LOCUS       NM_001106206            1907 bp    mRNA    linear   ROD 20-MAR-2023
DEFINITION  Rattus norvegicus F-box protein 5 (Fbxo5), mRNA.
ACCESSION   NM_001106206 XM_001065873 XM_214756
VERSION     NM_001106206.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1907)
  AUTHORS   Cappell SD, Mark KG, Garbett D, Pack LR, Rape M and Meyer T.
  TITLE     EMI1 switches from being a substrate to an inhibitor of APC/CCDH1
            to start the cell cycle
  JOURNAL   Nature 558 (7709), 313-317 (2018)
   PUBMED   29875408
REFERENCE   2  (bases 1 to 1907)
  AUTHORS   Liu L, Liu K, Yan Y, Chu Z, Tang Y and Tang C.
  TITLE     Two Transcripts of FBXO5 Promote Migration and Osteogenic
            Differentiation of Human Periodontal Ligament Mesenchymal Stem
            Cells
  JOURNAL   Biomed Res Int 2018, 7849294 (2018)
   PUBMED   29850565
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1907)
  AUTHORS   Chang L, Zhang Z, Yang J, McLaughlin SH and Barford D.
  TITLE     Atomic structure of the APC/C and its mechanism of protein
            ubiquitination
  JOURNAL   Nature 522 (7557), 450-454 (2015)
   PUBMED   26083744
REFERENCE   4  (bases 1 to 1907)
  AUTHORS   Chao TC, Chen KJ, Tang MC, Chan LC, Chen PM, Tzeng CH and Su Y.
  TITLE     Thymosin beta-4 knockdown in IEC-6 normal intestinal epithelial
            cells induces DNA re-replication via downregulating Emi1
  JOURNAL   J Cell Physiol 229 (11), 1639-1646 (2014)
   PUBMED   24615569
  REMARK    GeneRIF: Marked reductions in both RNA and protein levels of Emi1
            (early mitotic inhibitor 1) were also detected in Tbeta4
            -downregulated IEC-6 cells.
REFERENCE   5  (bases 1 to 1907)
  AUTHORS   Frye JJ, Brown NG, Petzold G, Watson ER, Grace CR, Nourse A, Jarvis
            MA, Kriwacki RW, Peters JM, Stark H and Schulman BA.
  TITLE     Electron microscopy structure of human APC/C(CDH1)-EMI1 reveals
            multimodal mechanism of E3 ligase shutdown
  JOURNAL   Nat Struct Mol Biol 20 (7), 827-835 (2013)
   PUBMED   23708605
REFERENCE   6  (bases 1 to 1907)
  AUTHORS   Lee H, Lee DJ, Oh SP, Park HD, Nam HH, Kim JM and Lim DS.
  TITLE     Mouse emi1 has an essential function in mitotic progression during
            early embryogenesis
  JOURNAL   Mol Cell Biol 26 (14), 5373-5381 (2006)
   PUBMED   16809773
REFERENCE   7  (bases 1 to 1907)
  AUTHORS   Hansen DV, Loktev AV, Ban KH and Jackson PK.
  TITLE     Plk1 regulates activation of the anaphase promoting complex by
            phosphorylating and triggering SCFbetaTrCP-dependent destruction of
            the APC Inhibitor Emi1
  JOURNAL   Mol Biol Cell 15 (12), 5623-5634 (2004)
   PUBMED   15469984
REFERENCE   8  (bases 1 to 1907)
  AUTHORS   Paronetto MP, Giorda E, Carsetti R, Rossi P, Geremia R and Sette C.
  TITLE     Functional interaction between p90Rsk2 and Emi1 contributes to the
            metaphase arrest of mouse oocytes
  JOURNAL   EMBO J 23 (23), 4649-4659 (2004)
   PUBMED   15526037
REFERENCE   9  (bases 1 to 1907)
  AUTHORS   Moshe Y, Boulaire J, Pagano M and Hershko A.
  TITLE     Role of Polo-like kinase in the degradation of early mitotic
            inhibitor 1, a regulator of the anaphase promoting
            complex/cyclosome
  JOURNAL   Proc Natl Acad Sci U S A 101 (21), 7937-7942 (2004)
   PUBMED   15148369
REFERENCE   10 (bases 1 to 1907)
  AUTHORS   Hsu JY, Reimann JD, Sorensen CS, Lukas J and Jackson PK.
  TITLE     E2F-dependent accumulation of hEmi1 regulates S phase entry by
            inhibiting APC(Cdh1)
  JOURNAL   Nat Cell Biol 4 (5), 358-366 (2002)
   PUBMED   11988738
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from CH474052.2.
            
            On or before Oct 4, 2007 this sequence version replaced
            XM_214756.4, XM_001065873.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC158745.1, SRR8487227.29176.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN06680445, SAMN16676811
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1907
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q11"
     gene            1..1907
                     /gene="Fbxo5"
                     /note="F-box protein 5"
                     /db_xref="GeneID:292263"
                     /db_xref="RGD:1309405"
     exon            1..204
                     /gene="Fbxo5"
                     /inference="alignment:Splign:2.1.0"
     CDS             126..1382
                     /gene="Fbxo5"
                     /codon_start=1
                     /product="F-box only protein 5"
                     /protein_id="NP_001099676.1"
                     /db_xref="GeneID:292263"
                     /db_xref="RGD:1309405"
                     /translation="MSRRACGDLPRPSSCLCPLDARTTVDGCKEESPVLSVTMKCFNC
                     NPDLLELEVVKTEDSGREGSYSPVCLEPSCDNCVGNHERLSFVESPIVGHDNKENQRV
                     QNILDSSKEVEELEASRLYEDSGYSSFIQSDSDDGILILENFRNSSQAHLLLSSQSPD
                     QHPNKNLLPALHFERVVCSTLKKNGKRNSKVDQEMLKEVIASGNITLQNIIGKKMGLE
                     HLDILAELSRRGCMHLLANIFMKLSGMDLINLSKVSRIWKKILESDKGAFQQYSKAMQ
                     RVIESNKLSLHASTRGYVVGRTALTCVQKSSTWAPPKNVQPSQRGQRGSVYSRHNEFL
                     EVAKTLKNNESLKACVRCNFPAKYDHYLERAVCKRESCKFEYCTKCLCAYHNNKDCLN
                     SKNLKASCKMGPLPGTKKSKKNLQRL"
     exon            205..871
                     /gene="Fbxo5"
                     /inference="alignment:Splign:2.1.0"
     exon            872..962
                     /gene="Fbxo5"
                     /inference="alignment:Splign:2.1.0"
     exon            963..1130
                     /gene="Fbxo5"
                     /inference="alignment:Splign:2.1.0"
     exon            1131..1907
                     /gene="Fbxo5"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gaaattcaaa gattttaaaa gtaccagctg gcgcctttta agagctacag ctcggcgccg
       61 cggctagcca cctctctctt gtggtcgccg ccacctcacc tgcattggaa cccaagtttt
      121 ccggcatgag ccggcgcgcc tgcggtgatc tcccccggcc gtcctcctgt ctctgccctc
      181 ttgacgcgcg gacgaccgtg gacggttgta aagaagaaag ccctgttctt tcggttacca
      241 tgaagtgttt taattgcaac cctgatcttt tggagcttga ggtggtgaag actgaggaca
      301 gtgggaggga aggttcctac agtcctgtgt gtttggaacc ttcctgtgac aattgtgttg
      361 gaaaccatga aagattgtct tttgtcgaat caccaattgt gggacatgat aacaaggaaa
      421 atcaacgtgt acaaaatata ctagatagtt caaaggaagt ggaagagctg gaggccagca
      481 gactgtatga ggacagcggc tactcctcat tcatacagag tgacagtgac gatggcatcc
      541 ttatcctgga gaatttcaga aacagttccc aggcccatct gctgctgtca tcgcagagcc
      601 cagaccagca tcccaacaaa aacctgctgc ctgccctgca ttttgaaaga gtggtttgct
      661 caacattaaa aaagaatggc aagcgaaact ctaaagtgga tcaagaaatg ctgaaggaag
      721 ttatcgccag cggaaacatt acactgcaaa atataattgg caagaaaatg ggcctggaac
      781 acctagatat cctggctgag ctctcccgga ggggatgtat gcacctgtta gctaatattt
      841 tcatgaagct cagcggcatg gacttaataa atttgtctaa agtgagcaga atttggaaga
      901 agatactaga aagcgataaa ggagcattcc agcaatacag caaagccatg cagagagtca
      961 ttgaaagcaa taagttgtca ctacatgctt caaccagagg atatgtcgtg ggcagaactg
     1021 cactaacctg tgttcaaaag tcatcgacct gggcacctcc caaaaatgtt caacccagtc
     1081 aacgtggtca gaggggttct gtctacagcc ggcacaatga gttcctggag gtggcaaaga
     1141 cattgaaaaa caacgaaagc ctcaaagcct gtgttcgctg taatttccct gcaaaatatg
     1201 accattattt agagcgagca gtctgcaaac gggaaagttg taaattcgaa tattgtacaa
     1261 agtgtctgtg tgcttaccat aacaacaaag actgtttgaa tagcaagaac ctaaaagcca
     1321 gctgcaaaat gggtcctttg cctggaacta aaaagagtaa aaagaactta caaagattgt
     1381 gaccttttag tcgatcaact gtacatcgta agggctactt taaaagaaaa aaaagaaaag
     1441 aaatccgatt ttaacttaaa gtaaatgtaa tgttgatccc ttttgtgaat ggaggacata
     1501 cagcctctta aaataatcac agcttaatgc taaaaaaatt aaatgtccat aaaacaccaa
     1561 gattgactta tgcaaaattt attttatcta tttgtagtta catgctaaga caaaattgat
     1621 tggacttttt ggcaagtgaa gtctggattt tttatggagt cttgaaaaca gatgtgcttc
     1681 agtgttagcc tctgagacac gttttaccaa atttgtatta tgtgcctatc aacttgagtc
     1741 tgtcaattta aatgtttgtc agtatgagct tttcagtgtt aagtatcctt tgtagagtcc
     1801 tgtttatttc tgaagtctat tttaatgttt ttatgtctgt aaatatctta ttatgtacca
     1861 aagaaaaaaa taaacataat tttgttacga taatcttgtc agaggtt
//
