LOCUS       NM_001025730            2345 bp    mRNA    linear   ROD 02-APR-2024
DEFINITION  Rattus norvegicus F-box and WD repeat domain containing 5 (Fbxw5),
            mRNA.
ACCESSION   NM_001025730 XM_342382
VERSION     NM_001025730.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2345)
  AUTHORS   Hui,X., Hu,F., Liu,J., Li,C., Yang,Y., Shu,S., Liu,P., Wang,F. and
            Li,S.
  TITLE     FBXW5 acts as a negative regulator of pathological cardiac
            hypertrophy by decreasing the TAK1 signaling to pro-hypertrophic
            members of the MAPK signaling pathway
  JOURNAL   J Mol Cell Cardiol 151, 31-43 (2021)
   PUBMED   32971071
  REMARK    GeneRIF: FBXW5 acts as a negative regulator of pathological cardiac
            hypertrophy by decreasing the TAK1 signaling to pro-hypertrophic
            members of the MAPK signaling pathway.
REFERENCE   2  (bases 1 to 2345)
  AUTHORS   Zhao,P., Chao,W. and Li,W.
  TITLE     FBXW5 reduction alleviates spinal cord injury (SCI) by blocking
            microglia activity: A mechanism involving p38 and JNK
  JOURNAL   Biochem Biophys Res Commun 514 (2), 558-564 (2019)
   PUBMED   31060780
  REMARK    GeneRIF: FBXW5 reduction alleviates spinal cord injury by blocking
            microglia activity and down-regulating p38 and JNK.
REFERENCE   3  (bases 1 to 2345)
  AUTHORS   Ha,J.Y., Kim,J.S., Kang,Y.H., Bok,E., Kim,Y.S. and Son,J.H.
  TITLE     Tnfaip8 l1/Oxi-beta binds to FBXW5, increasing autophagy through
            activation of TSC2 in a Parkinson's disease model
  JOURNAL   J Neurochem 129 (3), 527-538 (2014)
   PUBMED   24444419
  REMARK    GeneRIF: oxidative stress induces Tnfaip8 l1/Oxi-beta, which
            results in increased autophagy by its exclusive binding with FBXW5
            to stabilize TSC2
REFERENCE   4  (bases 1 to 2345)
  AUTHORS   Werner,A., Disanza,A., Reifenberger,N., Habeck,G., Becker,J.,
            Calabrese,M., Urlaub,H., Lorenz,H., Schulman,B., Scita,G. and
            Melchior,F.
  TITLE     SCFFbxw5 mediates transient degradation of actin remodeller Eps8 to
            allow proper mitotic progression
  JOURNAL   Nat Cell Biol 15 (2), 179-188 (2013)
   PUBMED   23314863
REFERENCE   5  (bases 1 to 2345)
  AUTHORS   Puklowski,A., Homsi,Y., Keller,D., May,M., Chauhan,S., Kossatz,U.,
            Grunwald,V., Kubicka,S., Pich,A., Manns,M.P., Hoffmann,I.,
            Gonczy,P. and Malek,N.P.
  TITLE     The SCF-FBXW5 E3-ubiquitin ligase is regulated by PLK4 and targets
            HsSAS-6 to control centrosome duplication
  JOURNAL   Nat Cell Biol 13 (8), 1004-1009 (2011)
   PUBMED   21725316
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 2345)
  AUTHORS   Ebstein,F., Lange,N., Urban,S., Seifert,U., Kruger,E. and
            Kloetzel,P.M.
  TITLE     Maturation of human dendritic cells is accompanied by functional
            remodelling of the ubiquitin-proteasome system
  JOURNAL   Int J Biochem Cell Biol 41 (5), 1205-1215 (2009)
   PUBMED   19028597
REFERENCE   7  (bases 1 to 2345)
  AUTHORS   Hu,J., Zacharek,S., He,Y.J., Lee,H., Shumway,S., Duronio,R.J. and
            Xiong,Y.
  TITLE     WD40 protein FBW5 promotes ubiquitination of tumor suppressor TSC2
            by DDB1-CUL4-ROC1 ligase
  JOURNAL   Genes Dev 22 (7), 866-871 (2008)
   PUBMED   18381890
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC099179.1.
            
            On Aug 31, 2012 this sequence version replaced NM_001025730.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC099179.1, SRR8487227.58696.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMD00132261, SAMD00132262
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-2345              BC099179.1         4-2348
FEATURES             Location/Qualifiers
     source          1..2345
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="3"
                     /map="3p13"
     gene            1..2345
                     /gene="Fbxw5"
                     /note="F-box and WD repeat domain containing 5"
                     /db_xref="GeneID:362081"
                     /db_xref="RGD:1305661"
     exon            1..105
                     /gene="Fbxw5"
                     /inference="alignment:Splign:2.1.0"
     exon            106..321
                     /gene="Fbxw5"
                     /inference="alignment:Splign:2.1.0"
     CDS             129..1838
                     /gene="Fbxw5"
                     /note="F-box and WD-40 domain-containing protein 5; F-box
                     and WD-40 domain protein 5"
                     /codon_start=1
                     /product="F-box/WD repeat-containing protein 5"
                     /protein_id="NP_001020901.1"
                     /db_xref="GeneID:362081"
                     /db_xref="RGD:1305661"
                     /translation="MDEGGMPLLPDSLVYQIFLSLGPADVLAAGLVCRQWQAVSRDEF
                     LWREQFYRYYQVARDVPRHPAATSWYEEFRRLYDMVPCVEVQTLKEHTDQVLHLSFSH
                     SGYQFASCSKDCTVKIWNNDLTISLLHSADMRPYNWSYTQFSQFNQDDSLLLASGVFL
                     GPHNSSSGEIAVISLDSFALLSRVRNKPYDVFGCWLTETSLISGNLHRIGDVTSCSVL
                     WLNNAFQDVESENVNVVKRLFKIQNLNASTIRTVMVADCSRFDSPDLLLDAGDQAGLP
                     CRVFDLGGDTEEEATDPGLHTSGSGHVKEGLRRVFDSVLDGHGQLSDCALETKVAELL
                     AQGHTKPPECPDADSRNKYLIFTTGCLTYSPHQIGIKQILPHQMTTAGPVLGEGRGSD
                     AFFDALDHVIDVHGHIIGMGLSPDNRYLYVNSRAWPPGSVVADPMQPPPIAEEIDLLV
                     FDLKTMREVKRALRAHRAYTPNDECFFIFLDVSRDFVASGAEDRHGYIWDRHYNICLA
                     KLRHEDVVNSVAFSPQEQELLLTASDDATIKAWRSPRIVRVLQAPHPRPRPFFSWFAS
                     HRR"
     exon            322..479
                     /gene="Fbxw5"
                     /inference="alignment:Splign:2.1.0"
     exon            480..654
                     /gene="Fbxw5"
                     /inference="alignment:Splign:2.1.0"
     exon            655..803
                     /gene="Fbxw5"
                     /inference="alignment:Splign:2.1.0"
     exon            804..1233
                     /gene="Fbxw5"
                     /inference="alignment:Splign:2.1.0"
     exon            1234..1381
                     /gene="Fbxw5"
                     /inference="alignment:Splign:2.1.0"
     exon            1382..1594
                     /gene="Fbxw5"
                     /inference="alignment:Splign:2.1.0"
     exon            1595..2319
                     /gene="Fbxw5"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ggctctctcc tgaagccaca cgacagccat tgggcagcag gagccccttc tcagaagaaa
       61 gttagccctg acctgaagtc ctgtggcagc aaggtcaaag acagggaccg tctgggcaga
      121 atgtcacgat ggatgagggg ggcatgcccc tgctccccga cagcctggtc taccagatct
      181 tcctgagctt gggccctgca gatgtgctgg ctgctgggct ggtgtgccgc cagtggcagg
      241 ctgtctcccg ggacgagttc ctatggaggg agcagttcta ccgctactac caggtggctc
      301 gcgatgtgcc ccgccaccca gcggccacat cctggtatga ggagttccgg cggctctatg
      361 acatggtgcc ctgtgtggag gtgcagacac tgaaggagca caccgaccag gtcctgcacc
      421 tcagcttctc ccactcgggg taccagtttg cctcctgctc caaggactgc acagtgaaga
      481 tctggaacaa tgacctgacc atctctctgc tgcacagtgc agatatgagg ccatacaact
      541 ggagttacac ccagttctcc cagttcaacc aggatgactc actgttgctg gcctcggggg
      601 tgttcctagg gccacataac tcctcctcag gcgagatagc tgtcatcagc ttagactcct
      661 tcgccctgct gtcgcgtgtg cgaaacaagc cctatgatgt gtttggctgc tggctcacag
      721 aaaccagcct catctcgggg aacctgcacc gcattggaga tgtcacctcc tgctcagtgc
      781 tgtggctcaa caatgccttc caggatgtgg agtcagagaa cgtcaacgtg gtaaagcggc
      841 tctttaagat ccagaacctc aatgccagca ccatccgcac cgtgatggtg gctgactgca
      901 gccgctttga tagcccggac ctcctgctgg atgctggtga ccaggctggg ctcccctgcc
      961 gagtctttga cctaggtggg gacactgaag aagaggccac tgacccaggt ttgcacacct
     1021 ctggttctgg ccatgtcaag gaaggtttac ggcgtgtgtt tgatagcgtc ctggatggac
     1081 atggacagct gtcagattgt gcactggaga ccaaggtggc tgagctgctg gcccagggcc
     1141 acaccaagcc cccagagtgt cctgacgctg acagcaggaa caagtacctc atcttcacca
     1201 ctggctgcct cacgtactca cctcatcaga tcggcatcaa gcagatcctg ccgcaccaga
     1261 tgacaactgc agggcccgtg ctgggcgagg gccggggctc tgatgccttc tttgatgccc
     1321 tggaccatgt cattgatgtg catgggcaca tcattggcat gggcctgtct cccgataaca
     1381 ggtacctgta tgtgaatagc cgtgcctggc cccctggctc agtggtcgcc gaccccatgc
     1441 agccaccacc cattgcagag gagattgact tgctggtgtt tgatctgaag accatgcggg
     1501 aggtgaagcg agctctgcga gcacaccgtg cctacacacc caatgatgag tgcttcttca
     1561 tctttctgga tgtcagcagg gattttgtgg ccagtggggc tgaagatcgg catggctata
     1621 tctgggaccg ccactacaac atctgcctag ccaagctgcg gcatgaggat gtggtcaact
     1681 cagtggcctt tagcccccag gagcaggagc tcttgttgac agccagcgat gatgccacta
     1741 tcaaagcctg gcgctcacca cgcattgttc gtgtcctgca ggctccacac ccacgcccac
     1801 gccccttctt ctcctggttt gccagccata ggcgctgaag gcttcagtga tttgagccat
     1861 tggaacctcc tggggaaaat gtcccctgtg gttccttact gccctgggac agagtagctt
     1921 atagcagtaa cgccttagga ggggcatcct gaccccaaca cacaacctgc tcactcagcc
     1981 gcaggcttag cactagggta ggccttgttg gcagcaccag agaccccatg ttagcctctt
     2041 ggccgccgtg gggtacacgg gacactggaa accctgttca cctaccctct tcccttgggt
     2101 tggccagctc acatagcccc aagctgacct ctgcctggta cctttcatac tcagccaaac
     2161 ccacaccctt ggcgtcttga gtgtaccctg ggtggcaggc cacaggcacc ggtctctgat
     2221 aattcgggtc ttgctactga tggagtggcc tgcagtggac catgggtgct gcatgctgca
     2281 ctcatgaact gtttgggcct gaataaacag ttggcaacaa aaaaaaaaaa aaaaaaaaaa
     2341 aaaaa
//
