LOCUS       NM_001012222            1819 bp    mRNA    linear   ROD 02-APR-2024
DEFINITION  Rattus norvegicus F-box protein 7 (Fbxo7), mRNA.
ACCESSION   NM_001012222 XM_345806
VERSION     NM_001012222.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1819)
  AUTHORS   Beilina,A. and Cookson,M.R.
  TITLE     Genes associated with Parkinson's disease: regulation of autophagy
            and beyond
  JOURNAL   J Neurochem 139 Suppl 1 (Suppl 1), 91-107 (2016)
   PUBMED   26223426
  REMARK    Review article
REFERENCE   2  (bases 1 to 1819)
  AUTHORS   Zhou,Z.D., Xie,S.P., Sathiyamoorthy,S., Saw,W.T., Sing,T.Y.,
            Ng,S.H., Chua,H.P., Tang,A.M., Shaffra,F., Li,Z., Wang,H., Ho,P.G.,
            Lai,M.K., Angeles,D.C., Lim,T.M. and Tan,E.K.
  TITLE     F-box protein 7 mutations promote protein aggregation in
            mitochondria and inhibit mitophagy
  JOURNAL   Hum Mol Genet 24 (22), 6314-6330 (2015)
   PUBMED   26310625
REFERENCE   3  (bases 1 to 1819)
  AUTHORS   Chen,C.M., Chen,I.C., Huang,Y.C., Juan,H.F., Chen,Y.L., Chen,Y.C.,
            Lin,C.H., Lee,L.C., Lee,C.M., Lee-Chen,G.J., Lai,Y.J. and Wu,Y.R.
  TITLE     FBXO7 Y52C polymorphism as a potential protective factor in
            Parkinson's disease
  JOURNAL   PLoS One 9 (7), e101392 (2014)
   PUBMED   25029497
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1819)
  AUTHORS   Burchell,V.S., Nelson,D.E., Sanchez-Martinez,A.,
            Delgado-Camprubi,M., Ivatt,R.M., Pogson,J.H., Randle,S.J., Wray,S.,
            Lewis,P.A., Houlden,H., Abramov,A.Y., Hardy,J., Wood,N.W.,
            Whitworth,A.J., Laman,H. and Plun-Favreau,H.
  TITLE     The Parkinson's disease-linked proteins Fbxo7 and Parkin interact
            to mediate mitophagy
  JOURNAL   Nat Neurosci 16 (9), 1257-1265 (2013)
   PUBMED   23933751
REFERENCE   5  (bases 1 to 1819)
  AUTHORS   Zhao,T., Severijnen,L.A., van der Weiden,M., Zheng,P.P.,
            Oostra,B.A., Hukema,R.K., Willemsen,R., Kros,J.M. and Bonifati,V.
  TITLE     FBXO7 immunoreactivity in alpha-synuclein-containing inclusions in
            Parkinson disease and multiple system atrophy
  JOURNAL   J Neuropathol Exp Neurol 72 (6), 482-488 (2013)
   PUBMED   23656991
REFERENCE   6  (bases 1 to 1819)
  AUTHORS   Zhao,T., De Graaff,E., Breedveld,G.J., Loda,A., Severijnen,L.A.,
            Wouters,C.H., Verheijen,F.W., Dekker,M.C., Montagna,P.,
            Willemsen,R., Oostra,B.A. and Bonifati,V.
  TITLE     Loss of nuclear activity of the FBXO7 protein in patients with
            parkinsonian-pyramidal syndrome (PARK15)
  JOURNAL   PLoS One 6 (2), e16983 (2011)
   PUBMED   21347293
  REMARK    Publication Status: Online-Only
REFERENCE   7  (bases 1 to 1819)
  AUTHORS   Ebstein,F., Lange,N., Urban,S., Seifert,U., Kruger,E. and
            Kloetzel,P.M.
  TITLE     Maturation of human dendritic cells is accompanied by functional
            remodelling of the ubiquitin-proteasome system
  JOURNAL   Int J Biochem Cell Biol 41 (5), 1205-1215 (2009)
   PUBMED   19028597
REFERENCE   8  (bases 1 to 1819)
  AUTHORS   Kirk,R., Laman,H., Knowles,P.P., Murray-Rust,J., Lomonosov,M.,
            Meziane el,K. and McDonald,N.Q.
  TITLE     Structure of a conserved dimerization domain within the F-box
            protein Fbxo7 and the PI31 proteasome inhibitor
  JOURNAL   J Biol Chem 283 (32), 22325-22335 (2008)
   PUBMED   18495667
REFERENCE   9  (bases 1 to 1819)
  AUTHORS   Chang,Y.F., Cheng,C.M., Chang,L.K., Jong,Y.J. and Yuo,C.Y.
  TITLE     The F-box protein Fbxo7 interacts with human inhibitor of apoptosis
            protein cIAP1 and promotes cIAP1 ubiquitination
  JOURNAL   Biochem Biophys Res Commun 342 (4), 1022-1026 (2006)
   PUBMED   16510124
REFERENCE   10 (bases 1 to 1819)
  AUTHORS   Hsu,J.M., Lee,Y.C., Yu,C.T. and Huang,C.Y.
  TITLE     Fbx7 functions in the SCF complex regulating Cdk1-cyclin
            B-phosphorylated hepatoma up-regulated protein (HURP) proteolysis
            by a proline-rich region
  JOURNAL   J Biol Chem 279 (31), 32592-32602 (2004)
   PUBMED   15145941
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC079382.1.
            
            On Feb 11, 2005 this sequence version replaced XM_345806.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC079382.1, SRR8487227.95893.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMD00132261,
                                           SAMD00132262 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1819
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="7"
                     /map="7q13"
     gene            1..1819
                     /gene="Fbxo7"
                     /note="F-box protein 7"
                     /db_xref="GeneID:366854"
                     /db_xref="RGD:1305648"
     exon            1..155
                     /gene="Fbxo7"
                     /inference="alignment:Splign:2.1.0"
     CDS             34..1602
                     /gene="Fbxo7"
                     /codon_start=1
                     /product="F-box only protein 7"
                     /protein_id="NP_001012222.1"
                     /db_xref="GeneID:366854"
                     /db_xref="RGD:1305648"
                     /translation="MKLRVRLQKRTQPLEVPESEPTLGQLRAHLIQDLLPTLGFSSDT
                     RFAITLNNKDALTGDEETLASYGIVSGDLICLVLEDEMPAPNLPSSTDSEHSSLQNND
                     QPPLAATSSQANIPDEQGSDSSHGQVTQYDAWTDDSMEGPSHSAEAVSIQDAMSVEEA
                     SGFHPLEPMLCSETEDGQVPHSLEALYQSAGCSTVSDALIVLVHLLMLESGYIPQGTE
                     AKAASMPEKWKSSGVYKLQYTHPLCEGGSAVLTCVPLGKLIMINATIKVNGGIKNVKS
                     VQLKPGAYVRRAEPGESAAKVYKDLKKLSRLFKDQLVYPLLAFTRQVLNLPDVFGLVV
                     LPLELKLRIFRLLDVHSVLALSAVCHDLLIASNDPLLWRCLYLRDFRDSTIRGPDTDW
                     KELYRKKHIQRKEAQRMRHVMYLPSVHPIPFCPIPVYPRPYLPTTLLPPGIIGGEYDE
                     RPILPSVGDPVTSLIPRPGEPPSQFRPVRPRFDPVGPLPGSNSLLPGRASPNNRFPFR
                     PGRGRSADNRLPYL"
     exon            156..450
                     /gene="Fbxo7"
                     /inference="alignment:Splign:2.1.0"
     exon            451..678
                     /gene="Fbxo7"
                     /inference="alignment:Splign:2.1.0"
     exon            679..820
                     /gene="Fbxo7"
                     /inference="alignment:Splign:2.1.0"
     exon            821..904
                     /gene="Fbxo7"
                     /inference="alignment:Splign:2.1.0"
     exon            905..1000
                     /gene="Fbxo7"
                     /inference="alignment:Splign:2.1.0"
     exon            1001..1177
                     /gene="Fbxo7"
                     /inference="alignment:Splign:2.1.0"
     exon            1178..1215
                     /gene="Fbxo7"
                     /inference="alignment:Splign:2.1.0"
     exon            1216..1793
                     /gene="Fbxo7"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cccgggccga ccgaggcttg cggtccgctc accatgaagc tgcgcgtgcg gcttcaaaag
       61 cggacccagc cgctcgaggt gccggagtcg gagccgacgc tcgggcagct gcgcgcgcac
      121 ctcatccagg acctgctgcc cacgttgggg ttcagttctg atacccgatt tgcaattaca
      181 ttgaacaaca aggatgccct cactggagat gaagagacct tggcttcata tgggattgtt
      241 tctggggact tgatatgttt ggttcttgaa gatgaaatgc cggcacctaa cttaccttca
      301 tctacagatt cagagcattc ctctctccag aataatgacc aacctccttt ggctgccacc
      361 tcaagccagg ctaacatccc agatgaacaa gggagtgatt catcccacgg acaggtcacc
      421 caatatgatg cctggaccga tgacagtatg gaaggaccta gtcacagtgc tgaagctgtg
      481 tcaattcagg acgccatgag tgtggaagag gcttctggtt tccatccact ggagccaatg
      541 ctctgcagtg aaacagagga cgggcaggtg ccacattccc tagaggccct gtaccagtca
      601 gccggctgct ccaccgtcag tgatgccttg atagtgctgg tgcatctcct tatgcttgag
      661 tcgggctaca tacctcaggg gactgaagcc aaagcagcat ccatgcctga gaaatggaag
      721 tcaagtggcg tatacaagct ccagtacaca catcctctct gtgagggcgg ctctgccgtg
      781 cttacctgtg tacctttggg aaagctcatc atgataaacg ctacaataaa agtcaacggt
      841 gggattaaaa atgtgaagtc agtgcagctg aagccaggag cctacgttcg cagagcagaa
      901 ccaggggaaa gtgcagctaa agtgtacaaa gatcttaaga agctctctcg tctcttcaaa
      961 gaccagctgg tgtaccctct tctggctttc acacgacaag tgctgaacct cccagatgtg
     1021 tttgggctgg ttgtccttcc actggagctg aaactacgca tcttccgact tctggatgtt
     1081 cattccgtcc tggctctgtc tgcagtctgc catgacctcc tcattgcatc aaatgaccca
     1141 ctgctgtgga ggtgcttgta tctgcgggat tttcgagaca gtactatcag aggtcctgac
     1201 acagattgga aagaattgta cagaaagaag cacatccaaa gaaaagaagc ccagaggatg
     1261 cggcatgtga tgtacctacc gtcagtccac cctatcccat tctgccccat tcccgtctac
     1321 cccaggccct accttcccac cacgctgctt cctccaggaa tcattggtgg tgaatatgat
     1381 gagaggccaa tattgcctag tgttggggac ccagtcacct cactcatccc aaggcctggg
     1441 gagcctccta gccagttccg tccagtcaga ccacgttttg atcctgttgg cccacttcca
     1501 ggatctaact ccctcttacc aggaagagct agccccaaca acagatttcc cttcagaccc
     1561 ggcaggggtc ggtcagctga caaccggcta ccatacctgt gaccgatttg gagacttcat
     1621 ggaaacgtag atgctgatct ctgctctcag ttctggttct gtgggcacca aggacaaggt
     1681 tgcccaaaga ggggttaggt gactgctggt ctctccactc tggattcccc tctgggatgg
     1741 agattgtggt actgacaatg ttctgtgtta tgttaataaa agtaaaaatt gcaaaaaaaa
     1801 aaaaaaaaaa aaaaaaaaa
//
