LOCUS       NM_053511               1293 bp    mRNA    linear   ROD 30-MAR-2024
DEFINITION  Rattus norvegicus F-box protein 2 (Fbxo2), mRNA.
ACCESSION   NM_053511
VERSION     NM_053511.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1293)
  AUTHORS   Nelson,D.E. and Laman,H.
  TITLE     A Competitive binding mechanism between Skp1 and exportin 1 (CRM1)
            controls the localization of a subset of F-box proteins
  JOURNAL   J Biol Chem 286 (22), 19804-19815 (2011)
   PUBMED   21378169
REFERENCE   2  (bases 1 to 1293)
  AUTHORS   Ebstein,F., Lange,N., Urban,S., Seifert,U., Kruger,E. and
            Kloetzel,P.M.
  TITLE     Maturation of human dendritic cells is accompanied by functional
            remodelling of the ubiquitin-proteasome system
  JOURNAL   Int J Biochem Cell Biol 41 (5), 1205-1215 (2009)
   PUBMED   19028597
REFERENCE   3  (bases 1 to 1293)
  AUTHORS   Kato,A., Rouach,N., Nicoll,R.A. and Bredt,D.S.
  TITLE     Activity-dependent NMDA receptor degradation mediated by
            retrotranslocation and ubiquitination
  JOURNAL   Proc Natl Acad Sci U S A 102 (15), 5600-5605 (2005)
   PUBMED   15809437
REFERENCE   4  (bases 1 to 1293)
  AUTHORS   Yoshida,Y., Adachi,E., Fukiya,K., Iwai,K. and Tanaka,K.
  TITLE     Glycoprotein-specific ubiquitin ligases recognize N-glycans in
            unfolded substrates
  JOURNAL   EMBO Rep 6 (3), 239-244 (2005)
   PUBMED   15723043
REFERENCE   5  (bases 1 to 1293)
  AUTHORS   Yoshida,Y., Tokunaga,F., Chiba,T., Iwai,K., Tanaka,K. and Tai,T.
  TITLE     Fbs2 is a new member of the E3 ubiquitin ligase family that
            recognizes sugar chains
  JOURNAL   J Biol Chem 278 (44), 43877-43884 (2003)
   PUBMED   12939278
REFERENCE   6  (bases 1 to 1293)
  AUTHORS   Yoshida,Y., Chiba,T., Tokunaga,F., Kawasaki,H., Iwai,K., Suzuki,T.,
            Ito,Y., Matsuoka,K., Yoshida,M., Tanaka,K. and Tai,T.
  TITLE     E3 ubiquitin ligase that recognizes sugar chains
  JOURNAL   Nature 418 (6896), 438-442 (2002)
   PUBMED   12140560
REFERENCE   7  (bases 1 to 1293)
  AUTHORS   Erhardt,J.A., Hynicka,W., DiBenedetto,A., Shen,N., Stone,N.,
            Paulson,H. and Pittman,R.N.
  TITLE     A novel F box protein, NFB42, is highly enriched in neurons and
            induces growth arrest
  JOURNAL   J Biol Chem 273 (52), 35222-35227 (1998)
   PUBMED   9857061
REFERENCE   8  (bases 1 to 1293)
  AUTHORS   Yehiely,F., Bamborough,P., Da Costa,M., Perry,B.J., Thinakaran,G.,
            Cohen,F.E., Carlson,G.A. and Prusiner,S.B.
  TITLE     Identification of candidate proteins binding to prion protein
  JOURNAL   Neurobiol Dis 3 (4), 339-355 (1997)
   PUBMED   9173930
  REMARK    Erratum:[Neurobiol Dis 2002 Jun;10(1):67-8]
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from
            JAXUCZ010000005.1.
            
            On Nov 26, 2020 this sequence version replaced NM_053511.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF098301.1, FQ214021.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760389
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-79                JAXUCZ010000005.1  163876079-163876157
            80-457              JAXUCZ010000005.1  163879116-163879493
            458-587             JAXUCZ010000005.1  163879849-163879978
            588-683             JAXUCZ010000005.1  163880048-163880143
            684-813             JAXUCZ010000005.1  163880699-163880828
            814-1293            JAXUCZ010000005.1  163881029-163881508
FEATURES             Location/Qualifiers
     source          1..1293
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="5"
                     /map="5q36"
     gene            1..1293
                     /gene="Fbxo2"
                     /note="F-box protein 2"
                     /db_xref="GeneID:85273"
                     /db_xref="RGD:621751"
     exon            1..79
                     /gene="Fbxo2"
                     /inference="alignment:Splign:2.1.0"
     CDS             58..948
                     /gene="Fbxo2"
                     /note="neural F box protein NFB42"
                     /codon_start=1
                     /product="F-box only protein 2"
                     /protein_id="NP_445963.2"
                     /db_xref="GeneID:85273"
                     /db_xref="RGD:621751"
                     /translation="MDGDGDPESVSHPEEASPEEQPEEAGAEASAEEEQPREEEEEET
                     EAVEYLAELPEPLLLRVLAELPATELVQACRLVCLRWKELVDGAPLWLLKCQQEGLVP
                     EGSADDERDHWQQFYFLSKRRRNLLRNPCGEEDLEGWCDVEHGGDGWRVEELPGDSGV
                     EFTHDDSVKKYFASSFEWCRKAQVIDLQAEGYWEELLDTTQPAIVVKDWYSGRTDAGS
                     LYELTVRLLSEHEDVLAEFNTGQVAVPEDGSWMEISHTFTDYGPGVRYVRFEHGGQDS
                     VYWKGWFGARVTNSSVWVEP"
     exon            80..457
                     /gene="Fbxo2"
                     /inference="alignment:Splign:2.1.0"
     exon            458..587
                     /gene="Fbxo2"
                     /inference="alignment:Splign:2.1.0"
     exon            588..683
                     /gene="Fbxo2"
                     /inference="alignment:Splign:2.1.0"
     exon            684..813
                     /gene="Fbxo2"
                     /inference="alignment:Splign:2.1.0"
     exon            814..1293
                     /gene="Fbxo2"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 agctccagga ctcgccaccc gcagcgctca ggctccactc tcgtcagcgc cgcagcgatg
       61 gatggagatg gtgatccaga gagtgtgagc caccccgaag aggcgagccc ggaggagcag
      121 cctgaggagg cgggcgccga ggcgagtgcg gaggaggagc agcccaggga ggaggaggag
      181 gaagagacag aggccgtgga gtaccttgcc gagttgcctg agccactgct gctgcgcgtg
      241 ctggcagagc tgcccgctac ggagctagtg caagcctgcc gcctggtgtg cctgcgctgg
      301 aaggagctgg tggacggcgc cccactgtgg ctgctcaagt gtcagcagga ggggctggtg
      361 cctgagggca gcgctgatga cgagcgggac cactggcaac agttctactt tctgagcaag
      421 aggaggcgca acctgctgcg taacccgtgt ggggaagagg acttggaggg ctggtgcgac
      481 gtggagcacg gtggggacgg ctggagagtg gaggaactgc ccggagacag tggggtggaa
      541 tttacccacg acgacagcgt taagaagtac ttcgcctcct ccttcgagtg gtgtcgcaaa
      601 gcgcaggtca ttgatctgca ggctgagggc tactgggagg agctactgga caccacccag
      661 cccgccatcg tggtgaagga ctggtactcg ggccgcacgg atgccggcag cctgtatgag
      721 ctcactgtga ggctgctgtc ggagcatgaa gatgtgctgg cggagttcaa tacgggacag
      781 gtggctgtgc cagaggatgg cagctggatg gagatctccc acactttcac cgactacggg
      841 ccaggcgtcc gctacgtccg cttcgagcac ggagggcagg actcggtcta ctggaagggc
      901 tggttcgggg cccgggtgac caacagtagc gtgtgggtgg aaccctgagg gacctcccct
      961 atccccacca tctgccctct agggcagaat cctggagtag aatggcctta atttagttgg
     1021 tagcgtcctc acctgcctcg tctacgcctt gcacctgcct ctctcccgcc ccttcctcca
     1081 gtctggtccc cgaggggaga gaaggatttg ttgcttttac tgtgggatgg cttccatttg
     1141 catccccatg ggcagtcgct tctagaatgt acgatccgat ccgagggggg aatggggctg
     1201 ctgctggatc ccgcgcacct agcattgtgc ctgcctcaga gtgggcactc aataaatatt
     1261 tgtccaaaga aggcaacaat ggaagcgcag atg
//
