LOCUS       NM_001109606            3624 bp    mRNA    linear   ROD 02-JUN-2024
DEFINITION  Rattus norvegicus F-box protein 3 (Fbxo3), mRNA.
ACCESSION   NM_001109606 XM_001064070 XM_001064129
VERSION     NM_001109606.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3624)
  AUTHORS   Gao,Y., Xiao,X., Luo,J., Wang,J., Peng,Q., Zhao,J., Jiang,N. and
            Zhao,Y.
  TITLE     E3 Ubiquitin Ligase FBXO3 Drives Neuroinflammation to Aggravate
            Cerebral Ischemia/Reperfusion Injury
  JOURNAL   Int J Mol Sci 23 (21), 13648 (2022)
   PUBMED   36362432
  REMARK    GeneRIF: E3 Ubiquitin Ligase FBXO3 Drives Neuroinflammation to
            Aggravate Cerebral Ischemia/Reperfusion Injury.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3624)
  AUTHORS   Wang,Q., Huang,P.Y., Wu,J.G., Zhang,T.Q., Li,L.F., Huang,L.D.,
            Yu,Y.M., Wang,M.H. and He,J.
  TITLE     miR-219a-5p inhibits the pyroptosis in knee osteoarthritis by
            inactivating the NLRP3 signaling via targeting FBXO3
  JOURNAL   Environ Toxicol 37 (11), 2673-2682 (2022)
   PUBMED   35962723
  REMARK    GeneRIF: miR-219a-5p inhibits the pyroptosis in knee osteoarthritis
            by inactivating the NLRP3 signaling via targeting FBXO3.
REFERENCE   3  (bases 1 to 3624)
  AUTHORS   Lin,T.B., Hsieh,M.C., Lai,C.Y., Cheng,J.K., Chau,Y.P., Ruan,T.,
            Chen,G.D. and Peng,H.Y.
  TITLE     Fbxo3-Dependent Fbxl2 Ubiquitination Mediates Neuropathic Allodynia
            through the TRAF2/TNIK/GluR1 Cascade
  JOURNAL   J Neurosci 35 (50), 16545-16560 (2015)
   PUBMED   26674878
  REMARK    GeneRIF: F-box protein 3 modifies the neuropathic pain pathway by
            inhibiting F-box and leucine-rich repeat protein 2-mediated TRAF2
            ubiquitination
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from CH473949.1.
            
            On or before Oct 4, 2007 this sequence version replaced
            XM_001064070.1, XM_001064129.1.
            
            ##Evidence-Data-START##
            RNAseq introns :: single sample supports all introns SAMD00132262,
                              SAMD00132263 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..3624
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="3"
                     /map="3q32"
     gene            1..3624
                     /gene="Fbxo3"
                     /note="F-box protein 3"
                     /db_xref="GeneID:690634"
                     /db_xref="RGD:1593433"
     exon            1..126
                     /gene="Fbxo3"
                     /inference="alignment:Splign:2.1.0"
     CDS             23..1465
                     /gene="Fbxo3"
                     /codon_start=1
                     /product="F-box only protein 3"
                     /protein_id="NP_001103076.1"
                     /db_xref="GeneID:690634"
                     /db_xref="RGD:1593433"
                     /translation="MAAVEAETGLLTLESLPTDPLLLILSFVDYRDLINCCYVSRRLS
                     QLSTHDPLWRRHCKKYWLITEEEKARKNQCWKSLFIATYSDVGRYINHYAAIKKAWDD
                     LKKYLEPRCPRMVLSLKEGAREEDLDAVEAQIGCKLPDDYRCSYRIHNGQKLVVPGLL
                     GSMALSNHYRSEDLLDVDTAAGGFQQRQGLKYCLPLTFCIHTGLSQYIAVEAAEGRNK
                     NEVFYQCPDQMARNPAAIDMFIIGATFTDWFTSYVNNVVSGGFPIIRDQIFRYIHDPE
                     CVATTGDITVSVSTSFLPELSSVHPPHYFFTYRIRIEMSRDALPEKACQLDSRYWRIT
                     NAKGDVEEVQGPGVVGEFPIISPGRIYEYTSCTTFSTTSGYMEGYYTFHFLYFKDKVF
                     NVAIPRFHMACPTFRVSIARLEMGPDEYEEMEEEAEEEEEEENDDSADMDESDESDED
                     ENESDEGEGEERRRRVFDVPIRRRRCSRLF"
     exon            127..216
                     /gene="Fbxo3"
                     /inference="alignment:Splign:2.1.0"
     exon            217..380
                     /gene="Fbxo3"
                     /inference="alignment:Splign:2.1.0"
     exon            381..495
                     /gene="Fbxo3"
                     /inference="alignment:Splign:2.1.0"
     exon            496..700
                     /gene="Fbxo3"
                     /inference="alignment:Splign:2.1.0"
     exon            701..746
                     /gene="Fbxo3"
                     /inference="alignment:Splign:2.1.0"
     exon            747..831
                     /gene="Fbxo3"
                     /inference="alignment:Splign:2.1.0"
     exon            832..954
                     /gene="Fbxo3"
                     /inference="alignment:Splign:2.1.0"
     exon            955..1070
                     /gene="Fbxo3"
                     /inference="alignment:Splign:2.1.0"
     exon            1071..1261
                     /gene="Fbxo3"
                     /inference="alignment:Splign:2.1.0"
     exon            1262..3624
                     /gene="Fbxo3"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 aggctgcagc gggctgggca agatggctgc cgtagaggcc gagacagggt tgctgaccct
       61 ggagtcgcta cccaccgacc ctctgctcct catcttatcc ttcgtggact acagggacct
      121 aatcaattgt tgctatgtta gtcgaagact tagccagcta tcaactcatg atccactgtg
      181 gagaagacat tgcaaaaaat actggctgat aactgaggaa gagaaagccc ggaagaatca
      241 gtgctggaaa tctctcttca tagctactta ctcagatgta ggaagataca tcaaccatta
      301 tgctgctatt aaaaaggcct gggatgacct caagaagtac ttggagccta ggtgtcctcg
      361 gatggtttta tctctgaaag agggtgcgcg tgaggaagac ctggatgcag tagaagctca
      421 gatcggttgc aagctccccg atgactatcg ctgctcatac cggatccaca atgggcagaa
      481 gttagtggtt ccaggattgc tgggaagcat ggcactgtca aatcactacc gctctgaaga
      541 tttattagac gttgacactg ctgccggagg atttcagcag agacagggac tgaaatactg
      601 tctcccttta accttttgca tacatactgg cttgagtcag tacatagctg tggaagctgc
      661 agagggccga aataaaaacg aagtgttcta ccagtgccca gatcaaatgg ctcggaatcc
      721 tgctgctatt gacatgttta tcataggtgc tacttttact gactggttta catcctatgt
      781 caacaatgtt gtatcaggtg gcttccccat catcagagac cagattttca gatatattca
      841 tgacccagag tgtgtagcaa caactggaga tattacagtc tcagtgtcca catcgtttct
      901 gccagaactc agttctgtgc acccaccaca ctatttcttc acataccgaa tcaggattga
      961 aatgtcaagg gatgctcttc ctgagaaggc ctgtcagttg gacagtcgct actggaggat
     1021 aacaaatgct aaaggggatg tggaggaagt ccagggacct ggagtagttg gtgaatttcc
     1081 aattattagc ccaggtcgga tatatgaata caccagctgc accacatttt ctacaacatc
     1141 aggctatatg gaagggtatt ataccttcca ttttctgtac tttaaggaca aggtctttaa
     1201 tgttgccatc ccacgattcc atatggcatg cccaacattc agggtgtcta tagcccgatt
     1261 ggaaatgggt cctgatgaat atgaagagat ggaggaggaa gctgaggagg aagaggaaga
     1321 ggaaaacgat gactcagcag acatggatga atccgatgaa tcagatgagg atgagaatga
     1381 atcagatgag ggtgaagggg aggagagaag gaggagggtc tttgatgttc ccatccgcag
     1441 acgccgctgc tctcgtcttt tttagctgct gctgaaggaa gctctggaat gacactattc
     1501 tgttaaatag atttgtcaat aatgtaaata attgtgctca gcatatagca ggaaactagc
     1561 acggaatgtt ccagacctag gctctacacg acactacatt aggagttgga tcgctttgct
     1621 ttgttttgtg gttgtaggta gcagaagaaa aggaaattgt tttctcttcc agagtccatg
     1681 ggagagcaat tctatagttg aagaacagat gttcctttgt ttaaaaatat tttctactta
     1741 aaaacaaaac acagaggtga agagaaaatt gttttgggtg aggattttat atgtagcaga
     1801 aatacccaca ccagggtaga agagactatg actgactgtg aaaagacccc ttctgttgtt
     1861 tagaaactaa caaaatttgt aattagcttc atccatttca tggttgttaa tagtttatac
     1921 tcatggggaa ctaaatgact aacttgaata ggaatagttt gccctttctt agacaatctg
     1981 tcctcgaatt agtctttgtc acacagacct tgagttgcag ttttcatcat tacttttaaa
     2041 atcttcaaca taactttgga ctttaaaagt tagagttctc acgctatgac ctttctcaca
     2101 tcatttacag attcctcatt ttaaatgtgg tttgtaaaag tacgtagagt gttgttaaag
     2161 attcttcaca atgtctcatg tagtctaaat ttgtaaatat gctttctgtt ctgtttcctt
     2221 atacatttgt ctaactttgt ggtaagtgat ctgaatttta tgttagggtt aggatatttt
     2281 cgtgaaacat ggattttttt gtaattatat aattgagagt ttggaatgaa atccttcaag
     2341 tgtcaaaaac tcctgtttta aaaacttttg tgtaagtgcc tatttcccgt agactgctga
     2401 gctttgttct taagctagaa gatggcagtg ctacttgctg gcctacagcc agaggacagc
     2461 aggtccattc agagttgact gctgcctttg attatgctct tttgctctcc atcaatattc
     2521 ctgtaaaaca gttcagtcgt ggagaaaatt taggaagaga gcgtcatgtt caagactaag
     2581 tgcctgctct cagggactat gagcaaactt gcccttttat gaagacagat cagaatattc
     2641 caagtcattt tcctacttac ctttcatagg agagtatact cacatggtgt ttcaacaaca
     2701 agccagcagc agcctcatct tctgtatacc acatctgttg aatgtatcgt tttttctcct
     2761 gtgcttgatt aaacctcatg ttgtttgttt gttatggccc cacagcatac ggaatcactg
     2821 ctaaggttga gagtaagttg tcatcaagtg atccacccag aaatgaaatt taaatgaagg
     2881 acttagaaac aaggggggtg gggatcactg atggctactg cttattaagt cagctgctct
     2941 accatagcta gaccctcaaa gaacaagagc agatgggaca taaattgttg gaacatctgc
     3001 ttcattgacg gcaatatgaa tatttcaaga aaggtcaata tcagatctgg aggcccttat
     3061 aatcacctga cttgacacaa atgtgccttc tacatcatga tgtccactgc caaagcaggg
     3121 tttgcctaca agagtgaaag agaagactag acctgactag gatgtcgggg ttactgagag
     3181 ctctgggtgg tctaaagtga ataatcgtta ggaaatttga aagtaagtgg taagcctgca
     3241 aacttgtggg tgaagaatgc taactttaaa aggtagaaac tgggtgtgtg gagtggttac
     3301 ttgccaacgc aaaccctcct ctattccatc taggtttgta taaaatacat tctgtgtggt
     3361 ttgcaaggtg ataaaatagc ttgtcactac aatcacctaa tgactcattt cttaaaatct
     3421 aatcccattg ttaagtgaga acatgactat tatcagactg ccaaatacta tcaggctacc
     3481 cttccttttt tttttttttt tttttctttt ttcttttttt cggagctggg gactgaactc
     3541 agggccttcc gcttgctagg caagccctct accactgagc taaatcccca acccccaggc
     3601 tacccttctt aaaaatagtc aact
//
