LOCUS       NM_001372021            4393 bp    mRNA    linear   ROD 31-MAR-2024
DEFINITION  Rattus norvegicus F-box protein 38 (Fbxo38), mRNA.
ACCESSION   NM_001372021 XM_006222583 XM_006254820
VERSION     NM_001372021.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 4393)
  AUTHORS   Meng,X., Liu,X., Guo,X., Jiang,S., Chen,T., Hu,Z., Liu,H., Bai,Y.,
            Xue,M., Hu,R., Sun,S.C., Liu,X., Zhou,P., Huang,X., Wei,L., Yang,W.
            and Xu,C.
  TITLE     FBXO38 mediates PD-1 ubiquitination and regulates anti-tumour
            immunity of T cells
  JOURNAL   Nature 564 (7734), 130-135 (2018)
   PUBMED   30487606
REFERENCE   2  (bases 1 to 4393)
  AUTHORS   Smaldone,S. and Ramirez,F.
  TITLE     Multiple pathways regulate intracellular shuttling of MoKA, a
            co-activator of transcription factor KLF7
  JOURNAL   Nucleic Acids Res 34 (18), 5060-5068 (2006)
   PUBMED   16990251
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000018.1 and BQ781227.1.
            
            On or before Aug 2, 2019 this sequence version replaced
            XM_006254820.3, XM_006222583.2.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26360190.941804.1,
                                           SRR26360194.2406629.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760383,
                                           SAMEA5760386 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-124               JAXUCZ010000018.1  58274139-58274262   c
            125-310             JAXUCZ010000018.1  58265836-58266021   c
            311-444             JAXUCZ010000018.1  58261230-58261363   c
            445-608             JAXUCZ010000018.1  58259226-58259389   c
            609-774             JAXUCZ010000018.1  58258852-58259017   c
            775-912             JAXUCZ010000018.1  58255779-58255916   c
            913-1050            JAXUCZ010000018.1  58254622-58254759   c
            1051-1144           JAXUCZ010000018.1  58252236-58252329   c
            1145-1275           JAXUCZ010000018.1  58250966-58251096   c
            1276-1446           JAXUCZ010000018.1  58247118-58247288   c
            1447-1589           JAXUCZ010000018.1  58245417-58245559   c
            1590-1803           JAXUCZ010000018.1  58244382-58244595   c
            1804-1920           JAXUCZ010000018.1  58242270-58242386   c
            1921-2100           JAXUCZ010000018.1  58240900-58241079   c
            2101-2841           JAXUCZ010000018.1  58238741-58239481   c
            2842-2942           JAXUCZ010000018.1  58234828-58234928   c
            2943-3045           JAXUCZ010000018.1  58234524-58234626   c
            3046-3212           JAXUCZ010000018.1  58231471-58231637   c
            3213-3358           JAXUCZ010000018.1  58230293-58230438   c
            3359-3462           JAXUCZ010000018.1  58229656-58229759   c
            3463-3576           JAXUCZ010000018.1  58229211-58229324   c
            3577-4374           JAXUCZ010000018.1  58227255-58228052   c
            4375-4393           BQ781227.1         1-19                c
FEATURES             Location/Qualifiers
     source          1..4393
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="18"
                     /map="18q12.1"
     gene            1..4393
                     /gene="Fbxo38"
                     /note="F-box protein 38"
                     /db_xref="GeneID:307390"
                     /db_xref="RGD:1311505"
     exon            1..124
                     /gene="Fbxo38"
                     /inference="alignment:Splign:2.1.0"
     exon            125..310
                     /gene="Fbxo38"
                     /inference="alignment:Splign:2.1.0"
     CDS             183..3755
                     /gene="Fbxo38"
                     /codon_start=1
                     /product="F-box only protein 38"
                     /protein_id="NP_001358950.1"
                     /db_xref="GeneID:307390"
                     /db_xref="RGD:1311505"
                     /translation="MGPRKKSVKVCVMDSEVPEEMTADEEKDYMNQLSHEVLCHIFRY
                     LPLQDIMCMECLSRKLKEAVTLYLRVVRVVDLCAGRWWEYMPSGFTDCSFLTLLKKMP
                     DVEQLYGLHPRYLERRRVRGHEAFSIPGVLEALQACPNLVGVETSHLELVESIWTYMP
                     HVHILGKFRNRNGAFPIPPENKLKIPIGAKIQTLHLVGVNVPEIPCIPMLRHLYMKWV
                     RLTKPQPFKDFLCISLRTFVMRNCAGPTNSLKYVPLVTGLASARNLEHLEMVRVPFLG
                     GLIQHVVEDSWRSGGFRNLHTIVLGACKNALEVDLGYLIITAARRLHEVRIQPSLTKD
                     GVFSALKMAELEFPQFETLHLGYVDEFLLQSRMANADLVKYGLADVVENPGIITDIGM
                     KAVNEVFSCIKYLAIYNCPHLHNPYNWISDHSRWTRLVDINLVRCHALKLDSFGQFVE
                     LLPSLEFISLDQMFREPPKGCARVGLSAGTGIGVSSALVSNQNSNNDNDNNAQNNNAN
                     IHDNNHHHPDDSDDDNDFRQDLQQGEAQFAADALNEMEDMVQDDGEVVAESGSGVPAH
                     QGVLPVDADEEQAGPSGLQRVVKPTPIAVHDSESDDEEDSLELQEVWIPKNGARRYSE
                     REEKTGDSGQPRETAAVSGKGKTPLRKRYNNSHQMGQAKQFPLEESSCEKGCQVTSEQ
                     IKADMKAARDISEKKKTKDVYPSCSTTAASTVGNSSSPSTASQSPDFVRTVTSGGSSE
                     PSPPEVDVSRQCVCSPGGSEDSEAMEEGDAESSVCPRCCCLRPQESQRRTSRRSDEER
                     PSTSRACVVNGADGTRSAFSFRTLPQGGSSGPAHDERTNGSGCGATGEDRRGSSQPES
                     CDVQSNEDYPRRPLTRARSRLSHVPLIPESEIAKTKPCHAMKRKRTADKSTSTSDPVI
                     EDDHVQVLVLKSKNLVGVTMTNCGITDLVLKDCPKMMFIHATRCRVLKHLKVENAPIV
                     NRFDYAQCKKLNMDQVLDQILRMPPERNRIIYLRPMQQVDTLTLEQKLFSGPYPYHIC
                     VIHEFSNPPNVRNKVRIRNWMDTIANINQELIKYEFFLEATRTEEDLKKYPKYPWGRE
                     IYTLEGVVDGAPYSMISDFPWLRSLRAAEPNSFARYDFEDDEESTIYAPRRKGQLSAD
                     ICMETIGEEISEMRQMKRGVFQRVVAIFIHYCDVNGEPVEDDYI"
     exon            311..444
                     /gene="Fbxo38"
                     /inference="alignment:Splign:2.1.0"
     exon            445..608
                     /gene="Fbxo38"
                     /inference="alignment:Splign:2.1.0"
     exon            609..774
                     /gene="Fbxo38"
                     /inference="alignment:Splign:2.1.0"
     exon            775..912
                     /gene="Fbxo38"
                     /inference="alignment:Splign:2.1.0"
     exon            913..1050
                     /gene="Fbxo38"
                     /inference="alignment:Splign:2.1.0"
     exon            1051..1144
                     /gene="Fbxo38"
                     /inference="alignment:Splign:2.1.0"
     exon            1145..1275
                     /gene="Fbxo38"
                     /inference="alignment:Splign:2.1.0"
     exon            1276..1446
                     /gene="Fbxo38"
                     /inference="alignment:Splign:2.1.0"
     exon            1447..1589
                     /gene="Fbxo38"
                     /inference="alignment:Splign:2.1.0"
     exon            1590..1803
                     /gene="Fbxo38"
                     /inference="alignment:Splign:2.1.0"
     exon            1804..1920
                     /gene="Fbxo38"
                     /inference="alignment:Splign:2.1.0"
     exon            1921..2100
                     /gene="Fbxo38"
                     /inference="alignment:Splign:2.1.0"
     exon            2101..2841
                     /gene="Fbxo38"
                     /inference="alignment:Splign:2.1.0"
     exon            2842..2942
                     /gene="Fbxo38"
                     /inference="alignment:Splign:2.1.0"
     exon            2943..3045
                     /gene="Fbxo38"
                     /inference="alignment:Splign:2.1.0"
     exon            3046..3212
                     /gene="Fbxo38"
                     /inference="alignment:Splign:2.1.0"
     exon            3213..3358
                     /gene="Fbxo38"
                     /inference="alignment:Splign:2.1.0"
     exon            3359..3462
                     /gene="Fbxo38"
                     /inference="alignment:Splign:2.1.0"
     exon            3463..3576
                     /gene="Fbxo38"
                     /inference="alignment:Splign:2.1.0"
     exon            3577..4375
                     /gene="Fbxo38"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 agctctgcgg aggtgggggc cgcaggaaga gtttgtcgcg attctccgtc cctctcaacc
       61 acaaaaacag acggagggcc ggcgtaagtg agccgcggcc tgggaggctg tcgcgaaggt
      121 ggaggtgttt tgaactaaaa tcaggagaga tttgatcttt gacactgagg ggaagcacag
      181 ccatgggacc acgaaagaaa agtgttaaag tgtgtgtgat ggacagtgag gtccccgagg
      241 aaatgacagc tgatgaagag aaggactaca tgaaccagct gtcacatgaa gtgctatgtc
      301 atattttcag gtacctgcca ctgcaggata tcatgtgcat ggaatgtctt tctcggaagc
      361 taaaggaagc agttactctg tatctgagag ttgtgagagt ggtggatctc tgcgcagggc
      421 ggtggtggga atatatgcca agtggcttca cagattgcag tttcctgaca cttttgaaga
      481 agatgccgga tgtcgagcag ctgtacggcc ttcaccctag atacctcgag aggcggagag
      541 tgaggggcca tgaggctttc agcattccag gggtcctgga ggccttgcaa gcctgcccaa
      601 acctggtggg tgtagaaaca tctcatttgg agttggtaga atccatttgg acatatatgc
      661 cgcatgttca tattttgggg aaatttcgta atcgtaacgg agcatttccg attcctcctg
      721 aaaataaact gaaaatcccc ataggagcca aaatccaaac tttgcattta gttggggtca
      781 atgttcctga aatcccttgt attcctatgc tgaggcacct gtacatgaag tgggtgagac
      841 tcactaaacc acagccgttc aaggatttcc tctgcatcag cttgcggact tttgtcatga
      901 ggaactgcgc aggaccaaca aattccttga aatacgtgcc cttggtaaca ggtctggcct
      961 ctgctcggaa cttggaacac ttggagatgg ttcgagtgcc tttcctgggc ggtctcatcc
     1021 agcatgtggt tgaagacagc tggagatcag gtggttttag gaatttgcac actattgtct
     1081 taggagcttg caagaatgcc cttgaagtag atcttggtta cctcatcatc actgctgcca
     1141 gaaggttaca tgaagttcgc atccagcctt ctttaaccaa agatggtgtc ttttctgccc
     1201 tgaagatggc agaattggag tttccccaat ttgaaaccct tcatctggga tatgtagatg
     1261 agttcttgct acagagcaga atggcgaatg cagatttggt gaagtatggt ttggctgatg
     1321 tggtagaaaa tcctggtatc attaccgata tcgggatgaa ggcagtcaac gaggttttct
     1381 cctgtatcaa gtatctggcg atttataact gtcctcatct acacaaccca tataattgga
     1441 tatcagatca ctctagatgg acccgactgg ttgatatcaa cctcgtgcgc tgccatgctt
     1501 tgaagctgga ttcttttggc cagtttgttg aattattgcc cagcctggag tttatttcgc
     1561 tggaccagat gtttcgtgag ccacccaagg gctgtgctcg agtaggtctg agtgcaggaa
     1621 ctggaattgg ggtttcctca gcgcttgtca gcaatcagaa ttccaacaat gacaatgata
     1681 ataatgctca gaataacaac gccaacatcc atgacaacaa tcaccatcac ccagacgact
     1741 cggatgacga caatgacttc cgtcaagacc tacaacaggg agaggcacag tttgcagccg
     1801 atgcactgaa tgagatggag gacatggtcc aggacgatgg agaggtggta gccgagagtg
     1861 gaagcggtgt gcccgctcac cagggagttc tgcctgtgga tgccgatgag gagcaagcag
     1921 gacctagtgg tctacagcgt gtagtaaaac caacaccaat tgctgttcat gattcagaga
     1981 gcgatgatga agaagacagt ctagaactcc aagaagtctg gattcctaag aatggtgctc
     2041 ggcgttactc agaacgggaa gaaaaaaccg gagactcagg acagcccagg gaaaccgcag
     2101 cagtaagtgg aaaaggcaag actccacttc gaaagaggta caacaactct catcagatgg
     2161 gccaggcgaa gcagtttccc ctggaggaga gcagctgtga gaaaggctgt caggtcacca
     2221 gtgaacagat caaagccgat atgaaagcag ctagggatat ttctgaaaag aaaaaaacca
     2281 aggatgttta tcccagctgc agcaccacgg ccgccagcac cgtgggaaac tccagctcgc
     2341 ccagcactgc ttctcagagc ccggactttg taaggacggt gaccagcggc ggctcttctg
     2401 agcctagccc tccagaggtg gatgtgtccc ggcagtgtgt ctgctcccct ggtgggtcag
     2461 aggactcgga ggccatggag gagggagatg cagagagctc cgtctgcccc agatgctgct
     2521 gtctcaggcc ccaggagtct caaaggagaa ctagcaggcg ttctgatgag gagcggcctt
     2581 cgaccagcag agcctgtgtt gtgaatggcg cggatggtac gagatccgcc ttttccttta
     2641 ggactctgcc acaagggggg tcttcaggcc cagcacatga tgagaggact aatgggagtg
     2701 gctgtggggc tacaggtgag gacaggaggg ggagctccca gcctgagagt tgtgacgtgc
     2761 agtctaatga agactaccct cggaggcccc taaccagggc caggagcaga ctgtcccatg
     2821 tcccgctgat acctgagtca gaaattgcca aaaccaagcc atgtcatgcc atgaaacgaa
     2881 agcgaacggc agataagtcg accagcacca gtgaccctgt gatcgaggat gaccatgtgc
     2941 aggttcttgt attgaaatcc aaaaatctcg ttggagtcac aatgacgaat tgtggaatca
     3001 cagatctagt gctgaaagac tgccccaaga tgatgttcat ccatgctacc aggtgcaggg
     3061 tgctgaagca cttaaaggtg gaaaatgcac cgattgtaaa ccgctttgac tacgcacagt
     3121 gcaagaaact aaatatggac caggtactcg accaaatact gaggatgcct ccggagagga
     3181 accgcatcat ctacctgcgc ccgatgcagc aggtagacac actaactctg gagcagaagc
     3241 tcttcagcgg cccctacccc taccacatct gcgtcatcca tgagttcagc aatcctccca
     3301 acgtgcgcaa caaggtgcgc attcgcaatt ggatggacac gatcgccaac atcaatcaag
     3361 agctcattaa atatgaattc ttcctggaag ccactcgaac tgaagaagat ttaaagaagt
     3421 accctaagta tccctggggg agagaaatct acactttaga gggtgttgtt gatggagctc
     3481 catactccat gatttccgac ttcccttggc tgaggtcact gcgggcagca gagcccaaca
     3541 gctttgccag atacgacttt gaagatgatg aagaaagtac catctatgct cctcgaagga
     3601 aaggacagtt gtcagcagac atttgcatgg agacaatcgg ggaggagatc tcagagatgc
     3661 gtcagatgaa gaggggtgta tttcagcgag tagtggccat ttttatccac tactgtgatg
     3721 tcaacggaga gccagttgaa gatgactaca tttaaataga cctttcctgg ctcttctggc
     3781 ccgaagcggc caagagtcta tacagaaacc ttgggcttgg aattgggagg ccctggctca
     3841 gtttgttata taggaaatat ataaggaaca tggaaattgt atacaaagat ttatatatag
     3901 aagaaatata caaagatact tccaaaagta atgcctttat agcctatgtt tatacatctt
     3961 aatttaaaga agtcatttag cactgattgt gttcacttgt cctgactgag ttctctgtgt
     4021 caggtgactg agcccatgtc ctctgctctt caccattgtc cttcagtctg tgcctttttc
     4081 ttctccagca gagccgtctg agtcagcctg ctaaagtgtt gtatcttgtg tgttttcgtt
     4141 atcataatgc cagctaaacc cttagtcaga gaagattacg tttctgtact aagatgtagt
     4201 tcttcttttc ttagtgttta tatttggcat attgatttaa ataaaaattc atgaccttaa
     4261 aaaaatgaat ttgaagggca aatagagttt ccagagcatt tctagttatt tatttccaca
     4321 ttcaattgtg tatatgcttt atcttgaaca taaaataaac atttagtaaa aacttaaaaa
     4381 aaaaaaaaaa aaa
//
