LOCUS       NM_001395595            4235 bp    mRNA    linear   ROD 22-MAR-2023
DEFINITION  Rattus norvegicus F-box and WD repeat domain containing 11
            (Fbxw11), transcript variant 1, mRNA.
ACCESSION   NM_001395595 XM_006246093
VERSION     NM_001395595.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 4235)
  AUTHORS   Jakobsen L, Vanselow K, Skogs M, Toyoda Y, Lundberg E, Poser I,
            Falkenby LG, Bennetzen M, Westendorf J, Nigg EA, Uhlen M, Hyman AA
            and Andersen JS.
  TITLE     Novel asymmetrically localizing components of human centrosomes
            identified by complementary proteomics methods
  JOURNAL   EMBO J 30 (8), 1520-1535 (2011)
   PUBMED   21399614
REFERENCE   2  (bases 1 to 4235)
  AUTHORS   Wu K, Kovacev J and Pan ZQ.
  TITLE     Priming and extending: a UbcH5/Cdc34 E2 handoff mechanism for
            polyubiquitination on a SCF substrate
  JOURNAL   Mol Cell 37 (6), 784-796 (2010)
   PUBMED   20347421
REFERENCE   3  (bases 1 to 4235)
  AUTHORS   Peschiaroli A, Skaar JR, Pagano M and Melino G.
  TITLE     The ubiquitin-specific protease USP47 is a novel beta-TRCP
            interactor regulating cell survival
  JOURNAL   Oncogene 29 (9), 1384-1393 (2010)
   PUBMED   19966869
REFERENCE   4  (bases 1 to 4235)
  AUTHORS   Ebstein F, Lange N, Urban S, Seifert U, Kruger E and Kloetzel PM.
  TITLE     Maturation of human dendritic cells is accompanied by functional
            remodelling of the ubiquitin-proteasome system
  JOURNAL   Int J Biochem Cell Biol 41 (5), 1205-1215 (2009)
   PUBMED   19028597
REFERENCE   5  (bases 1 to 4235)
  AUTHORS   Seo E, Kim H, Kim R, Yun S, Kim M, Han JK, Costantini F and Jho EH.
  TITLE     Multiple isoforms of beta-TrCP display differential activities in
            the regulation of Wnt signaling
  JOURNAL   Cell Signal 21 (1), 43-51 (2009)
   PUBMED   18929646
REFERENCE   6  (bases 1 to 4235)
  AUTHORS   Peschiaroli A, Dorrello NV, Guardavaccaro D, Venere M, Halazonetis
            T, Sherman NE and Pagano M.
  TITLE     SCFbetaTrCP-mediated degradation of Claspin regulates recovery from
            the DNA replication checkpoint response
  JOURNAL   Mol Cell 23 (3), 319-329 (2006)
   PUBMED   16885022
REFERENCE   7  (bases 1 to 4235)
  AUTHORS   Sabile A, Meyer AM, Wirbelauer C, Hess D, Kogel U, Scheffner M and
            Krek W.
  TITLE     Regulation of p27 degradation and S-phase progression by Ro52 RING
            finger protein
  JOURNAL   Mol Cell Biol 26 (16), 5994-6004 (2006)
   PUBMED   16880511
REFERENCE   8  (bases 1 to 4235)
  AUTHORS   Cohen S, Achbert-Weiner H and Ciechanover A.
  TITLE     Dual effects of IkappaB kinase beta-mediated phosphorylation on
            p105 Fate: SCF(beta-TrCP)-dependent degradation and
            SCF(beta-TrCP)-independent processing
  JOURNAL   Mol Cell Biol 24 (1), 475-486 (2004)
   PUBMED   14673179
REFERENCE   9  (bases 1 to 4235)
  AUTHORS   Bhatia N, Herter JR, Slaga TJ, Fuchs SY and Spiegelman VS.
  TITLE     Mouse homologue of HOS (mHOS) is overexpressed in skin tumors and
            implicated in constitutive activation of NF-kappaB
  JOURNAL   Oncogene 21 (10), 1501-1509 (2002)
   PUBMED   11896578
REFERENCE   10 (bases 1 to 4235)
  AUTHORS   Heissmeyer V, Krappmann D, Hatada EN and Scheidereit C.
  TITLE     Shared pathways of IkappaB kinase-induced SCF(betaTrCP)-mediated
            ubiquitination and degradation for the NF-kappaB precursor p105 and
            IkappaBalpha
  JOURNAL   Mol Cell Biol 21 (4), 1024-1035 (2001)
   PUBMED   11158290
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JACYVU010000219.1.
            
            [WARNING] On Apr 3, 2024 this sequence was replaced by
            NM_001395595.3.
            
            On Nov 18, 2022 this sequence version replaced NM_001395595.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            RNAseq introns :: single sample supports all introns SAMD00132266,
                              SAMD00132286 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-189               JACYVU010000219.1  5266240-5266428
            190-291             JACYVU010000219.1  5302562-5302663
            292-354             JACYVU010000219.1  5328569-5328631
            355-580             JACYVU010000219.1  5333028-5333253
            581-767             JACYVU010000219.1  5342804-5342990
            768-858             JACYVU010000219.1  5344395-5344485
            859-996             JACYVU010000219.1  5351314-5351451
            997-1115            JACYVU010000219.1  5353364-5353482
            1116-1365           JACYVU010000219.1  5355042-5355291
            1366-1484           JACYVU010000219.1  5357788-5357906
            1485-1595           JACYVU010000219.1  5358379-5358489
            1596-1674           JACYVU010000219.1  5359328-5359406
            1675-1860           JACYVU010000219.1  5359737-5359922
            1861-4235           JACYVU010000219.1  5361514-5363888
FEATURES             Location/Qualifiers
     source          1..4235
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="10"
                     /map="10q12"
     gene            1..4235
                     /gene="Fbxw11"
                     /note="F-box and WD repeat domain containing 11"
                     /db_xref="GeneID:303024"
                     /db_xref="RGD:1309121"
     exon            1..189
                     /gene="Fbxw11"
                     /inference="alignment:Splign:2.1.0"
     CDS             145..1836
                     /gene="Fbxw11"
                     /note="isoform 1 is encoded by transcript variant 1;
                     F-box/WD repeat-containing protein 11; F-box and WD-40
                     domain protein 11"
                     /codon_start=1
                     /product="F-box/WD repeat-containing protein 11 isoform 1"
                     /protein_id="NP_001382524.1"
                     /db_xref="GeneID:303024"
                     /db_xref="RGD:1309121"
                     /translation="MEPDSVIEDKTIELMCSVPRSLWLGCANLVESMCALSCLQSMPS
                     VRCLQNTSVMEDQNEDESPKKSALWQISNGTSSVIVSRKRPSEGNYQKEKDLCIKYFD
                     QWSESDQVEFVEHLISRMCHYQHGHINSYLKPMLQRDFITALPEQGLDHIAENILSYL
                     DARSLCAAELVCKEWQRVISEGMLWKKLIERMVRTDPLWKGLSERRGWDQYLFKNRPT
                     DGPPNSFYRSLYPKIIQDIETIESNWRCGRHNLQRIQCRSENSKGVYCLQYDDDKIIS
                     GLRDNSIKIWDKSSLECLKVLTGHTGSVLCLQYDERVIVTGSSDSTVRVWDVNTGEVL
                     NTLIHHNEAVLHLRFSNGLMVTCSKDRSIAVWDMASATDITLRRVLVGHRAAVNVVDF
                     DDKYIVSASGDRTIKVWSTSTCEFVRTLNGHKRGIACLQYRDRLVVSGSSDNTIRLWD
                     IECGACLRVLEGHEELVRCIRFDNKRIVSGAYDGKIKVWDLQAALDPRAPASTLCLRT
                     LVEHSGRVFRLQFDEFQIISSSHDDTILIWDFLNVPPSAQNETRSPSRTYTYISR"
     exon            190..291
                     /gene="Fbxw11"
                     /inference="alignment:Splign:2.1.0"
     exon            292..354
                     /gene="Fbxw11"
                     /inference="alignment:Splign:2.1.0"
     exon            355..580
                     /gene="Fbxw11"
                     /inference="alignment:Splign:2.1.0"
     exon            581..767
                     /gene="Fbxw11"
                     /inference="alignment:Splign:2.1.0"
     exon            768..858
                     /gene="Fbxw11"
                     /inference="alignment:Splign:2.1.0"
     exon            859..996
                     /gene="Fbxw11"
                     /inference="alignment:Splign:2.1.0"
     exon            997..1115
                     /gene="Fbxw11"
                     /inference="alignment:Splign:2.1.0"
     exon            1116..1365
                     /gene="Fbxw11"
                     /inference="alignment:Splign:2.1.0"
     exon            1366..1484
                     /gene="Fbxw11"
                     /inference="alignment:Splign:2.1.0"
     exon            1485..1595
                     /gene="Fbxw11"
                     /inference="alignment:Splign:2.1.0"
     exon            1596..1674
                     /gene="Fbxw11"
                     /inference="alignment:Splign:2.1.0"
     exon            1675..1860
                     /gene="Fbxw11"
                     /inference="alignment:Splign:2.1.0"
     exon            1861..4235
                     /gene="Fbxw11"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 agggcggagc tgccggcggc ccgggcgggc tggcagctag agtgggtgcc agagctgcct
       61 ccgccgccgc cgctgccacc gcctcctccg cccgggccgt tcgctgctga gcggagagag
      121 cgaggcgggg ccgccggggc cgccatggag cccgactcgg tgattgaaga caagaccatc
      181 gagctcatgt gttctgtgcc aaggtctttg tggctaggct gcgccaacct ggtagagagc
      241 atgtgcgcac tgagttgcct gcagagcatg cccagtgtca gatgtctcca gaacacttca
      301 gttatggaag atcaaaatga agacgagtcc ccaaagaaaa gtgctctttg gcagataagt
      361 aatggaacgt catctgtgat tgtctccaga aagaggccat cggaggggaa ctaccagaaa
      421 gaaaaggact tgtgcatcaa gtactttgac cagtggtctg aatcagatca ggtagaattt
      481 gtggagcatc ttatctcacg aatgtgtcat tatcagcatg gacatattaa ctcttacctg
      541 aagcccatgt tgcagcggga cttcatcacc gctttaccag agcaaggctt agatcacata
      601 gcagagaaca ttctttccta cctggatgcc aggtctctgt gtgcagcaga gctggtgtgt
      661 aaagagtggc agcgggtgat ctccgagggg atgctttgga agaagctgat cgagaggatg
      721 gtgcgcaccg accctctctg gaagggactc tcagaaagaa gaggctggga tcagtacctg
      781 tttaaaaaca gacctacaga tggccctccc aactcatttt atagatcatt atacccaaag
      841 attatccagg acatagagac catagaatcc aactggcggt gtggacggca caacttgcag
      901 aggatccagt gccgctctga aaatagtaag ggcgtctact gtttgcaata tgatgatgac
      961 aaaattatca gtggcctccg agacaactct atcaagatct gggataaaag cagcttggaa
     1021 tgtttgaaag tgctaacggg acacacgggc tctgtcctct gcctccagta tgatgaacga
     1081 gtcattgtaa ctggttcttc agactctaca gtgagagtct gggatgtgaa cacgggggaa
     1141 gttctcaaca cactcatcca ccacaacgaa gccgtgctgc acttacgctt cagcaacgga
     1201 ctgatggtga cttgttccaa ggaccgctcc atcgctgtgt gggacatggc ttctgccact
     1261 gatatcactt tacgccgtgt cctggttggc caccgtgctg ctgtcaatgt agtagacttt
     1321 gatgataagt acatcgtgtc tgcctctgga gacaggacta ttaaagtgtg gagcacgagc
     1381 acctgtgagt tcgtccgcac tctgaatggg cacaagcgag gcattgcctg tctgcagtac
     1441 cgggaccggc ttgttgttag tggatcatca gataatacca tccggttatg ggatattgaa
     1501 tgtggtgcct gtttaagagt cctagagggg cacgaagagt tggtccggtg catccgtttt
     1561 gataacaaga ggattgtcag tggcgcctat gacgggaaga ttaaagtctg ggatttgcag
     1621 gctgctcttg accctcgggc cccagcaagc acattgtgtc tgcgcacctt ggtggaacac
     1681 tctggacgtg tgtttcggct gcagtttgat gagtttcaga tcatcagcag ctcccatgat
     1741 gacactattt tgatttggga ttttttaaat gtgcctccca gtgcccagaa tgagacacgt
     1801 tctccctcca gaacctacac ctatatctcc agatagcagc ctgcactttg gcccaatctg
     1861 ggtttcctgg tcttgaacta ctggctacat ggctatcaca tgcctaaggg agttcattcg
     1921 ttcacggctg agttttgggg ctggacttgg ttccagatgc tgggtagaca cagagcagcc
     1981 ccaccctcta gccccgacat ttctcactgc gccccagctc tacttggaga aggacttctt
     2041 agctcatccc tgcgagtagg gcagcagctc atgcccctcc cttccgtgaa gaccccagcg
     2101 cttccgacgc acacgttccc aagaaggaca cagcaaaggc cgtcaggaga agccctgctt
     2161 ctgatttacg tcgtcgcttt gcgccttggt ttggtactaa aagcagcctt gtgttcttgg
     2221 tgacgtgctg ggtgccaaac gactacccag agtcttcagg gcttttctct gcagcctcag
     2281 cttctcctta gaccgccagt cacagtcacg tcgctccgac gacctgcata ggaatgtgtc
     2341 ggacggacaa tgggcagacc tggattatct tagtattttt ggattacact tcctttctgt
     2401 ttcagtttct tttaatttaa agaataagtg gttatattac ctctgcacag gtaatatagc
     2461 tattttcttt attaactgtt ctctgtttcc tcttcatctt ctgatacttg gtagaataac
     2521 acctttatct gagtgcttgc ctcctaattt aaaatactgt acccgcatgt agatataatg
     2581 tacataacga ttcaagctca aagcggctgg ccagccccct gcgcctgaga cactactgtg
     2641 gagaaggtca cacctgactc cagggttgct gtgctggcct agaaccttcc ttcagtattc
     2701 acttgggttt cagttgtcac tgtctgtgtg tgcagtatgt gctttcagat ggcacttgag
     2761 aagtttccct tgtgtgtttg ttgtgtggca actgcagtgg gcaggtatct gcagtctcca
     2821 cacctctgtt gtttccctca tgagtacctt cagagctggt gctcccctcc tcagggtggt
     2881 cattggcttc tctgtccaac aacctatcac agggcagtga ccctgagaca gtgagatggt
     2941 ggccccaggg acggggctcc tggctctggg ctccctgcac tctgatgggc tgctgagtta
     3001 gagcctgtgg agcaggtcag ctgttcagag cccacattgg ggacaaggca ctcgtgtgtg
     3061 tgtgtgtgtg tgtgtgtgtg tgtgtgtgtg tgtgtgtgtg tgtgtgtgtg tgtgtgtgag
     3121 tgacagcccc aggccctgtc agctttggtg acactcatca ctttggttca agaatctcaa
     3181 agttcccgag tgagagtggc acacaggcag gagatgggtg acattatttc cctcttccaa
     3241 gattaagttt tgatttgccc cttgccattg tatccaaaga tcaaggaatg tcagtacggt
     3301 tttaaaggac caaccagccc tccctgtgaa tgaagcctct tcccgtggaa gtccactcta
     3361 ggagagagac agcctctggg ctccgctggt cctggcattg tgatgcggtg gggtcagtgt
     3421 gtactggatg tgtttactgg gtttggcttt cctttttaga tttttaatgt tttagttttg
     3481 tttgtttgtt ttcccgatta aatcattctc acatgcttcc atgtttgttt ctgagaggtg
     3541 ggggcttaaa tgtatagaaa gtaggcccca gcccataagg ggtgtgaaca caccacctca
     3601 cagctcgtca cccatttgac aggaacgccc aggggagagg agaggagagg agaggagggg
     3661 aggggaggag gggagctctg cacaattgga cttttctgtt gtttctgcat gtttaatata
     3721 gaagttcctg tcggtccttg ggagatcatg gccttcagat atgcacacga cctttgaatt
     3781 gtgcctacta attatagcag gggacttggg tacccaagga attccagttt ctgggactac
     3841 agtagtaact cccagctgta ctctggactt tattttgcta accgtaattg aacaactgta
     3901 aattactgct atattaatgt gttaaagcac tggggtagtc taattctaac tggtaattaa
     3961 ttatgtttgc caattatctg tttgaaataa atatgtgtct gaacagctat tgaacctgtt
     4021 aaattgtaca gatattatca tgacggcttt gtactgtgga atgtgcttaa taaaaacaaa
     4081 agtttgacct ttgtccaata aattgctaag taatgtcaat aaatgaagac gagtattatg
     4141 cagtccagct gacctggctt cctggcgatt gttaacttca gctaatccac gccaatacgc
     4201 taaataaagt gttgcagtgc cccgctgtcc tgtca
//
