LOCUS       NM_001398607            4261 bp    mRNA    linear   ROD 01-APR-2024
DEFINITION  Rattus norvegicus F-box protein 45 (Fbxo45), mRNA.
ACCESSION   NM_001398607 XM_017598223
VERSION     NM_001398607.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 4261)
  AUTHORS   Tada,H., Okano,H.J., Takagi,H., Shibata,S., Yao,I., Matsumoto,M.,
            Saiga,T., Nakayama,K.I., Kashima,H., Takahashi,T., Setou,M. and
            Okano,H.
  TITLE     Fbxo45, a novel ubiquitin ligase, regulates synaptic activity
  JOURNAL   J Biol Chem 285 (6), 3840-3849 (2010)
   PUBMED   19996097
REFERENCE   2  (bases 1 to 4261)
  AUTHORS   Peschiaroli,A., Scialpi,F., Bernassola,F., Pagano,M. and Melino,G.
  TITLE     The F-box protein FBXO45 promotes the proteasome-dependent
            degradation of p73
  JOURNAL   Oncogene 28 (35), 3157-3166 (2009)
   PUBMED   19581926
REFERENCE   3  (bases 1 to 4261)
  AUTHORS   Saiga,T., Fukuda,T., Matsumoto,M., Tada,H., Okano,H.J., Okano,H.
            and Nakayama,K.I.
  TITLE     Fbxo45 forms a novel ubiquitin ligase complex and is required for
            neuronal development
  JOURNAL   Mol Cell Biol 29 (13), 3529-3543 (2009)
   PUBMED   19398581
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000011.1.
            
            On Dec 20, 2021 this sequence version replaced XM_017598223.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26360194.2137141.1,
                                           SRR26643298.67112.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760386
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-361               JAXUCZ010000011.1  82056457-82056817
            362-718             JAXUCZ010000011.1  82064628-82064984
            719-4261            JAXUCZ010000011.1  82068538-82072080
FEATURES             Location/Qualifiers
     source          1..4261
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="11"
                     /map="11q22"
     gene            1..4261
                     /gene="Fbxo45"
                     /gene_synonym="RGD1311861"
                     /note="F-box protein 45"
                     /db_xref="GeneID:288042"
                     /db_xref="RGD:1311861"
     exon            1..361
                     /gene="Fbxo45"
                     /gene_synonym="RGD1311861"
                     /inference="alignment:Splign:2.1.0"
     CDS             35..904
                     /gene="Fbxo45"
                     /gene_synonym="RGD1311861"
                     /note="F-box only protein 45"
                     /codon_start=1
                     /product="F-box/SPRY domain-containing protein 1"
                     /protein_id="NP_001385536.1"
                     /db_xref="GeneID:288042"
                     /db_xref="RGD:1311861"
                     /translation="MAAPGPGAGAASGGASGGAGASGGAGASAGAGSASSGIGGRLPS
                     RVLELVFSYLELSELRSCALVCKHWYRCLHGDENSEVWRSLCARSLAEEALRTDILCN
                     LPSYKAKVRAFQHAFSTNDCSRNVYIKKNGFTLHRNPIAQSTDGARTKIGFSEGRHAW
                     EVWWEGPLGTVAVIGIATKRAPMQCQGYVALLGSDDQSWGWNLVDNNLLHNGEVNGSF
                     PQCNNAPKYQIGERIRVILDMEDKTLAFERGYEFLGVAFRGLPKACLYPAVSAVYGNT
                     EVTLVYLGKPLDG"
     exon            362..718
                     /gene="Fbxo45"
                     /gene_synonym="RGD1311861"
                     /inference="alignment:Splign:2.1.0"
     exon            719..4261
                     /gene="Fbxo45"
                     /gene_synonym="RGD1311861"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ggcagcggcg gccctcgggc cggctggtga ggcgatggcg gcgccgggcc cgggggctgg
       61 ggcagcctcg ggcggcgcta gcggcggcgc cggcgccagc ggcggcgccg gcgccagcgc
      121 cggcgcggga tccgcgtcct ccgggatcgg cggccggttg cccagccggg tgctggagtt
      181 ggtgttctcc tacctggagc tgtccgagct gcggagctgc gccctggtgt gcaagcactg
      241 gtaccgctgc ctccacggcg atgagaacag cgaggtgtgg cggagcctgt gcgcccgcag
      301 cctagcagaa gaggctctgc gcacggacat cctctgcaac ctgcccagct acaaggccaa
      361 ggtacgtgct ttccaacatg ccttcagcac gaacgactgc tccaggaatg tctacatcaa
      421 gaagaatggc tttacattac atcggaaccc catcgctcag agcaccgatg gtgcaaggac
      481 caagattggt ttcagtgagg gccgccacgc ctgggaagtc tggtgggagg gccctttggg
      541 cactgtggca gtgataggga ttgctacgaa acgggccccc atgcagtgcc aaggttatgt
      601 ggctttgctg gggagcgacg accagagctg gggctggaat ctggtggaca ataatctact
      661 acataatggg gaagtcaatg gcagctttcc acagtgcaac aatgcaccca aatatcagat
      721 aggagagaga atccgagtca tcttggacat ggaagataag actttagcct ttgagcgtgg
      781 gtatgagttc ctgggggttg ccttccgagg acttccaaaa gcctgcttat acccagcagt
      841 ttctgcagta tatggcaaca cagaagtgac tttggtttat cttggaaaac ctttggatgg
      901 atgacagtgg ctttctggaa aggacagtgg agaagagatc tatgtgtgga aagtagaacc
      961 acgaagtgaa gtatcatgtg tgcatgccca agaaacatcc tgaagacaca tgaagttgag
     1021 aactagagaa gcaactctac aacagagatg gtcatagtgt ttcctctttc cactgggcca
     1081 gaaaatcctc agggttgcag ttggttgagt gggcagttga cagacatatg catgttgtca
     1141 cagagtcttc tctaagttag cagtgtgtga cttccagctt aaaggtgagc gtgtagagac
     1201 gctgtaggag ggaatcgcag gagtttatgt agagttcatg gagaaggctc ggtcccatct
     1261 tacatctgcc tgtccctcct ccagtccctt tatttctagc cagcttgact tagaaagtat
     1321 gaaactggct gggttttatt taatattttt aatatattga gaagcatggt ctgcctggac
     1381 tgcacttctc tagcaatgag aaataaaatc gtgcagctat tttaaaagtt gtatatataa
     1441 tgtatataaa actgtaaaaa aaggggggca aaggcattgc tttgttctac ttcaatttct
     1501 taaaaatcac tacatggtac aacattagag tgacattagg ggacagtagg gtaggagaga
     1561 gaagaggaga catgtgctgg ctcatttggt agtgtttggg ctcatagtcc atggctagaa
     1621 gagaattatg ataaaggttc ctcagttggt taaaggcggg aagcaggtct acttacaatt
     1681 atgcatatgc ccagggctga ttcagaagta taggaatgtg cctcctggca tctggcttca
     1741 gtgtttggcc ttctgagaac tggtctccac acagaacagt ctcagctgct cttacagtac
     1801 tcagtatgag cactgttagt ataaacccta gcagaacaca tggtcagcgg ttcttttatt
     1861 tcttaacttt ataatgctgt agatgttatg aagaattttt aatttcatat tgtttacatt
     1921 atacaacagt cgaggcctca aagtctccat tggggctgtc atcaaatgtt tactcacccg
     1981 tctgaaccag tgccggcctg caccaggtca ggccagagtg ttcctaatca cctaggtgtt
     2041 gccccctggg atttaatgct gaaaacttca ggttggcagc aatatggaag cttcattgca
     2101 aagaggtgaa tgttatttcc tgttttaacc cctaaaactt ctcactaaca cttagcacat
     2161 gagctgaggt ggctgttgat ttttttcttt tgctagaaca gaaacatctt tctgtataaa
     2221 aggataatta atatggttcc gatacataag aattgttgaa ggcaagtaaa atctttgtac
     2281 tttttacatg attgctgtat gtatattttg ttttaaatct aataaaatta gggacagaga
     2341 gcagcttgct ggggttcttg aggcccttga taattaaatt tgtcaatact gctatgaagc
     2401 aggaggcttg gccacacaac ggtctgtatc gcctcctgag agggttacag gtatttattg
     2461 tacatttgat ctgttgcttg agaaagagaa atttgttaaa gattcttttg ataatctgta
     2521 tcaagaagaa accttgtaca aagtggaatt atatgtatta gagaagatag ctggcccagg
     2581 aattgttttg gttttcctgt ttttttgtgt tgtttcgttt cgttttgttt ttctgctcta
     2641 gaacaactca atatggtggc atttaagaat tgatgaaagc cctggttaag gatggagact
     2701 gactggttaa gaggatggag actgactagt taagaggatg gagactgact gactagttaa
     2761 gaggatagag actgactagt taggaggatg gagactgact agttaagagg atggagagtg
     2821 actagttagg aggatggaga ctgactagtt aggaggatga agactgacta gttaggagga
     2881 tggagactga ctagttagga ggatggagac tgactagtta ggaggatgga gagtgactag
     2941 ttaggaggat ggagactgac tagtaggagg atggagactg actagttagg aggatggaga
     3001 ctgactagtt aggaggatgg agactgacta gttaggagga tggagactga ctagttagga
     3061 ggatggagac tgactagtta agaggatgga gactgactag ttacaaggcg ccagcagtcc
     3121 atatatactt gctgcctctt cagctgtgac ggcccctcaa gcttctcgtg agtttgatgc
     3181 ataacttctg ttttttgtct tgttgttggt aaatattcat tcgcaacaag tttttgaagg
     3241 tgctgactgg aaaacaaaat cacgtggtta ttcatttctc attgaactta gagtcggata
     3301 attgcctaac aatttaacac caagctgttc tctctgtgtc ttgtcttgtt tttggttttt
     3361 taaaagactg gttctcactt tgtagctcag gctatccgtg atctcacagc ggtctcccta
     3421 cgtcagcctc cccagaactg ggattagaga tataagctac attcccagaa caacaagcca
     3481 ttttagctca aagatttgaa tgttcctagt taggatgggc atctagagaa cagaggacct
     3541 tcatttataa cctgatctat ttactagaaa tcttgttact agagaccagt agtggctgcc
     3601 cagatcatta aggcaaactg ctcagtgttg aaggaagtca tgttcttgtt ggtgcttaaa
     3661 gagcgtgttt ccacacacag ttgtacctga gtcagtgctg ctcaagtatg gctggatctc
     3721 agagtggctt aaaacatact aagcttgggt ccgtatcctg attctggtgt cagaactggg
     3781 atatgctctg accataagga tttaaaaatg ccctggtttc agaatgctac caaaggttga
     3841 gagcagttgt gctcaatttc ccttagaggt ttcccatcta caaagtagga aattcttgct
     3901 cccctcacta cctcacaagg atacagaggg tgcacgagag cgcactggga gtgttggcgt
     3961 tgtgggtaga ggacgctgta gaagtgcaag catctgtcac agttctcaat ttcagctgca
     4021 gccgcgatcg aaaacggata attgaatttg ttgttgttgt aggaagctct taatgtgatt
     4081 ccgtgaggaa gcatgtaggg gtggagcaaa cgttgatgac tactcttatt cactatggtc
     4141 ttctagccta cttgaaactg gcggttatat tatctaagtt ttcataggaa agaagaaata
     4201 ttaaggctta attctgtaat gttcattggc tcataattca ttaaaaagtt catacaagga
     4261 a
//
