LOCUS       NM_001414926            4738 bp    mRNA    linear   ROD 01-APR-2024
DEFINITION  Rattus norvegicus F-box protein 31 (Fbxo31), transcript variant 2,
            mRNA.
ACCESSION   NM_001414926 XM_039097937
VERSION     NM_001414926.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 4738)
  AUTHORS   Mir,A., Sritharan,K., Mittal,K., Vasli,N., Araujo,C., Jamil,T.,
            Rafiq,M.A., Anwar,Z., Mikhailov,A., Rauf,S., Mahmood,H.,
            Shakoor,A., Ali,S., So,J., Naeem,F., Ayub,M. and Vincent,J.B.
  TITLE     Truncation of the E3 ubiquitin ligase component FBXO31 causes
            non-syndromic autosomal recessive intellectual disability in a
            Pakistani family
  JOURNAL   Hum Genet 133 (8), 975-984 (2014)
   PUBMED   24623383
REFERENCE   2  (bases 1 to 4738)
  AUTHORS   Vadhvani,M., Schwedhelm-Domeyer,N., Mukherjee,C. and Stegmuller,J.
  TITLE     The centrosomal E3 ubiquitin ligase FBXO31-SCF regulates neuronal
            morphogenesis and migration
  JOURNAL   PLoS One 8 (2), e57530 (2013)
   PUBMED   23469015
REFERENCE   3  (bases 1 to 4738)
  AUTHORS   Santra,M.K., Wajapeyee,N. and Green,M.R.
  TITLE     F-box protein FBXO31 mediates cyclin D1 degradation to induce G1
            arrest after DNA damage
  JOURNAL   Nature 459 (7247), 722-725 (2009)
   PUBMED   19412162
REFERENCE   4  (bases 1 to 4738)
  AUTHORS   Ebstein,F., Lange,N., Urban,S., Seifert,U., Kruger,E. and
            Kloetzel,P.M.
  TITLE     Maturation of human dendritic cells is accompanied by functional
            remodelling of the ubiquitin-proteasome system
  JOURNAL   Int J Biochem Cell Biol 41 (5), 1205-1215 (2009)
   PUBMED   19028597
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000019.1.
            
            On Dec 15, 2022 this sequence version replaced XM_039097937.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643296.39048.1,
                                           SRR26643289.42910.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760383,
                                           SAMEA5760386 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-348               JAXUCZ010000019.1  66564327-66564674   c
            349-420             JAXUCZ010000019.1  66551015-66551086   c
            421-507             JAXUCZ010000019.1  66549177-66549263   c
            508-584             JAXUCZ010000019.1  66545143-66545219   c
            585-752             JAXUCZ010000019.1  66544575-66544742   c
            753-827             JAXUCZ010000019.1  66543300-66543374   c
            828-937             JAXUCZ010000019.1  66539855-66539964   c
            938-1091            JAXUCZ010000019.1  66539084-66539237   c
            1092-1438           JAXUCZ010000019.1  66537965-66538311   c
            1439-4738           JAXUCZ010000019.1  66533437-66536736   c
FEATURES             Location/Qualifiers
     source          1..4738
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="19"
                     /map="19q12"
     gene            1..4738
                     /gene="Fbxo31"
                     /gene_synonym="RGD1561069"
                     /note="F-box protein 31"
                     /db_xref="GeneID:498959"
                     /db_xref="RGD:1561069"
     exon            1..348
                     /gene="Fbxo31"
                     /gene_synonym="RGD1561069"
                     /inference="alignment:Splign:2.1.0"
     CDS             51..1661
                     /gene="Fbxo31"
                     /gene_synonym="RGD1561069"
                     /note="isoform 2 is encoded by transcript variant 2; F-box
                     only protein 31"
                     /codon_start=1
                     /product="F-box only protein 31 isoform 2"
                     /protein_id="NP_001401855.1"
                     /db_xref="GeneID:498959"
                     /db_xref="RGD:1561069"
                     /translation="MAVCARLCGVGPARGCRRRQQRRGPAETAAADSEADTDPEEERI
                     EAGPARCSLLELPPELLVEIFASLPGTDLPSLAQVCSRFRRILHTDTIWRRRCREEYG
                     VCENLRKLEITGVSCRDVYAKRINPRVKSGRFMKILPDYEHMEYRDVYTCLLHRYRHI
                     LGLWQPDIGPYGGLLNVVVDGLFIIGWMYLPPHDPHVGDPMRFKPLFRIHLMERKSAT
                     VECMYGHKGPHNGHIQIVKRDEFSTKCNQTDHHRMSGGRQEEFRTWLREEWGRTLEDI
                     FHEHMQELILMKFIYTSQYDNCLTYRRIYLPPSHPDDLIKPGLFKGTYGSHGLEIVML
                     SFHGSRARGTKITGDPNIPAGQQTVEIDLQRRIQLPDVENLRNFNELSRIVLEVREQV
                     RQEQEAGEGPAPHREPAVKDPEGPPAKASKEAGPGAEAAEQSSTSGQGQPFVLPAGVS
                     SRNEDYPRTCRLCFYGTGLIAGHGFTSPERTPGVFVLFDEDRFGFLWLELKSFSLYSR
                     VQATFQNADAPSPQAFDEMLRNIQSLTS"
     exon            349..420
                     /gene="Fbxo31"
                     /gene_synonym="RGD1561069"
                     /inference="alignment:Splign:2.1.0"
     exon            421..507
                     /gene="Fbxo31"
                     /gene_synonym="RGD1561069"
                     /inference="alignment:Splign:2.1.0"
     exon            508..584
                     /gene="Fbxo31"
                     /gene_synonym="RGD1561069"
                     /inference="alignment:Splign:2.1.0"
     exon            585..752
                     /gene="Fbxo31"
                     /gene_synonym="RGD1561069"
                     /inference="alignment:Splign:2.1.0"
     exon            753..827
                     /gene="Fbxo31"
                     /gene_synonym="RGD1561069"
                     /inference="alignment:Splign:2.1.0"
     exon            828..937
                     /gene="Fbxo31"
                     /gene_synonym="RGD1561069"
                     /inference="alignment:Splign:2.1.0"
     exon            938..1091
                     /gene="Fbxo31"
                     /gene_synonym="RGD1561069"
                     /inference="alignment:Splign:2.1.0"
     exon            1092..1438
                     /gene="Fbxo31"
                     /gene_synonym="RGD1561069"
                     /inference="alignment:Splign:2.1.0"
     exon            1439..4738
                     /gene="Fbxo31"
                     /gene_synonym="RGD1561069"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gctgtgcgtg cgcgctcgct cgcgtgcgcg cgtccgcggt agtgacgggc atggcggtgt
       61 gtgctcggct ctgcggcgtg ggccccgcgc gtgggtgccg ccgccgccag cagcgccgcg
      121 gcccggccga gactgcggcg gcggacagtg aggcggacac ggaccccgag gaggagcgca
      181 tcgaggcggg gccggcgcgt tgctccctgc tggagctgcc tcccgagctg ctagtggaga
      241 tcttcgcgtc gctgcccggc accgacctgc ccagcctggc gcaggtctgc agcaggttcc
      301 gtcgcatcct gcacaccgac accatctgga gaaggcgctg ccgcgaggag tatggcgttt
      361 gtgagaacct gcggaagctg gagatcacag gcgtgtcttg ccgggacgtc tatgccaagc
      421 gtataaaccc tcgtgtgaag tcaggacgct tcatgaaaat tcttcctgat tacgaacaca
      481 tggagtacag agatgtgtac acctgcctgc ttcaccggta cagacacatt ttggggctgt
      541 ggcagccaga tattgggccg tatggaggat tgctgaacgt cgtggtggat ggactcttca
      601 tcatcgggtg gatgtacctg cctcctcatg acccccacgt tggcgacccc atgcgattca
      661 agcccctatt taggatccat ctgatggaga ggaagtcggc cacggtggag tgtatgtacg
      721 gccacaaagg gccccacaat ggccatatcc agattgtgaa gagggatgag ttctccacca
      781 agtgtaacca gacagatcac cacaggatgt ctggtgggag gcaggaggag tttcggacgt
      841 ggctgaggga ggagtggggc cgcacgctgg aagacatctt ccacgagcac atgcaggagc
      901 tgattctgat gaagttcatc tacaccagtc agtacgacaa ctgcctgacc taccggcgga
      961 tctacctccc tcccagccac cccgatgacc tcatcaagcc tggcctcttt aagggcacct
     1021 acggcagcca tgggctggaa atcgtgatgc ttagcttcca cggctctcgt gccaggggca
     1081 ccaagatcac gggcgacccc aacatccccg cggggcagca gactgtggag attgacctgc
     1141 agcgccgcat ccagctgcca gacgtggaga acctccgaaa cttcaatgag ctctccagga
     1201 tcgtcctgga ggtccgggag caggtgcggc aggagcagga ggctggcgag ggccccgctc
     1261 cacaccggga gcctgcagtc aaggaccctg aagggccacc tgctaaggcc agcaaagagg
     1321 ccggccctgg agctgaggcc gctgagcagt catccacgtc tgggcaggga cagccgtttg
     1381 tgcttcctgc gggtgtcagc tcgaggaatg aggattaccc ccgcacctgc cggttatgtt
     1441 tctatggcac aggcctcatc gctggccatg gctttacgag ccccgagcgt acccccggcg
     1501 tcttcgtcct gttcgatgag gaccgctttg ggtttctctg gctggaactg aagtccttca
     1561 gtctgtacag ccgagtccag gccaccttcc agaacgccga cgcaccatcg ccacaggcct
     1621 tcgatgagat gctcaggaac atccagtctc tcacctcctg acctcctcgt gggcgggcgg
     1681 agaggccgcg ccggcgcccg ggtgggggaa gcatgcactt tagaaatgaa cgcacacctc
     1741 ctcaccgggg tcctggtcgc cctgagacgc ccttgtatag tgtgtaacat actcttgtac
     1801 atttgatttg ttggtagcta tgaaggtgaa cgtgaagcac tgtgggaaaa taaacggagt
     1861 tgagcaagga tgaatctgaa tggttggtgc ctgtggcaca gagaatcaaa cggatgcgtg
     1921 ggatggtggc gtcgggctca gggaccctga tgggtttcca tctcctcact ggcttgctta
     1981 gattttacga gggcattcga ccatgacctg gttctggttg ctaggggcca ccaaggactg
     2041 caagggagtc tctactctgg cccctagtgg tctctgggcc acacctccgc tagcagtaga
     2101 gccaggctgt gaggccagct acttgcttgt ccccagcagc cacatgctct cccttggtcc
     2161 tctctctgtg tttatctgga gggcctgccc tgctggacac catgttcctg atgcttttct
     2221 ttcatagctg tgctggtgcc ttccacagtg ttgacggtgt cagcggagga cgctgtgaag
     2281 cccttcggag gtgaatgaga gacagtcctg tagacggttg cacttctgtg tgcattatta
     2341 attcagagca ttactgactg agggcttacc tgttcgcaga ccctgagggc tgggccatgc
     2401 tagcatctgt gtttgggaaa cctgagccca gcattagtgt cttctaaggg cagaggctaa
     2461 gagctcagac ctttcggagt gtctgccagc gcttccagtg ttagcaggct tctaggctgc
     2521 cctttcccta tggctgttca tcctctgtgg cttcggcaag ccctggtttt aagaactcat
     2581 cctactggtg agggacctta ggaagatgac aggcatgtga ggatggctat attctgatag
     2641 ctggaagggc tggtagactc aggaaaggtg gtgtggtgta ggaagcttta ggatttgtca
     2701 ggagctgtat gtaacagacc tgctgtgagc tgccaggaca ggtcctgact tctagtttct
     2761 tttgtagaat tgggctccag gccttgtgtt acttcccctg ttagtcagga gaggctttgg
     2821 acagtggtga gtgtgactga agccacaggg ccagtggagt ccaggcagtt gggcacgcag
     2881 gtggctctcg tcaggtgtca ctggggaaaa gcaaaagtat gtgttactca gaagcggagc
     2941 cttgctttgg ggaggctcca tctagttcag ggttttctta agtgtcctcg gccgctgcca
     3001 gttaagtcag ggcagtcact ccgtattagc caaacacaca ccggctttcc taaacacggg
     3061 gcccgtttgc cgcaggttga tgagggccaa catcgccgtt ggatgtagtg cggcctcgtg
     3121 tagagaacag ctaggtcctg ttactccact gaggcaagtg gacgtcattg tccctgggcc
     3181 tcaccaggtc agcaccgttg gttggtcctc attttgctcc tcaggctgca tagctagccc
     3241 atggattttt ggagagaagg cgccttgtgg ctttgcacac tcggcctgcc ctgtgtgcgg
     3301 agatggtgtg ggtaaggtca gaggcaagcc tcaggaagtt tctagcgggg actgaattct
     3361 tttgagtgat cgctgatgtc tgtttatgtc ctgatttgtt taggcctggc cgcgtcaggc
     3421 cattggctgc tgttacccag acctcagaca tcaacggtct gtcagtggtg ggagagctgg
     3481 actccatgtc ttggtcccga ctcaccttgt gtcccttaga gatcagctgt ctggctcctt
     3541 gtgttgtgag ttcagactct gggccgttcc cactgcacat ttcttatatt tccccttggg
     3601 acctccctgt ccccgcatgt ctacctgggg gcttggcagt ggcttctgtc cagatgctgt
     3661 accagtcagg cccccctcac atcatgtggt ggtacactcg cctgttagcc ttcttcctcc
     3721 actgagaact tggagctgag catgctgtgg cctggccagc tgggactcct accccagccc
     3781 tccagcggtt ctctctgccc ggctcgctgt gaatggtgta ccgcctttgt gtatgttcac
     3841 ctttcggtac ctgtggccat tagtggcgcg gacctatccc gctcagctgt caggacttcg
     3901 tgaaccccag gacagctaca cttcctagtt tgggactgtc tttttctcaa gacagtgggg
     3961 tgcagacagc accaagcact tggcctgtaa tgggatgctg ggcggaacag ctgcctgtgc
     4021 agcacccctt gcgctgctcc ccgcctttgt cctgacgggg aagtgtcctg tgtaaccctc
     4081 acctggtcca cctccccagg tcaccatctc ccattggctg tggaagacca agtctggttc
     4141 tgggggagag tggactagct ccctggagaa actgtaaatg gggtgggagt agggcacggt
     4201 ttagaactct gtgaggcact ggcggtcgca gcccccggcc tagctcccaa gaagggttta
     4261 atgctggggt agtgacactg aaggaacctg ctgggtgctt ctctgtggct ggatcctccg
     4321 tttgcacgga gaccagcacg aagtgacaag atgtgctctt ctaacctgtt tcttgtgctc
     4381 gggagcctgt tgggagaatg gggtttgtct ggagcatgcc ctcccacccc ccaactctgg
     4441 acagagggtg gctctttttt tttttttttt tttttttggt tctttttttc ggagctgggg
     4501 accgaaccca gggccttgcg cttcctaggc aaacgctcta ccactgagct aaatccccaa
     4561 ccccttaaga gggtggctct tagaagctct ctcaggtcag ctctgctttg cccaagggtc
     4621 agggaaggac cctggaactg tagctgctgt ttgcctggtg cctgacgtca cctgtgtctc
     4681 tcgccaggac gtgtgtggtt ctcctttcag ttctcagtaa acctgttttt gaagcctt
//
