctt ccaatcagag catctgcaac aaaaagtcat ttttctgaag tggaaaagct
     3961 taaattactg tgaattgttt gtgtacagtt accatgaagc attctttttc tttctttttt
     4021 tttttttttt tttttttttt tcctttttct tttttttctt tttttttttt ctttttcttt
     4081 tttttttttt tttttttttg ccaaccattg ccaatgtcaa tcaatcacag tattagcctc
     4141 tgttaatcta tttactgttg cttctatata cactcttcaa tgcatatgtt gctcaaagat
     4201 ggcaagttgt cctgggttct gtgagtcctg aggtggattt agttcttgat gctggtgcta
     4261 gaagtaggtc ttcaaatacg ggatcgttgt cccacccctg tactgtactc ccagtggcca
     4321 aacttattta tgctgctaaa tgaaagaaag aaaaagcaaa ttattttttt ttttattttt
     4381 tttctgctgt gacgttttag tcccagactg aattccaaat ttgctctagt ttggttacag
     4441 aaaaaaaaaa aaaaaaaaga cttttttgcc actgaaactt gagccatctg tgcctctaag
     4501 aggctgagaa tggaaaagtt tcagataata aagagtgaag tttgcctgca aataaagaat
     4561 cgagagtgtg tgcaaagctt attttctttt atctgggcaa aaattaaaac acattccttg
     4621 ggacagagcc tgaggtgcct gttctgtgga gaaacttctt tttgagggct gtggtgaatg
     4681 gatgaacata catagtaaaa ctgacaagat attttaaaga tatatataat acaaaacaaa
     4741 aggaagttgc tggtcagtcg taccatcgta cagtatttgg gaaaacaact gttacagttt
     4801 cattgctctg agtgactgac gtgagaggaa ttcgctctgc agtgccgctg tcgctcccgt
     4861 gccagcgcgt ggagcgagcg agcggggtca gatggtccgc ctcattcacc aggagccgta
     4921 actcaagctg aactgtgaaa gtggttaaca ctgtatccta ggccgtcttt ttttttcctc
     4981 ctcctgttta tttttttgtt tgttttattt atagtctgat ttaaaacaat cagattccag
     5041 ttggttaatt ttagttatgt aacaacctga caagatggag gaaaacaacc tgtaaaggga
     5101 ttgtgtctat ggtttgattc acttagaaat tttattttct tataacttaa gtgcaataaa
     5161 atgtgttttt tcatgtta
//
