LOCUS       NM_181631               3726 bp    mRNA    linear   ROD 02-JUN-2024
DEFINITION  Rattus norvegicus F-box protein 11 (Fbxo11), mRNA.
ACCESSION   NM_181631
VERSION     NM_181631.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3726)
  AUTHORS   Ma,X.E., Liu,B. and Zhao,C.X.
  TITLE     Modulation of Ca2+-induced Ca2+ release by ubiquitin protein ligase
            E3 component n-recognin UBR3 and 6 in cardiac myocytes
  JOURNAL   Channels (Austin) 14 (1), 326-335 (2020)
   PUBMED   32988261
REFERENCE   2  (bases 1 to 3726)
  AUTHORS   Zhang,Y., Yang,G., He,X., Chen,S., Zhang,F. and Fang,X.
  TITLE     LINC01436, regulating miR-585 and FBXO11, is an oncogenic lncRNA in
            the progression of gastric cancer
  JOURNAL   Cell Biol Int 44 (3), 882-893 (2020)
   PUBMED   31829474
REFERENCE   3  (bases 1 to 3726)
  AUTHORS   Ba,Z., Zhou,Y., Yang,Z., Xu,J. and Zhang,X.
  TITLE     miR-324-5p upregulation potentiates resistance to cisplatin by
            targeting FBXO11 signalling in non-small cell lung cancer cells
  JOURNAL   J Biochem 166 (6), 517-527 (2019)
   PUBMED   31778188
REFERENCE   4  (bases 1 to 3726)
  AUTHORS   Ma,Y., Deng,F., Li,P., Chen,G., Tao,Y. and Wang,H.
  TITLE     The tumor suppressive miR-26a regulation of FBXO11 inhibits
            proliferation, migration and invasion of hepatocellular carcinoma
            cells
  JOURNAL   Biomed Pharmacother 101, 648-655 (2018)
   PUBMED   29518611
REFERENCE   5  (bases 1 to 3726)
  AUTHORS   Sun,C., Tao,Y., Gao,Y., Xia,Y., Liu,Y., Wang,G. and Gu,Y.
  TITLE     F-box protein 11 promotes the growth and metastasis of gastric
            cancer via PI3K/AKT pathway-mediated EMT
  JOURNAL   Biomed Pharmacother 98, 416-423 (2018)
   PUBMED   29278851
REFERENCE   6  (bases 1 to 3726)
  AUTHORS   Duan,S., Cermak,L., Pagan,J.K., Rossi,M., Martinengo,C., di
            Celle,P.F., Chapuy,B., Shipp,M., Chiarle,R. and Pagano,M.
  TITLE     FBXO11 targets BCL6 for degradation and is inactivated in diffuse
            large B-cell lymphomas
  JOURNAL   Nature 481 (7379), 90-93 (2012)
   PUBMED   22113614
REFERENCE   7  (bases 1 to 3726)
  AUTHORS   Ebstein,F., Lange,N., Urban,S., Seifert,U., Kruger,E. and
            Kloetzel,P.M.
  TITLE     Maturation of human dendritic cells is accompanied by functional
            remodelling of the ubiquitin-proteasome system
  JOURNAL   Int J Biochem Cell Biol 41 (5), 1205-1215 (2009)
   PUBMED   19028597
REFERENCE   8  (bases 1 to 3726)
  AUTHORS   Hardisty-Hughes,R.E., Tateossian,H., Morse,S.A., Romero,M.R.,
            Middleton,A., Tymowska-Lalanne,Z., Hunter,A.J., Cheeseman,M. and
            Brown,S.D.
  TITLE     A mutation in the F-box gene, Fbxo11, causes otitis media in the
            Jeff mouse
  JOURNAL   Hum Mol Genet 15 (22), 3273-3279 (2006)
   PUBMED   17035249
REFERENCE   9  (bases 1 to 3726)
  AUTHORS   Cook,J.R., Lee,J.H., Yang,Z.H., Krause,C.D., Herth,N., Hoffmann,R.
            and Pestka,S.
  TITLE     FBXO11/PRMT9, a new protein arginine methyltransferase,
            symmetrically dimethylates arginine residues
  JOURNAL   Biochem Biophys Res Commun 342 (2), 472-481 (2006)
   PUBMED   16487488
REFERENCE   10 (bases 1 to 3726)
  AUTHORS   Nolan,P.M., Peters,J., Strivens,M., Rogers,D., Hagan,J., Spurr,N.,
            Gray,I.C., Vizor,L., Brooker,D., Whitehill,E., Washbourne,R.,
            Hough,T., Greenaway,S., Hewitt,M., Liu,X., McCormack,S.,
            Pickford,K., Selley,R., Wells,C., Tymowska-Lalanne,Z., Roby,P.,
            Glenister,P., Thornton,C., Thaung,C., Stevenson,J.A., Arkell,R.,
            Mburu,P., Hardisty,R., Kiernan,A., Erven,A., Steel,K.P.,
            Voegeling,S., Guenet,J.L., Nickols,C., Sadri,R., Nasse,M.,
            Isaacs,A., Davies,K., Browne,M., Fisher,E.M., Martin,J., Rastan,S.,
            Brown,S.D. and Hunter,J.
  TITLE     A systematic, genome-wide, phenotype-driven mutagenesis programme
            for gene function studies in the mouse
  JOURNAL   Nat Genet 25 (4), 440-443 (2000)
   PUBMED   10932191
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from AY274810.1.
            
            On Jun 17, 2003 this sequence version replaced NM_181631.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AY274810.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMD00132261, SAMD00132262
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..3726
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="6"
                     /map="6q12"
     gene            1..3726
                     /gene="Fbxo11"
                     /gene_synonym="Vit1"
                     /note="F-box protein 11"
                     /db_xref="GeneID:301674"
                     /db_xref="RGD:727935"
     exon            1..126
                     /gene="Fbxo11"
                     /gene_synonym="Vit1"
                     /inference="alignment:Splign:2.1.0"
     CDS             19..2550
                     /gene="Fbxo11"
                     /gene_synonym="Vit1"
                     /note="F-box only protein 11-like"
                     /codon_start=1
                     /product="F-box only protein 11"
                     /protein_id="NP_853662.1"
                     /db_xref="GeneID:301674"
                     /db_xref="RGD:727935"
                     /translation="MVAEESGPGAQNSPYQLRRKTLLPKRTACPTKNSMEGASTSTTE
                     NFGHRAKRARVSGKSQDLSAAPAEQYLQEKLPDEVVLKIFSYLLEQDLCRAACVCKRF
                     SELANDPILWKRLYMEVFEYTRPMMHPEPGKFYQINPEEYEHPNPWKESFQQLYKGAH
                     VKPGFAEHFYSNPARYKGRENMLYYDTIEDALGGVQEAHFDGLIFVHSGIYTDEWIYI
                     ESPITMIGAAPGKVADKVIIENTRDSTFVFMEGSEDAYVGYMTIRFNPDDKSAQHHNA
                     HHCLEITVNCSPIIDHCIIRSTCTVGSAVCVSGQGACPTIKHCNISDCENVGLYITDH
                     AQGIYEDNEISNNALAGIWVKNHGNPIIRRNHIHHGRDVGVFTFDHGMGYFESCNIHR
                     NRIAGFEVKAYANPTVVRCEIHHGQTGGIYVHEKGRGQFIENKIYANNFAGVWITSNS
                     DPTIRGNSIFNGNQGGVYIFGDGRGLIEGNDIYGNALAGIQIRTNSCPIVRHNKIHDG
                     QHGGIYVHEKGQGVIEENEVYSNTLAGVWVTTGSTPVLRRNRIHSGKQVGVYFYDNGH
                     GVLEDNDIYNHMYSGVQIRTGSNPKIRRNKIWGGQNGGILVYNSGLGCIEDNEIFDNA
                     MAGVWIKTDSNPTLRRNKIHDGRDGGICIFNGGRGLLEENDIFRNAQAGVLISTNSHP
                     VLRKNRIFDGFAAGIEITNHATATLEGNQIFNNRFGGLFLASGVNVTMKDNKIMNNQD
                     AIEKAVSRGQCLYKISSYTSYPMHDFYRCHTCNTTDRNAICVNCIKKCHQGHDVEFIR
                     HDRFFCDCGAGTLSNPCTLAGEPTHDTDTLYDSAPPIESNTLQHN"
     exon            127..208
                     /gene="Fbxo11"
                     /gene_synonym="Vit1"
                     /inference="alignment:Splign:2.1.0"
     exon            209..353
                     /gene="Fbxo11"
                     /gene_synonym="Vit1"
                     /inference="alignment:Splign:2.1.0"
     exon            354..483
                     /gene="Fbxo11"
                     /gene_synonym="Vit1"
                     /inference="alignment:Splign:2.1.0"
     exon            484..567
                     /gene="Fbxo11"
                     /gene_synonym="Vit1"
                     /inference="alignment:Splign:2.1.0"
     exon            568..700
                     /gene="Fbxo11"
                     /gene_synonym="Vit1"
                     /inference="alignment:Splign:2.1.0"
     exon            701..807
                     /gene="Fbxo11"
                     /gene_synonym="Vit1"
                     /inference="alignment:Splign:2.1.0"
     exon            808..919
                     /gene="Fbxo11"
                     /gene_synonym="Vit1"
                     /inference="alignment:Splign:2.1.0"
     exon            920..1026
                     /gene="Fbxo11"
                     /gene_synonym="Vit1"
                     /inference="alignment:Splign:2.1.0"
     exon            1027..1164
                     /gene="Fbxo11"
                     /gene_synonym="Vit1"
                     /inference="alignment:Splign:2.1.0"
     exon            1165..1382
                     /gene="Fbxo11"
                     /gene_synonym="Vit1"
                     /inference="alignment:Splign:2.1.0"
     exon            1383..1468
                     /gene="Fbxo11"
                     /gene_synonym="Vit1"
                     /inference="alignment:Splign:2.1.0"
     exon            1469..1563
                     /gene="Fbxo11"
                     /gene_synonym="Vit1"
                     /inference="alignment:Splign:2.1.0"
     exon            1564..1686
                     /gene="Fbxo11"
                     /gene_synonym="Vit1"
                     /inference="alignment:Splign:2.1.0"
     exon            1687..1772
                     /gene="Fbxo11"
                     /gene_synonym="Vit1"
                     /inference="alignment:Splign:2.1.0"
     exon            1773..1849
                     /gene="Fbxo11"
                     /gene_synonym="Vit1"
                     /inference="alignment:Splign:2.1.0"
     exon            1850..1993
                     /gene="Fbxo11"
                     /gene_synonym="Vit1"
                     /inference="alignment:Splign:2.1.0"
     exon            1994..2104
                     /gene="Fbxo11"
                     /gene_synonym="Vit1"
                     /inference="alignment:Splign:2.1.0"
     exon            2105..2212
                     /gene="Fbxo11"
                     /gene_synonym="Vit1"
                     /inference="alignment:Splign:2.1.0"
     exon            2213..2321
                     /gene="Fbxo11"
                     /gene_synonym="Vit1"
                     /inference="alignment:Splign:2.1.0"
     exon            2322..2420
                     /gene="Fbxo11"
                     /gene_synonym="Vit1"
                     /inference="alignment:Splign:2.1.0"
     exon            2421..3726
                     /gene="Fbxo11"
                     /gene_synonym="Vit1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gatgatgttc ctgcagatat ggttgcagaa gaatcaggtc ctggtgcaca aaacagtcca
       61 taccagcttc gtagaaaaac tcttttgcca aaaagaacag cgtgtcctac aaagaacagc
      121 atggagggcg cctctacttc aactacagaa aacttcggcc atcgagcgaa gcgggcaaga
      181 gtgtctggga agtcacaaga tctgtcagca gcacccgctg aacagtatct tcaggagaag
      241 ctaccagatg aagtagtttt aaaaatattc tcttatttgc tggaacaaga tctttgtaga
      301 gctgcttgtg tgtgtaaacg cttcagtgaa cttgctaatg atccaatttt gtggaaacga
      361 ttatatatgg aagtatttga atatacccgg cctatgatgc atcctgaacc tggtaaattc
      421 taccagatta atccagaaga atatgaacat ccaaatccat ggaaagagag ttttcaacag
      481 ttgtataaag gtgcacacgt aaagccggga tttgcggaac atttctatag taatcctgcc
      541 agatacaaag ggagagaaaa catgttgtat tatgatacta ttgaagatgc ccttggcgga
      601 gtacaagaag cacattttga tgggcttatc tttgttcatt ctggaatata tactgatgaa
      661 tggatatata ttgaatctcc aatcactatg attggtgcag cacctgggaa ggttgcagac
      721 aaggtcatca ttgagaacac tagagactcc actttcgttt ttatggaagg ttctgaggac
      781 gcttacgttg gatatatgac aataagattc aaccctgatg acaaatctgc ccagcatcac
      841 aacgcgcacc actgcctaga gatcacagtc aactgcagcc ccattatcga ccactgtatc
      901 atccgaagca catgcacagt tggctctgca gtgtgtgtca gcggtcaggg ggcgtgtccc
      961 actatcaagc attgtaacat cagtgactgt gaaaacgtcg gcctctatat aacagatcat
     1021 gcacagggaa tatatgaaga taatgaaatt tctaataatg cattagctgg gatttgggtt
     1081 aaaaatcatg gaaatccaat tattagacgg aatcacattc atcatggacg tgatgttggt
     1141 gtattcacat ttgatcatgg catgggctac tttgaaagtt gcaacataca cagaaacagg
     1201 atagcaggct ttgaggtaaa agcctacgct aatcccacag tggttcgatg tgaaattcac
     1261 catgggcaga ctggaggaat atatgtccat gagaaaggaa gaggacaatt tatagagaat
     1321 aaaatctatg caaacaactt cgcaggcgta tggattacct caaatagtga cccaacaata
     1381 agggggaatt ctatatttaa tggaaatcaa ggaggagttt acatctttgg tgatggacga
     1441 ggccttatag aaggaaatga catttatggt aatgcgttag caggaattca gattaggaca
     1501 aacagttgtc ctattgttcg acataacaaa attcacgatg gacagcatgg tgggatttat
     1561 gtgcatgaaa agggacaagg tgtaatagaa gaaaatgaag tttacagcaa caccctggct
     1621 ggcgtctggg tgacaactgg cagcacgcca gtactaagaa gaaatcggat acacagtggc
     1681 aagcaggtcg gtgtttattt ctatgacaat ggacatggtg ttctagaaga taacgatatc
     1741 tacaatcata tgtattcagg ggttcagata aggactggaa gcaaccccaa aattagaaga
     1801 aacaaaattt ggggaggaca aaatggtgga attctagttt ataattctgg tctaggctgt
     1861 atagaagaca atgaaatctt cgacaacgca atggctggcg tctggattaa aacagacagc
     1921 aatcctacgc tgagacggaa taaaatccac gatggaaggg atggcggcat ctgtatattt
     1981 aatgggggtc gaggtctcct tgaagaaaat gatattttca ggaacgctca agcaggtgtt
     2041 cttatcagca ccaacagtca tccagtctta agaaaaaaca gaatattcga tggatttgct
     2101 gcaggtattg aaattacaaa tcatgcaact gcaacactag aaggcaatca gatttttaac
     2161 aacagatttg gaggcttatt tttagcatct ggtgttaacg tgacaatgaa agataacaag
     2221 ataatgaaca atcaagatgc catagaaaag gctgttagta gaggacaatg tttatataaa
     2281 atatcaagtt ataccagcta tcccatgcat gacttctaca gatgtcatac ttgtaacacc
     2341 acagatcgaa atgccatatg tgtgaactgc attaagaagt gccatcaggg acatgatgta
     2401 gagttcatta gacatgatag gtttttctgt gactgtggtg ctggaacact gtccaatcct
     2461 tgtacattag ctggtgagcc aacacatgat acagacacac tatatgactc tgccccacct
     2521 atagagtcta atacgttgca gcacaactga actccttccc taagaaaaag tcctgccatc
     2581 ctaacataac ttaaaacatc ttttggaaga taaaatactt gcccatgcta cagaaagaga
     2641 ctgtactgaa aaaatggaca cacaaggtca gttgacacta tgaagctcaa gctaccaaaa
     2701 agaaagtggc aatatattga ctcaggatct caaggctggg tattttagca ttactgtgta
     2761 aagactttga agggacagaa gtgaagaaat aagctgcagt tttgtacaga tgccaacctc
     2821 tggaaagctg gtgttgttac agctagcatc gaatgcagtc tgacttgcag tagtgacctt
     2881 caacagactt cagctttgtc gctgccgtta tggacatggg taccaattgc ttttgtaata
     2941 tggtaaatgt gagctagcac ttctgcattg atttttttta acatgtattc agattgagaa
     3001 tatgatttta atgctttaat ctcatgtagt ttgtttttaa tttcaagcca atcttattgt
     3061 acttgaatgt gccctgtttt gttagcacac ctagacttgc tgtaactgta ctcatgtccc
     3121 agatgtacgt tctttctatg aaagagaaaa acactaatct taaattatat ccagcaatgt
     3181 ttctggtatc ctttaagaaa agttaagact attatttcct tccctttcct gtgcagcatt
     3241 caaaaaaaaa aaaaatcacc cctagaaaaa gtgagtgttt taatgagact tcctaggaag
     3301 ggatgcactg taaaacaaaa gtattcttgt atctcagttt tgtgaaaggt aaaaactact
     3361 atgttttaaa gtacacttta gaaagtctct tcaaaacagt cctgtatttg aactctgttc
     3421 atagttttta tttgaacagt ttagacaaaa cagctggaaa ttacggcaat ttcctgcatt
     3481 aagctgagac cagtatatat gcagctctat acagtttcat agcgcccccc cccatttatg
     3541 tgtattggtg acagtgggta taaacagcct gaaagtgtat gcatgtacca taacatctag
     3601 acttaatata ttgtggagta ttcaataacc attatgtaga aggtagataa gaattaaaag
     3661 ggtttaattt cctagaaaga aaatggaaaa atggtcattt ttaaaaaata aagtttatta
     3721 gatcat
//
