LOCUS       NM_138917                876 bp    mRNA    linear   ROD 02-JUN-2024
DEFINITION  Rattus norvegicus F-box protein 6 (Fbxo6), mRNA.
ACCESSION   NM_138917
VERSION     NM_138917.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 876)
  AUTHORS   Groisman,B., Shenkman,M., Ron,E. and Lederkremer,G.Z.
  TITLE     Mannose trimming is required for delivery of a glycoprotein from
            EDEM1 to XTP3-B and to late endoplasmic reticulum-associated
            degradation steps
  JOURNAL   J Biol Chem 286 (2), 1292-1300 (2011)
   PUBMED   21062743
REFERENCE   2  (bases 1 to 876)
  AUTHORS   Zhang,Y.W., Brognard,J., Coughlin,C., You,Z., Dolled-Filhart,M.,
            Aslanian,A., Manning,G., Abraham,R.T. and Hunter,T.
  TITLE     The F box protein Fbx6 regulates Chk1 stability and cellular
            sensitivity to replication stress
  JOURNAL   Mol Cell 35 (4), 442-453 (2009)
   PUBMED   19716789
REFERENCE   3  (bases 1 to 876)
  AUTHORS   Ebstein,F., Lange,N., Urban,S., Seifert,U., Kruger,E. and
            Kloetzel,P.M.
  TITLE     Maturation of human dendritic cells is accompanied by functional
            remodelling of the ubiquitin-proteasome system
  JOURNAL   Int J Biochem Cell Biol 41 (5), 1205-1215 (2009)
   PUBMED   19028597
REFERENCE   4  (bases 1 to 876)
  AUTHORS   Yoshida,Y., Adachi,E., Fukiya,K., Iwai,K. and Tanaka,K.
  TITLE     Glycoprotein-specific ubiquitin ligases recognize N-glycans in
            unfolded substrates
  JOURNAL   EMBO Rep 6 (3), 239-244 (2005)
   PUBMED   15723043
REFERENCE   5  (bases 1 to 876)
  AUTHORS   Yoshida,Y., Tokunaga,F., Chiba,T., Iwai,K., Tanaka,K. and Tai,T.
  TITLE     Fbs2 is a new member of the E3 ubiquitin ligase family that
            recognizes sugar chains
  JOURNAL   J Biol Chem 278 (44), 43877-43884 (2003)
   PUBMED   12939278
REFERENCE   6  (bases 1 to 876)
  AUTHORS   Ilyin,G.P., Serandour,A.L., Pigeon,C., Rialland,M., Glaise,D. and
            Guguen-Guillouzo,C.
  TITLE     A new subfamily of structurally related human F-box proteins
  JOURNAL   Gene 296 (1-2), 11-20 (2002)
   PUBMED   12383498
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from AF393484.1.
            
            On Jun 10, 2007 this sequence version replaced NM_138917.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF393484.1, BC063148.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760389, SAMEA5760396
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..876
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="Sprague-Dawley"
                     /db_xref="taxon:10116"
                     /chromosome="5"
                     /map="5q36"
     gene            1..876
                     /gene="Fbxo6"
                     /gene_synonym="Fbg2; Fbxo6b"
                     /note="F-box protein 6"
                     /db_xref="GeneID:192351"
                     /db_xref="RGD:620418"
     exon            1..280
                     /gene="Fbxo6"
                     /gene_synonym="Fbg2; Fbxo6b"
                     /inference="alignment:Splign:2.1.0"
     CDS             22..876
                     /gene="Fbxo6"
                     /gene_synonym="Fbg2; Fbxo6b"
                     /note="F-box/G-domain protein 2; F-box protein that
                     recognizes sugar chains 2; F-box only protein 6b; F-box
                     only protein 6 b"
                     /codon_start=1
                     /product="F-box only protein 6"
                     /protein_id="NP_620272.3"
                     /db_xref="GeneID:192351"
                     /db_xref="RGD:620418"
                     /translation="MVNINELPENILLELFTHVPAPQLLRNCRLVCSLWRDLIDVMTL
                     WKRKSLREGFVTKDRDEPVDDWKIFYILCSLQRNLLRNPCAEENLRSWRIDSNGGDEW
                     KVESLPGDHGTSFPDTKVKKYFVTSYGMCLKSQMVDLKAEGYSEKLLDTVRPDIVVKD
                     WFAPRADCGCTYHLRVQLASADYIVLASFEPPPVTIEQWNDASWQEISHTFSNYPPGV
                     RHILFQHGGKDTQFWKGWYGPRVTNSSIIVSHRTAKNPAPARTLPEEDTSNRRKILSF
                     GSWEDLSP"
     exon            281..407
                     /gene="Fbxo6"
                     /gene_synonym="Fbg2; Fbxo6b"
                     /inference="alignment:Splign:2.1.0"
     exon            408..503
                     /gene="Fbxo6"
                     /gene_synonym="Fbg2; Fbxo6b"
                     /inference="alignment:Splign:2.1.0"
     exon            504..639
                     /gene="Fbxo6"
                     /gene_synonym="Fbg2; Fbxo6b"
                     /inference="alignment:Splign:2.1.0"
     exon            640..876
                     /gene="Fbxo6"
                     /gene_synonym="Fbg2; Fbxo6b"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gaacatagct ccactgccat catggtcaac atcaacgagc tgccggagaa cattctactg
       61 gaactgttca cccacgtccc ggccccacag ctgctgcgca actgccgcct ggtctgcagc
      121 ctctggcgag acctcatcga tgtgatgacc ctctggaagc gcaagagcct tcgagagggc
      181 tttgtcacca aagaccggga cgagcctgtg gatgactgga agatcttcta tatcctgtgc
      241 agtctgcaaa ggaacctcct tcggaacccg tgtgccgaag agaacctgag atcatggcgg
      301 atagactcca atgggggaga tgagtggaag gtggagagcc tccctgggga ccacggcaca
      361 agctttcctg acaccaaggt caagaagtat tttgtcacct cttatgggat gtgcctcaag
      421 tcccagatgg tggacctcaa agccgagggc tactctgaaa agctgctgga caccgttcgg
      481 ccggacattg tggttaaaga ctggtttgcc ccacgagcag actgcggctg tacctatcac
      541 ctccgggtac agctggcctc tgccgactac attgtcctag cctcctttga gcctccgcct
      601 gtgaccatcg aacagtggaa tgacgccagc tggcaagaga tctcccacac cttctccaat
      661 taccctcctg gcgtccgtca catccttttt caacatgggg gcaaggacac acagttctgg
      721 aaaggctggt atggtccccg tgtcaccaac agcagcatca tcgtcagcca caggacagcc
      781 aagaaccccg cccctgccag aactctaccg gaggaagaca ctagtaatag gaggaagata
      841 ctcagctttg gctcctggga agacctaagc ccttag
//
