LOCUS       NM_133521               1487 bp    mRNA    linear   ROD 31-MAR-2024
DEFINITION  Rattus norvegicus F-box protein 32 (Fbxo32), mRNA.
ACCESSION   NM_133521
VERSION     NM_133521.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1487)
  AUTHORS   Mochalova,E.P., Belova,S.P., Kostrominova,T.Y., Shenkman,B.S. and
            Nemirovskaya,T.L.
  TITLE     Differences in the Role of HDACs 4 and 5 in the Modulation of
            Processes Regulating MAFbx and MuRF1 Expression during Muscle
            Unloading
  JOURNAL   Int J Mol Sci 21 (13), 4815 (2020)
   PUBMED   32646070
  REMARK    GeneRIF: Differences in the Role of HDACs 4 and 5 in the Modulation
            of Processes Regulating MAFbx and MuRF1 Expression during Muscle
            Unloading.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1487)
  AUTHORS   Mochalova,E.P., Belova,S.P., Mirzoev,T.M., Shenkman,B.S. and
            Nemirovskaya,T.L.
  TITLE     Atrogin-1/MAFbx mRNA expression is regulated by histone deacetylase
            1 in rat soleus muscle under hindlimb unloading
  JOURNAL   Sci Rep 9 (1), 10263 (2019)
   PUBMED   31311969
  REMARK    GeneRIF: Atrogin-1/MAFbx mRNA expression is regulated by histone
            deacetylase 1 in rat soleus muscle under hindlimb unloading.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1487)
  AUTHORS   Cai,M., Wang,Q., Liu,Z., Jia,D., Feng,R. and Tian,Z.
  TITLE     Effects of different types of exercise on skeletal muscle atrophy,
            antioxidant capacity and growth factors expression following
            myocardial infarction
  JOURNAL   Life Sci 213, 40-49 (2018)
   PUBMED   30312703
  REMARK    GeneRIF: Exercise down-regulated the mRNA levels of murf1 and
            atrogin-1, decreased reactive oxygen species level, increased
            antioxidant capacity, regulated the expression of insulin-like
            growth factor 1 (IGF1), mechano growth factor (MGF), Neuregulin1
            (NRG1) and Myostatin (MSTN), and activated Akt and Erk1/2
            signalings in soleus muscle.
REFERENCE   4  (bases 1 to 1487)
  AUTHORS   Kang,S.H., Lee,H.A., Kim,M., Lee,E., Sohn,U.D. and Kim,I.
  TITLE     Forkhead box O3 plays a role in skeletal muscle atrophy through
            expression of E3 ubiquitin ligases MuRF-1 and atrogin-1 in
            Cushing's syndrome
  JOURNAL   Am J Physiol Endocrinol Metab 312 (6), E495-E507 (2017)
   PUBMED   28246104
  REMARK    GeneRIF: Data suggest that FOXO3a plays a role in muscle atrophy
            through regulation of expression of MuRF1 and atrogin-1 in skeletal
            muscle in Cushing's syndrome. (FOXO3a = forkhead box protein O3a;
            MuRF1 = muscle-specific RING finger protein 1)
REFERENCE   5  (bases 1 to 1487)
  AUTHORS   Gerlinger-Romero,F., Yonamine,C.Y., Junior,D.C., Esteves,J.V. and
            Machado,U.F.
  TITLE     Dysregulation between TRIM63/FBXO32 expression and soleus muscle
            wasting in diabetic rats: potential role of miR-1-3p, -29a/b-3p,
            and -133a/b-3p
  JOURNAL   Mol Cell Biochem 427 (1-2), 187-199 (2017)
   PUBMED   28000044
  REMARK    GeneRIF: Independent of the metabolic condition, after muscle
            contraction, both TRIM63 and FBXO32 proteins correlated
            significantly with miR-1-3p, miR-29a/b-3p, and miR-133a/b-3p.
REFERENCE   6  (bases 1 to 1487)
  AUTHORS   Maragno,A.L., Baqui,M.M. and Gomes,M.D.
  TITLE     FBXO25, an F-box protein homologue of atrogin-1, is not induced in
            atrophying muscle
  JOURNAL   Biochim Biophys Acta 1760 (6), 966-972 (2006)
   PUBMED   16714087
  REMARK    GeneRIF: FBXO25 is a novel F-box protein analogous to atrogin-1,
            which is not involved in muscle atrophy.
REFERENCE   7  (bases 1 to 1487)
  AUTHORS   Miyabara,E.H., Aoki,M.S., Soares,A.G. and Moriscot,A.S.
  TITLE     Expression of tropism-related genes in regenerating skeletal muscle
            of rats treated with cyclosporin-A
  JOURNAL   Cell Tissue Res 319 (3), 479-489 (2005)
   PUBMED   15726428
  REMARK    GeneRIF: Atrogin-1 is involved in the early stages of skeletal
            muscle regeneration in rats, independently of calcineurin.
REFERENCE   8  (bases 1 to 1487)
  AUTHORS   Dehoux,M., Van Beneden,R., Pasko,N., Lause,P., Verniers,J.,
            Underwood,L., Ketelslegers,J.M. and Thissen,J.P.
  TITLE     Role of the insulin-like growth factor I decline in the induction
            of atrogin-1/MAFbx during fasting and diabetes
  JOURNAL   Endocrinology 145 (11), 4806-4812 (2004)
   PUBMED   15284206
  REMARK    GeneRIF: IGF-I inhibits atrogin-1/MAFbx expression
REFERENCE   9  (bases 1 to 1487)
  AUTHORS   Dehoux,M.J., van Beneden,R.P., Fernandez-Celemin,L., Lause,P.L. and
            Thissen,J.P.
  TITLE     Induction of MafBx and Murf ubiquitin ligase mRNAs in rat skeletal
            muscle after LPS injection
  JOURNAL   FEBS Lett 544 (1-3), 214-217 (2003)
   PUBMED   12782319
  REMARK    GeneRIF: MafBx and Murf mRNA are up-regulated in response to LPS
            and might play a role in the muscle proteolysis observed
REFERENCE   10 (bases 1 to 1487)
  AUTHORS   Bodine,S.C., Latres,E., Baumhueter,S., Lai,V.K., Nunez,L.,
            Clarke,B.A., Poueymirou,W.T., Panaro,F.J., Na,E., Dharmarajan,K.,
            Pan,Z.Q., Valenzuela,D.M., DeChiara,T.M., Stitt,T.N.,
            Yancopoulos,G.D. and Glass,D.J.
  TITLE     Identification of ubiquitin ligases required for skeletal muscle
            atrophy
  JOURNAL   Science 294 (5547), 1704-1708 (2001)
   PUBMED   11679633
  REMARK    GeneRIF: Alternate name for this locus:  MAFbx.  Alias:  MAFbx.
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000007.1.
            
            On Oct 11, 2022 this sequence version replaced NM_133521.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643296.20026.1,
                                           SRR26643295.28800.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760383,
                                           SAMEA5760386 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-352               JAXUCZ010000007.1  91654140-91654491   c
            353-450             JAXUCZ010000007.1  91647244-91647341   c
            451-500             JAXUCZ010000007.1  91645648-91645697   c
            501-593             JAXUCZ010000007.1  91644671-91644763   c
            594-687             JAXUCZ010000007.1  91633300-91633393   c
            688-872             JAXUCZ010000007.1  91632337-91632521   c
            873-1055            JAXUCZ010000007.1  91623706-91623888   c
            1056-1199           JAXUCZ010000007.1  91622512-91622655   c
            1200-1487           JAXUCZ010000007.1  91620925-91621212   c
FEATURES             Location/Qualifiers
     source          1..1487
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="7"
                     /map="7q33"
     gene            1..1487
                     /gene="Fbxo32"
                     /gene_synonym="Atrogin1; MAFbx"
                     /note="F-box protein 32"
                     /db_xref="GeneID:171043"
                     /db_xref="RGD:620373"
     exon            1..352
                     /gene="Fbxo32"
                     /gene_synonym="Atrogin1; MAFbx"
                     /inference="alignment:Splign:2.1.0"
     CDS             237..1289
                     /gene="Fbxo32"
                     /gene_synonym="Atrogin1; MAFbx"
                     /note="component of SCF E3 ubiquitin ligase; involved in
                     ubiquitin-mediated protein degradation during skeletal
                     muscle atrophy; atrogin-1; muscle atrophy F-box protein;
                     atrophy gene 1"
                     /codon_start=1
                     /product="F-box only protein 32"
                     /protein_id="NP_598205.2"
                     /db_xref="GeneID:171043"
                     /db_xref="RGD:620373"
                     /translation="MPFLGQDWRSPGQSWVKTADGWKRFLDEKSGTFVSDLSSYCNKE
                     NLFNSLNYDVAAKKRKKDIQNSKTKTQYFHQEKWIYVHKGSTKERHGYCTLGEAFNRL
                     DFSTAILDSRRFNYVVRLLELIAKSQLTSLSGIAQKNFMNILEKVVLKVLEDQQNIRL
                     IRELLQTLYTSLCTLVQRVGKSVLVGNINMWVYRMETILHWQQQLNSIQISRPAFKGL
                     TITDLPVCLQLNIMQRLSDGRDLVSLGQAAPDLHVLSEDRLLWKRLCQYHFSERQIRK
                     RLILSDKGQLDWKKMYFKLVRCYPRREQYGVTLQLCKHCHILSWKGTDHPCTANNPES
                     CSVSLSPQDFINLFKF"
     exon            353..450
                     /gene="Fbxo32"
                     /gene_synonym="Atrogin1; MAFbx"
                     /inference="alignment:Splign:2.1.0"
     exon            451..500
                     /gene="Fbxo32"
                     /gene_synonym="Atrogin1; MAFbx"
                     /inference="alignment:Splign:2.1.0"
     exon            501..593
                     /gene="Fbxo32"
                     /gene_synonym="Atrogin1; MAFbx"
                     /inference="alignment:Splign:2.1.0"
     exon            594..687
                     /gene="Fbxo32"
                     /gene_synonym="Atrogin1; MAFbx"
                     /inference="alignment:Splign:2.1.0"
     exon            688..872
                     /gene="Fbxo32"
                     /gene_synonym="Atrogin1; MAFbx"
                     /inference="alignment:Splign:2.1.0"
     exon            873..1055
                     /gene="Fbxo32"
                     /gene_synonym="Atrogin1; MAFbx"
                     /inference="alignment:Splign:2.1.0"
     exon            1056..1199
                     /gene="Fbxo32"
                     /gene_synonym="Atrogin1; MAFbx"
                     /inference="alignment:Splign:2.1.0"
     exon            1200..1487
                     /gene="Fbxo32"
                     /gene_synonym="Atrogin1; MAFbx"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 attcccgaag tcaggacgcg acacgcgacc ctcctcagcg cctgatcccc tgccagtgca
       61 aggaccctcg cgcccaccca ggacccgcaa ccctccacat cagttccccg actcttgttc
      121 cagttgccgc ctgcgttccc tagcgtcttc ccagagcggc gcatcccctg ggcaagccag
      181 gccggttcct ggctgtcgat ccgtcctatc cgtcggtcgc gtccgctctc ggtaccatgc
      241 cgttccttgg tcaggactgg cggtccccgg gccagagctg ggtgaagacg gcggacggct
      301 ggaagcgctt cttggatgag aaaagcggca ccttcgtgag cgacctcagc agttactgca
      361 acaaggagaa tctgttcaac agcctgaact acgatgttgc agccaagaag agaaagaaag
      421 acatacagaa cagcaaaacc aaaactcagt atttccatca ggagaagtgg atctatgttc
      481 acaaagggag tactaaggag cgccatggat actgcacttt gggggaagct ttcaacagac
      541 tggacttctc gactgccatc ctggattcca gaagattcaa ctacgtagta aggctgttgg
      601 agctgatagc aaagtcacag ctcacatccc tgagtggcat cgcccaaaag aacttcatga
      661 acattttgga aaaagtagta ctgaaagttc ttgaagacca gcaaaacata agactcatac
      721 gggaacttct ccagaccctc tacacatcct tatgcacgct ggtccagaga gtcggcaagt
      781 ccgtgctggt gggcaacatc aacatgtggg tgtatcgaat ggagaccatt ctacactggc
      841 aacagcagct gaacagcatc cagatcagca ggccggcctt caaaggcctc acgatcaccg
      901 acctgcctgt gtgcttacaa ctgaacatca tgcagaggct gagcgatggg cgggacctgg
      961 tcagcctggg ccaggcagcc ccagacctgc atgtgctcag tgaagaccgg ctactgtgga
     1021 agagactctg ccagtaccac ttctcagagc ggcagatccg caagcgattg atcttgtctg
     1081 acaaagggca gctggattgg aagaagatgt actttaagct tgtgcgatgt tacccaagaa
     1141 gagaacagta tggggtcacc ctgcagcttt gcaaacactg ccacattctc tcctggaagg
     1201 gcactgacca tccatgcacg gccaacaacc cagagagctg ctccgtctca ctttcacccc
     1261 aagactttat taacttgttc aagttctgaa cacgcacacg ccaacacttc agaaggcccc
     1321 tgattggatg gttgggagtc tggacacttc gtttgtaaat agtgtacatt tgaagcattg
     1381 gcctgaaact gctgggatac gtcatggaga agacaacggt gggaagagat gcggttgcca
     1441 atggaaactt acaaatgtga atttcacatt acaactggta cagaaaa
//
