LOCUS       NP_001101305             454 aa            linear   ROD 03-APR-2024
DEFINITION  F-box/WD repeat-containing protein 2 [Rattus norvegicus].
ACCESSION   NP_001101305 XP_001080206 XP_231162
VERSION     NP_001101305.1
DBSOURCE    REFSEQ: accession NM_001107835.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (residues 1 to 454)
  AUTHORS   Ebstein,F., Lange,N., Urban,S., Seifert,U., Kruger,E. and
            Kloetzel,P.M.
  TITLE     Maturation of human dendritic cells is accompanied by functional
            remodelling of the ubiquitin-proteasome system
  JOURNAL   Int J Biochem Cell Biol 41 (5), 1205-1215 (2009)
   PUBMED   19028597
REFERENCE   2  (residues 1 to 454)
  AUTHORS   Maruyama,S., Hatakeyama,S., Nakayama,K., Ishida,N., Kawakami,K. and
            Nakayama,K.
  TITLE     Characterization of a mouse gene (Fbxw6) that encodes a homologue
            of Caenorhabditis elegans SEL-10
  JOURNAL   Genomics 78 (3), 214-222 (2001)
   PUBMED   11735228
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC166990.1.
            
            On or before Oct 4, 2007 this sequence version replaced
            XP_001080206.1, XP_231162.3.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC166990.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760396, SAMEA5760400
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..454
                     /organism="Rattus norvegicus"
                     /db_xref="taxon:10116"
                     /chromosome="3"
                     /map="3p11"
     Protein         1..454
                     /product="F-box/WD repeat-containing protein 2"
                     /note="F-box and WD-40 domain protein 2; protein MD6;
                     F-box and WD-40 domain-containing protein 2"
                     /calculated_mol_wt=51277
     Region          55..94
                     /region_name="F-box_FBXW2"
                     /note="F-box domain found in F-box/WD repeat-containing
                     protein 2 (FBXW2) and similar proteins; cd22131"
                     /db_xref="CDD:438903"
     Site            order(60,64,67..68,71..72,76,78..79,83..85,87)
                     /site_type="other"
                     /note="putative Skp1 binding site [polypeptide binding]"
                     /db_xref="CDD:438903"
     Region          140..447
                     /region_name="WD40"
                     /note="WD40 domain, found in a number of eukaryotic
                     proteins that cover a wide variety of functions including
                     adaptor/regulatory modules in signal transduction,
                     pre-mRNA processing and cytoskeleton assembly; typically
                     contains a GH dipeptide 11-24 residues from...; cl29593"
                     /db_xref="CDD:475233"
     Region          146..183
                     /region_name="WD 1. /evidence=ECO:0000255"
                     /note="propagated from UniProtKB/Swiss-Prot (B2RZ17.1)"
     Site            order(147,163,167,173..174,186..187,201,205,211..212,
                     224..225,242,247,253..254,267,294,297,304..305,320..321,
                     340,344,350..351,362,379,384,390..391,418..419,437,442)
                     /site_type="active"
                     /note="structural tetrad [active]"
                     /db_xref="CDD:238121"
     Region          151..185
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          185..221
                     /region_name="WD 2. /evidence=ECO:0000255"
                     /note="propagated from UniProtKB/Swiss-Prot (B2RZ17.1)"
     Region          188..223
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          224..265
                     /region_name="WD 3. /evidence=ECO:0000255"
                     /note="propagated from UniProtKB/Swiss-Prot (B2RZ17.1)"
     Region          229..265
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          276..314
                     /region_name="WD 4. /evidence=ECO:0000255"
                     /note="propagated from UniProtKB/Swiss-Prot (B2RZ17.1)"
     Region          281..319
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Site            298
                     /site_type="acetylation"
                     /note="N6-acetyllysine.
                     /evidence=ECO:0000250|UniProtKB:Q9UKT8; propagated from
                     UniProtKB/Swiss-Prot (B2RZ17.1)"
     Region          327..362
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          377..417
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          423..445
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     CDS             1..454
                     /gene="Fbxw2"
                     /coded_by="NM_001107835.2:146..1510"
                     /db_xref="GeneID:311881"
                     /db_xref="RGD:1310460"
ORIGIN      
        1 merkdfetwl dnisvtflsl tdlqknetld hlislsgavq lrhlsnnlet llkrdflkll
       61 plelsfyllk wldpqtlltc clvskqwnkv isactevwqt acknlgwqid dsvqdalhwk
      121 kvylkailrm kqledheafe tsslighsar vyalyykdgl lctgsddlsa klwdvstgqc
      181 vygiqthtca avkfdeqklv tgsfdntvac wewssgartq hfrghtgavf svdysdeldi
      241 lvsgsadfav kvwalsagtc lntltghtew vtkvvlqqck vksllhspgd yillsadkye
      301 ikiwpigrei nckclktlsv sedrsiclqp rlhfdgkyiv cssalglyqw dfasydilrv
      361 iktpevanla llgfgdvfal lfdnhylyim dlrteslisr wplpeyrksk rgssflagea
      421 swlngldghn dtglvfatsm pdhsihlvlw kehg
//
