LOCUS       NM_001107835            1929 bp    mRNA    linear   ROD 03-APR-2024
DEFINITION  Rattus norvegicus F-box and WD repeat domain containing 2 (Fbxw2),
            mRNA.
ACCESSION   NM_001107835 XM_001080206 XM_231162
VERSION     NM_001107835.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1929)
  AUTHORS   Ebstein,F., Lange,N., Urban,S., Seifert,U., Kruger,E. and
            Kloetzel,P.M.
  TITLE     Maturation of human dendritic cells is accompanied by functional
            remodelling of the ubiquitin-proteasome system
  JOURNAL   Int J Biochem Cell Biol 41 (5), 1205-1215 (2009)
   PUBMED   19028597
REFERENCE   2  (bases 1 to 1929)
  AUTHORS   Maruyama,S., Hatakeyama,S., Nakayama,K., Ishida,N., Kawakami,K. and
            Nakayama,K.
  TITLE     Characterization of a mouse gene (Fbxw6) that encodes a homologue
            of Caenorhabditis elegans SEL-10
  JOURNAL   Genomics 78 (3), 214-222 (2001)
   PUBMED   11735228
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC166990.1.
            
            On May 11, 2008 this sequence version replaced NM_001107835.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC166990.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760396, SAMEA5760400
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1929
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="3"
                     /map="3p11"
     gene            1..1929
                     /gene="Fbxw2"
                     /note="F-box and WD repeat domain containing 2"
                     /db_xref="GeneID:311881"
                     /db_xref="RGD:1310460"
     exon            1..125
                     /gene="Fbxw2"
                     /inference="alignment:Splign:2.1.0"
     exon            126..635
                     /gene="Fbxw2"
                     /inference="alignment:Splign:2.1.0"
     CDS             146..1510
                     /gene="Fbxw2"
                     /note="F-box and WD-40 domain protein 2; protein MD6;
                     F-box and WD-40 domain-containing protein 2"
                     /codon_start=1
                     /product="F-box/WD repeat-containing protein 2"
                     /protein_id="NP_001101305.1"
                     /db_xref="GeneID:311881"
                     /db_xref="RGD:1310460"
                     /translation="MERKDFETWLDNISVTFLSLTDLQKNETLDHLISLSGAVQLRHL
                     SNNLETLLKRDFLKLLPLELSFYLLKWLDPQTLLTCCLVSKQWNKVISACTEVWQTAC
                     KNLGWQIDDSVQDALHWKKVYLKAILRMKQLEDHEAFETSSLIGHSARVYALYYKDGL
                     LCTGSDDLSAKLWDVSTGQCVYGIQTHTCAAVKFDEQKLVTGSFDNTVACWEWSSGAR
                     TQHFRGHTGAVFSVDYSDELDILVSGSADFAVKVWALSAGTCLNTLTGHTEWVTKVVL
                     QQCKVKSLLHSPGDYILLSADKYEIKIWPIGREINCKCLKTLSVSEDRSICLQPRLHF
                     DGKYIVCSSALGLYQWDFASYDILRVIKTPEVANLALLGFGDVFALLFDNHYLYIMDL
                     RTESLISRWPLPEYRKSKRGSSFLAGEASWLNGLDGHNDTGLVFATSMPDHSIHLVLW
                     KEHG"
     exon            636..830
                     /gene="Fbxw2"
                     /inference="alignment:Splign:2.1.0"
     exon            831..964
                     /gene="Fbxw2"
                     /inference="alignment:Splign:2.1.0"
     exon            965..1051
                     /gene="Fbxw2"
                     /inference="alignment:Splign:2.1.0"
     exon            1052..1221
                     /gene="Fbxw2"
                     /inference="alignment:Splign:2.1.0"
     exon            1222..1888
                     /gene="Fbxw2"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ctccctttcc ccgcaggcgc catggctgcg gagcggaccc ggccgctgcg acgctctggc
       61 ggcccgagcg cgcctagtcg gtgtgagccc ggcgcgaggt cccgggcccc ggggcgctcg
      121 ctcaggtaaa tatttccata accttatgga gagaaaggac tttgagacat ggcttgataa
      181 catttctgtt acatttcttt ctctgacgga cttgcagaaa aatgaaactc tggaccacct
      241 gattagtctg agtggggcag tccagctcag gcatctctcc aataacctgg agactctcct
      301 caagcgggac ttcctcaaac tccttcccct ggagctcagt ttttatttgt taaaatggct
      361 cgatcctcag actttgctca catgctgcct ggtctctaag cagtggaata aggtgataag
      421 tgcctgcaca gaggtgtggc agactgcatg taaaaatttg ggctggcaaa tagatgattc
      481 tgttcaggac gcattgcact ggaagaaggt ttacttgaag gctattttga ggatgaagca
      541 actggaggac catgaagcct ttgagacctc atcattaatt ggacatagtg ccagagtgta
      601 tgcactttac tacaaggatg gacttctctg tacagggtca gatgatttgt ctgcaaagct
      661 gtgggatgta agcacagggc agtgtgttta cggcatccag acccacactt gtgcagccgt
      721 gaagttcgat gaacagaagc ttgtgacagg ctcctttgac aacactgtgg cctgctggga
      781 atggagttcc ggagccagga cccagcactt ccgggggcac acaggggcgg tgttcagtgt
      841 ggactacagt gatgaactgg atattttggt gagtggctct gcggacttcg ctgtgaaagt
      901 atgggcttta tctgctggga catgcctgaa cacactcact gggcacacag aatgggtcac
      961 caaggtggtt ctgcagcagt gcaaagtcaa gtctctcttg cacagccctg gggactacat
     1021 ccttttaagt gcagacaagt acgagatcaa gatttggcca attgggagag aaatcaactg
     1081 taagtgctta aagacattgt ctgtctctga ggatagaagt atctgcctac agccaagact
     1141 tcattttgat ggaaaataca ttgtctgtag ttcagccctg ggtctgtacc agtgggactt
     1201 tgccagttat gatatcctca gggtcatcaa gacacctgag gtagcaaact tggccttgct
     1261 tggctttgga gatgtcttcg ctctgctgtt tgacaaccac tacctataca tcatggactt
     1321 gaggacagag agcctaatta gccgctggcc tctgccagag tacaggaaat caaagagagg
     1381 ctccagcttc ctggcaggcg aagcgtcctg gctgaatgga ctggatgggc acaatgacac
     1441 gggcttagtc tttgctacca gcatgcctga ccacagtatt cacctggttt tatggaagga
     1501 gcatggctga caccaagcgc taccaccgct gactgacttt gggtgccagg gctgcgggtt
     1561 ttgggtgcaa catctgtggc agccaactgc atgaaccaaa gttctcacct aaaggtatca
     1621 tcacgcagtg cacaatcatt tatctgtttg ccaggggcca gggctgggcg gggagggctt
     1681 gttttactga catacaccgc agcatgctaa tgggacacac cattgacttc atctgtactt
     1741 agttctgttg gtcagtgtac gaggttgcat ttttggattt atctttctga gtggaatatt
     1801 gagtaaagaa agttaaatga ttcactaatc tgctaattgg ttgcccataa aagcacatgg
     1861 agtctgttat taaagttttt ttccaataaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa
     1921 aaaaaaaaa
//
