LOCUS       NM_001107672            1993 bp    mRNA    linear   ROD 26-FEB-2024
DEFINITION  Rattus norvegicus F-box protein 4 (Fbxo4), mRNA.
ACCESSION   NM_001107672 XM_001054338 XM_227090
VERSION     NM_001107672.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1993)
  AUTHORS   Kim J and Chung IK.
  TITLE     The splicing factor U2AF65 stabilizes TRF1 protein by inhibiting
            its ubiquitin-dependent proteolysis
  JOURNAL   Biochem Biophys Res Commun 443 (3), 1124-1130 (2014)
   PUBMED   24389012
REFERENCE   2  (bases 1 to 1993)
  AUTHORS   Vaites LP, Lee EK, Lian Z, Barbash O, Roy D, Wasik M, Klein-Szanto
            AJ, Rustgi AK and Diehl JA.
  TITLE     The Fbx4 tumor suppressor regulates cyclin D1 accumulation and
            prevents neoplastic transformation
  JOURNAL   Mol Cell Biol 31 (22), 4513-4523 (2011)
   PUBMED   21911473
REFERENCE   3  (bases 1 to 1993)
  AUTHORS   Nelson DE and Laman H.
  TITLE     A Competitive binding mechanism between Skp1 and exportin 1 (CRM1)
            controls the localization of a subset of F-box proteins
  JOURNAL   J Biol Chem 286 (22), 19804-19815 (2011)
   PUBMED   21378169
REFERENCE   4  (bases 1 to 1993)
  AUTHORS   Li Y and Hao B.
  TITLE     Structural basis of dimerization-dependent ubiquitination by the
            SCF(Fbx4) ubiquitin ligase
  JOURNAL   J Biol Chem 285 (18), 13896-13906 (2010)
   PUBMED   20181953
REFERENCE   5  (bases 1 to 1993)
  AUTHORS   Zeng Z, Wang W, Yang Y, Chen Y, Yang X, Diehl JA, Liu X and Lei M.
  TITLE     Structural basis of selective ubiquitination of TRF1 by SCFFbx4
  JOURNAL   Dev Cell 18 (2), 214-225 (2010)
   PUBMED   20159592
REFERENCE   6  (bases 1 to 1993)
  AUTHORS   Ebstein F, Lange N, Urban S, Seifert U, Kruger E and Kloetzel PM.
  TITLE     Maturation of human dendritic cells is accompanied by functional
            remodelling of the ubiquitin-proteasome system
  JOURNAL   Int J Biochem Cell Biol 41 (5), 1205-1215 (2009)
   PUBMED   19028597
REFERENCE   7  (bases 1 to 1993)
  AUTHORS   Lee TH, Perrem K, Harper JW, Lu KP and Zhou XZ.
  TITLE     The F-box protein FBX4 targets PIN2/TRF1 for ubiquitin-mediated
            degradation and regulates telomere maintenance
  JOURNAL   J Biol Chem 281 (2), 759-768 (2006)
   PUBMED   16275645
REFERENCE   8  (bases 1 to 1993)
  AUTHORS   Cenciarelli C, Chiaur DS, Guardavaccaro D, Parks W, Vidal M and
            Pagano M.
  TITLE     Identification of a family of human F-box proteins
  JOURNAL   Curr Biol 9 (20), 1177-1179 (1999)
   PUBMED   10531035
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from CH474048.2.
            
            On or before Oct 4, 2007 this sequence version replaced
            XM_227090.4, XM_001054338.1.
            
            ##Evidence-Data-START##
            RNAseq introns :: mixed sample support SAMD00132261, SAMD00132262
                              [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1993
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="2"
                     /map="2q16"
     gene            1..1993
                     /gene="Fbxo4"
                     /note="F-box protein 4"
                     /db_xref="GeneID:310363"
                     /db_xref="RGD:1307580"
     exon            1..651
                     /gene="Fbxo4"
                     /inference="alignment:Splign:2.1.0"
     CDS             331..1626
                     /gene="Fbxo4"
                     /codon_start=1
                     /product="F-box only protein 4"
                     /protein_id="NP_001101142.1"
                     /db_xref="GeneID:310363"
                     /db_xref="RGD:1307580"
                     /translation="MSHSGPPRPGAAPSRPAWLVPAGRAETEAERLGNRCARPCLAEP
                     AAMAGSEPRGAGSPPPASDWGRLEAAILSGWRTFWNSVGKERATRTASRKEEAEETSA
                     LTRLPIDVQLYILSFLSPHDLCQLGSTDHYWNETVRDPILWRYFLFRDLPSWSSVDWK
                     SLPDLEILKKPISEVTDSTCFDYMEVYKMCCPYTRRALKASRPMYGAVTSFLHSLIIQ
                     NEPRFAMFGPGLEELNTSLVLSLMSSEDLCPTAGLPHRQIDGIGSGVSFQLSNQHKFN
                     ILILYSTTRKERDRAREEHTSTVNKMFSLQSEGDEQQGSRYSVIPQIQKVCEVVDGFI
                     YVANAEAHRRHEWQDEFSRIMAMTDPAFGSSGRPMLVLSCISQADVKRMPCFYLAHEL
                     RLSLLNHPWMVQDTEAETLTGFLNGIEWILEEVESKHAK"
     exon            652..887
                     /gene="Fbxo4"
                     /inference="alignment:Splign:2.1.0"
     exon            888..1108
                     /gene="Fbxo4"
                     /inference="alignment:Splign:2.1.0"
     exon            1109..1184
                     /gene="Fbxo4"
                     /inference="alignment:Splign:2.1.0"
     exon            1185..1360
                     /gene="Fbxo4"
                     /inference="alignment:Splign:2.1.0"
     exon            1361..1536
                     /gene="Fbxo4"
                     /inference="alignment:Splign:2.1.0"
     exon            1537..1993
                     /gene="Fbxo4"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 agtcagccaa ggtcaatgtc attaataaca gatgggactt tttggagcac tttagttcca
       61 caggctcttg atcgtctcca tgtttttgct aaactccagt aaagcggtag attgctgatt
      121 ccaaaacaca gaagcacaca tacagcctac ttaataccta actcttaagg ggaagcaagt
      181 gttagaacca agattacaga aaaagggttg gctgttccac aagccctagc tccctgctcc
      241 ttgtggtggt gcctagagcc agggacctag aggatatgta gtctgggtta acatcagcgg
      301 tcattcggcc aagggtttgt gctaaccggg atgagtcatt ccgggccacc tcggcctgga
      361 gccgcgccca gcagaccagc ctggctcgtc ccagcggggc gggcggagac ggaggccgag
      421 cggctgggaa accggtgcgc ccggccgtgt ctcgcggagc ccgcagccat ggctggaagc
      481 gagccccgcg gagccggctc cccgccgccc gccagcgact ggggccgcct ggaggctgct
      541 atcctgagcg gctggaggac cttctggaat tcggtgggca aggagcgggc gacgcggacg
      601 gcctcccgga aggaggaggc ggaggagacg agcgcgctga cgcggctgcc gattgatgtg
      661 cagctgtata tcttgtcatt tctttcaccc catgacctgt gccagttggg aagtacagat
      721 cactattgga atgaaactgt aagagaccca attctctgga gatactttct gtttcgagat
      781 ctcccttctt ggtcctctgt tgattggaag tcacttccgg atctagagat attaaaaaag
      841 cccatatctg aggtcaccga cagcacatgt tttgattaca tggaggttta taaaatgtgc
      901 tgtccatata cgagaagagc cttgaaagcc agccgtccta tgtatggagc ggttacctct
      961 ttcttacact cactgatcat tcagaatgaa ccccggtttg ctatgtttgg accaggtttg
     1021 gaagaactga acacatcttt ggtgttgagt ttgatgtctt ctgaggatct ttgcccaact
     1081 gctggtttac ctcatagaca gattgacggt attggatctg gagtcagttt ccagttgagc
     1141 aatcaacaca aattcaacat cctgatactg tactcaacta ccagaaagga aagagacaga
     1201 gcgagggagg agcacacaag cacggttaac aagatgttca gcctacagag cgagggagac
     1261 gagcaacagg ggagccgcta cagcgttatc ccacagattc agaaagtgtg tgaggttgta
     1321 gatgggttta tctacgtggc aaatgctgaa gctcatagac gtcatgaatg gcaagatgaa
     1381 ttttctcgta ttatggccat gacagatcca gcttttggat cttcaggaag accaatgctg
     1441 gttttatctt gtatttctca agcagatgta aaaagaatgc cttgttttta tttagctcat
     1501 gaacttcgtc tcagtcttct gaaccaccca tggatggtcc aggatacaga ggctgagact
     1561 ctgactggtt tcttgaatgg cattgagtgg attcttgaag aagtagaatc taagcatgcg
     1621 aaatgaagtt cctttgggac cctgggaagc cgcacgtcat ggtgtatgtg tttccggtcc
     1681 ctcctgttcc tgcctctctg gaggagggct gtttactgga cagctactac agctgggctt
     1741 ctgacacttt accatgaatc agcagcaagc ttcaatccta ctacttttcc acaaaatgaa
     1801 ctctcacatt tttgataatt ttatattttc tgtctttttg aaaatattaa attctgtaaa
     1861 accaaagttt gtggttcttt catttctcat ggtctctctt ttgctatcaa ggtggcccca
     1921 ctaggaagca gtaagcctgc ttagcacacc atgggatcgt taggatcttt caaggactca
     1981 ctaactgctt atc
//
